Full Text Journal Articles by
Author Thomas M Gress

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The German National Case Collection for Familial Pancreatic Carcinoma (FaPaCa)—Knowledge Gained in 20 Years.

Detlef Klaus Bartsch, Elvira Matthäi, Ioannis Mintziras, Christian Bauer, Jens Figiel, Mercede Sina-Boemers, Thomas M Gress, Peter Langer, Emily P Slater,

<h4>Background</h4>Familial pancreatic carcinoma (FPC) is a rare hereditary tumor syndrome with a heterogeneous clinical phenotype. The study of FPC also contributes to a better understanding of the more common sporadic pancreatic ductal adenocarcinoma (PDAC). We report on the past 20 years' experience of the German National Case Collection for Familial ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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Unraveling the Molecular Tumor-Promoting Regulation of Cofilin-1 in Pancreatic Cancer.

Silke D Werle, Julian D Schwab, Marina Tatura, Sandra Kirchhoff, Robin Szekely, Ramona Diels, Nensi Ikonomi, Bence Sipos, Jan Sperveslage, Thomas M Gress, Malte Buchholz, Hans A Kestler,

Cofilin-1 (CFL1) overexpression in pancreatic cancer correlates with high invasiveness and shorter survival. Besides a well-documented role in actin remodeling, additional cellular functions of CFL1 remain poorly understood. Here, we unraveled molecular tumor-promoting functions of CFL1 in pancreatic cancer. For this purpose, we first show that a knockdown of CFL1 ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(4):]

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The POLD1R689W variant increases the sensitivity of colorectal cancer cells to ATR and CHK1 inhibitors.

Albert Job, Marina Tatura, Cora Schäfer, Veronika Lutz, Hanna Schneider, Brigitte Lankat-Buttgereit, Alexandra Zielinski, Kerstin Borgmann, Christian Bauer, Thomas M Gress, Malte Buchholz, Eike Gallmeier,

Inhibition of the kinase ATR, a central regulator of the DNA damage response, eliminates subsets of cancer cells in certain tumors. As previously shown, this is at least partly attributable to synthetic lethal interactions between ATR and POLD1, the catalytic subunit of the polymerase δ. Various POLD1 variants have been ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18924]

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The Immune Microenvironment in Pancreatic Cancer.

Magdalena Huber, Corinna U Brehm, Thomas M Gress, Malte Buchholz, Bilal Alashkar Alhamwe, Elke Pogge von Strandmann, Emily P Slater, Jörg W Bartsch, Christian Bauer, Matthias Lauth,

The biology of solid tumors is strongly determined by the interactions of cancer cells with their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) represents a paradigmatic example for the multitude of possible tumor-stroma interactions. PDAC has proven particularly refractory to novel immunotherapies, which is a fact ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(19):]

Cited: 1 time

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International consensus guidelines on interventional endoscopy in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.

Masayuki Kitano, Thomas M Gress, Pramod K Garg, Takao Itoi, Atsushi Irisawa, Hiroyuki Isayama, Atsushi Kanno, Kei Takase, Michael Levy, Ichiro Yasuda, Phillipe Lévy, Shuiji Isaji, Carlos Fernandez-Del Castillo, Asbjørn M Drewes, Andrea R G Sheel, John P Neoptolemos, Tooru Shimosegawa, Marja Boermeester, C Mel Wilcox, David C Whitcomb,

BACKGROUND/OBJECTIVES:This paper is part of the international consensus guidelines on chronic pancreatitis, presenting for interventional endoscopy. METHODS:An international working group with experts on interventional endoscopy evaluated 26 statements generated from evidence on 9 clinically relevant questions. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to evaluate the ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2020, 20(6):1045-1055]

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Long-term outcome of surgical resection in patients with gastroenteropancreatic neuroendocrine neoplasia: results from a German nation-wide multi-centric registry.

Nehara Begum, Sebastian Maasberg, Andreas Pascher, Ursula Plöckinger, Thomas M Gress, Christine Wurst, Frank Weber, Andreas Raffel, Markus Krausch, Katharina Holzer, Detlef K Bartsch, Thomas J Musholt, Tobias Keck, Martin Anlauf, Anja Rinke, Ulrich-Frank Pape, Peter E Goretzki, ,

BACKGROUND:Neuroendocrine neoplasia (NEN) are rare and heterogenous tumours. Few data exist on the impact of surgical therapy. MATERIALS AND METHODS:This is a retrospective analysis of prospectively collected data of gastroenteropancreatic NEN in the German NET-Registry (1999-2012). It focuses on patients without distant metastases (limited disease, LD, stage I-IIIB). RESULTS:Data of ... Read more >>

Langenbecks Arch Surg (Langenbeck's archives of surgery)
[2020, 405(2):145-154]

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Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses.

Esther Molina-Montes, Claudia Coscia, Paulina Gómez-Rubio, Alba Fernández, Rianne Boenink, Marta Rava, Mirari Márquez, Xavier Molero, Matthias Löhr, Linda Sharp, Christoph W Michalski, Antoni Farré, José Perea, Michael O'Rorke, William Greenhalf, Mar Iglesias, Adonina Tardón, Thomas M Gress, Victor M Barberá, Tatjana Crnogorac-Jurcevic, Luis Muñoz-Bellvís, J Enrique Dominguez-Muñoz, Harald Renz, Joaquim Balcells, Eithne Costello, Lucas Ilzarbe, Jörg Kleeff, Bo Kong, Josefina Mora, Damian O'Driscoll, Ignasi Poves, Aldo Scarpa, Jingru Yu, Manuel Hidalgo, Rita T Lawlor, Weimin Ye, Alfredo Carrato, Francisco X Real, Núria Malats, ,

<h4>Objectives</h4>To characterise the association between type 2 diabetes mellitus (T2DM) subtypes (new-onset T2DM (NODM) or long-standing T2DM (LSDM)) and pancreatic cancer (PC) risk, to explore the direction of causation through Mendelian randomisation (MR) analysis and to assess the mediation role of body mass index (BMI).<h4>Design</h4>Information about T2DM and related factors ... Read more >>

Gut (Gut)
[2021, 70(2):319-329]

Cited: 1 time

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Microenvironmental Determinants of Pancreatic Cancer.

Elisabeth Hessmann, Soeren M Buchholz, Ihsan Ekin Demir, Shiv K Singh, Thomas M Gress, Volker Ellenrieder, Albrecht Neesse,

Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment (TME) that dynamically evolves during tumor progression. The TME consists of different non-neoplastic cells such as cancer-associated fibroblasts, immune cells, endothelial cells, and neurons. Furthermore, abundant ... Read more >>

Physiol Rev (Physiological reviews)
[2020, 100(4):1707-1751]

Cited: 4 times

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Radical intended surgery for highly selected stage IV neuroendocrine neoplasms G3.

Elettra Merola, Massimo Falconi, Anja Rinke, Stefan Staettner, Felix Krendl, Stefano Partelli, Valentina Andreasi, Thomas M Gress, Andreas Pascher, Ruza Arsenic, Claudio Doglioni, Daniel Kaemmerer, Bertram Wiedenmann, Marianne E Pavel,

<h4>Background</h4>Stage IV gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) G3 are the NENs with the worst prognosis. According to ENETS guidelines, platinum-based chemotherapy is the standard treatment for this population. Surgery is only considered in highly selected "resectable" NENs with usually lower Ki67. However, the role of surgery with curative intent has been ... Read more >>

Am J Surg (American journal of surgery)
[2020, 220(2):284-289]

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Correction: Interaction between somatostatin analogues and targeted therapies in neuroendocrine tumor cells.

Sebastian Krug, Jan-Philipp Mordhorst, Fabian Moser, Katharina Theuerkorn, Claudia Ruffert, Maren Egidi, Anja Rinke, Thomas M Gress, Patrick Michl,

[This corrects the article DOI: 10.1371/journal.pone.0218953.]. ... Read more >>

PLoS One (PloS one)
[2020, 15(2):e0228905]

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Safety of Prophylactic Gastrostomy Tube Placement and Gastrostomy Tube Usage in Patients Treated by Radio(chemo)therapy for Head and Neck Cancer.

Hannah L Sieron, Fabian Eberle, Thomas M Gress, Andreas H Mahnken, Susanne Wiegand,

BACKGROUND:A gastrostomy feeding tube is one method for long-term feeding support in patients undergoing radio(chemo)therapy for head and neck cancer (HNC). The aim of this study was to analyze the safety of prophylactic gastrostomy tube placement and usage in HNSCC patients. PATIENTS AND METHODS:HNC patients undergoing percutaneous endoscopic gastrostomy (PEG) ... Read more >>

Anticancer Res (Anticancer research)
[2020, 40(2):1167-1173]

Cited: 1 time

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Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships.

Esther Molina-Montes, Lisa Van Hoogstraten, Paulina Gomez-Rubio, Matthias Löhr, Linda Sharp, Xavier Molero, Mirari Márquez, Christoph W Michalski, Antoni Farré, José Perea, Michael O'Rorke, William Greenhalf, Lucas Ilzarbe, Adonina Tardon, Thomas M Gress, Victor M Barberà, Tatjana Crnogorac-Jurcevic, Luis Muñoz-Bellvis, Enrique Domínguez-Muñoz, Joaquim Balsells, Eithne Costello, Mar Iglesias, Jorg Kleeff, Bo Kong, Josefina Mora, Damian O'Driscoll, Ignasi Poves, Aldo Scarpa, Jingru Yu, Weimin Ye, Manuel Hidalgo, Alfredo Carrato, Rita Lawlor, Francisco X Real, Nuria Malats, ,

BACKGROUND:Despite smoking being a well-established risk factor for pancreatic cancer, there is a need to further characterize pancreatic cancer risk according to lifespan smoking patterns and other smoking features, such as tobacco type. Our aim was to deeply investigate them within a large European case-control study. METHODS:Tobacco smoking habits and ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2020, 29(5):1009-1018]

Cited: 4 times

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Surgery with Radical Intent: Is There an Indication for G3 Neuroendocrine Neoplasms?

Elettra Merola, Anja Rinke, Stefano Partelli, Thomas M Gress, Valentina Andreasi, Attila Kollár, Aurel Perren, Emanuel Christ, Francesco Panzuto, Andreas Pascher, Henning Jann, Ruza Arsenic, Birgit Cremer, Daniel Kaemmerer, Patrizia Kump, Rainer W Lipp, Abbas Agaimy, Bertram Wiedenmann, Massimo Falconi, Marianne E Pavel,

<h4>Background</h4>While platinum-based chemotherapy represents the standard treatment for advanced grade 3 (G3) neuroendocrine neoplasms (NENs) according to the European Neuroendocrine Tumor Society guidelines, the role of radical-intended surgery in these patients, as well as the use of adjuvant chemotherapy, are still controversial. The aim of the present work is to ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2020, 27(5):1348-1355]

Cited: 3 times

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Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium.

Michael Goggins, Kasper Alexander Overbeek, Randall Brand, Sapna Syngal, Marco Del Chiaro, Detlef K Bartsch, Claudio Bassi, Alfredo Carrato, James Farrell, Elliot K Fishman, Paul Fockens, Thomas M Gress, Jeanin E van Hooft, R H Hruban, Fay Kastrinos, Allison Klein, Anne Marie Lennon, Aimee Lucas, Walter Park, Anil Rustgi, Diane Simeone, Elena Stoffel, Hans F A Vasen, Djuna L Cahen, Marcia Irene Canto, Marco Bruno, ,

BACKGROUND AND AIM:The International Cancer of the Pancreas Screening Consortium met in 2018 to update its consensus recommendations for the management of individuals with increased risk of pancreatic cancer based on family history or germline mutation status (high-risk individuals). METHODS:A modified Delphi approach was employed to reach consensus among a ... Read more >>

Gut (Gut)
[2020, 69(1):7-17]

Cited: 11 times

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Author Correction: TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression.

Silvia Ottaviani, Justin Stebbing, Adam E Frampton, Sladjana Zagorac, Jonathan Krell, Alexander de Giorgio, Sara M Trabulo, Van T M Nguyen, Luca Magnani, Hugang Feng, Elisa Giovannetti, Niccola Funel, Thomas M Gress, Long R Jiao, Ylenia Lombardo, Nicholas R Lemoine, Christopher Heeschen, Leandro Castellano,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):3738]

Cited: 1 time

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Interaction between somatostatin analogues and targeted therapies in neuroendocrine tumor cells.

Sebastian Krug, Jan-Philipp Mordhorst, Fabian Moser, Katharina Theuerkorn, Claudia Ruffert, Maren Egidi, Anja Rinke, Thomas M Gress, Patrick Michl,

Somatostatin analogues (SSA) represent the standard of care for symptom control in patients with functional gastro-entero-pancreatic neuroendocrine tumors (GEP-NET). In addition, SSA exert significant anti-proliferative effects in mid-gut and pancreatic NET (PanNET). In parallel, molecularly targeted therapies (MTT) have been shown to improve progression free survival (PFS) in patients with ... Read more >>

PLoS One (PloS one)
[2019, 14(6):e0218953]

Cited: 1 time

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Controversies on the endoscopic and surgical management of pain in patients with chronic pancreatitis: pros and cons!

Asbjørn Mohr Drewes, Marinus A Kempeneers, Dana K Andersen, Lars Arendt-Nielsen, Marc G Besselink, Marja A Boermeester, Stefan Bouwense, Marco Bruno, Martin Freeman, Thomas M Gress, Jeanin E van Hooft, Bart Morlion, Søren Schou Olesen, Hjalmar van Santvoort, Vikesh Singh, John Windsor,

Gut (Gut)
[2019, 68(8):1343-1351]

Cited: 4 times

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Testing of Helicobacter pylori by Endoscopic Biopsy: The Clinical Dilemma of Suppressive Conditions.

Richard F Knoop, Golo Petzold, Ahmad Amanzada, Sebastian C B Bremer, Thomas M Gress, Volker Ellenrieder, Albrecht Neesse, Steffen Kunsch,

<h4>Background and aims</h4>Testing for Helicobacter pylori is frequently conducted during esophagogastroduodenoscopy (EGD). Suppressive conditions such as the intake of proton-pump inhibitors (PPIs), preceded antibiotic treatment or recent upper gastrointestinal bleeding impair H. pylori test quality. The aim of our study was to evaluate the frequency and pattern of H. pylori ... Read more >>

Digestion (Digestion)
[2020, 101(5):552-556]

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Brain metastases in patients with neuroendocrine neoplasms: risk factors and outcome.

Sebastian Krug, Freya Teupe, Patrick Michl, Thomas M Gress, Anja Rinke,

<h4>Background</h4>Brain metastases (BM) are rarely reported in patients with neuroendocrine carcinoma (NEC) of non-lung origin and neuroendocrine tumors (NET) of the gastroenteropancreatic (GEP) or bronchopulmonary system. However, symptomatic brain metastases are associated with dismal prognosis, so early detection and treatment could be advisable.<h4>Methods</h4>We retrospectively analyzed 51 patients with GEP-NEN and ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):362]

Cited: 1 time

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Therapeutic targeting of tumor-associated macrophages in pancreatic neuroendocrine tumors.

Sebastian Krug, Rami Abbassi, Heidi Griesmann, Bence Sipos, Dominik Wiese, Peter Rexin, Annika Blank, Aurel Perren, Johannes Haybaeck, Stefan Hüttelmaier, Anja Rinke, Thomas M Gress, Patrick Michl,

Pancreatic neuroendocrine tumors (PNETs) represent a heterogeneous group of neuroendocrine neoplasms with varying biological behavior and response to treatment. Although targeted therapies have been shown to improve the survival for patients at advanced stage, resistance to current therapies frequently occurs during the course of therapy. Previous reports indicate that the ... Read more >>

Int J Cancer (International journal of cancer)
[2018, 143(7):1806-1816]

Cited: 5 times

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DYRK1B regulates Hedgehog-induced microtubule acetylation.

Rajeev Singh, Philipp Simon Holz, Katrin Roth, Anna Hupfer, Wolfgang Meissner, Rolf Müller, Malte Buchholz, Thomas M Gress, Hans-Peter Elsässer, Ralf Jacob, Matthias Lauth,

The posttranslational modification (PTM) of tubulin subunits is important for the physiological functions of the microtubule (MT) cytoskeleton. Although major advances have been made in the identification of enzymes carrying out MT-PTMs, little knowledge is available on how intercellular signaling molecules and their associated pathways regulate MT-PTM-dependent processes inside signal-receiving ... Read more >>

Cell Mol Life Sci (Cellular and molecular life sciences : CMLS)
[2019, 76(1):193-207]

Cited: 3 times

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High Prevalence of Pathological Hydrogen Breath Tests in Patients with Functional Dyspepsia.

Golo Petzold, Ahmad Amanzada, Thomas M Gress, Volker Ellenrieder, Albrecht Neesse, Steffen Kunsch,

<h4>Background/aims</h4>The aim of the study is to investigate the frequency of pathological hydrogen breath tests (HBT) in patients with clinical features of functional dyspepsia (FD) meeting the Rome criteria and normal testing of upper endoscopy and abdominal sonography.<h4>Methods</h4>We retrospectively included patients who underwent HBT (lactose, fructose, or glucose) between 2006 ... Read more >>

Digestion (Digestion)
[2019, 100(3):186-191]

Cited: 1 time

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Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors.

Albert Job, Lisa-Maria Schmitt, Lisa von Wenserski, Brigitte Lankat-Buttgereit, Thomas M Gress, Malte Buchholz, Eike Gallmeier,

The phosphoinositide 3-kinase-related kinase ATR is a central regulator of the DNA damage response. Its chemical inhibition eliminates subsets of cancer cells in various tumor types. This effect is caused at least partly by the synthetically lethal relationship between ATR and certain DNA repair genes. In a previous screen using ... Read more >>

Neoplasia (Neoplasia (New York, N.Y.))
[2018, 20(11):1135-1143]

Cited: 3 times

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Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

Albrecht Neesse, Christian Alexander Bauer, Daniel Öhlund, Matthias Lauth, Malte Buchholz, Patrick Michl, David A Tuveson, Thomas M Gress,

Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote tumour progression, metastasis niche formation and therapeutic resistance. Intensive research of recent years has revealed an incredible heterogeneity and complexity of the different components ... Read more >>

Gut (Gut)
[2019, 68(1):159-171]

Cited: 42 times

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Smoking and bone mineral density: comprehensive analyses of the third National Health and Nutrition Examination Survey (NHANES III).

Dominik Strozyk, Thomas M Gress, Lutz P Breitling,

Some questions remain on the relationship between smoking and bone health. Detailed analyses of the relationship between smoking and BMD are presented, essentially ruling out non-linear associations as an explanation for inconsistent results in the literature. INTRODUCTION:To provide comprehensive multiple regression and dose-response analyses of the association between smoking behavior ... Read more >>

Arch Osteoporos (Archives of osteoporosis)
[2018, 13(1):16]

Cited: 4 times

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