Full Text Journal Articles by
Author Thomas Kirchner

Advertisement

Find full text journal articles






Electronic cigarettes as a harm reduction strategy among patients with COPD: protocol for an open-label two arm randomized controlled pilot trial.

Elizabeth R Stevens, Lei Lei, Charles M Cleland, Mahathi Vojjala, Omar El-Shahawy, Kenneth I Berger, Thomas R Kirchner, Scott E Sherman,

<h4>Background</h4>Smoking cessation is the most effective means of slowing the decline of lung function associated with chronic obstructive pulmonary disease (COPD). While effective smoking cessation treatments are available, they are underutilized and nearly half of people with COPD continue to smoke. By addressing both nicotine and behavioral dependence, electronic cigarettes ... Read more >>

Addict Sci Clin Pract (Addiction science & clinical practice)
[2022, 17(1):2]

Cited: 0 times

View full text PDF listing >>



Therapy-Related Transcriptional Subtypes in Matched Primary and Recurrent Head and Neck Cancer.

Peter Weber, Axel Künstner, Julia Hess, Kristian Unger, Sebastian Marschner, Christian Idel, Julika Ribbat-Idel, Philipp Baumeister, Olivier Gires, Christoph Walz, Sibylle Rietzler, Laura Valeanu, Timm Herkommer, Lisa Kreutzer, Olena Klymenko, Guido Drexler, Thomas Kirchner, Cornelius Maihöfer, Ute Ganswindt, Axel Walch, Michael Sterr, Heiko Lickert, Martin Canis, Dirk Rades, Sven Perner, Mauricio Berriel Diaz, Stefan Herzig, Kirsten Lauber, Barbara Wollenberg, Hauke Busch, Claus Belka, Horst Zitzelsberger,

<h4>Purpose</h4>The genetic relatedness between primary and recurrent head and neck squamous cell carcinomas (HNSCC) reflects the extent of heterogeneity and therapy-driven selection of tumor subpopulations. Yet, current treatment of recurrent HNSCC ignores the molecular characteristics of therapy-resistant tumor populations.<h4>Experimental design</h4>From 150 tumors, 74 primary HNSCCs were RNA sequenced and 38 ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma.

Florencia Cidre-Aranaz, Jing Li, Tilman L B Hölting, Martin F Orth, Roland Imle, Stefanie Kutschmann, Giulia Ammirati, Katharina Ceranski, Martha Julia Carreño-Gonzalez, Merve Kasan, Aruna Marchetto, Cornelius M Funk, Felix Bestvater, Simone Bersini, Chiara Arrigoni, Matteo Moretti, Uwe Thiel, Daniel Baumhoer, Felix Sahm, Stefan M Pfister, Wolfgang Hartmann, Uta Dirksen, Laura Romero-Pérez, Ana Banito, Shunya Ohmura, Julian Musa, Thomas Kirchner, Maximilian M L Knott, Thomas G P Grünewald,

Mol Cancer (Molecular cancer)
[2022, 21(1):1]

Cited: 0 times

View full text PDF listing >>



Rab31-dependent regulation of transforming growth factor ß expression in breast cancer cells.

Susanne Soelch, Nathalie Beaufort, Daniela Loessner, Matthias Kotzsch, Ute Reuning, Thomas Luther, Thomas Kirchner, Viktor Magdolen,

<h4>Background</h4>The small GTP-binding protein Rab31 plays an important role in the modulation of tumor biological-relevant processes, including cell proliferation, adhesion, and invasion. As an underlying mechanism, Rab31 is presumed to act as a molecular switch between a more proliferative and an invasive phenotype. This prompted us to analyze whether Rab31 ... Read more >>

Mol Med (Molecular medicine (Cambridge, Mass.))
[2021, 27(1):158]

Cited: 0 times

View full text PDF listing >>



EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma

Kai Voeltzke, Katerina Scharov, Cornelius Funk, Alisa Kahler, Daniel Picard, Laura Hauffe, Martin Orth, Marc Remke, Irene Esposito, Thomas Kirchner, Alexander Schramm, Barak Rotblat, Thomas Grünewald, Guido Reifenberger, Gabriel Leprivier,

<h4>ABSTRACT</h4> <h4>Background</h4> Neuroblastoma (NB) accounts for 15% of cancer-related deaths in childhood despite considerable therapeutic improvements. While several risk factors, including MYCN amplification and alterations in RAS and p53 pathway genes, have been defined in NB, the clinical outcome is very variable and difficult to predict. Since genes of the ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Expression of CIB1 correlates with colorectal liver metastases but not with peritoneal carcinomatosis.

Sven Jacob, Florian Bösch, Markus B Schoenberg, Elise Pretzsch, Christopher Lampert, Ren Haoyu, Bernhard W Renz, Marlies Michl, Jörg Kumbrink, Thomas Kirchner, Jens Werner, Martin K Angele, Jens Neumann,

<h4>Background</h4>Molecular differences in colorectal cancer (CRC) are associated with the metastatic route. Patient survival is mainly driven by metastatic spread thus it is imperative to understand its key drivers to develop biomarkers for risk stratification, follow-up protocols and personalized therapy. Thus, this study aimed to identify genes associated with the ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):1243]

Cited: 0 times

View full text PDF listing >>



Novel Multimodal Management of Post-Partum Synchronous Metastatic Pulmonary EBV-Associated Lymphoepithelioma-Like Carcinoma (LELC)-A Case Report.

Montserrat Pazos, Chukwuka Eze, Kathrin Kahnert, Maria Delius, Amanda Tufman, Irene Alba-Alejandre, Marcus Unterrainer, Jens Neumann, Thomas Kirchner, Farkhad Manapov,

Primary Epstein-Barr-Virus (EBV)-associated pulmonary lymphoepithelioma-like carcinoma (LELC) is an aggressive rare cancer. Higher incidences have been observed in Asian sub-populations. Multimodal treatment paradigms have emerged as promising novel strategies in the management of advanced NSCLC. In this report, we describe the case of a 34-year-old female patient of Asian origin ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(11):]

Cited: 0 times

View full text PDF listing >>



p130Cas Is Correlated with EREG Expression and a Prognostic Factor Depending on Colorectal Cancer Stage and Localization Reducing FOLFIRI Efficacy.

Jörg Kumbrink, Pan Li, Agnes Pók-Udvari, Frederick Klauschen, Thomas Kirchner, Andreas Jung,

p130 Crk-associated substrate (p130Cas) is associated with poor prognosis and treatment resistance in breast and lung cancers. To elucidate p130Cas functional and clinical role in colorectal cancer (CRC) progression/therapy resistance, we performed cell culture experiments and bioinformatic/statistical analyses of clinical data sets. p130Cas expression was associated with poor survival in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(22):]

Cited: 0 times

View full text PDF listing >>



Tumor DNA-methylome derived epigenetic fingerprint identifies HPV-negative head and neck patients at risk for locoregional recurrence after postoperative radiochemotherapy.

Bouchra Tawk, Ute Wirkner, Christian Schwager, Katrin Rein, Karim Zaoui, Philippe A Federspil, Sebastian Adeberg, Annett Linge, Ute Ganswindt, Julia Hess, Kristian Unger, Ingeborg Tinhofer, Volker Budach, Fabian Lohaus, Mechthild Krause, Maja Guberina, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca L Grosu, Henning Schäfer, Daniel Zips, Stephanie E Combs, Steffi Pigorsch, Horst Zitzelsberger, Philipp Baumeister, Thomas Kirchner, Melanie Bewerunge-Hudler, Wilko Weichert, Jochen Hess, Esther Herpel, Claus Belka, Michael Baumann, Jürgen Debus, Amir Abdollahi, ,

Biomarkers with relevance for loco-regional therapy are needed in human papillomavirus negative aka HPV(-) head and neck squamous cell carcinoma (HNSCC). Based on the premise that DNA methylation pattern is highly conserved, we sought to develop a reliable and robust methylome-based classifier identifying HPV(-) HNSCC patients at risk for loco-regional ... Read more >>

Int J Cancer (International journal of cancer)
[2022, 150(4):603-616]

Cited: 0 times

View full text PDF listing >>



Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer.

Sophie L Boos, Leon P Loevenich, Sebastian Vosberg, Thomas Engleitner, Rupert Öllinger, Jörg Kumbrink, Matjaz Rokavec, Marlies Michl, Philipp A Greif, Andreas Jung, Heiko Hermeking, Jens Neumann, Thomas Kirchner, Roland Rad, Peter Jung,

<h4>Background & aims</h4>Patient-derived tumor organoids recapitulate the characteristics of colorectal cancer (CRC) and provide an ideal platform for preclinical evaluation of personalized treatment options. We aimed to model the acquisition of chemotolerance during first-line combination chemotherapy in metastatic CRC organoids.<h4>Methods</h4>We performed next-generation sequencing to study the evolution of KRAS wild-type ... Read more >>

Cell Mol Gastroenterol Hepatol (Cellular and molecular gastroenterology and hepatology)
[2022, 13(2):517-540]

Cited: 0 times

View full text PDF listing >>



The association of immunosurveillance and distant metastases in colorectal cancer.

Sven Jacob, Vindi Jurinovic, Christopher Lampert, Elise Pretzsch, Jörg Kumbrink, Jens Neumann, Ren Haoyu, Bernhard W Renz, Thomas Kirchner, Markus O Guba, Jens Werner, Martin K Angele, Florian Bösch,

<h4>Background</h4>Colorectal cancer (CRC) is the third most common malignancy worldwide, but the key driver to distant metastases is still unknown. This study aimed to elucidate the link between immunosurveillance and organotropism of metastases in CRC by evaluating different gene signatures and pathways.<h4>Material and methods</h4>CRC patients undergoing surgery at the Department ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2021, 147(11):3333-3341]

Cited: 0 times

View full text PDF listing >>



Consensus molecular subtypes in metastatic colorectal cancer treated with sequential versus combined fluoropyrimidine, bevacizumab and irinotecan (XELAVIRI trial).

Arndt Stahler, Volker Heinemann, Veronika Schuster, Kathrin Heinrich, Annika Kurreck, Clemens Gießen-Jung, Ludwig Fischer von Weikersthal, Florian Kaiser, Thomas Decker, Swantje Held, Ullrich Graeven, Ingo Schwaner, Claudio Denzlinger, Michael Schenk, Jens Neumann, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Sebastian Stintzing, Dominik P Modest,

<h4>Background</h4>The XELAVIRI trial compared sequential (fluoropyrimidine and bevacizumab; irinotecan (Iri) at progression) versus initial combination therapy (fluoropyrimidine, bevacizumab, Iri) of treatment-naïve metastatic colorectal cancer (mCRC). In the confirmatory analysis, the primary end-point (non-inferiority of sequential therapy regarding time to failure of strategy, TFS) was not met. Nevertheless, significant differences regarding ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 157:71-80]

Cited: 1 time

View full text PDF listing >>



MSI testing : What's new? What should be considered?

Josef Rüschoff, Gustavo Baretton, Hendrik Bläker, Wolfgang Dietmaier, Manfred Dietel, Arndt Hartmann, Lars-Christian Horn, Korinna Jöhrens, Thomas Kirchner, Ruth Knüchel, Doris Mayr, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Peter Schirmacher, Markus Tiemann, Katharina Tiemann, Wilko Weichert, Reinhard Büttner,

Based on new trial data regarding immune checkpoint inhibitors (ICIs), the detection of high-grade microsatellite instability (MSI-H) or underlying deficient mismatch repair protein (dMMR) is now becoming increasingly important for predicting treatment response. For the first time, a PD‑1 ICI (pembrolizumab) has been approved by the European Medicines Agency (EMA) for ... Read more >>

Pathologe (Der Pathologe)
[2021, 42(Suppl 1):110-118]

Cited: 0 times

View full text PDF listing >>



Correction: Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer - translational results from the AIO-PK0104 Phase 3 study.

Michael Guenther, Michael Haas, Volker Heinemann, Stephan Kruger, Christoph Benedikt Westphalen, Michael von Bergwelt-Baildon, Julia Mayerle, Jens Werner, Thomas Kirchner, Stefan Boeck, Steffen Ormanns,

Br J Cancer (British journal of cancer)
[2021, 125(3):466]

Cited: 0 times

View full text PDF listing >>



Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma.

Shunya Ohmura, Aruna Marchetto, Martin F Orth, Jing Li, Susanne Jabar, Andreas Ranft, Endrit Vinca, Katharina Ceranski, Martha J Carreño-Gonzalez, Laura Romero-Pérez, Fabienne S Wehweck, Julian Musa, Felix Bestvater, Maximilian M L Knott, Tilman L B Hölting, Wolfgang Hartmann, Uta Dirksen, Thomas Kirchner, Florencia Cidre-Aranaz, Thomas G P Grünewald,

Mol Cancer (Molecular cancer)
[2021, 20(1):97]

Cited: 1 time

View full text PDF listing >>



Multiple illumination learned spectral decoloring for quantitative optoacoustic oximetry imaging.

Thomas Kirchner, Martin Frenz,

<h4>Significance</h4>Quantitative measurement of blood oxygen saturation (sO2) with optoacoustic (OA) imaging is one of the most sought after goals of quantitative OA imaging research due to its wide range of biomedical applications.<h4>Aim</h4>A method for accurate and applicable real-time quantification of local sO2 with OA imaging.<h4>Approach</h4>We combine multiple illumination (MI) sensing ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2021, 26(8):]

Cited: 0 times

View full text PDF listing >>



Mutational profiles of metastatic colorectal cancer treated with FOLFIRI plus cetuximab or bevacizumab before and after secondary resection (AIO KRK 0306; FIRE-3).

Arndt Stahler, Volker Heinemann, Julian Walter Holch, Jobst Christian von Einem, Christoph Benedikt Westphalen, Kathrin Heinrich, Laura Schlieker, Ivan Jelas, Annabel Helga Sophie Alig, Laura Elisabeth Fischer, Lena Weiss, Dominik Paul Modest, Ludwig Fischer von Weikersthal, Thomas Decker, Alexander Kiani, Markus Moehler, Florian Kaiser, Thomas Kirchner, Andreas Jung, Sebastian Stintzing,

Secondary resection of metastases is recommended in metastatic colorectal cancer (mCRC). Data describing changes in mutational profiles of corresponding primary tumor and metastatic tissue after conversion treatment are limited. Next generation sequencing was performed in formalin-fixed mCRC samples from patients of the FIRE-3 trial (FOLFIRI plus cetuximab or bevacizumab) before ... Read more >>

Int J Cancer (International journal of cancer)
[2021, 149(11):1935-1943]

Cited: 0 times

View full text PDF listing >>



Status quo of ALK testing in lung cancer: results of an EQA scheme based on in-situ hybridization, immunohistochemistry, and RNA/DNA sequencing.

Philipp Jurmeister, Claudia Vollbrecht, Korinna Jöhrens, Daniela Aust, Anke Behnke, Albrecht Stenzinger, Roland Penzel, Volker Endris, Peter Schirmacher, Annette Fisseler-Eckhoff, Jens Neumann, Thomas Kirchner, Reinhard Büttner, Sabine Merkelbach-Bruse, Hans Kreipe, Danny Jonigk, Wolfram Jochum, Regulo Rodriguez, Manfred Dietel, David Horst, Michael Hummel, Maximilian von Laffert,

With this external quality assessment (EQA) scheme, we aim to investigate the diagnostic performance of the currently available methods for the detection of ALK alterations in non-small cell lung cancer on a national scale, namely, in situ hybridization (ISH), immunohistochemistry (IHC), and RNA/DNA sequencing (NGS). The EQA scheme cohort consisted ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, 479(2):247-255]

Cited: 0 times

View full text PDF listing >>



Mass spectrometry imaging identifies metabolic patterns associated with malignant potential in pheochromocytoma and paraganglioma.

Masanori Murakami, Na Sun, Christian Greunke, Annette Feuchtinger, Stefan Kircher, Timo Deutschbein, Thomas Papathomas, Nicole Bechmann, Paal William Wallace, Mirko Peitzsch, Esther Korpershoek, Juliane Friemel, Anne-Paule Gimenez-Roqueplo, Mercedes Robledo, Henri J L M Timmers, Letizia Canu, Achim Weber, Ronald R de Krijger, Martin Fassnacht, Thomas Knösel, Thomas Kirchner, Martin Reincke, Axel Karl Walch, Matthias Kroiss, Felix Beuschlein,

<h4>Objective</h4>Within the past decade, important genetic drivers of pheochromocytoma and paraganglioma (PPGLs) development have been identified. The pathophysiological mechanism that translates these alterations into functional autonomy and potentially malignant behavior has not been elucidated in detail. Here we used MALDI-mass spectrometry imaging (MALDI-MSI) of formalin-fixed paraffin-embedded tissue specimens to comprehensively ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2021, 185(1):179-191]

Cited: 1 time

View full text PDF listing >>



Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation

Martin Orth, Didier Surdez, Aruna Marchetto, Sandrine Grossetête, Julia Gerke, Sakina Zaidi, Javier Alonso, Ana Sastre, Sylvain Baulande, Martin Sill, Florencia Cidre-Aranaz, Shunya Ohmura, Thomas Kirchner, Stefanie Hauck, Eva Reischl, Melissa Gymrek, Stefan Pfister, Konstantin Strauch, Olivier Delattre, Thomas Grünewald,

<h4>ABSTRACT</h4> Cell lines have been essential for major discoveries in cancer including Ewing sarcoma (EwS). EwS is a highly aggressive pediatric bone or soft-tissue cancer characterized by oncogenic EWSR1-ETS fusion transcription factors converting polymorphic GGAA-microsatellites (mSats) into neo-enhancers. However, further detailed mechanistic evaluation of gene regulation in EwS have been ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



[MSI testing : What is new? What should be considered? German version].

Josef Rüschoff, Gustavo Baretton, Hendrik Bläker, Wolfgang Dietmaier, Manfred Dietel, Arndt Hartmann, Lars-Christian Horn, Korinna Jöhrens, Thomas Kirchner, Ruth Knüchel, Doris Mayr, Sabine Merkelbach-Bruse, Hans-Ulrich Schildhaus, Peter Schirmacher, Markus Tiemann, Katharina Tiemann, Wilko Weichert, Reinhard Büttner,

Based on new trial data regarding immune checkpoint inhibitors (ICIs), the detection of high-grade microsatellite instability (MSI-H) or underlying deficient mismatch repair protein (dMMR) is now becoming increasingly important for predicting treatment response. For the first time, a PD‑1 ICI (pembrolizumab) has been approved by the European Medicines Agency (EMA) for ... Read more >>

Pathologe (Der Pathologe)
[2021, 42(4):414-423]

Cited: 1 time

View full text PDF listing >>



Implementation of Precision Oncology for Patients with Metastatic Breast Cancer in an Interdisciplinary MTB Setting.

Elena Sultova, C Benedikt Westphalen, Andreas Jung, Joerg Kumbrink, Thomas Kirchner, Doris Mayr, Martina Rudelius, Steffen Ormanns, Volker Heinemann, Klaus H Metzeler, Philipp A Greif, Anna Hester, Sven Mahner, Nadia Harbeck, Rachel Wuerstlein,

The advent of molecular diagnostics and the rising number of targeted therapies have facilitated development of precision oncology for cancer patients. In order to demonstrate its impact for patients with metastatic breast cancer (mBC), we initiated a Molecular Tumor Board (MTB) to provide treatment recommendations for mBC patients who had ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(4):]

Cited: 1 time

View full text PDF listing >>



Therapeutic and prognostic implications of NOTCH and MAPK signaling in bladder cancer.

Gerald B Schulz, Sefer Elezkurtaj, Teresa Börding, Eva Marina Schmidt, Manal Elmasry, Christian G Stief, Thomas Kirchner, Alexander Karl, David Horst,

Signaling pathways that drive bladder cancer (BC) progression may be promising and specific targets for systemic therapy. Here, we investigated the clinical significance and targetability of NOTCH and mitogen-activated protein kinase (MAPK) signaling for this aggressive malignancy. We assessed NOTCH1 and MAPK activity in 222 stage III and IV BC ... Read more >>

Cancer Sci (Cancer science)
[2021, 112(5):1987-1996]

Cited: 3 times

View full text PDF listing >>



Learned spectral decoloring enables photoacoustic oximetry.

Janek Gröhl, Thomas Kirchner, Tim J Adler, Lina Hacker, Niklas Holzwarth, Adrián Hernández-Aguilera, Mildred A Herrera, Edgar Santos, Sarah E Bohndiek, Lena Maier-Hein,

The ability of photoacoustic imaging to measure functional tissue properties, such as blood oxygenation sO[Formula: see text], enables a wide variety of possible applications. sO[Formula: see text] can be computed from the ratio of oxyhemoglobin HbO[Formula: see text] and deoxyhemoglobin Hb, which can be distuinguished by multispectral photoacoustic imaging due ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):6565]

Cited: 4 times

View full text PDF listing >>



Detection of gene fusions using targeted next-generation sequencing: a comparative evaluation.

Carina Heydt, Christina B Wölwer, Oscar Velazquez Camacho, Svenja Wagener-Ryczek, Roberto Pappesch, Janna Siemanowski, Jan Rehker, Florian Haller, Abbas Agaimy, Karl Worm, Thomas Herold, Nicole Pfarr, Wilko Weichert, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Wolfgang Goering, Irene Esposito, Reinhard Buettner, Axel M Hillmer, Sabine Merkelbach-Bruse,

<h4>Background</h4>Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene fusions is therefore essential.<h4>Methods</h4>Five commercially available parallel sequencing assays were evaluated for their ability to detect gene fusions in eight cell lines and 18 FFPE tissue samples carrying a variety of known gene fusions. ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2021, 14(1):62]

Cited: 6 times

View full text PDF listing >>



Advertisement


Disclaimer

1.407 s