Full Text Journal Articles by
Author Thomas Hilberg

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Sport and Venous Thromboembolism—Site, Accompanying Features, Symptoms, and Diagnosis.

Thomas Hilberg, Pia Ransmann, Thorsten Hagedorn,

<h4>Background</h4>The occurrence of venous thromboembolisms (VTE) in association with sporting activity has been described but not yet systematically explored. The aim of this study was to determine the sites at which VTE occur in athletes, the accompanying features, and the special features of the symptoms and diagnosis, so that physicians ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

Cited: 0 times

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Endothelial Function in Patients With Von Willebrand Disease.

Stephanie Noone, Ralf Schubert, Stephan Fichtlscherer, Thomas Hilberg, Sonja Alesci, Wolfgang Miesbach,

In patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because the life expectancy of these patients has increased. The research question of this study was whether patients with vWD show a different endothelial function compared to the general population. A total of 37 patients with ... Read more >>

Clin Appl Thromb Hemost (Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis)
[2021, 27:1076029620984546]

Cited: 0 times

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A single bout of coordination training does not lead to EIH in young healthy men - a RCT.

Marie Herzig, Steffen Krüger, Thomas Hilberg,

<h4>Objectives</h4>Physical activity can lead to hypoalgesic effects and is often recommended as part of multidisciplinary pain management. Based on the idea, that in future specific and more differentiated sports therapeutic interventions could be used for a multidisciplinary pain management, various type of sports and their effects on pain sensitivity should ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2021, 21(1):145-151]

Cited: 0 times

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Novel cardiovascular biomarkers in patients with cardiovascular diseases undergoing intensive physical exercise.

Moritz Mirna, Michael Lichtenauer, Bernhard Wernly, Vera Paar, Christian Jung, Daniel Kretzschmar, Madlen Uhlemann, Marcus Franz, Uta C Hoppe, P Christian Schulze, Thomas Hilberg, Volker Adams, Michael Sponder, Sven Möbius-Winkler,

<h4>Background</h4>In this trial, we analyzed the plasma levels of novel biomarkers that reflect different pathophysiological pathways (sST2: mechanical strain, IGF-BP2: metabolic pathways, suPAR and GDF-15: inflammatory processes) in patients undergoing physical exercise to investigate the effects of training on their plasma concentrations.<h4>Methods</h4>Plasma concentrations of novel biomarkers (sST2, IGF-BP2, suPAR and ... Read more >>

Panminerva Med (Panminerva medica)
[2020, 62(3):135-142]

Cited: 1 time

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Understanding the pain profile in patients with haemophilia: Impaired descending pain inhibition as measured by conditioned pain modulation.

Steffen Krüger, Thomas Hilberg,

INTRODUCTION:Haemophilic arthropathy is associated with pain that often becomes chronic, likely caused by peripheral and central mechanisms. In the field of haemophilia, to our knowledge, the role of the descending pain pathway, which can also be involved in these pain processes, has not been examined to date. AIM:In light of ... Read more >>

Haemophilia (Haemophilia : the official journal of the World Federation of Hemophilia)
[2020, 26(2):236-242]

Cited: 0 times

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The effect of resistance exercise on strength and safety outcome for people with haemophilia: A systematic review.

Barbara Wagner, Steffen Krüger, Thomas Hilberg, Cihan Ay, Timothy Hasenoehrl, Dominikus Franz-Xaver Huber, Richard Crevenna,

INTRODUCTION:Haemophilia is a congenital bleeding disorder with severe musculoskeletal complications. Resistance exercise is important to increase joint stability and to improve physical performance. AIM:This review aimed to investigate the safety and efficacy of resistance exercise interventions on people with haemophilia (PwH) and evaluate whether the American College of Sports Medicine ... Read more >>

Haemophilia (Haemophilia : the official journal of the World Federation of Hemophilia)
[2020, 26(2):200-215]

Cited: 2 times

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Effects of high-intensity interval training in a three-week cardiovascular rehabilitation: a randomized controlled trial.

Udo F Wehmeier, Alexander Schweitzer, Armin Jansen, Herbert Probst, Stephan Grüter, Silke Hähnchen, Thomas Hilberg,

OBJECTIVE:The aim of this study was to assess the benefit of using high-intensity interval training for cardiovascular patients undergoing outpatient rehabilitation in a standard short-term (three-week) program in Germany. DESIGN:This is a randomized controlled trial (RCT). SETTING:This study was conducted at Cardiowell (Wuppertal, Germany), an outpatient rehabilitation center. INTERVENTION:Patients underwent ... Read more >>

Clin Rehabil (Clinical rehabilitation)
[2020, 34(5):646-655]

Cited: 0 times

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Establishing an online physical exercise program for people with hemophilia.

Barbara Wagner, Axel Seuser, Steffen Krüger, Marie Luca Herzig, Thomas Hilberg, Cihan Ay, Timothy Hasenöhrl, Richard Crevenna,

<h4>Background</h4>Hemophilia is a congenital bleeding disorder with an estimated frequency of 1:10,000 births. Repeated joint bleeding is a hallmark of the disorder and leads to painful hemophilic arthropathy. Regular exercise can help improve joint stability and function, reduce the risk of injury and bleeding and improve physical fitness and quality of life. ... Read more >>

Wien Klin Wochenschr (Wiener klinische Wochenschrift)
[2019, 131(21-22):558-566]

Cited: 3 times

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Posturographic and ankle muscle activation characteristics in patients with haemophilia.

Eduard Kurz, Marco Herbsleb, Holger H W Gabriel, Thomas Hilberg,

<h4>Introduction</h4>The objective of this work was to examine the interrelations of posturographic and surface EMG (SEMG) characteristics of ankle muscles in patients with haemophilia while standing naturally.<h4>Methods</h4>Surface EMG of five bilaterally recorded ankle muscles was conducted in 24 patients with haemophilia (PwH, age: 42 [11] years, mean [SD], 22 A, ... Read more >>

Haemophilia (Haemophilia : the official journal of the World Federation of Hemophilia)
[2019, 25(1):136-143]

Cited: 1 time

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Programmed Sports Therapy (PST) in People with Haemophilia (PwH) "Sports Therapy Model for Rare Diseases".

Thomas Hilberg,

Sports and exercise therapy becomes more and more integrated in the treatment plan of different diseases. Although the benefits of this therapy are of high quality evidence, e.g. in cardiovascular diseases, no concepts of sports therapy are available as a treatment option for rare diseases.During the last eighteen years, we ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2018, 13(1):38]

Cited: 1 time

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Follow-up of a 6-month Programmed Sports Therapy (PST) in patients with haemophilia.

Britta Runkel, Thomas Hilberg,

Studies describe benefits of exercise in Patients with haemophilia (PwH), but research on training sustainability is rare. Aim of this study was to observe the follow-up of a guided 6-month training intervention in PwH. This study included 28 PwH after a training intervention (RCT) over 6 months. N=17 continued training ... Read more >>

Hamostaseologie (Hamostaseologie)
[2017, 37(S 01):S9-S14]

Cited: 1 time

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Acute Effects of Different Exercise Protocols on the Circulating Vascular microRNAs -16, -21, and -126 in Trained Subjects.

Patrick Wahl, Udo F Wehmeier, Felix J Jansen, Yvonne Kilian, Wilhelm Bloch, Nikos Werner, Joachim Mester, Thomas Hilberg,

<b>Aim:</b> mircoRNAs (miRNAs), small non-coding RNAs regulating gene expression, are stably secreted into the blood and circulating miRNAs (c-miRNAs) may play an important role in cell-cell communication. Furthermore, c-miRNAs might serve as novel biomarkers of the current vascular cell status. Here, we examined how the levels of three vascular c-miRNAs ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:643]

Cited: 23 times

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Changes of standard physiological-perceptual markers and circulating MicroRNAs in response to tennis match-play: A case report of two elite players.

Matthias Wilhelm Hoppe, Christian Baumgart, Thomas Hilberg, Jürgen Freiwald, Udo Frank Wehmeier,

This study aimed to describe the acute changes of both standard physiological-perceptual markers and circulating microRNAs in response to tennis match-play in a detailed case report. Two elite male baseliners with comparable tennis experience were tested for anthropometric and fitness related variables and played 2 h of match-play on a ... Read more >>

J Hum Kinet (Journal of human kinetics)
[2016, 51:71-81]

Cited: 1 time

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Acute Response of Circulating Vascular Regulating MicroRNAs during and after High-Intensity and High-Volume Cycling in Children.

Yvonne Kilian, Udo F Wehmeier, Patrick Wahl, Joachim Mester, Thomas Hilberg, Billy Sperlich,

<h4>Aim</h4>The aim of the present study was to analyze the response of vascular circulating microRNAs (miRNAs; miR-16, miR-21, miR-126) and the VEGF mRNA following an acute bout of HIIT and HVT in children.<h4>Methods</h4>Twelve healthy competitive young male cyclists (14.4 ± 0.8 years; 57.9 ± 9.4 ml·min(-1)·kg(-1) peak oxygen uptake) performed ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:92]

Cited: 13 times

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Pain thresholds following maximal endurance exercise.

Steffen Krüger, Dominik Khayat, Meike Hoffmeister, Thomas Hilberg,

<h4>Purpose</h4>Physical exercise causes alterations in pain sensitivity. Many studies verified so-called exercise-induced analgesia caused by submaximal aerobic intensity. This study aimed to determine the effect of an endurance exercise to exhaustion on pain sensitivity of healthy young men.<h4>Method</h4>Pressure pain thresholds (PPTs) [in Newton, (N)] of 50 healthy males (mean age ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2016, 116(3):535-540]

Cited: 3 times

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Coronary Collateral Growth Induced by Physical Exercise: Results of the Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable Coronary Artery Disease (EXCITE) Trial.

Sven Möbius-Winkler, Madlen Uhlemann, Volker Adams, Marcus Sandri, Sandra Erbs, Karsten Lenk, Norman Mangner, Ulrike Mueller, Jennifer Adam, Martin Grunze, Susanne Brunner, Thomas Hilberg, Meinhard Mende, Axel P Linke, Gerhard Schuler,

<h4>Background</h4>A well-developed coronary collateral circulation provides a potential source of blood supply in coronary artery disease. However, the prognostic importance and functional relevance of coronary collaterals is controversial with the association between exercise training and collateral growth still unclear.<h4>Methods and results</h4>This prospective, open-label study randomly assigned 60 patients with significant ... Read more >>

Circulation (Circulation)
[2016, 133(15):1438-48; discussion 1448]

Cited: 22 times

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Capillary earlobe blood may be used for RNA isolation, gene expression assays and microRNA quantification.

Udo F Wehmeier, Thomas Hilberg,

An increasing number of studies examining gene expression associated with diseases in children is likely, in the near future, to provide simple and easy to use methods for the isolation of RNA for gene expression profiling. Prerequisites for such studies are likely to encompass the use of small amounts of ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2014, 9(1):211-216]

Cited: 3 times

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Repeated autologous intraarticular blood injections as an animal model for joint pain in haemophilic arthropathy.

Michael Karl Boettger, Susanne Krucker, Mieczyslaw Gajda, Hans-Georg Schaible, Thomas Hilberg,

<h4>Introduction</h4>Haemophilic arthropathy following recurrent joint bleedings is one of the major disease-related complications in people with haemophilia (PWH), leading to mostly chronic joint pain. Since many antinociceptive principles interfere with the clotting system, PWH are restricted in treatment options, thereby defining a medical need for novel therapeutic principles. However, we ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2013, 15(5):R148]

Cited: 3 times

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Impact of different exercise training modalities on the coronary collateral circulation and plaque composition in patients with significant coronary artery disease (EXCITE trial): study protocol for a randomized controlled trial.

Madlen Uhlemann, Volker Adams, Karsten Lenk, Axel Linke, Sandra Erbs, Jennifer Adam, Holger Thiele, Thomas Hilberg, Matthias Gutberlet, Martin Grunze, Gerhard C Schuler, Sven Möbius-Winkler,

<h4>Background</h4>Exercise training (ET) in addition to optimal medical therapy (OMT) in patients with stable coronary artery disease (CAD) has been demonstrated to be superior to percutaneous coronary interventions (PCI) with respect to the composite endpoint of death, myocardial infarction, stroke, revascularization and hospitalization due to worsening of angina. One mechanism ... Read more >>

Trials (Trials)
[2012, 13:167]

Cited: 4 times

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Endurance training modifies exercise-induced activation of blood coagulation: RCT.

Thomas Hilberg, Kathleen Menzel, Udo F Wehmeier,

Randomized controlled trials (RCTs) on the topic of physical training and blood coagulation are rare and the effects are unclear. The aim of this study was to investigate whether endurance training adjusts blood coagulation and fibrinolysis at rest and after exercise. The study included 50 healthy untrained non-smokers randomized into ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2013, 113(6):1423-1430]

Cited: 7 times

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Circulating microRNA-126 increases after different forms of endurance exercise in healthy adults.

Madlen Uhlemann, Sven Möbius-Winkler, Sven Fikenzer, Jennifer Adam, Maren Redlich, Stefan Möhlenkamp, Thomas Hilberg, Gerhard C Schuler, Volker Adams,

<h4>Background</h4>MicroRNAs (miRNAs) are small non-coding molecules regulating gene expression. Recently circulating miRNAs could be detected in the plasma, serving as novel biomarkers. Different forms of exercise mobilize progenitor cells from the bone marrow, helping in tissue repair. Data of different forms of exercise on endothelial cell damage are lacking. The ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2014, 21(4):484-491]

Cited: 66 times

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Joint pain in people with hemophilia depends on joint status.

Thomas Hilberg, Doerte Czepa, David Freialdenhoven, Michael Karl Boettger,

Recurrent joint bleedings in people with hemophilia (PWH) often progress into the full clinical picture of hemophilic arthropathy, accompanied by chronic pain. Although chronic pain is commonly present in PWH, investigations assessing pain thresholds have not been performed yet. Thus, the aim of this study was to obtain objective and ... Read more >>

Pain (Pain)
[2011, 152(9):2029-2035]

Cited: 19 times

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Blood coagulation and fibrinolysis in healthy, untrained subjects: effects of different exercise intensities controlled by individual anaerobic threshold.

Kathleen Menzel, Thomas Hilberg,

The influence of different exercise intensities on haemostasis in healthy, untrained subjects has not been intensively studied. We investigated untrained subjects for alterations in coagulation and fibrinolysis induced by two exercise intensities, precisely controlled by individual anaerobic threshold (IAT). Twenty-five healthy, untrained non-smokers (age 25 ± 3 years; relative VO(2) ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2011, 111(2):253-260]

Cited: 19 times

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Coagulation and fibrinolysis are in balance after moderate exercise in middle-aged participants.

Kathleen Menzel, Thomas Hilberg,

Increased age is associated with a higher risk of thrombotic events. The aim of this study was to investigate the age-related changes in hemostasis before and after moderate exercise controlled by individual anaerobic threshold as recommended for rehabilitation training. In this study, 24 young (25 +/- 1 years) and 24 ... Read more >>

Clin Appl Thromb Hemost (Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis)
[2009, 15(3):348-355]

Cited: 7 times

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Time-dependent mobilization of circulating progenitor cells during strenuous exercise in healthy individuals.

Sven Möbius-Winkler, Thomas Hilberg, Kathleen Menzel, Eva Golla, Agnieszka Burman, Gerhard Schuler, Volker Adams,

Exercise stimulates the release of hematopoietic and endothelial progenitor cells (EPC) from the bone marrow. However, no data are available concerning the time frame of EPC release during strenuous exercise. The aim of the present study was to investigate the time-dependent release of progenitor cells during strenuous exercise. Eighteen healthy ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2009, 107(6):1943-1950]

Cited: 92 times

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