Full Text Journal Articles by
Author Thomas H Smith

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Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing.

Yiying Wang, Roberta A Mittelstaedt, Rebecca Wynne, Ying Chen, Xuefei Cao, Levan Muskhelishvili, Kelly Davis, Timothy W Robison, Wei Sun, Elizabeth K Schmidt, Thomas H Smith, Zachary K Norgaard, Charles C Valentine, Jeffry Yaplee, Lindsey N Williams, Jesse J Salk, Robert H Heflich,

The organotypic human air-liquid-interface (ALI) airway tissue model has been used as an in vitro cell culture system for evaluating the toxicity of inhaled substances. ALI airway cultures are highly differentiated, which has made it challenging to evaluate genetic toxicology endpoints. In the current study, we assayed DNA damage with ... Read more >>

Environ Mol Mutagen (Environmental and molecular mutagenesis)
[2021, 62(5):306-318]

Cited: 1 time

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CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma.

Arjun Khunger, Erin Piazza, Sarah Warren, Thomas H Smith, Xing Ren, Andrew White, Nathan Elliott, Alessandra Cesano, Joseph M Beechem, John M Kirkwood, Ahmad A Tarhini,

Patients with locally/regionally advanced melanoma were treated with neoadjuvant combination immunotherapy with high-dose interferon α-2b (HDI) and ipilimumab in a phase I clinical trial. Tumor specimens were obtained prior to the initiation of neoadjuvant therapy, at the time of surgery and progression if available. In this study, gene expression profiles ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0245287]

Cited: 2 times

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Effects of Nitrogen Application on Nitrogen Fixation in Common Bean Production.

Yarmilla Reinprecht, Lyndsay Schram, Frédéric Marsolais, Thomas H Smith, Brett Hill, Karl Peter Pauls,

The nitrogen fixing ability of common bean (<i>Phaseolus vulgaris</i> L.) in association with rhizobia is often characterized as poor compared to other legumes, and nitrogen fertilizers are commonly used in bean production to achieve high yields, which in general inhibits nitrogen fixation. In addition, plants cannot take up all the ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2020, 11:1172]

Cited: 1 time

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Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia.

Jayakumar Vadakekolathu, Mark D Minden, Tressa Hood, Sarah E Church, Stephen Reeder, Heidi Altmann, Amy H Sullivan, Elena J Viboch, Tasleema Patel, Narmin Ibrahimova, Sarah E Warren, Andrea Arruda, Yan Liang, Thomas H Smith, Gemma A Foulds, Michael D Bailey, James Gowen-MacDonald, John Muth, Marc Schmitz, Alessandra Cesano, A Graham Pockley, Peter J M Valk, Bob Löwenberg, Martin Bornhäuser, Sarah K Tasian, Michael P Rettig, Jan K Davidson-Moncada, John F DiPersio, Sergio Rutella,

Acute myeloid leukemia (AML) is a molecularly and clinically heterogeneous hematological malignancy. Although immunotherapy may be an attractive modality to exploit in patients with AML, the ability to predict the groups of patients and the types of cancer that will respond to immune targeting remains limited. This study dissected the ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(546):]

Cited: 26 times

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Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function.

Ying Lin, Jacob M Wozniak, Neil J Grimsey, Sravan Girada, Anand Patwardhan, Olivia Molinar-Inglis, Thomas H Smith, John D Lapek, David J Gonzalez, JoAnn Trejo,

Thrombin, a procoagulant protease, cleaves and activates protease-activated receptor-1 (PAR1) to promote inflammatory responses and endothelial dysfunction. In contrast, activated protein C (APC), an anticoagulant protease, activates PAR1 through a distinct cleavage site and promotes anti-inflammatory responses, prosurvival, and endothelial barrier stabilization. The distinct tethered ligands formed through cleavage of ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(9):5039-5048]

Cited: 5 times

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Superovulation alters global DNA methylation in early mouse embryo development.

Bo Yu, Thomas H Smith, Stephanie L Battle, Shannon Ferrell, R David Hawkins,

Assisted reproductive technologies are known to alter the developmental environment of gametes and early embryos during the most dynamic period of establishing the epigenome. This may result in the introduction of errors during active DNA methylation reprogramming. Controlled ovarian hyperstimulation, or superovulation, is a ubiquitously used intervention which has been ... Read more >>

Epigenetics (Epigenetics)
[2019, 14(8):780-790]

Cited: 2 times

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Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin.

Thomas H Smith, Julia G Li, Michael R Dores, JoAnn Trejo,

Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4 (PAR4) has been shown to dimerize with the purinergic receptor ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2017, 292(33):13867-13878]

Cited: 14 times

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Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins.

Thomas H Smith, Luisa J Coronel, Julia G Li, Michael R Dores, Marvin T Nieman, JoAnn Trejo,

Protease-activated receptor-4 (PAR4) is a G protein-coupled receptor (GPCR) for thrombin and is proteolytically activated, similar to the prototypical PAR1. Due to the irreversible activation of PAR1, receptor trafficking is intimately linked to signal regulation. However, unlike PAR1, the mechanisms that control PAR4 trafficking are not known. Here, we sought ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2016, 291(35):18453-18464]

Cited: 9 times

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Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.

Neil J Grimsey, Berenice Aguilar, Thomas H Smith, Phillip Le, Amanda L Soohoo, Manojkumar A Puthenveedu, Victor Nizet, JoAnn Trejo,

Protease-activated receptor 1 (PAR1) is a G protein-coupled receptor (GPCR) for thrombin and promotes inflammatory responses through multiple pathways including p38 mitogen-activated protein kinase signaling. The mechanisms that govern PAR1-induced p38 activation remain unclear. Here, we define an atypical ubiquitin-dependent pathway for p38 activation used by PAR1 that regulates endothelial ... Read more >>

J Cell Biol (The Journal of cell biology)
[2015, 210(7):1117-1131]

Cited: 32 times

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N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.

Antonio G Soto, Thomas H Smith, Buxin Chen, Supriyo Bhattacharya, Isabel Canto Cordova, Terry Kenakin, Nagarajan Vaidehi, JoAnn Trejo,

Protease-activated receptor-1 (PAR1) is a G-protein-coupled receptor (GPCR) for the coagulant protease thrombin. Similar to other GPCRs, PAR1 is promiscuous and couples to multiple heterotrimeric G-protein subtypes in the same cell and promotes diverse cellular responses. The molecular mechanism by which activation of a given GPCR with the same ligand ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2015, 112(27):E3600-8]

Cited: 26 times

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Antineoplastic agents. 599. Total synthesis of dolastatin 16.

George R Pettit, Thomas H Smith, Pablo M Arce, Erik J Flahive, Collin R Anderson, Jean-Charles Chapuis, Jun-Ping Xu, Thomas L Groy, Paul E Belcher, Christian B Macdonald,

The first 23-step total synthesis of the cyclodepsipeptide dolastatin 16 (1) has been achieved. Synthesis of the dolaphenvaline and dolamethylleuine amino acid units using simplified methods improved the overall efficiency. The formation of the 25-membered macrocycle employing lactonization with 2-methyl-6-nitrobenzoic anhydride completed a key step in the synthesis. Regrettably, the ... Read more >>

J Nat Prod (Journal of natural products)
[2015, 78(3):476-485]

Cited: 5 times

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A general method for site specific fluorescent labeling of recombinant chemokines.

Tetsuya Kawamura, Bryan Stephens, Ling Qin, Xin Yin, Michael R Dores, Thomas H Smith, Neil Grimsey, Ruben Abagyan, Joann Trejo, Irina Kufareva, Mark M Fuster, Catherina L Salanga, Tracy M Handel,

Chemokines control cell migration in many contexts including development, homeostasis, immune surveillance and inflammation. They are also involved in a wide range of pathological conditions ranging from inflammatory diseases and cancer, to HIV. Chemokines function by interacting with two types of receptors: G protein-coupled receptors on the responding cells, which ... Read more >>

PLoS One (PloS one)
[2014, 9(1):e81454]

Cited: 12 times

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Cofactoring and dimerization of proteinase-activated receptors.

Huilan Lin, Allen P Liu, Thomas H Smith, JoAnn Trejo,

Proteinase-activated receptors (PARs) are G protein-coupled receptors that transmit cellular responses to extracellular proteases and have important functions in vascular physiology, development, inflammation, and cancer progression. The established paradigm for PAR activation involves proteolytic cleavage of the extracellular N terminus, which reveals a new N terminus that functions as a ... Read more >>

Pharmacol Rev (Pharmacological reviews)
[2013, 65(4):1198-1213]

Cited: 50 times

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Risk factors of non-alcoholic fatty liver disease in patients with inflammatory bowel disease.

Achuthan Sourianarayanane, Gaurav Garg, Thomas H Smith, Mujtaba I Butt, Arthur J McCullough, Bo Shen,

<h4>Background</h4>Metabolic risk factors are associated with non-alcoholic fatty liver disease (NAFLD), but they are less frequent in inflammatory bowel disease (IBD).<h4>Aim</h4>This study evaluates the frequency of NAFLD and its risk factors among IBD patients including anti-TNF-α therapy.<h4>Methods</h4>IBD patients who underwent abdominal imaging from January, 2009 to December, 2010 were analyzed ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2013, 7(8):e279-85]

Cited: 43 times

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Antineoplastic agents. 590. X-ray crystal structure of dolastatin 16 and syntheses of the dolamethylleuine and dolaphenvaline units.

George R Pettit, Thomas H Smith, Jun-Ping Xu, Delbert L Herald, Erik J Flahive, Collin R Anderson, Paul E Belcher, John C Knight,

Three advances necessary to bring dolastatin 16 (1) into full-scale preclinical development as an anticancer drug have been accomplished. The X-ray crystal structure of dolastatin 16 has been solved, which allowed stereoselective syntheses of its two new amino acid units, dolamethylleuine (Dml) and dolaphenvaline (Dpv), to be completed. The X-ray ... Read more >>

J Nat Prod (Journal of natural products)
[2011, 74(5):1003-1008]

Cited: 3 times

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Laterally driven interfaces in the three-dimensional Ising lattice gas.

Thomas H R Smith, Oleg Vasilyev, Anna Maciołek, Matthias Schmidt,

We study the steady state of a phase-separated driven Ising lattice gas in three dimensions using computer simulations with Kawasaki dynamics. An external force field F(z) acts in the x direction parallel to the interface, creating a lateral order parameter current j^{x}(z) which varies with distance z from the interface. ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2010, 82(2 Pt 1):021126]

Cited: 1 time

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Interfaces in driven Ising models: shear enhances confinement.

Thomas H R Smith, Oleg Vasilyev, Douglas B Abraham, Anna Maciołek, Matthias Schmidt,

We use a phase-separated driven two-dimensional Ising lattice gas to study fluid interfaces exposed to shear flow parallel to the interface. The interface is stabilized by two parallel walls with opposing surface fields, and a driving field parallel to the walls is applied which (i) either acts locally at the ... Read more >>

Phys Rev Lett (Physical review letters)
[2008, 101(6):067203]

Cited: 3 times

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Antineoplastic agents. 561. Total synthesis of respirantin.

George R Pettit, Thomas H Smith, Song Feng, John C Knight, Rui Tan, Robin K Pettit, Peter A Hinrichs,

Total synthesis of the 18-membered ring cyclodepsipeptide believed to be respirantin (1b) has been achieved. The key step in the synthesis is an intramolecular transesterification of the beta-ketoester alcohol 6 to afford the protected macrocycle 5. The synthetic product was shown to be identical to a natural product presumed to ... Read more >>

J Nat Prod (Journal of natural products)
[2007, 70(7):1073-1083]

Cited: 8 times

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