Full Text Journal Articles by
Author Thomas Graven Nielsen

Advertisement

Find full text journal articles






Alterations in pronociceptive and antinociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Megan E McPhee, Henrik Bjarke Vaegter, Thomas Graven-Nielsen,

Altered pronociceptive and antinociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions, alterations are well-established, but in populations with low back pain (LBP), there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to ... Read more >>

Pain (Pain)
[2020, 161(3):464-475]

Cited: 0 times

View full text PDF listing >>



Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI.

Sarina J Iwabuchi, Yue Xing, William J Cottam, Marianne M Drabek, Arman Tadjibaev, Gwen S Fernandes, Kristian K Petersen, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Ana M Valdes, Weiya Zhang, Michael Doherty, David Walsh, Dorothee P Auer,

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pain pathways are associated with pain chronicity following e.g. post-operative pain after knee replacement. Other factors such as low mood, anxiety and tendency to catastrophize are also important contributors. We aimed to investigate brain imaging features ... Read more >>

Pain (Pain)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

The Effect of Stress on Repeated Painful Stimuli with and Without Painful Conditioning.

Morten Hoegh, Jeppe N Poulsen, Laura Petrini, Thomas Graven-Nielsen,

OBJECTIVES:Stress and pain have been interrelated in clinical widespread pain conditions. Studies indicate that acute experimental stress in healthy volunteers has a negative effect on the descending inhibitory pain control system and thus the ability to inhibit one painful stimulus with another (conditioned pain modulation [CPM]) although without effect on ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2020, 21(2):317-325]

Cited: 0 times

View full text PDF listing >>



Mechanistic pain profiling in young adolescents with patellofemoral pain before and after treatment: a prospective cohort study.

Sinéad Holden, Michael Skovdal Rathleff, Kristian Thorborg, Per Holmich, Thomas Graven-Nielsen,

Patellofemoral pain (PFP) is a common complaint among young sports active adolescents. This study evaluated the longitudinal changes in pronociceptive and antinociceptive mechanisms in young adolescents with PFP, their impact on prognosis, and responsiveness to treatment. Adolescents (N = 151, aged 10-14 years) diagnosed with PFP were compared with age-matched ... Read more >>

Pain (Pain)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Pain, Sports Participation, and Physical Function in 10-14 Year Olds With Patellofemoral Pain and Osgood Schlatter: A Matched Cross-Sectional Study of 252 Adolescents.

Michael Skovdal Rathleff, Lukasz Winiarski, Kasper Krommes, Thomas Graven-Nielsen, Per Hölmich, Jens Lykkegaard Olesen, Sinead Holden, Kristian Thorborg,

STUDY DESIGN:Cross-sectional study. BACKGROUND:Patellofemoral pain (PFP) and Osgood-Schlatter disease (OSD) are common in adolescents, but we lack knowledge on these conditions and their impact in young adolescents (<15 years). OBJECTIVES:Compare pain, physical activity, quality of life, strength and knee function between adolescents with PFP or OSD, compared to pain-free controls. ... Read more >>

J Orthop Sports Phys Ther (The Journal of orthopaedic and sports physical therapy)
[2020, :1-26]

Cited: 0 times

View full text PDF listing >>



Temporal aspects of endogenous pain modulation during a noxious stimulus prolonged for 1 day.

Marie Hoeger Bement, Kristian K Petersen, Line B Sørensen, Hjalte H Andersen, Thomas Graven-Nielsen,

BACKGROUND:This study investigated (a) if a prolonged noxious stimulus (24-hr topical capsaicin) in healthy adults would impair central pain inhibitory and facilitatory systems measured as a reduction in conditioned pain modulation (CPM) and enhancement of temporal summation of pain (TSP) and (b) if acute pain relief or exacerbation (cooling and ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2019, :]

Cited: 0 times

View full text PDF listing >>



Head repositioning accuracy is influenced by experimental neck pain in those most accurate but not when adding a cognitive task.

Steffan Wittrup McPhee Christensen, Anneli Peolsson, Simone May Agger, Mikkel Svindt, Thomas Graven-Nielsen, Rogerio Pessoto Hirata,

Background and aims Neck pain can impair perception of cervical movement, but how this is affected by attention is unknown. In this study, the effects of experimental neck pain on head repositioning accuracy during standardized head movements were investigated. Methods Experimental neck pain was induced by injecting hypertonic saline into ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2019, 20(1):191-203]

Cited: 0 times

View full text PDF listing >>



Recurrent low back pain patients demonstrate facilitated pronociceptive mechanisms when in pain, and impaired antinociceptive mechanisms with and without pain.

Megan E McPhee, Thomas Graven-Nielsen,

Low back pain (LBP) has been inconsistently associated with enhanced pronociceptive and impaired antinociceptive mechanisms. It remains unknown whether alterations are causal, consequential, or coincidental to pain presence. This study investigated pronociceptive and antinociceptive mechanisms in recurrent LBP (RLBP) patients across painful and pain-free periods, compared with age/sex-matched asymptomatic controls. ... Read more >>

Pain (Pain)
[2019, 160(12):2866-2876]

Cited: 0 times

View full text PDF listing >>



Recurrent neck pain patients exhibit altered joint motion pattern during cervical flexion and extension movements.

Ning Qu, Thomas Graven-Nielsen, Rene Lindstrøm, Victoria Blogg Andersen Dc, Rogerio Pessoto Hirata,

BACKGROUND:Impaired sensorimotor ability has been demonstrated in recurrent neck pain patients. It is however not clear if cervical joint motion and pressure pain sensitivity in recurrent neck pain patients are different from asymptomatic controls. METHODS:Cervical flexion and extension motions were examined by video-fluoroscopy and pressure pain thresholds were assessed bilaterally ... Read more >>

Clin Biomech (Bristol, Avon) (Clinical biomechanics (Bristol, Avon))
[2019, 71:125-132]

Cited: 0 times

View full text PDF listing >>



Alterations in pro-nociceptive and anti-nociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Megan E McPhee, Henrik Bjarke Vaegter, Thomas Graven-Nielsen,

Altered pro-nociceptive and anti-nociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions alterations are well-established, but in low back pain (LBP) populations there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to address ... Read more >>

Pain (Pain)
[2019, :]

Cited: 0 times

View full text PDF listing >>



Towards a brain signature of chronic pain using cerebral blood flow spatial covariance analysis in people with chronic knee pain

Sarina Iwabuchi, Yue Xing, William Cottam, Marianne Drabek, Arman Tadjibaev, Gwen Fernandes, Kristian Petersen, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Ana Valdes, Weiya Zhang, Michael Doherty, David Walsh, Dorothee Auer,

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladaptive modulation of central pain pathways is associated with pain chronicity following e.g. chronic post-operative pain after knee replacement. Other factors such as low mood, anxiety and tendency to catastrophize seem to also be important contributors. We aimed ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Isometric exercise and pain in patellar tendinopathy: A randomized crossover trial.

Sinéad Holden, Kristian Lyng, Thomas Graven-Nielsen, Henrik Riel, Jens Lykkegaard Olesen, Lars Henrik Larsen, Michael Skovdal Rathleff,

OBJECTIVES:The aim of this study was to compare the acute effects of isometric versus dynamic resistance exercise on pain during a pain-provoking activity, and exercise-induced hypoalgesia in participants with patellar tendinopathy. DESIGN:This study was a pre-registered randomised crossover study. Participants were blinded to the study hypothesis. METHODS:Participants (N = 21) performed a ... Read more >>

J Sci Med Sport (Journal of science and medicine in sport)
[2020, 23(3):208-214]

Cited: 0 times

View full text PDF listing >>



Motor adaptation varies between individuals in the transition to sustained pain.

Simon J Summers, Lucy S Chipchase, Rogerio Hirata, Thomas Graven-Nielsen, Rocco Cavaleri, Siobhan M Schabrun,

Musculoskeletal pain is associated with altered motor control that, despite short-term benefit, is hypothesised to have long-term consequences, contributing to the development of chronic pain. However, data on how motor control is altered when pain is sustained beyond a transient event are scarce. Here, we investigated motor adaptation, and its ... Read more >>

Pain (Pain)
[2019, 160(9):2115-2125]

Cited: 1 time

View full text PDF listing >>



Nerve growth factor-induced muscle hyperalgesia facilitates ischaemic contraction-evoked pain.

Line Bay Sørensen, Parisa Gazerani, Thomas Graven-Nielsen,

BACKGROUND:Intramuscular injection of Nerve Growth Factor (NGF) may influence the responsiveness of active chemo-sensitive channels affecting muscle pain sensitivity. This double-blinded crossover study in healthy humans assessed contraction-evoked pain responses and pain sensitivity during acute ischaemia in the tibialis anterior (TA) muscle before and 24 hr after five distributed NGF injections ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2019, 23(10):1814-1825]

Cited: 0 times

View full text PDF listing >>



Delayed effects of attention on pain sensitivity and conditioned pain modulation.

Morten Hoegh, David A Seminowicz, Thomas Graven-Nielsen,

BACKGROUND:Efficacy of pain modulation is assessed as the difference in pain sensitivity during a painful conditioning, compared to before (conditioning pain modulation, CPM). Attention can be assessed with the Stroop task, in which participants report the number of words on a screen; either congruent or incongruent with the value of ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2019, 23(10):1850-1862]

Cited: 1 time

View full text PDF listing >>



Exercise-induced hypoalgesia in young adult females with long-standing patellofemoral pain - A randomized crossover study.

Christian L Straszek, Michael S Rathleff, Thomas Graven-Nielsen, Kristian K Petersen, Ewa M Roos, Sinead Holden,

BACKGROUND:Patellofemoral pain (PFP) is a common knee pain condition where hip and knee exercises help improve treatment outcomes. This study compared the acute effect of hip versus knee exercises on anti-nociceptive and pro-nociceptive mechanisms in young females with long-standing PFP. METHODS:In this randomized cross-over study, 29 females with PFP performed ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2019, 23(10):1780-1789]

Cited: 0 times

View full text PDF listing >>



Experimental knee-related pain enhances attentional interference on postural control.

Eneida Yuri Suda, Rogerio Pessoto Hirata, Thorvaldur Palsson, Nicolas Vuillerme, Isabel C N Sacco, Thomas Graven-Nielsen,

PURPOSE:To quantify how postural stability is modified during experimental pain while performing different cognitively demanding tasks. METHODS:Sixteen healthy young adults participated in the experiment. Pain was induced by intramuscular injection of hypertonic saline solution (1 mL, 6%) in both vastus medialis and vastus lateralis muscles (0.9% isotonic saline was used as ... Read more >>

Eur. J. Appl. Physiol. (European journal of applied physiology)
[2019, 119(9):2053-2064]

Cited: 0 times

View full text PDF listing >>



Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate.

Ryan G Larsen, Jens M Thomsen, Rogerio P Hirata, Rudi Steffensen, Eva R Poulsen, Jens B Frøkjaer, Thomas Graven-Nielsen,

Unaccustomed eccentric exercise leads to impaired microvascular function but the underlying mechanism is unknown. In this study, we evaluated the role of oxidative stress and of nitric oxide (NO) bioavailability. Thirty young men and women performed eccentric contractions of the tibialis anterior (TA) muscle (ECC), with the contralateral leg serving ... Read more >>

Physiol Rep (Physiological reports)
[2019, 7(13):e14162]

Cited: 0 times

View full text PDF listing >>



Corticomotor excitability reduction induced by experimental pain remains unaffected by performing a working memory task as compared to staying at rest.

Dennis B Larsen, Thomas Graven-Nielsen, Rogerio P Hirata, David Seminowicz, Siobhan Schabrun, Shellie A Boudreau,

Experimental pain inhibits primary motor cortex (M1) excitability. Attenuating pain-related inhibition of M1 excitability may be useful during rehabilitation in individuals with pain. One strategy to attenuate M1 excitability is to influence prefrontal and premotor cortex activity. Working memory tasks, e.g. the two-back task (TBT), engage prefrontal and premotor cortices ... Read more >>

Exp Brain Res (Experimental brain research)
[2019, 237(9):2205-2215]

Cited: 0 times

View full text PDF listing >>



Assessment of conditioned pain modulation in healthy participants and patients with chronic pain: manifestations and implications for pain progression.

Kristian K Petersen, Megan E McPhee, Morten S Hoegh, Thomas Graven-Nielsen,

PURPOSE OF REVIEW:The purpose of this review is to summarize recent findings on conditioned pain modulation (CPM) in humans with a focus on methodology, factors modulating CPM, and the potential for CPM as a clinical marker for pain progression. RECENT FINDINGS:CPM can be evoked by combining different stimulus modalities with ... Read more >>

Curr Opin Support Palliat Care (Current opinion in supportive and palliative care)
[2019, 13(2):99-106]

Cited: 0 times

View full text PDF listing >>



Chronic widespread pain patients show disrupted cortical connectivity in default mode and salience networks, modulated by pain sensitivity.

Helene van Ettinger-Veenstra, Peter Lundberg, Péter Alföldi, Martin Södermark, Thomas Graven-Nielsen, Anna Sjörs, Maria Engström, Björn Gerdle,

Purpose: The remodeling of functional neuronal connectivity in chronic widespread pain (CWP) patients remains largely unexplored. This study aimed to investigate functional connectivity in CWP patients in brain networks related to chronic pain for changes related to pain sensitivity, psychological strain, and experienced pain. Patients and methods: Functional connectivity strength ... Read more >>

J Pain Res (Journal of pain research)
[2019, 12:1743-1755]

Cited: 0 times

View full text PDF listing >>



Sessions of Prolonged Continuous Theta Burst Stimulation or High-frequency 10 Hz Stimulation to Left Dorsolateral Prefrontal Cortex for 3 Days Decreased Pain Sensitivity by Modulation of the Efficacy of Conditioned Pain Modulation.

Enrico De Martino, Ana Mércia Fernandes, Ricardo Galhardoni, Carolina De Oliveira Souza, Daniel Ciampi De Andrade, Thomas Graven-Nielsen,

The 10 Hz repetitive transcranial magnetic stimulation (10 Hz-rTMS) to the left dorsolateral prefrontal cortex produces analgesia, probably by activating the pain modulation system. A newer rTMS paradigm, called theta burst stimulation (TBS), has been developed. Unlike 10 Hz-rTMS, prolonged continuous TBS (pcTBS) mimics endogenous theta rhythms, which can improve ... Read more >>

J Pain (The journal of pain : official journal of the American Pain Society)
[2019, 20(12):1459-1469]

Cited: 0 times

View full text PDF listing >>



Conditioning pain modulation reduces pain only during the first stimulation of the temporal summation of pain paradigm in healthy participants.

Sinead Holden, Kristian Kjaer Petersen, Lars Arendt-Nielsen, Thomas Graven-Nielsen,

BACKGROUND:Pro-nociceptive and anti-nociceptive mechanisms are commonly assessed in clinical and experimental pain studies, but their potential interaction is not well understood. OBJECTIVES:Investigate the effect of conditioning pain modulation (CPM) on temporal summation of pain (TSP). METHODS:Twenty healthy participants underwent cuff algometry assessment on the lower legs to establish the pressure pain ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2019, 23(7):1390-1396]

Cited: 0 times

View full text PDF listing >>



Do sensorimotor cortex activity, an individual's capacity for neuroplasticity, and psychological features during an episode of acute low back pain predict outcome at 6 months: a protocol for an Australian, multisite prospective, longitudinal cohort study.

Luke C Jenkins, Wei-Ju Chang, Valentina Buscemi, Matthew Liston, Barbara Toson, Michael Nicholas, Thomas Graven-Nielsen, Michael Ridding, Paul W Hodges, James H McAuley, Siobhan M Schabrun,

INTRODUCTION:Low back pain (LBP) is the leading cause of disability worldwide, with prevalence doubling in the past 14 years. To date, prognostic screening tools display poor discrimination and offer no net benefit of screening over and above a 'treat all' approach. Characteristics of the primary sensory (S1) and motor (M1) ... Read more >>

BMJ Open (BMJ open)
[2019, 9(5):e029027]

Cited: 1 time

View full text PDF listing >>



Activity Modification and Load Management of Adolescents With Patellofemoral Pain: A Prospective Intervention Study Including 151 Adolescents.

Michael Skovdal Rathleff, Thomas Graven-Nielsen, Per Hölmich, Lukasz Winiarski, Kasper Krommes, Sinéad Holden, Kristian Thorborg,

BACKGROUND:Patellofemoral pain (PFP) affects 7% of adolescents, especially those who are highly active. Exercise-focused treatments show limited effect and overlook activity modification and load management. As many adolescents continue at high levels of sports despite pain, a new strategy addressing this problem is warranted. PURPOSE:To investigate the effects of a ... Read more >>

Am J Sports Med (The American journal of sports medicine)
[2019, 47(7):1629-1637]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
2.9997 s