Full Text Journal Articles by
Author Thomas Graven Nielsen

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Pain Catastrophizing, Self-reported Disability, and Temporal Summation of Pain Predict Self-reported Pain in Low Back Pain Patients 12 Weeks After General Practitioner Consultation: A Prospective Cohort Study.

Kristian K Petersen, Martin B Jensen, Thomas Graven-Nielsen, Lissa V Hauerslev, Lars Arendt-Nielsen, Michael S Rathleff,

OBJECTIVES:Patients with low back pain (LBP) often demonstrate pain sensitization, high degree of pain catastrophizing, and psychological distress. This study investigated whether pain sensitization mechanisms, the Pain Catastrophizing Scale (PCS), and Start Back Screening Tool were associated with pain in recurrent LBP patients 12 weeks after consulting their general practitioner ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2020, 36(10):757-763]

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Individualized Augmented Reality Training Reduces Phantom Pain and Cortical Reorganization in Amputees: A Proof of Concept Study.

Mikkel Thøgersen, Jamila Andoh, Christopher Milde, Thomas Graven-Nielsen, Herta Flor, Laura Petrini,

Phantom limb pain (PLP) may be relieved using a visual representation of an intact limb. However, patients with distorted (telescoped) phantoms seem unable to associate with visualizations of intact limbs. A virtual arm visualization was matched to the individual's phantom perception and controlled in an augmented reality (AR) intervention. Seven ... Read more >>

J Pain (The journal of pain : official journal of the American Pain Society)
[2020, :]

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Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI.

Sarina J Iwabuchi, Yue Xing, William J Cottam, Marianne M Drabek, Arman Tadjibaev, Gwen S Fernandes, Kristian K Petersen, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Ana M Valdes, Weiya Zhang, Michael Doherty, David Walsh, Dorothee P Auer,

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pain pathways are associated with pain chronicity, for example, in postoperative pain after knee replacement. Other factors such as low mood, anxiety, and tendency to catastrophize are also important contributors. We aimed to investigate brain imaging ... Read more >>

Pain (Pain)
[2020, 161(6):1255-1263]

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Activation of the descending pain modulatory system using cuff pressure algometry: Back translation from man to rat.

Tatum M Cummins, Mateusz M Kucharczyk, Thomas Graven-Nielsen, Kirsty Bannister,

BACKGROUND:Diffuse noxious inhibitory controls (DNIC) as measured in rat and conditioned pain modulation (CPM), the supposed psychophysical paradigm of DNIC measured in humans, are unique manifestations of an endogenous descending modulatory pathway that is activated by the application of a noxious conditioning stimulus. The predictive value of the human CPM ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2020, 24(7):1330-1338]

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Stimulus predictability moderates the withdrawal strategy in response to repetitive noxious stimulation in humans.

Fabricio A Jure, Federico G Arguissain, José A Biurrun Manresa, Thomas Graven-Nielsen, Ole Kæseler Andersen,

Nociceptive withdrawal reflex (NWR) is a protective reaction to a noxious stimulus, resulting in withdrawal of the affected area and thus preventing potential tissue damage. This involuntary reaction consists of neural circuits, biomechanical strategies, and muscle activity that ensure an optimal withdrawal. Studies of lower limb NWR indicate that the ... Read more >>

J. Neurophysiol. (Journal of neurophysiology)
[2020, 123(6):2201-2208]

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Mechanistic pain profiling in young adolescents with patellofemoral pain before and after treatment: a prospective cohort study.

Sinéad Holden, Michael Skovdal Rathleff, Kristian Thorborg, Per Holmich, Thomas Graven-Nielsen,

Patellofemoral pain (PFP) is a common complaint among young sports active adolescents. This study evaluated the longitudinal changes in pronociceptive and antinociceptive mechanisms in young adolescents with PFP, their impact on prognosis, and responsiveness to treatment. Adolescents (N = 151, aged 10-14 years) diagnosed with PFP were compared with age-matched ... Read more >>

Pain (Pain)
[2020, 161(5):1065-1071]

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Activity Modification and Knee Strengthening for Osgood-Schlatter Disease: A Prospective Cohort Study.

Michael S Rathleff, Lukasz Winiarski, Kasper Krommes, Thomas Graven-Nielsen, Per Hölmich, Jens Lykkegard Olesen, Sinéad Holden, Kristian Thorborg,

Background:Osgood-Schlatter disease (OSD) affects 1 in 10 adolescents. There is a lack of evidence-based interventions, and passive approaches (eg, rest and avoidance of painful activities) are often prescribed. Purpose:To investigate an intervention consisting of education on activity modification and knee-strengthening exercises designed for adolescents with OSD. Study Design:Case series; Level ... Read more >>

Orthop J Sports Med (Orthopaedic journal of sports medicine)
[2020, 8(4):2325967120911106]

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Alterations in pronociceptive and antinociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Megan E McPhee, Henrik Bjarke Vaegter, Thomas Graven-Nielsen,

Altered pronociceptive and antinociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions, alterations are well-established, but in populations with low back pain (LBP), there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to ... Read more >>

Pain (Pain)
[2020, 161(3):464-475]

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Testosterone replacement therapy of opioid-induced male hypogonadism improved body composition but not pain perception: a double-blind, randomized, and placebo-controlled trial.

Dorte Glintborg, Henrik Bjarke Vaegter, Louise Lehmann Christensen, Emma Bendix, Thomas Graven-Nielsen, Per Grünwald Andersen, Marianne Andersen,

Background:Hypogonadism is prevalent during opioid treatment, but the effect of testosterone replacement treatment (TRT) on body composition, pain perception, and adrenal function is unclear. Purpose:To measure changes in body composition, pain perception, quality of life, and adrenal function after TRT or placebo in opioid-treated men with chronic non-malignant pain. Methods:Double-blind, ... Read more >>

Eur. J. Endocrinol. (European journal of endocrinology)
[2020, 182(6):539-548]

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The Effect of Stress on Repeated Painful Stimuli with and Without Painful Conditioning.

Morten Hoegh, Jeppe N Poulsen, Laura Petrini, Thomas Graven-Nielsen,

OBJECTIVES:Stress and pain have been interrelated in clinical widespread pain conditions. Studies indicate that acute experimental stress in healthy volunteers has a negative effect on the descending inhibitory pain control system and thus the ability to inhibit one painful stimulus with another (conditioned pain modulation [CPM]) although without effect on ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2020, 21(2):317-325]

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Temporal aspects of endogenous pain modulation during a noxious stimulus prolonged for 1 day.

Marie Hoeger Bement, Kristian K Petersen, Line B Sørensen, Hjalte H Andersen, Thomas Graven-Nielsen,

BACKGROUND:This study investigated (a) if a prolonged noxious stimulus (24-hr topical capsaicin) in healthy adults would impair central pain inhibitory and facilitatory systems measured as a reduction in conditioned pain modulation (CPM) and enhancement of temporal summation of pain (TSP) and (b) if acute pain relief or exacerbation (cooling and ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2020, 24(4):752-760]

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Pain, Sports Participation, and Physical Function in Adolescents With Patellofemoral Pain and Osgood-Schlatter Disease: A Matched Cross-sectional Study.

Michael Skovdal Rathleff, Lukasz Winiarski, Kasper Krommes, Thomas Graven-Nielsen, Per Hölmich, Jens Lykkegaard Olesen, Sinéad Holden, Kristian Thorborg,

OBJECTIVE:To compare pain, physical activity, quality of life, strength, and knee function in adolescents with patellofemoral pain (PFP) and Osgood-Schlatter disease (OSD) to those in pain-free controls. DESIGN:Cross-sectional study. METHODS:Self-report questionnaires were used to describe pain, physical activity, knee function, and quality of life in participants with PFP (n = ... Read more >>

J Orthop Sports Phys Ther (The Journal of orthopaedic and sports physical therapy)
[2020, 50(3):149-157]

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Head repositioning accuracy is influenced by experimental neck pain in those most accurate but not when adding a cognitive task.

Steffan Wittrup McPhee Christensen, Anneli Peolsson, Simone May Agger, Mikkel Svindt, Thomas Graven-Nielsen, Rogerio Pessoto Hirata,

Background and aims Neck pain can impair perception of cervical movement, but how this is affected by attention is unknown. In this study, the effects of experimental neck pain on head repositioning accuracy during standardized head movements were investigated. Methods Experimental neck pain was induced by injecting hypertonic saline into ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2019, 20(1):191-203]

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Recurrent low back pain patients demonstrate facilitated pronociceptive mechanisms when in pain, and impaired antinociceptive mechanisms with and without pain.

Megan E McPhee, Thomas Graven-Nielsen,

Low back pain (LBP) has been inconsistently associated with enhanced pronociceptive and impaired antinociceptive mechanisms. It remains unknown whether alterations are causal, consequential, or coincidental to pain presence. This study investigated pronociceptive and antinociceptive mechanisms in recurrent LBP (RLBP) patients across painful and pain-free periods, compared with age/sex-matched asymptomatic controls. ... Read more >>

Pain (Pain)
[2019, 160(12):2866-2876]

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Recurrent neck pain patients exhibit altered joint motion pattern during cervical flexion and extension movements.

Ning Qu, Thomas Graven-Nielsen, Rene Lindstrøm, Victoria Blogg Andersen Dc, Rogerio Pessoto Hirata,

BACKGROUND:Impaired sensorimotor ability has been demonstrated in recurrent neck pain patients. It is however not clear if cervical joint motion and pressure pain sensitivity in recurrent neck pain patients are different from asymptomatic controls. METHODS:Cervical flexion and extension motions were examined by video-fluoroscopy and pressure pain thresholds were assessed bilaterally ... Read more >>

Clin Biomech (Bristol, Avon) (Clinical biomechanics (Bristol, Avon))
[2020, 71:125-132]

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Alterations in pro-nociceptive and anti-nociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Megan E McPhee, Henrik Bjarke Vaegter, Thomas Graven-Nielsen,

Altered pro-nociceptive and anti-nociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions alterations are well-established, but in low back pain (LBP) populations there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to address ... Read more >>

Pain (Pain)
[2019, :]

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Towards a brain signature of chronic pain using cerebral blood flow spatial covariance analysis in people with chronic knee pain

Sarina Iwabuchi, Yue Xing, William Cottam, Marianne Drabek, Arman Tadjibaev, Gwen Fernandes, Kristian Petersen, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Ana Valdes, Weiya Zhang, Michael Doherty, David Walsh, Dorothee Auer,

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladaptive modulation of central pain pathways is associated with pain chronicity following e.g. chronic post-operative pain after knee replacement. Other factors such as low mood, anxiety and tendency to catastrophize seem to also be important contributors. We aimed ... Read more >>

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Isometric exercise and pain in patellar tendinopathy: A randomized crossover trial.

Sinéad Holden, Kristian Lyng, Thomas Graven-Nielsen, Henrik Riel, Jens Lykkegaard Olesen, Lars Henrik Larsen, Michael Skovdal Rathleff,

OBJECTIVES:The aim of this study was to compare the acute effects of isometric versus dynamic resistance exercise on pain during a pain-provoking activity, and exercise-induced hypoalgesia in participants with patellar tendinopathy. DESIGN:This study was a pre-registered randomised crossover study. Participants were blinded to the study hypothesis. METHODS:Participants (N = 21) performed a ... Read more >>

J Sci Med Sport (Journal of science and medicine in sport)
[2020, 23(3):208-214]

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Motor adaptation varies between individuals in the transition to sustained pain.

Simon J Summers, Lucy S Chipchase, Rogerio Hirata, Thomas Graven-Nielsen, Rocco Cavaleri, Siobhan M Schabrun,

Musculoskeletal pain is associated with altered motor control that, despite short-term benefit, is hypothesised to have long-term consequences, contributing to the development of chronic pain. However, data on how motor control is altered when pain is sustained beyond a transient event are scarce. Here, we investigated motor adaptation, and its ... Read more >>

Pain (Pain)
[2019, 160(9):2115-2125]

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Nerve growth factor-induced muscle hyperalgesia facilitates ischaemic contraction-evoked pain.

Line Bay Sørensen, Parisa Gazerani, Thomas Graven-Nielsen,

BACKGROUND:Intramuscular injection of Nerve Growth Factor (NGF) may influence the responsiveness of active chemo-sensitive channels affecting muscle pain sensitivity. This double-blinded crossover study in healthy humans assessed contraction-evoked pain responses and pain sensitivity during acute ischaemia in the tibialis anterior (TA) muscle before and 24 hr after five distributed NGF injections ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2019, 23(10):1814-1825]

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Delayed effects of attention on pain sensitivity and conditioned pain modulation.

Morten Hoegh, David A Seminowicz, Thomas Graven-Nielsen,

BACKGROUND:Efficacy of pain modulation is assessed as the difference in pain sensitivity during a painful conditioning, compared to before (conditioning pain modulation, CPM). Attention can be assessed with the Stroop task, in which participants report the number of words on a screen; either congruent or incongruent with the value of ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2019, 23(10):1850-1862]

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Exercise-induced hypoalgesia in young adult females with long-standing patellofemoral pain - A randomized crossover study.

Christian L Straszek, Michael S Rathleff, Thomas Graven-Nielsen, Kristian K Petersen, Ewa M Roos, Sinead Holden,

BACKGROUND:Patellofemoral pain (PFP) is a common knee pain condition where hip and knee exercises help improve treatment outcomes. This study compared the acute effect of hip versus knee exercises on anti-nociceptive and pro-nociceptive mechanisms in young females with long-standing PFP. METHODS:In this randomized cross-over study, 29 females with PFP performed ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2019, 23(10):1780-1789]

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Experimental knee-related pain enhances attentional interference on postural control.

Eneida Yuri Suda, Rogerio Pessoto Hirata, Thorvaldur Palsson, Nicolas Vuillerme, Isabel C N Sacco, Thomas Graven-Nielsen,

PURPOSE:To quantify how postural stability is modified during experimental pain while performing different cognitively demanding tasks. METHODS:Sixteen healthy young adults participated in the experiment. Pain was induced by intramuscular injection of hypertonic saline solution (1 mL, 6%) in both vastus medialis and vastus lateralis muscles (0.9% isotonic saline was used as ... Read more >>

Eur. J. Appl. Physiol. (European journal of applied physiology)
[2019, 119(9):2053-2064]

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Impaired microvascular reactivity after eccentric muscle contractions is not restored by acute ingestion of antioxidants or dietary nitrate.

Ryan G Larsen, Jens M Thomsen, Rogerio P Hirata, Rudi Steffensen, Eva R Poulsen, Jens B Frøkjaer, Thomas Graven-Nielsen,

Unaccustomed eccentric exercise leads to impaired microvascular function but the underlying mechanism is unknown. In this study, we evaluated the role of oxidative stress and of nitric oxide (NO) bioavailability. Thirty young men and women performed eccentric contractions of the tibialis anterior (TA) muscle (ECC), with the contralateral leg serving ... Read more >>

Physiol Rep (Physiological reports)
[2019, 7(13):e14162]

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Corticomotor excitability reduction induced by experimental pain remains unaffected by performing a working memory task as compared to staying at rest.

Dennis B Larsen, Thomas Graven-Nielsen, Rogerio P Hirata, David Seminowicz, Siobhan Schabrun, Shellie A Boudreau,

Experimental pain inhibits primary motor cortex (M1) excitability. Attenuating pain-related inhibition of M1 excitability may be useful during rehabilitation in individuals with pain. One strategy to attenuate M1 excitability is to influence prefrontal and premotor cortex activity. Working memory tasks, e.g. the two-back task (TBT), engage prefrontal and premotor cortices ... Read more >>

Exp Brain Res (Experimental brain research)
[2019, 237(9):2205-2215]

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