Full Text Journal Articles by
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Reader response: Early hemodynamic predictors of good outcome and reperfusion injury after endovascular treatment.

Thomas Gattringer, Kurt Niederkorn, Benno Ikenberg, Christian Enzinger, Markus Kneihsl,

Neurology (Neurology)
[2020, 94(18):801-802]

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Cortical superficial siderosis: Fine dark lines, harbingers of doom.

Vasileios-Arsenios Lioutas, Thomas Gattringer,

Neurology (Neurology)
[2020, 94(17):729-730]

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A Fulminant Case of Demyelinating Encephalitis With Extensive Cortical Involvement Associated With Anti-MOG Antibodies.

Sonja Hochmeister, Thomas Gattringer, Martin Asslaber, Verena Stangl, Michaela Tanja Haindl, Christian Enzinger, Romana Höftberger,

Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (MOG-Abs) are commonly associated with clinical presentations as acute disseminated encephalomyelitis (ADEM) in both adults and children and anti-aquaporin 4 antibody-seronegative neuromyelitis optica spectrum disorder (NMOSD) and related syndromes such as optic neuritis, myelitis, and brainstem encephalitis. Most often, the presence of MOG-Abs is associated ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:31]

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Early Progressive Changes in White Matter Integrity Are Associated with Stroke Recovery.

Daniela Pinter, Thomas Gattringer, Simon Fandler-Höfler, Markus Kneihsl, Sebastian Eppinger, Hannes Deutschmann, Alexander Pichler, Birgit Poltrum, Gernot Reishofer, Stefan Ropele, Reinhold Schmidt, Christian Enzinger,

Information on microstructural white matter integrity has been shown to explain post-stroke recovery beyond clinical measures and focal brain damage. Especially, knowledge about early white matter changes might improve prediction of outcome. We investigated 42 acute reperfused ischemic stroke patients (mean age 66.5 years, 40% female, median admission NIHSS 9.5) with ... Read more >>

Transl Stroke Res (Translational stroke research)
[2020, :]

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Single mean arterial blood pressure drops during stroke thrombectomy under general anaesthesia are associated with poor outcome.

Simon Fandler-Höfler, Stefan Heschl, Placido Argüelles-Delgado, Markus Kneihsl, Eva Hassler, Marton Magyar, Andreas Kainz, Andrea Berghold, Kurt Niederkorn, Hannes Deutschmann, Franz Fazekas, Thomas Gattringer,

BACKGROUND:We examined the influence of periprocedural blood pressure (BP), especially critical BP drops, on 3-month functional outcome in stroke patients undergoing mechanical thrombectomy (MT) under general anaesthesia (GA). METHODS:We screened all patients with anterior circulation large vessel occlusion receiving MT under GA at our centre from January 2011 to June ... Read more >>

J. Neurol. (Journal of neurology)
[2020, 267(5):1331-1339]

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Mean Platelet Volume Does Not Predict Restenosis After Carotid Artery Stenting in Whites.

Melanie Haidegger, Markus Kneihsl, Kurt Niederkorn, Hannes Deutschmann, Michael Augustin, Gerit Wünsch, Simon Fandler-Höfler, Susanna Horner, Franz Fazekas, Christian Enzinger, Thomas Gattringer,

Background and Purpose- Mean platelet volume (MPV) indicates platelet activity possibly affecting patient's risk for progressive atherosclerotic disease. A recent study identified elevated MPV as a predictor of in-stent restenosis (ISR) after carotid artery stenting (CAS) in a Chinese population. However, the role of MPV on the development of ISR ... Read more >>

Stroke (Stroke)
[2020, 51(3):986-989]

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Early renal dysfunction and fibroblast growth factor-23 in patients with small vessel disease-related stroke.

Simon Fandler-Höfler, Christian Enzinger, Markus Kneihsl, Daniela Pinter, Sebastian Eppinger, Barbara Obermayer-Pietsch, Anna Goritschan, Hildegard Hafner-Giessauf, Alexander R Rosenkranz, Franz Fazekas, Thomas Gattringer,

Interactions between cerebral small vessel disease (CSVD) and renal dysfunction (RD) have been reported, but previous studies were mostly retrospective and limited to measurements of estimated glomerular filtration rate (eGFR). In this prospective, longitudinal study of patients with CSVD-related recent small subcortical infarcts (RSSI), we aimed at a comprehensive exploration ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15410]

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Global Outcome Assessment Life-long after stroke in young adults initiative-the GOAL initiative: study protocol and rationale of a multicentre retrospective individual patient data meta-analysis.

Merel S Ekker, Mina A Jacob, Myrna ME van Dongen, Karoliina Aarnio, Arunkar K Annamalai, Antonio Arauz, Marcel Arnold, Miguel A Barboza, Manuel Bolognese, Raf Brouns, Batnairamdal Chuluun, Enkhzaya Chuluunbaatar, Byambasuren Dagvajantsan, Stephanie Debette, Adi Don, Chris Enzinger, Esme Ekizoglu, Simon Fandler-Höfler, Franz Fazekas, Anette Fromm, Thomas Gattringer, Giosue Gulli, Michael Hoffmann, Thiago F Hora, Christina Jern, Katarina Jood, Masahiro Kamouchi, Young Seo Kim, Takanari Kitazono, Steven J Kittner, Timothy J Kleinig, Catharina J M Klijn, Janika Korv, Tsong-Hai Lee, Didier Leys, Noortje AM Maaijwee, Nicolas Martinez-Majander, João Pedro Marto, Man M Mehndiratta, Victoria Mifsud, Vinicius V Montanaro, Mayowa O Owolabi, Vinod B Patel, Matthew C Phillips, Bartlomiej Piechowski-Iozwiak, Aleksandra Pikula, Jose Luis Ruiz-Sandoval, Bettina Sarnowski, Floris HBM Schreuder, Rick H Swartz, K S Tan, David Tanne, T Tatlisumak, Vincent Thijs, Anil M Tuladhar, Miguel Viana-Baptista, Riina Vibo, Teddy Y Wu, Nilüfer Yesilot, Ulrike Waje-Andreassen, Alessandro Pezzini, Jukka Putaala, Frank-Erik de Leeuw,

INTRODUCTION:Worldwide, 2 million patients aged 18-50 years suffer a stroke each year, and this number is increasing. Knowledge about global distribution of risk factors and aetiologies, and information about prognosis and optimal secondary prevention in young stroke patients are limited. This limits evidence-based treatment and hampers the provision of appropriate ... Read more >>

BMJ Open (BMJ open)
[2019, 9(11):e031144]

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Morphological MRI phenotypes of multiple sclerosis differ in resting-state brain function.

Daniela Pinter, Christian F Beckmann, Franz Fazekas, Michael Khalil, Alexander Pichler, Thomas Gattringer, Stefan Ropele, Siegrid Fuchs, Christian Enzinger,

We aimed to assess differences in resting-state functional connectivity (FC) between distinct morphological MRI-phenotypes in multiple sclerosis (MS). Out of 180 MS patients, we identified those with high T2-hyperintense lesion load (T2-LL) and high normalized brain volume (NBV; a predominately white matter damage group, WMD; N = 37) and patients with low ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):16221]

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Predictors of Lesion Cavitation After Recent Small Subcortical Stroke.

Thomas Gattringer, Maria Valdes Hernandez, Anna Heye, Paul A Armitage, Stephen Makin, Francesca Chappell, Daniela Pinter, Fergus Doubal, Christian Enzinger, Franz Fazekas, Joanna M Wardlaw,

Morphologic evolution of recent small subcortical infarcts (RSSI) ranges from lesion disappearance to lacune formation and the reasons for this variability are still poorly understood. We hypothesized that diffusion tensor imaging (DTI) and blood-brain-barrier (BBB) abnormalities early on can predict tissue damage 1 year after an RSSI. We studied prospectively recruited ... Read more >>

Transl Stroke Res (Translational stroke research)
[2020, 11(3):402-411]

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[Use of smartphone apps in secondary stroke prevention].

Viktoria Fruhwirth, Christian Enzinger, Elisabeth Weiss, Andreas Schwerdtfeger, Thomas Gattringer, Daniela Pinter,

Modifiable risk factors such as hypertension, obesity or smoking have been reported to explain up to 90% of risk for ischemic stroke. Treatment of these risk factors is known to decrease the risk of recurrent stroke events. We performed a computer-based literature research from June to August 2018 using the electronic ... Read more >>

Wien Med Wochenschr (Wiener medizinische Wochenschrift (1946))
[2020, 170(1-2):41-54]

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Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial.

Bastian Cheng, Florent Boutitie, Alina Nickel, Anke Wouters, Tae-Hee Cho, Martin Ebinger, Matthias Endres, Jochen B Fiebach, Jens Fiehler, Ivana Galinovic, Josep Puig, Vincent Thijs, Robin Lemmens, Keith W Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z Simonsen, Christian Gerloff, Götz Thomalla, ,

Background and Purpose- Relative signal intensity of acute ischemic stroke lesions in fluid-attenuated inversion recovery (fluid-attenuated inversion recovery relative signal intensity [FLAIR-rSI]) magnetic resonance imaging is associated with time elapsed since stroke onset with higher intensities signifying longer time intervals. In the randomized controlled WAKE-UP trial (Efficacy and Safety of ... Read more >>

Stroke (Stroke)
[2020, 51(1):209-215]

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Comment on: External Validation of the PREMISE Score in the Athens Stroke Registry.

Thomas Gattringer, Alexandra Posekany, Stefan Kiechl, Franz Fazekas, Christian Enzinger,

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2019, 28(11):104334]

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Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial.

Rustam Al-Shahi Salman, David P Minks, Dipayan Mitra, Mark A Rodrigues, Priya Bhatnagar, Johann C du Plessis, Yogish Joshi, Martin S Dennis, Gordon D Murray, David E Newby, Peter A G Sandercock, Nikola Sprigg, Jacqueline Stephen, Cathie L M Sudlow, David J Werring, William N Whiteley, Joanna M Wardlaw, Philip M White, ,

BACKGROUND:Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2019, 18(7):643-652]

Cited: 5 times

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Blood Biomarkers of Heart Failure and Hypercoagulation to Identify Atrial Fibrillation-Related Stroke.

Markus Kneihsl, Thomas Gattringer, Egbert Bisping, Daniel Scherr, Reinhard Raggam, Harald Mangge, Christian Enzinger, Simon Fandler-Höfler, Sebastian Eppinger, Christina Hermetter, Bernd Bucnik, Birgit Poltrum, Kurt Niederkorn, Franz Fazekas,

Background and Purpose- Occult atrial fibrillation (AF) causes a relevant proportion of initially cryptogenic stroke (CS), but prolonged rhythm monitoring is difficult to apply to all such patients. We hypothesized that blood biomarkers indicating heart failure (NT-proBNP [N-terminal pro-brain natriuretic peptide]) and hypercoagulability (D-dimer, AT-III [antithrombin-III]) were associated with AF-related ... Read more >>

Stroke (Stroke)
[2019, 50(8):2223-2226]

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Are morphologic features of recent small subcortical infarcts related to specific etiologic aspects?

Sebastian Eppinger, Thomas Gattringer, Lena Nachbaur, Simon Fandler, Lukas Pirpamer, Stefan Ropele, Joanna Wardlaw, Christian Enzinger, Franz Fazekas,

Background:Recent small subcortical infarcts (RSSIs) mostly result from the occlusion of a single, small, brain artery due to intrinsic cerebral small-vessel disease (CSVD). Some RSSIs may be attributable to other causes such as cardiac embolism or large-artery disease, and their association with coexisting CSVD and vascular risk factors may vary ... Read more >>

Ther Adv Neurol Disord (Therapeutic advances in neurological disorders)
[2019, 12:1756286419835716]

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Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Duncan Wilson, Gareth Ambler, Keon-Joo Lee, Jae-Sung Lim, Masayuki Shiozawa, Masatoshi Koga, Linxin Li, Caroline Lovelock, Hugues Chabriat, Michael Hennerici, Yuen Kwun Wong, Henry Ka Fung Mak, Luis Prats-Sánchez, Alejandro Martínez-Domeño, Shigeru Inamura, Kazuhisa Yoshifuji, Ethem Murat Arsava, Solveig Horstmann, Jan Purrucker, Bonnie Yin Ka Lam, Adrian Wong, Young Dae Kim, Tae-Jin Song, Maarten Schrooten, Robin Lemmens, Sebastian Eppinger, Thomas Gattringer, Ender Uysal, Zeynep Tanriverdi, Natan M Bornstein, Einor Ben Assayag, Hen Hallevi, Jun Tanaka, Hideo Hara, Shelagh B Coutts, Lisa Hert, Alexandros Polymeris, David J Seiffge, Philippe Lyrer, Ale Algra, Jaap Kappelle, Rustam Al-Shahi Salman, Hans R Jäger, Gregory Y H Lip, Heinrich P Mattle, Leonidas D Panos, Jean-Louis Mas, Laurence Legrand, Christopher Karayiannis, Thanh Phan, Sarah Gunkel, Nicolas Christ, Jill Abrigo, Thomas Leung, Winnie Chu, Francesca Chappell, Stephen Makin, Derek Hayden, David J Williams, M Eline Kooi, Dianne H K van Dam-Nolen, Carmen Barbato, Simone Browning, Kim Wiegertjes, Anil M Tuladhar, Noortje Maaijwee, Christine Guevarra, Chathuri Yatawara, Anne-Marie Mendyk, Christine Delmaire, Sebastian Köhler, Robert van Oostenbrugge, Ying Zhou, Chao Xu, Saima Hilal, Bibek Gyanwali, Christopher Chen, Min Lou, Julie Staals, Régis Bordet, Nagaendran Kandiah, Frank-Erik de Leeuw, Robert Simister, Aad van der Lugt, Peter J Kelly, Joanna M Wardlaw, Yannie Soo, Felix Fluri, Velandai Srikanth, David Calvet, Simon Jung, Vincent I H Kwa, Stefan T Engelter, Nils Peters, Eric E Smith, Yusuke Yakushiji, Dilek Necioglu Orken, Franz Fazekas, Vincent Thijs, Ji Hoe Heo, Vincent Mok, Roland Veltkamp, Hakan Ay, Toshio Imaizumi, Beatriz Gomez-Anson, Kui Kai Lau, Eric Jouvent, Peter M Rothwell, Kazunori Toyoda, Hee-Joon Bae, Joan Marti-Fabregas, David J Werring, ,

BACKGROUND:Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. We ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2019, 18(7):653-665]

Cited: 2 times

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Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial.

,

BACKGROUND:Antiplatelet therapy reduces the risk of major vascular events for people with occlusive vascular disease, although it might increase the risk of intracranial haemorrhage. Patients surviving the commonest subtype of intracranial haemorrhage, intracerebral haemorrhage, are at risk of both haemorrhagic and occlusive vascular events, but whether antiplatelet therapy can be ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10191):2613-2623]

Cited: 2 times

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Planning of stroke care and urgent prehospital care across Europe: Results of the ESO/ESMINT/EAN/SAFE Survey.

Sònia Abilleira, Diana Aguiar de Sousa, Thomas Gattringer, Adam Kobayashi, Franz Fazekas, Istvan Szikora, Valery Feigin, Valeria Caso, Miquel Gallofré, Urs Fischer, ,

Introduction:Adequate planning and implementation of stroke systems of care is key to guarantee a rapid healthcare response and delivery of specific reperfusion therapies among candidates. We assessed the availability of stroke care plans in Europe, and evaluated their impact on rates of reperfusion therapies for stroke. Patients:Based on the European ... Read more >>

Eur Stroke J (European stroke journal)
[2019, 4(4):329-336]

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Predicting Early Mortality of Acute Ischemic Stroke.

Thomas Gattringer, Alexandra Posekany, Kurt Niederkorn, Michael Knoflach, Birgit Poltrum, Sebastian Mutzenbach, Hans-Peter Haring, Julia Ferrari, Wilfried Lang, Johann Willeit, Stefan Kiechl, Christian Enzinger, Franz Fazekas, ,

Background and Purpose- Several risk factors are known to increase mid- and long-term mortality of ischemic stroke patients. Information on predictors of early stroke mortality is scarce but often requested in clinical practice. We therefore aimed to develop a rapidly applicable tool for predicting early mortality at the stroke unit. ... Read more >>

Stroke (Stroke)
[2019, 50(2):349-356]

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Diagnostic accuracy of noncontrast CT imaging markers in cerebral venous thrombosis.

Pieter-Jan Buyck, Susanna M Zuurbier, Carlos Garcia-Esperon, Miguel A Barboza, Paolo Costa, Irene Escudero, Dimitri Renard, Robin Lemmens, Nicole Hinteregger, Franz Fazekas, Jordi Jimenez Conde, Eva Giralt-Steinhauer, Sini Hiltunen, Antonio Arauz, Alessandro Pezzini, Joan Montaner, Jukka Putaala, Christian Weimar, Leonid Churilov, Thomas Gattringer, Hamed Asadi, Turgut Tatlisumak, Jonathan M Coutinho, Philippe Demaerel, Vincent Thijs,

OBJECTIVE:To assess the added diagnostic value of semiquantitative imaging markers on noncontrast CT scans in cerebral venous thrombosis (CVT). METHODS:In a retrospective, multicenter, blinded, case-control study of patients with recent onset (<2 weeks) CVT, 3 readers assessed (1) the accuracy of the visual impression of CVT based on a combination ... Read more >>

Neurology (Neurology)
[2019, 92(8):e841-e851]

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Neurofilaments as biomarkers in neurological disorders.

Michael Khalil, Charlotte E Teunissen, Markus Otto, Fredrik Piehl, Maria Pia Sormani, Thomas Gattringer, Christian Barro, Ludwig Kappos, Manuel Comabella, Franz Fazekas, Axel Petzold, Kaj Blennow, Henrik Zetterberg, Jens Kuhle,

Neuroaxonal damage is the pathological substrate of permanent disability in various neurological disorders. Reliable quantification and longitudinal follow-up of such damage are important for assessing disease activity, monitoring treatment responses, facilitating treatment development and determining prognosis. The neurofilament proteins have promise in this context because their levels rise upon neuroaxonal ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2018, 14(10):577-589]

Cited: 47 times

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Abnormal Blood Flow on Transcranial Duplex Sonography Predicts Poor Outcome After Stroke Thrombectomy.

Markus Kneihsl, Kurt Niederkorn, Hannes Deutschmann, Christian Enzinger, Birgit Poltrum, Susanna Horner, Daniela Thaler, Julia Kraner, Simon Fandler, Isabella Colonna, Franz Fazekas, Thomas Gattringer,

Background and Purpose- Hemodynamic changes following mechanical thrombectomy for large vessel occlusion stroke could be associated with complications and might affect prognosis. We investigated postinterventional middle cerebral artery blood flow on transcranial duplex sonography (TCD) and its prognostic value for anterior large vessel occlusion stroke patients. Methods- We identified all ... Read more >>

Stroke (Stroke)
[2018, 49(11):2780-2782]

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Access to and delivery of acute ischaemic stroke treatments: A survey of national scientific societies and stroke experts in 44 European countries.

Diana Aguiar de Sousa, Rascha von Martial, Sònia Abilleira, Thomas Gattringer, Adam Kobayashi, Miquel Gallofré, Franz Fazekas, Istvan Szikora, Valery Feigin, Valeria Caso, Urs Fischer,

Introduction:Acute stroke unit care, intravenous thrombolysis and endovascular treatment significantly improve the outcome for patients with ischaemic stroke, but data on access and delivery throughout Europe are lacking. We assessed best available data on access and delivery of acute stroke unit care, intravenous thrombolysis and endovascular treatment throughout Europe. Methods:A ... Read more >>

Eur Stroke J (European stroke journal)
[2019, 4(1):13-28]

Cited: 6 times

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Cerebrovascular disorders.

Franz Fazekas, Thomas Gattringer, Christian Enzinger,

PURPOSE OF REVIEW:Not unexpected from the variety of cerebrovascular disorders and their morphologic and clinical consequences the contributions of neuroimaging are also quite diverse and go with different approaches in different directions. By reviewing the recent advances in these various areas, we will attempt to highlight those contributions, which may ... Read more >>

Curr. Opin. Neurol. (Current opinion in neurology)
[2018, 31(4):345-353]

Cited: 0 times

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