Full Text Journal Articles by
Author Thomas A Bowman


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Arachidonic acid as a target for treating hypertriglyceridemia reproduced by a causal network analysis and an intervention study.

Azam Yazdani, Akram Yazdani, Thomas A Bowman, Francesco Marotta, John P Cooke, Ahmad Samiei,

Metabolomics (Metabolomics : Official journal of the Metabolomic Society)
[2018, 14(6):78]

Cited: 1 time

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A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction.

Elizabeth A Killion, Andrew R Reeves, Mahmoud A El Azzouny, Qing-Wu Yan, Defne Surujon, John D Griffin, Thomas A Bowman, Chunyan Wang, Nirupa R Matthan, Eric L Klett, Dong Kong, John W Newman, Xianlin Han, Mi-Jeong Lee, Rosalind A Coleman, Andrew S Greenberg,

<h4>Objective</h4>Regulation of fatty acid (FA) metabolism is central to adipocyte dysfunction during diet-induced obesity (DIO). Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (AA), but the in vivo actions of ACSL4 are unknown. The purpose of our studies was ... Read more >>

Mol Metab (Molecular metabolism)
[2018, 9:43-56]

Cited: 22 times

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Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice.

Lucia Russo, Harrison T Muturi, Hilda E Ghadieh, Simona S Ghanem, Thomas A Bowman, Hye Lim Noh, Sezin Dagdeviren, Godwin Y Dogbey, Jason K Kim, Garrett Heinrich, Sonia M Najjar,

<h4>Aims/hypothesis</h4>The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1 <sup>-/-</sup>) or with liver-specific inactivation (L-SACC1) of Cc1 (also known as Ceacam1) gene display hyperinsulinaemia resulting from impaired insulin clearance, insulin resistance, steatohepatitis and obesity. Because increased lipolysis contributes to the metabolic phenotype ... Read more >>

Diabetologia (Diabetologia)
[2017, 60(12):2463-2474]

Cited: 17 times

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Reduced Hepatic Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Level in Obesity.

Garrett Heinrich, Harrison T Muturi, Khadijeh Rezaei, Qusai Y Al-Share, Anthony M DeAngelis, Thomas A Bowman, Hilda E Ghadieh, Simona S Ghanem, Deqiang Zhang, Robert S Garofalo, Lei Yin, Sonia M Najjar,

Impairment of insulin clearance is being increasingly recognized as a critical step in the development of insulin resistance and metabolic disease. The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes insulin clearance. Null deletion or liver-specific inactivation of Ceacam1 in mice causes a defect in insulin clearance, insulin resistance, steatohepatitis, ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2017, 8:54]

Cited: 12 times

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Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease.

Garrett Heinrich, Hilda E Ghadieh, Simona S Ghanem, Harrison T Muturi, Khadijeh Rezaei, Qusai Y Al-Share, Thomas A Bowman, Deqiang Zhang, Robert S Garofalo, Lei Yin, Sonia M Najjar,

The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in particular in the context of its relationship to insulin resistance and visceral obesity. Work on the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in mice has resolved some of the related questions. CEACAM1 promotes insulin clearance by enhancing ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2017, 8:8]

Cited: 19 times

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Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption.

Thomas A Bowman, Kayleigh R O'Keeffe, Theresa D'Aquila, Qing Wu Yan, John D Griffin, Elizabeth A Killion, Deanna M Salter, Douglas G Mashek, Kimberly K Buhman, Andrew S Greenberg,

<h4>Objective</h4>The family of acyl-CoA synthetase enzymes (ACSL) activates fatty acids within cells to generate long chain fatty acyl CoA (FACoA). The differing metabolic fates of FACoAs such as incorporation into neutral lipids, phospholipids, and oxidation pathways are differentially regulated by the ACSL isoforms. In vitro studies have suggested a role for ... Read more >>

Mol Metab (Molecular metabolism)
[2016, 5(3):210-220]

Cited: 30 times

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Diet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice.

Anna C Pfalzer, Paula-Dene C Nesbeth, Laurence D Parnell, Lakshmanan K Iyer, Zhenhua Liu, Anne V Kane, C-Y Oliver Chen, Albert K Tai, Thomas A Bowman, Martin S Obin, Joel B Mason, Andrew S Greenberg, Sang-Woon Choi, Jacob Selhub, Ligi Paul, Jimmy W Crott,

Obesity is a risk factor for colorectal cancer (CRC), and alterations in the colonic microbiome and metabolome may be mechanistically involved in this relationship. The relative contribution of diet and obesity per se are unclear. We compared the effect of diet- and genetically-induced obesity on the intestinal microbiome and metabolome ... Read more >>

PLoS One (PloS one)
[2015, 10(8):e0135758]

Cited: 23 times

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Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue.

Sumona G Lester, Lucia Russo, Simona S Ghanem, Saja S Khuder, Anthony M DeAngelis, Emily L Esakov, Thomas A Bowman, Garrett Heinrich, Qusai Y Al-Share, Marcia F McInerney, William M Philbrick, Sonia M Najjar,

CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying global Ceacam1 null mice (Cc1(-/-) ), C57/BL6J mice fed a high-fat (HF) diet exhibited reduced hepatic CEACAM1 levels and impaired insulin clearance, followed by hyperinsulinemia, insulin resistance, and visceral obesity. Conversely, forced liver-specific expression of CEACAM1 protected insulin ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2015, 6:116]

Cited: 11 times

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Shaping the Future of Research: a perspective from junior scientists.

Gary S McDowell, Kearney T W Gunsalus, Drew C MacKellar, Sarah A Mazzilli, Vaibhav P Pai, Patricia R Goodwin, Erica M Walsh, Avi Robinson-Mosher, Thomas A Bowman, James Kraemer, Marcella L Erb, Eldi Schoenfeld, Leila Shokri, Jonathan D Jackson, Ayesha Islam, Matthew D Mattozzi, Kristin A Krukenberg, Jessica K Polka,

The landscape of scientific research and funding is in flux as a result of tight budgets, evolving models of both publishing and evaluation, and questions about training and workforce stability. As future leaders, junior scientists are uniquely poised to shape the culture and practice of science in response to these ... Read more >>

F1000Res (F1000Research)
[2014, 3:291]

Cited: 21 times

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FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress.

Sandra Pereira, Edward Park, Yusaku Mori, C Andrew Haber, Ping Han, Toyoyoshi Uchida, Laura Stavar, Andrei I Oprescu, Khajag Koulajian, Alexander Ivovic, Zhiwen Yu, Deling Li, Thomas A Bowman, Jay Dewald, Jamel El-Benna, David N Brindley, Roger Gutierrez-Juarez, Tony K T Lam, Sonia M Najjar, Robert A McKay, Sanjay Bhanot, I George Fantus, Adria Giacca,

Fat-induced hepatic insulin resistance plays a key role in the pathogenesis of type 2 diabetes in obese individuals. Although PKC and inflammatory pathways have been implicated in fat-induced hepatic insulin resistance, the sequence of events leading to impaired insulin signaling is unknown. We used Wistar rats to investigate whether PKCδ ... Read more >>

Am J Physiol Endocrinol Metab (American journal of physiology. Endocrinology and metabolism)
[2014, 307(1):E34-46]

Cited: 52 times

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Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease.

James L McManaman, Elise S Bales, David J Orlicky, Matthew Jackman, Paul S MacLean, Shannon Cain, Amanda E Crunk, Ayla Mansur, Christine E Graham, Thomas A Bowman, Andrew S Greenberg,

The cytoplasmic lipid droplet (CLD) protein perilipin-2 (Plin2) is expressed in multiple nonadipose tissues, where it is thought to play a role in regulating their lipid storage properties. However, the extent to which Plin2 functions in nutrient utilization and metabolism, or how it influences the consequences of over-feeding, remains unclear. ... Read more >>

J Lipid Res (Journal of lipid research)
[2013, 54(5):1346-1359]

Cited: 91 times

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Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis.

Andrew S Greenberg, Fredric B Kraemer, Krishnakant G Soni, Mark P Jedrychowski, Qing-Wu Yan, Christine E Graham, Thomas A Bowman, Ayla Mansur,

EMBO J (The EMBO journal)
[2011, 30(21):4337-4339]

Cited: 9 times

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Sensing and responding to compliance changes during manual ventilation using a lung model: can we teach healthcare providers to improve?

Thomas A Bowman, Alix Paget-Brown, Jeanne Carroll, Matthew J Gurka, John Kattwinkel,

<h4>Objective</h4>To test the hypothesis that an educational intervention would improve the resuscitator's ability to provide on-target volume ventilation during pulmonary compliance changes.<h4>Study design</h4>Neonatal professionals (n = 27) ventilated an electromechanical lung model simulating a 3-kg baby while targeting a tidal volume of 4-6 mL/kg. In this preintervention and postintervention study, ... Read more >>

J Pediatr (The Journal of pediatrics)
[2012, 160(3):372-376.e1]

Cited: 5 times

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Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity.

Thomas A Bowman, Sadeesh K Ramakrishnan, Meenakshi Kaw, Sang Jun Lee, Payal R Patel, Varun K Golla, Raymond E Bourey, Per Magnus Haram, Lauren G Koch, Steven L Britton, Ulrik Wisløff, Abraham D Lee, Sonia M Najjar,

Rats selectively bred for low aerobic running capacity exhibit the metabolic syndrome, including hyperinsulinemia, insulin resistance, visceral obesity, and dyslipidemia. They also exhibit features of nonalcoholic steatohepatitis, including chicken-wire fibrosis, inflammation, and oxidative stress. Hyperinsulinemia in these rats is associated with impaired hepatic insulin clearance. The current studies aimed to ... Read more >>

Endocrinology (Endocrinology)
[2010, 151(11):5157-5164]

Cited: 26 times

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Mice with null mutation of Ceacam I develop nonalcoholic steatohepatitis.

Sumona Ghosh, Meenakshi Kaw, Payal R Patel, Kelly J Ledford, Thomas A Bowman, Marcia F McInerney, Sandra K Erickson, Raymond E Bourey, Sonia M Najjar,

Transgenic liver-specific inactivation of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM1) impairs hepatic insulin clearance and causes hyperinsuline-mia, insulin resistance, elevation in hepatic and serum triglyceride levels, and visceral obesity. It also predisposes to nonalchoholic steatohepatitis (NASH) in response to a high-fat diet. To discern whether this phenotype reflects a ... Read more >>

Hepat Med (Hepatic medicine : evidence and research)
[2010, 2010(2):69-78]

Cited: 19 times

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Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice.

Manya Warrier, Terry D Hinds, Kelly J Ledford, Harrison A Cash, Payal R Patel, Thomas A Bowman, Lance A Stechschulte, Weidong Yong, Weinian Shou, Sonia M Najjar, Edwin R Sanchez,

Although FK506-binding protein 52 (FKBP52) is an established positive regulator of glucocorticoid receptor (GR) activity, an in vivo role for FKBP52 in glucocorticoid control of metabolism has not been reported. To address this question, FKBP52(+/-) mice were placed on a high-fat (HF) diet known to induce obesity, hepatic steatosis, and ... Read more >>

Endocrinology (Endocrinology)
[2010, 151(7):3225-3236]

Cited: 33 times

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Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism.

Anthony M DeAngelis, Garrett Heinrich, Tong Dai, Thomas A Bowman, Payal R Patel, Sang Jun Lee, Eun-Gyoung Hong, Dae Young Jung, Anke Assmann, Rohit N Kulkarni, Jason K Kim, Sonia M Najjar,

<h4>Objective</h4>Liver-specific inactivation of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) by a dominant-negative transgene (l-SACC1 mice) impaired insulin clearance, caused insulin resistance, and increased hepatic lipogenesis. To discern whether this phenotype reflects a physiological function of CEACAM1 rather than the effect of the dominant-negative transgene, we characterized the metabolic phenotype ... Read more >>

Diabetes (Diabetes)
[2008, 57(9):2296-2303]

Cited: 63 times

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