Full Text Journal Articles by
Author Therese S Salameh


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Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics.

Therese S Salameh, Elizabeth M Rhea, Konrad Talbot, William A Banks,

Among the more promising treatments proposed for Alzheimer's disease (AD) and Parkinson's disease (PD) are those reducing brain insulin resistance. The antidiabetics in the class of incretin receptor agonists (IRAs) reduce symptoms and brain pathology in animal models of AD and PD, as well as glucose utilization in AD cases ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2020, 180:114187]

Cited: 9 times

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Disruption of the hippocampal and hypothalamic blood-brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate.

Therese S Salameh, William G Mortell, Aric F Logsdon, D Allan Butterfield, William A Banks,

<h4>Background</h4>Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood-retinal barrier (BRB) and blood-brain barrier (BBB) are hallmarks of subsequent retinal edema and central nervous system dysfunction. However, the mechanisms by which diet or metabolic syndrome induces dysfunction are not ... Read more >>

Fluids Barriers CNS (Fluids and barriers of the CNS)
[2019, 16(1):1]

Cited: 12 times

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Routes for the delivery of insulin to the central nervous system: A comparative review.

Elizabeth M Rhea, Therese S Salameh, William A Banks,

Central nervous system (CNS) insulin resistance is a condition in which the cells within the CNS do not respond to insulin appropriately and is often linked to aberrant CNS insulin levels. CNS insulin is primarily derived from the periphery. Aberrant CNS insulin levels can arise due to various factors including ... Read more >>

Exp Neurol (Experimental neurology)
[2019, 313:10-15]

Cited: 6 times

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Ghrelin transport across the blood-brain barrier can occur independently of the growth hormone secretagogue receptor.

Elizabeth M Rhea, Therese S Salameh, Sarah Gray, Jingjing Niu, William A Banks, Jenny Tong,

<h4>Objective</h4>The blood-brain barrier (BBB) regulates the entry of substrates and peptides into the brain. Ghrelin is mainly produced in the stomach but exerts its actions in the central nervous system (CNS) by crossing the BBB. Once present in the CNS, ghrelin can act in the hypothalamus to regulate food intake, ... Read more >>

Mol Metab (Molecular metabolism)
[2018, 18:88-96]

Cited: 7 times

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Gut reactions: How the blood-brain barrier connects the microbiome and the brain.

Aric F Logsdon, Michelle A Erickson, Elizabeth M Rhea, Therese S Salameh, William A Banks,

A growing body of evidence indicates that the microbiome interacts with the central nervous system (CNS) and can regulate many of its functions. One mechanism for this interaction is at the level of the blood-brain barriers (BBBs). In this minireview, we examine the several ways the microbiome is known to ... Read more >>

Exp Biol Med (Maywood) (Experimental biology and medicine (Maywood, N.J.))
[2018, 243(2):159-165]

Cited: 30 times

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Michelle A Erickson, Joseph Jude, Hengjiang Zhao, Elizabeth M Rhea, Therese S Salameh, William Jester, Shelley Pu, Jenna Harowitz, Ngan Nguyen, William A Banks, Reynold A Panettieri, Kelly L Jordan-Sciutto,

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2018, 32(1):535]

Cited: 0 times

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Blood-Brain Barriers in Obesity.

Elizabeth M Rhea, Therese S Salameh, Aric F Logsdon, Angela J Hanson, Michelle A Erickson, William A Banks,

After decades of rapid increase, the rate of obesity in adults in the USA is beginning to slow and the rate of childhood obesity is stabilizing. Despite these improvements, the obesity epidemic continues to be a major health and financial burden. Obesity is associated with serious negative health outcomes such ... Read more >>

AAPS J (The AAPS journal)
[2017, 19(4):921-930]

Cited: 25 times

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Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents.

Dora Werling, William A Banks, Therese S Salameh, Timea Kvarik, Laszlo Akos Kovacs, Alexandra Vaczy, Edina Szabo, Flora Mayer, Rita Varga, Andrea Tamas, Gabor Toth, Zsolt Biro, Tamas Atlasz, Dora Reglodi,

The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has two active forms, PACAP1-27 and PACAP1-38. Among the well-established actions are PACAP's neurotrophic and neuroprotective effects, which have also been proven in models of different retinopathies. The route of delivery is usually intravitreal in studies proving PACAP's retinoprotective effects. Recently, we ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(3):]

Cited: 11 times

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Blood-Brain Barrier Disruption and Neurovascular Unit Dysfunction in Diabetic Mice: Protection with the Mitochondrial Carbonic Anhydrase Inhibitor Topiramate.

Therese S Salameh, Gul N Shah, Tulin O Price, Melvin R Hayden, William A Banks,

All forms of diabetes mellitus are characterized by chronic hyperglycemia, resulting in the development of a number of microvascular and macrovascular pathologies. Diabetes is also associated with changes in brain microvasculature, leading to dysfunction and ultimately disruption of the blood-brain barrier (BBB). These changes are correlated with a decline in ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2016, 359(3):452-459]

Cited: 29 times

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Ocular Delivery of PACAP1-27 Protects the Retina From Ischemic Damage in Rodents.

Dora Werling, Dora Reglodi, William A Banks, Therese S Salameh, Krisztina Kovacs, Timea Kvarik, Alexandra Vaczy, Laszlo Kovacs, Flora Mayer, Bese Danyadi, Emese Lokos, Andrea Tamas, Gabor Toth, Zsolt Biro, Tamas Atlasz,

<h4>Purpose</h4>Pituitary adenylate cyclase activating polypeptide (PACAP) is neuroprotective in neuronal injuries. Bilateral common carotid artery occlusion (BCCAO) causes chronic hypoperfusion-induced degeneration in the rat retina, where we proved the retinoprotective effect of intravitreal PACAP. Although this route of administration is a common clinical practice in several diseases, easier routes are ... Read more >>

Invest Ophthalmol Vis Sci (Investigative ophthalmology & visual science)
[2016, 57(15):6683-6691]

Cited: 17 times

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Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit.

William A Banks, Alicia M Gray, Michelle A Erickson, Therese S Salameh, Mamatha Damodarasamy, Nader Sheibani, James S Meabon, Emily E Wing, Yoichi Morofuji, David G Cook, May J Reed,

<h4>Background</h4>Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain.<h4>Methods</h4>We used lipopolysaccharide (LPS) to induce inflammation and BBB disruption in mice. BBB disruption was measured using ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2015, 12:223]

Cited: 142 times

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Intranasal Delivery of Proteins and Peptides in the Treatment of Neurodegenerative Diseases.

M Elizabeth Meredith, Therese S Salameh, William A Banks,

The blood-brain barrier (BBB) is a major impediment to the therapeutic delivery of peptides and proteins to the brain. Intranasal delivery often provides a non-invasive means to bypass the BBB. Advantages of using intranasal delivery include minimizing exposure to peripheral organs and tissues, thus reducing systemic side effects. It also ... Read more >>

AAPS J (The AAPS journal)
[2015, 17(4):780-787]

Cited: 51 times

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Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition.

Therese S Salameh, Kristin M Bullock, Isabel A Hujoel, Michael L Niehoff, Tami Wolden-Hanson, Junghyun Kim, John E Morley, Susan A Farr, William A Banks,

Intranasal insulin has shown efficacy in patients with Alzheimer's disease (AD), but there are no preclinical studies determining whether or how it reaches the brain. Here, we showed that insulin applied at the level of the cribriform plate via the nasal route quickly distributed throughout the brain and reversed learning ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2015, 47(3):715-728]

Cited: 43 times

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Intranasal administration as a route for drug delivery to the brain: evidence for a unique pathway for albumin.

Joseph A Falcone, Therese S Salameh, Xiang Yi, Benjamin J Cordy, William G Mortell, Alexander V Kabanov, William A Banks,

A variety of compounds will distribute into the brain when placed at the cribriform plate by intranasal (i.n.) administration. In this study, we investigated the ability of albumin, a protein that can act as a drug carrier but is excluded from brain by the blood-brain barrier, to distribute into the ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2014, 351(1):54-60]

Cited: 24 times

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Songbird frequency selectivity and temporal resolution vary with sex and season.

Megan D Gall, Therese S Salameh, Jeffrey R Lucas,

Many species of songbirds exhibit dramatic seasonal variation in song output. Recent evidence suggests that seasonal changes in auditory processing are coincident with seasonal variation in vocal output. Here, we show, for the first time, that frequency selectivity and temporal resolution of the songbird auditory periphery change seasonally and in ... Read more >>

Proc Biol Sci (Proceedings. Biological sciences)
[2013, 280(1751):20122296]

Cited: 11 times

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