Full Text Journal Articles by
Author Theresa A Laguna

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Management of chronic pulmonary disease in the time of coronavirus disease 2019.

John Palla, Theresa A Laguna,

<h4>Purpose of review</h4>The purpose of this review is to discuss the most recent data describing the impact of coronavirus disease 2019 (COVID-19) on the pediatric population with chronic pulmonary disease. We specifically focus on children with asthma, cystic fibrosis (CF), and lung transplant recipients.<h4>Recent findings</h4>Children with asthma, CF, and lung ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2021, 33(3):294-301]

Cited: 0 times

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Rates of adverse and serious adverse events in children with cystic fibrosis.

Jessica E Pittman, Umer Khan, Theresa A Laguna, Sonya Heltshe, Christopher H Goss, Don B Sanders,

<h4>Background</h4>Cystic fibrosis (CF) is an autosomal recessive disease characterized by chronic sinopulmonary symptoms and chronic gastrointestinal symptoms that begins in infancy. Children with CF are increasingly being included in clinical trials. In order to fully evaluate the impact of new therapies in future clinical trials, an understanding of baseline adverse ... Read more >>

J Cyst Fibros (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2021, :]

Cited: 0 times

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Preferences for disclosing adverse childhood experiences for children and adults with cystic fibrosis.

Wadsworth A Williams, Manu Jain, Theresa A Laguna, Susanna A McColley,

<h4>Introduction</h4>The 2017-2018 National Survey of Children's Health estimates that 30 million (42%) US children have experienced at least one adverse childhood experience (ACE), including abuse, neglect, and household dysfunction. ACEs negatively impact long-term health, and there has been no study of ACEs in cystic fibrosis (CF). We assessed willingness to ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2021, 56(5):921-927]

Cited: 0 times

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Cystic fibrosis diagnosed by state newborn screening: Or is it?

Maura Fox, Angelique Mercier, Adrienne Savant, Theresa A Laguna,

Newborn screening for cystic fibrosis is universal across the United States; however, each state chooses the method by which they screen. Illinois employs a two-step process which includes the measurement of the immunoreactive trypsinogen followed by an assay designed to detect 74 of the most common genetic mutations in the ... Read more >>

SAGE Open Med Case Rep (SAGE open medical case reports)
[2020, 8:2050313X20939421]

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A proposal for the addressing the needs of the pediatric pulmonary work force.

Benjamin Gaston, Theresa A Laguna, Terry L Noah, James Hagood, Judith Voynow, Thomas Ferkol, Marc Hershenson, Katie Boyne, Angela Delecaris, Kristie Ross, David Gozal, Juan C Celedón, Steven H Abman, Paul Moore, Stephanie Davis, David N Cornfield, Thomas Murphy,

Unprecedented opportunities and daunting difficulties are anticipated in the future of pediatric pulmonary medicine. To address these issues and optimize pediatric pulmonary training, a group of faculty from various institutions met in 2019 and proposed specific, long-term solutions to the emerging problems in the field. Input on these ideas was ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(8):1859-1867]

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Cystic Fibrosis Transmembrane Conductance Regulator Genotype, Not Circulating Catecholamines, Influences Cardiovascular Function in Patients with Cystic Fibrosis.

Alexander L Bisch, Courtney M Wheatley, Sarah E Baker, Elizabeth R Peitzman, Erik H Van Iterson, Theresa A Laguna, Wayne J Morgan, Eric M Snyder,

<h4>Background</h4>Cystic fibrosis (CF) is a genetic disease affecting multiple organ systems of the body and is characterized by mutation in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). Previous work has shown that a single dose of aβ-agonist increases cardiac output (Q) and stroke volume (SV) and ... Read more >>

Clin Med Insights Circ Respir Pulm Med (Clinical medicine insights. Circulatory, respiratory and pulmonary medicine)
[2019, 13:1179548419835788]

Cited: 1 time

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Unexpected Height Loss in an Adolescent With Cystic Fibrosis.

Anne Schendel, Jillian Mai, Rachel Espinosa, Carlye T Tomcyzk, Theresa A Laguna,

This case report describes an adolescent with pancreatic insufficient cystic fibrosis, malnutrition, and cystic fibrosis-related diabetes found to have a loss in height at a routine outpatient clinic visit. He was subsequently admitted to the hospital for treatment of a pulmonary exacerbation and was found to have multiple, nontraumatic vertebral ... Read more >>

Glob Pediatr Health (Global pediatric health)
[2018, 5:2333794X18773662]

Cited: 0 times

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Biomarkers of inflammation in infants with cystic fibrosis.

Theresa A Laguna, Cynthia B Williams, Myra G Nunez, Cole Welchlin-Bradford, Catherine E Moen, Cavan S Reilly, Chris H Wendt,

BACKGROUND:There are urgent needs for clinically relevant biomarkers to identify children with cystic fibrosis (CF) at risk for more progressive lung disease and to serve as outcome measures for clinical trials. Our objective was to investigate three targeted biomarkers in a population of asymptomatic CF infants. METHODS:Urine, blood and lung ... Read more >>

Respir Res (Respiratory research)
[2018, 19(1):6]

Cited: 6 times

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Airway microbiota across age and disease spectrum in cystic fibrosis.

Edith T Zemanick, Brandie D Wagner, Charles E Robertson, Richard C Ahrens, James F Chmiel, John P Clancy, Ronald L Gibson, William T Harris, Geoffrey Kurland, Theresa A Laguna, Susanna A McColley, Karen McCoy, George Retsch-Bogart, Kurtis T Sobush, Pamela L Zeitlin, Mark J Stevens, Frank J Accurso, Scott D Sagel, J Kirk Harris,

Our objectives were to characterise the microbiota in cystic fibrosis (CF) bronchoalveolar lavage fluid (BALF), and determine its relationship to inflammation and disease status.BALF from paediatric and adult CF patients and paediatric disease controls undergoing clinically indicated bronchoscopy was analysed for total bacterial load and for microbiota by 16S rDNA ... Read more >>

Eur Respir J (The European respiratory journal)
[2017, 50(5):]

Cited: 50 times

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Objective Measurement of Adherence to Out-Patient Airway Clearance Therapy by High-Frequency Chest Wall Compression in Cystic Fibrosis.

Christina L Mikesell, Robert R Kempainen, Theresa A Laguna, Jeremiah S Menk, Andrew R Wey, Philippe R Gaillard, Warren E Regelmann,

<h4>Background</h4>Objective measures of adherence to high-frequency chest wall compression (HFCWC), a form of airway clearance therapy for patients with cystic fibrosis, are lacking. We used a novel electronic monitoring device integrated into an HFCWC vest to measure adherence compared with self-reported adherence. We determined factors that influenced adherence and how ... Read more >>

Respir Care (Respiratory care)
[2017, 62(7):920-927]

Cited: 2 times

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Airway Microbiota in Bronchoalveolar Lavage Fluid from Clinically Well Infants with Cystic Fibrosis.

Theresa A Laguna, Brandie D Wagner, Cynthia B Williams, Mark J Stevens, Charles E Robertson, Cole W Welchlin, Catherine E Moen, Edith T Zemanick, Jonathan K Harris,

<h4>Background</h4>Upper airway cultures guide the identification and treatment of lung pathogens in infants with cystic fibrosis (CF); however, this may not fully reflect the spectrum of bacteria present in the lower airway. Our objectives were to characterize the airway microbiota using bronchoalveolar lavage fluid (BALF) from asymptomatic CF infants during ... Read more >>

PLoS One (PloS one)
[2016, 11(12):e0167649]

Cited: 23 times

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Abdominal Pain in a 17-Year-Old Girl With Pancreatic Insufficient Cystic Fibrosis.

Alyssa R Wojciechowski, Carlye T Tomczyk, Theresa A Laguna,

Clin Pediatr (Phila) (Clinical pediatrics)
[2017, 56(1):100-103]

Cited: 0 times

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Metabolomics analysis identifies novel plasma biomarkers of cystic fibrosis pulmonary exacerbation.

Theresa A Laguna, Cavan S Reilly, Cynthia B Williams, Cole Welchlin, Chris H Wendt,

<h4>Background</h4>Cystic fibrosis (CF) lung disease is characterized by infection, inflammation, lung function decline, and intermittent pulmonary exacerbations. However, the link between pulmonary exacerbation and lung disease progression remains unclear. Global metabolomic profiling can provide novel mechanistic insight into a disease process in addition to putative biomarkers for future study. Our ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2015, 50(9):869-877]

Cited: 15 times

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Editorial Commentary: Pseudomonas aeruginosa Eradication: How Do We Measure Success?

Edith T Zemanick, Theresa A Laguna,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2015, 61(5):716-718]

Cited: 1 time

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Sputum club cell protein concentration is associated with pulmonary exacerbation in cystic fibrosis.

Theresa A Laguna, Cynthia B Williams, Kyle R Brandy, Cole Welchlin-Bradford, Catherine E Moen, Cavan S Reilly, Christine H Wendt,

<h4>Background</h4>Cystic fibrosis (CF) patients exhibit a progressive decline in lung function accelerated by intermittent pulmonary exacerbations. There are urgent needs for clinically relevant biomarkers to aid in the diagnosis and management of a CF pulmonary exacerbation, in addition to providing insight into its pathophysiology. Club cell secretory protein (CCSP) is ... Read more >>

J Cyst Fibros (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2015, 14(3):334-340]

Cited: 6 times

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Fifteen-year-old girl with severe obstructive lung disease, pansinusitis, and failure to thrive.

Michael K Taylor, Laura A McCauley, Chelsea K A Alexander, Theresa A Laguna,

Clin Pediatr (Phila) (Clinical pediatrics)
[2014, 53(10):1016-1018]

Cited: 0 times

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Vitamin D deficiency is associated with pulmonary exacerbations in children with cystic fibrosis.

Laura A McCauley, William Thomas, Theresa A Laguna, Warren E Regelmann, Antoinette Moran, Lynda E Polgreen,

<h4>Rationale</h4>Recent literature suggests vitamin D has an effect on lung function and on the lung's ability to fight infection, both important in the cystic fibrosis (CF) population as predictors of morbidity and mortality.<h4>Objectives</h4>Our study assessed associations between vitamin D and % predicted lung function, pulmonary exacerbations, and first Pseudomonas aeruginosa ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2014, 11(2):198-204]

Cited: 22 times

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Inflammation and airway microbiota during cystic fibrosis pulmonary exacerbations.

Edith T Zemanick, J Kirk Harris, Brandie D Wagner, Charles E Robertson, Scott D Sagel, Mark J Stevens, Frank J Accurso, Theresa A Laguna,

<h4>Background</h4>Pulmonary exacerbations (PEx), frequently associated with airway infection and inflammation, are the leading cause of morbidity in cystic fibrosis (CF). Molecular microbiologic approaches detect complex microbiota from CF airway samples taken during PEx. The relationship between airway microbiota, inflammation, and lung function during CF PEx is not well understood.<h4>Objective</h4>To determine ... Read more >>

PLoS One (PloS one)
[2013, 8(4):e62917]

Cited: 94 times

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To sweat or not to sweat: is that enough to diagnose cystic fibrosis?

Theresa A Laguna,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2012, 186(8):700-701]

Cited: 0 times

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Increased adherence to CFF practice guidelines for pulmonary medications correlates with improved FEV1.

Brooke M Moore, Theresa A Laguna, Meixia Liu, John J McNamara,

<h4>Background</h4>CFF practice guidelines recommend patients ≥age 6 use dornase alfa and hypertonic saline daily, and those ≥age 6 colonized with Pseudomonas aeruginosa use inhaled tobramycin and oral azithromycin to improve lung function and reduce pulmonary exacerbations. A decline in FEV1 was noted in our 2008 CF Center Report. We hypothesized ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2013, 48(8):747-753]

Cited: 9 times

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Urinary desmosine: a biomarker of structural lung injury during CF pulmonary exacerbation.

Theresa A Laguna, Brandie D Wagner, Barry Starcher, Heidi K Luckey Tarro, Shelley A Mann, Scott D Sagel, Frank J Accurso,

<h4>Rationale</h4>Cystic fibrosis (CF) lung disease is characterized by structural changes and remodeling in airway architecture and lung parenchyma. Neutrophilic inflammation and infection lead to injury and breakdown of airway matrix constituents, including elastin. The non-invasive measurement of urinary desmosine (UDes), a breakdown product of elastin, may be reflective of ongoing ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2012, 47(9):856-863]

Cited: 12 times

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Incidental sinusitis in a pediatric intensive care unit.

Brooke M Moore, Karen Blumberg, Theresa A Laguna, Meixia Liu, Erin E Zielinski, Stephen C Kurachek,

<h4>Objective</h4>Intubation is a risk factor for nosocomial sinusitis in adult intensive care patients. Sinusitis in intubated adults can be an occult cause of fever. In children, nasal intubation may increase the risk of sinusitis. No pediatric study has determined the frequency of nosocomial sinusitis in the pediatric intensive care unit ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2012, 13(2):e64-8]

Cited: 4 times

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Comparison of quantitative sweat chloride methods after positive newborn screen for cystic fibrosis.

Theresa A Laguna, Nan Lin, Qi Wang, Bonnie Holme, John McNamara, Warren E Regelmann,

<h4>Objectives</h4>Rapid and reliable confirmatory sweat testing following a positive newborn screen (NBS) for cystic fibrosis (CF) is preferred to allow for early diagnosis and to decrease parental anxiety. The Cystic Fibrosis Foundation (CFF) recently recommended a quantity not sufficient (QNS) rate of ≤ 10% in infants <3 months of age ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2012, 47(8):736-742]

Cited: 9 times

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The need for vigilance: the case of a false-negative newborn screen for cystic fibrosis.

Christina T Dunn, Mary M Skrypek, Amy L R Powers, Theresa A Laguna,

Cystic fibrosis (CF) is the most common life-limiting recessive genetic disorder in the white population. CF is caused by abnormalities in the gene that codes for the cystic fibrosis transmembrane conductance regulator protein (CFTR) and may result in severe chronic lung disease, poor growth, and malnutrition. Physicians often do not ... Read more >>

Pediatrics (Pediatrics)
[2011, 128(2):e446-9]

Cited: 5 times

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Epilepsy: an anticipatory presentation of pediatric Wegener's granulomatosis.

Brooke M Moore, Steven M Rothman, H Brent Clark, Richard K Vehe, Theresa A Laguna,

Wegener's granulomatosis is a necrotizing, granulomatous vasculitis that primarily affects the respiratory tract and kidneys. It is rare in children. Few pediatric and adult case reports described seizures and central nervous system involvement at initial presentation, and none described central nervous system involvement in the absence of respiratory or renal ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2010, 43(1):49-52]

Cited: 4 times

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