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Author Thaqif El Khassawna

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Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae.

Sabine Stoetzel, Deeksha Malhan, Ute Wild, Christian Helbing, Fathi Hassan, Sameh Attia, Klaus D Jandt, Christian Heiss, Thaqif El Khassawna,

Osseointegration is a prerequisite for the long-term success of implants. Titanium implants are preferred for their biocompatibility and mechanical properties. Nonetheless, the need for early and immediate loading requires enhancing these properties by adding bioactive coatings. In this preclinical study, extracellular matrix properties and cellular balance at the implant/bone interface ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 23(1):]

Cited: 0 times

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Mortality, Risk Factors and Risk Assessment after Periprosthetic Femoral Fractures-A Retrospective Cohort Study.

Thaqif El Khassawna, Gero Knapp, Nadja Scheibler, Deeksha Malhan, Nike Walter, Christoph Biehl, Volker Alt, Christian Heiss, Markus Rupp,

Periprosthetic femoral fracture (PFF) is a devastating complication. Here, the authors aimed to determine the influence of the timing of surgery as a risk factor for mortality and poor postoperative outcome in patients suffering from PFF. A retrospective descriptive analysis of patients treated for PFF between January 2010 and March ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(19):]

Cited: 1 time

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Bone Status in a Mouse Model of Experimental Autoimmune-Orchitis.

Fabian Hemm, Monika Fijak, Jan Belikan, Marian Kampschulte, Thaqif El Khassawna, Adrian Pilatz, Christian Heiss, Katrin Susanne Lips,

Investigations in male patients with fertility disorders revealed a greater risk of osteoporosis. The rodent model of experimental autoimmune-orchitis (EAO) was established to analyze the underlying mechanisms of male infertility and causes of reduced testosterone concentration. Hence, we investigated the impact of testicular dysfunction in EAO on bone status. Male ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(15):]

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Awareness of predatory journals and open access publishing among orthopaedic and trauma surgeons - results from an online survey in Germany.

Elke Maurer, Nike Walter, Tina Histing, Lydia Anastasopoulou, Thaqif El Khassawna, Lisa Wenzel, Volker Alt, Markus Rupp,

<h4>Background</h4>Along with emerging open access journals (OAJ) predatory journals increasingly appear. As they harm accurate and good scientific research, we aimed to examine the awareness of predatory journals and open access publishing among orthopaedic and trauma surgeons.<h4>Methods</h4>In an online survey between August and December 2019 the knowledge on predatory journals ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2021, 22(1):365]

Cited: 0 times

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DXA reference values of the humanoid sheep model in preclinical studies.

Christoph Biehl, Jakob Schmitt, Sabine Stoetzel, Deeksha Malhan, Fathi Hassan, Gero Knapp, Christian Heiss, Thaqif El Khassawna,

<h4>Background</h4>Merino land sheep are a popular pre-clinical large animal model in research on systemic skeletal diseases such as osteoporosis. Interpretation of studies is difficult because many reference parameters are missing or not established. This study aims to determine the reference parameters of the skeletal system (peak bone mass = PBM, ... Read more >>

PeerJ (PeerJ)
[2021, 9:e11183]

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Large Animal Model of Osteoporotic Defect Healing: An Alternative to Metaphyseal Defect Model.

Markus Rupp, Christoph Biehl, Deeksha Malhan, Fathi Hassan, Sameh Attia, Sebastian Rosch, Annemarie B Schäfer, Erin McMahon, Marian Kampschulte, Christian Heiss, Thaqif El Khassawna,

Osteoporosis is a common metabolic disorder diagnosed by lower bone density and higher risk of fracture. Fragility fractures because of osteoporosis are associated with high mortality rate. Deep understanding of fracture healing in osteoporosis is important for successful treatment. Therefore, the FDA approved the use of small and large animal ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2021, 11(3):]

Cited: 0 times

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Is Biofeedback through an Intra-Aural Device an Effective Method to Treat Bruxism? Case Series and Initial Experience.

Kira Pfeiffer, Thaqif El Khassawna, Deeksha Malhan, Christine Langer, Barbara Sommer, Mohamed Mekhemar, Hans-Peter Howaldt, Sameh Attia,

Biofeedback was reported as an effective concept for bruxism treatment, through increasing patient's awareness of the habit. During bruxing both ear canals become tighter, therefore, an in-ear device can provide biofeedback. The in-ear device is fitted to the ear canal in physiological status, during bruxing the ear-canal tightens resulting in ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 18(1):]

Cited: 2 times

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The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis.

Melanie Timmen, Heriburg Hidding, Martin Götte, Thaqif El Khassawna, Daniel Kronenberg, Richard Stange,

The heparan sulfate proteoglycan Syndecan-1, a mediator of signals between the extracellular matrix and cells involved is able to interact with OPG, one of the major regulators of osteoclastogenesis. The potential of osteoblasts to induce osteoclastogenesis is characterized by a switch of OPG (low osteoclastogenic potential) towards RANKL production (high ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20510]

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Early osteoimmunomodulatory effects of magnesium-calcium-zinc alloys.

Maryam Rahmati, Sabine Stötzel, Thaqif El Khassawna, Kamila Iskhahova, D C Florian Wieland, Berit Zeller Plumhoff, Håvard Jostein Haugen,

Today, substantial attention is given to biomaterial strategies for bone regeneration, and among them, there is a growing interest in using immunomodulatory biomaterials. The ability of a biomaterial to induce neo vascularization and macrophage polarization is a major factor in defining its success. Magnesium (Mg)-based degradable alloys have attracted significant ... Read more >>

J Tissue Eng (Journal of tissue engineering)
[2021, 12:20417314211047100]

Cited: 1 time

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The heparan sulfate proteoglycan Syndecan-1 influences local bone cell communication via the RANKL/OPG axis

Melanie Timmen, Heriburg Hidding, Martin Götte, Thaqif El Khassawna, Daniel Kronenberg, Richard Stange,

The heparan sulfate proteoglycan Syndecan-1, a mediator of signals between the extracellular matrix and cells involved is able to interact with OPG, one of the major regulators of osteoclastogenesis. The potential of osteoblasts to induce osteoclastogenesis is characterized by a switch of OPG (low osteoclastogenic potential) towards RANKL production (high ... Read more >>

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Oral Rehabilitation of Hypodontia Patients Using an Endosseous Dental Implant: Functional and Aesthetic Results.

Sameh Attia, Heidrun Schaaf, Thaqif El Khassawna, Deeksha Malhan, Katharina Mausbach, Hans-Peter Howaldt, Philipp Streckbein,

Hypodontia often leads to limited bone availability of the alveolar ridges. Oral rehabilitation of severe hypodontia patients is challenging. In this retrospective study, we evaluated the functional and aesthetic results after dental implants in hypodontia patients, corroborated by Albrektsson implant success criteria. Over a period of 15 years (2000-2015), a ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(10):]

Cited: 6 times

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Computed tomography for managing periprosthetic femoral fractures. A retrospective analysis.

Markus Rupp, Stefanie Kern, Abdullah Ismat, Thaqif El Khassawna, Gero Knapp, Gabor Szalay, Christian Heiss, Christoph Biehl,

<h4>Background</h4>Periprosthetic fractures (PPF) present a common cause for revision surgery after arthroplasty. The choice of performing either an osteosynthesis or revision arthroplasty depends on the orthopedic implant anchored and loosening. Standard diagnostics include x-ray imaging. CT is usually performed to confirm implant loosening in case of ambiguous diagnosis on standard ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2019, 20(1):258]

Cited: 1 time

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Do Systemic Factors Influence the Fate of Nonunions to Become Atrophic? A Retrospective Analysis of 162 Cases.

Markus Rupp, Stefanie Kern, Thaqif El Khassawna, Abdullah Ismat, Deeksha Malhan, Volker Alt, Christian Heiss, Michael J Raschke,

<h4>Introduction</h4>Nonunions are a challenge for orthopedic surgeons. In hypertrophic nonunions, improvement of mechanical stability usually is the satisfactory treatment, whereas in atrophic nonunions improvement of the biological environment is most important. However, scientific evidence revealed that "avital" nonunions are not avascular and fibrous tissue contains cells with osteogenic potential. To ... Read more >>

Biomed Res Int (BioMed research international)
[2019, 2019:6407098]

Cited: 2 times

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Functional and aesthetic treatment outcomes after immediate jaw reconstruction using a fibula flap and dental implants.

Sameh Attia, Jörg Wiltfang, Philipp Streckbein, Jan-Falco Wilbrand, Thaqif El Khassawna, Katharina Mausbach, Hans-Peter Howaldt, Heidrun Schaaf,

<h4>Purpose</h4>Microvascular fibula flap surgery is a reliable and effective procedure for reconstructing the jaws after tumour surgery. This procedure allows the placement of dental implants after bone consolidation. This study was designed to evaluate the oral, functional, and aesthetic rehabilitation of tumour patients with immediate fibula transfer and dental implants ... Read more >>

J Craniomaxillofac Surg (Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery)
[2019, 47(5):786-791]

Cited: 8 times

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An Optimized Approach to Perform Bone Histomorphometry.

Deeksha Malhan, Matthias Muelke, Sebastian Rosch, Annemarie B Schaefer, Felix Merboth, David Weisweiler, Christian Heiss, Ignacio Arganda-Carreras, Thaqif El Khassawna,

Bone histomorphometry allows quantitative evaluation of bone micro-architecture, bone formation, and bone remodeling by providing an insight to cellular changes. Histomorphometry plays an important role in monitoring changes in bone properties because of systemic skeletal diseases like osteoporosis and osteomalacia. Besides, quantitative evaluation plays an important role in fracture healing ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2018, 9:666]

Cited: 8 times

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Osteocytes.

Markus Rupp, Felix Merboth, Diaa Eldin Daghma, Christoph Biehl, Thaqif El Khassawna, Christian Heiß,

For a long time, osteocytes were regarded as passive bystanders of bone metabolism. Bone remodeling was considered to be an interplay between bone forming osteoblasts and bone degrading osteoclasts. However, the dogma of osteocytes as bystanders within the bone has changed fundamentally since the turn of the millenium. Rather than ... Read more >>

Z Orthop Unfall (Zeitschrift fur Orthopadie und Unfallchirurgie)
[2019, 157(2):154-163]

Cited: 1 time

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Predatory journals: a major threat in orthopaedic research.

Markus Rupp, Lydia Anastasopoulou, Elke Wintermeyer, Deeksha Malhaan, Thaqif El Khassawna, Christian Heiss,

Predatory publishing is a major threat to contemporary publishing, as it offers 'to unaware scientist's', a quick open-access publication against fees without peer-review procedures.. Lack of peer-review leads to unethical practices, as plagiarism, publication of unscientific falsified data, and even unsafe clinical practices. As these journals threaten the credibility of academic ... Read more >>

Int Orthop (International orthopaedics)
[2019, 43(3):509-517]

Cited: 3 times

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Application of donepezil increased collagen 1 expression in mesenchymal stroma cells of an ovine osteoporosis model.

Robert Josef Nachlinger, Vivien Kauschke, Katja Trinkaus, Thaqif El Khassawna, Christian Heiss, Katrin Susanne Lips,

<h4>Objectives</h4>Donepezil inhibits the acetylcholine degradation molecule acetylcholinesterase (AChE). Clinical studies reported that Alzheimer's disease (AD) patients with hip fractures had improved bone quality and better fracture healing if they were treated with AD medication donepezil. We asked whether mesenchymal stroma cells (MSC) from an osteoporosis sheep model treated with donepezil ... Read more >>

J Musculoskelet Neuronal Interact (Journal of musculoskeletal & neuronal interactions)
[2018, 18(3):354-365]

Cited: 3 times

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Better is the foe of good: Outcome of operatively treated ankle fractures in the elderly.

Markus Rupp, Stefan Kockmann, Thaqif El Khassawna, Michael J Raschke, Christian Heiss, Sabine Ochman,

<h4>Background</h4>Ankle fractures are the second most common fractures of the lower extremities. Nonetheless, no standardized treatment protocol for unstable ankle fractures of the elderly exists today. Choices to treat ankle fractures are debated controversially, including (1) conservative treatment, (2) open reduction and internal fixation (ORIF), and (3) primary hind-foot arthrodesis. ... Read more >>

Foot (Edinb) (Foot (Edinburgh, Scotland))
[2018, 36:15-20]

Cited: 0 times

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Nonsurgical Clinical Management of Periapical Lesions Using Calcium Hydroxide-Iodoform-Silicon-Oil Paste.

Qusai Al Khasawnah, Fathi Hassan, Deeksha Malhan, Markus Engelhardt, Diaa Eldin S Daghma, Dima Obidat, Katrin S Lips, Thaqif El Khassawna, Christian Heiss,

<h4>Background</h4>The study aim is to avoid tooth extraction by nonsurgical treatment of periapical lesion. It assesses healing progress in response to calcium hydroxide-iodoform-silicon oil paste (CHISP). Numeric Pain Rating Scale was used to validate the approach. Furthermore, CHISP was used to treat cystic lesions secondary to posttraumatic avulsion of permanent ... Read more >>

Biomed Res Int (BioMed research international)
[2018, 2018:8198795]

Cited: 1 time

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A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model.

Felix Schulze, Deeksha Malhan, Thaqif El Khassawna, Christian Heiss, Anja Seckinger, Dirk Hose, Angela Rösen-Wolff,

<h4>Background</h4>In order to better understand the multifactorial nature of osteoporosis, animal models are utilized and compared to healthy controls. Female sheep are well established as a model for osteoporosis induced by ovariectomy, calcium and vitamin D low diet, application of steroids, or a combination of these treatments. Transcriptional studies can ... Read more >>

BMC Genomics (BMC genomics)
[2017, 18(1):975]

Cited: 9 times

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Strontium and bisphosphonate coated iron foam scaffolds for osteoporotic fracture defect healing.

Seemun Ray, Ulrich Thormann, Marlen Eichelroth, Matthäus Budak, Christoph Biehl, Markus Rupp, Ursula Sommer, Thaqif El Khassawna, Francisca I Alagboso, Marian Kampschulte, Marcus Rohnke, Anja Henß, Klaus Peppler, Vanessa Linke, Peter Quadbeck, Axel Voigt, Florian Stenger, Daniel Karl, Reinhard Schnettler, Christian Heiss, Katrin S Lips, Volker Alt,

The purpose of this work was to investigate new bone formation in macroporous iron foams coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) and empty defect in a critical size metaphyseal bone defect model in ovariectomized rats. 60 female rats were subjected to bilateral ovariectomy ... Read more >>

Biomaterials (Biomaterials)
[2018, 157:1-16]

Cited: 8 times

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A New Clinically Relevant T-Score Standard to Interpret Bone Status in a Sheep Model.

Christian Heiss, Stefanie Kern, Deeksha Malhan, Wolfgang Böcker, Markus Engelhardt, Diaa Eldin S Daghma, Sabine Stoetzel, Jakob Schmitt, Matthias Ivo, Vivien Kauschke, Katrin S Lips, Kamen Tushtev, Kurosch Rezwan, Thaqif El Khassawna,

BACKGROUND Osteoporosis is diagnosed by bone loss using a radiological parameter called T-score. Preclinical studies use DXA to evaluate bone status were the T-score is referenced on bone mineral density (BMD) values of the same animals before treatment. Clinically, the reference BMD represents values of an independent group of healthy ... Read more >>

Med Sci Monit Basic Res (Medical science monitor basic research)
[2017, 23:326-335]

Cited: 5 times

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A novel, hydroxyapatite-based screw-like device for anterior cruciate ligament (ACL) reconstructions.

Thomas C Schumacher, Kamen Tushtev, Ulrich Wagner, Caroline Becker, Marzellus Große Holthaus, Sebastian B Hein, Janne Haack, Christian Heiss, Markus Engelhardt, Thaqif El Khassawna, Kurosch Rezwan,

<h4>Background</h4>Rupture of the anterior cruciate ligament (ACL) is one of the most common injuries of the knee. Common techniques for ACL reconstruction require a graft fixation using interference screws. Nowadays, these interference screws are normally made of titanium or polymer/ceramic composites. The main challenge of application of a fixation device ... Read more >>

Knee (The Knee)
[2017, 24(5):933-939]

Cited: 1 time

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Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine.

Diaa Eldin S Daghma, Deeksha Malhan, Paul Simon, Sabine Stötzel, Stefanie Kern, Fathi Hassan, Katrin Susanne Lips, Christian Heiss, Thaqif El Khassawna,

Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlooked. The current study ... Read more >>

J Bone Miner Metab (Journal of bone and mineral metabolism)
[2018, 36(3):297-306]

Cited: 7 times

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