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Author Tetsuo Takehara

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Prediction model for hepatocellular carcinoma occurrence in patients with hepatitis C in the era of direct-acting anti-virals.

Yuki Tahata, Ryotaro Sakamori, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Hideki Hagiwara, Yasuharu Imai, Naoki Hiramatsu, Shinji Tamura, Keiji Yamamoto, Masahide Oshita, Kazuyoshi Ohkawa, Taizo Hijioka, Hiroyuki Fukui, Toshifumi Ito, Yoshinori Doi, Yukinori Yamada, Takayuki Yakushijin, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehara, ,

<h4>Background</h4>Several factors associated with hepatocellular carcinoma (HCC) occurrence after sustained virological response (SVR) in patients with hepatitis C have been reported. However, few validation studies have been performed in the era of direct-acting anti-virals (DAAs).<h4>Aims</h4>To develop a prediction model for HCC occurrence after DAA-mediated SVR and validate its usefulness.<h4>Methods</h4>We analysed ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Activation of p53 After Irradiation Impairs the Regenerative Capacity of the Mouse Liver.

Makiko Urabe, Hayato Hikita, Yoshinobu Saito, Shinnosuke Kudo, Kenji Fukumoto, Naoki Mizutani, Yuta Myojin, Akira Doi, Katsuhiko Sato, Sadatsugu Sakane, Yuki Makino, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara,

Radiation therapy is one of the treatment methods for hepatocellular carcinoma. However, radiation tolerance of the liver is low, and the detailed effect of radiation on liver regeneration has not been clarified. C57BL/6J mice or hepatocyte-specific p53 knockout (KO) mice (albumin [Alb]-Cre Trp53<sup>flox/flox</sup> ) were irradiated with a single fraction ... Read more >>

Hepatol Commun (Hepatology communications)
[2021, :]

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Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020.

Katsutoshi Tokushige, Kenichi Ikejima, Masafumi Ono, Yuichiro Eguchi, Yoshihiro Kamada, Yoshito Itoh, Norio Akuta, Masato Yoneda, Motoh Iwasa, Masashi Yoneda, Motoyuki Otsuka, Nobuharu Tamaki, Tomomi Kogiso, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike,

Nonalcoholic fatty liver disease (NAFLD) has become a serious public health issue not only in Western countries but also in Japan. Within the wide spectrum of NAFLD, nonalcoholic steatohepatitis (NASH) is a progressive form of disease that often develops into liver cirrhosis and increases the risk of hepatocellular carcinoma (HCC). ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2021, :]

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Suppression of autophagy promotes fibroblast activation in p53-deficient colorectal cancer cells.

Takanori Inoue, Yoshito Hayashi, Yoshiki Tsujii, Shunsuke Yoshii, Akihiko Sakatani, Keiichi Kimura, Ryotaro Uema, Minoru Kato, Hirotsugu Saiki, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara,

Deficiency of p53 in cancer cells activates the transformation of normal tissue fibroblasts into carcinoma-associated fibroblasts; this promotes tumor progression through a variety of mechanisms in the tumor microenvironment. The role of autophagy in carcinoma-associated fibroblasts in tumor progression has not been elucidated. We aimed to clarify the significance of ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):19524]

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Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020.

Katsutoshi Tokushige, Kenichi Ikejima, Masafumi Ono, Yuichiro Eguchi, Yoshihiro Kamada, Yoshito Itoh, Norio Akuta, Masato Yoneda, Motoh Iwasa, Masashi Yoneda, Motoyuki Otsuka, Nobuharu Tamaki, Tomomi Kogiso, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike,

Nonalcoholic fatty liver disease (NAFLD) has become a serious public health issue not only in Western countries but also in Japan. Within the wide spectrum of NAFLD, nonalcoholic steatohepatitis (NASH) is a progressive form of disease that often develops into liver cirrhosis and increases the risk of hepatocellular carcinoma (HCC). ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2021, 51(10):1013-1025]

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The First Transileocolic Obliteration for Refractory Esophageal Varices: A Case Report and Review of the Literature.

Yoshifumi Fujii, Ryotaro Sakamori, Ryoko Yamada, Teppei Yoshioka, Takahiro Kodama, Minoru Shigekawa, Hayato Hikita, Satoshi Tanaka, Hisashi Ishida, Eiji Mita, Hidenari Hongyo, Hiroki Higashihara, Takehiro Noda, Hidetoshi Eguchi, Tomohide Tatsumi, Tetsuo Takehara,

Transileocolic obliteration (TIO) is a useful treatment for gastric, duodenal, or rectal varices. However, TIO for esophageal varices has not yet been reported. We herein report successful TIO performed for refractory esophageal varices with a large paraesophageal vein, with no subsequent recurrence of varices. ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2021, :]

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Vascular endothelial growth factor-A is an Immunohistochemical biomarker for the efficacy of bevacizumab-containing chemotherapy for duodenal and jejunal adenocarcinoma.

Takahiro Amano, Hideki Iijima, Shinichiro Shinzaki, Taku Tashiro, Shuko Iwatani, Mizuki Tani, Yuriko Otake, Takeo Yoshihara, Aya Sugimoto, Satoshi Egawa, Shinjiro Yamaguchi, Kazuo Kinoshita, Manabu Araki, Motohiro Hirao, Yuko Sakakibara, Satoshi Hiyama, Hiroyuki Ogawa, Koji Nagaike, Jun Murata, Masato Komori, Yorihide Okuda, Takashi Kizu, Yoshiki Tsujii, Yoshito Hayashi, Takahiro Inoue, Hidekazu Takahashi, Tsunekazu Mizushima, Eiichi Morii, Tetsuo Takehara,

<h4>Background</h4>The efficacy and safety of bevacizumab-containing chemotherapy for patients with metastatic duodenal and jejunal adenocarcinoma (mDJA) are unclear. The present study aimed to evaluate the efficacy of bevacizumab and to explore immunohistochemical markers that can predict the efficacy of bevacizumab for patients with mDJA.<h4>Methods</h4>This multicentre study included patients with histologically ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):978]

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Geriatric nutritional risk index as a prognostic indicator in elderly patients with early colorectal cancer undergoing endoscopic submucosal dissection.

Minoru Kato, Yoshito Hayashi, Hiromu Fukuda, Shinjiro Yamaguchi, Takuya Inoue, Hideharu Ogiyama, Shinji Kitamura, Masato Komori, Katsumi Yamamoto, Masashi Yamamoto, Kengo Nagai, Masanori Nakahara, Satoshi Egawa, Takuya Yamada, Akira Sasakawa, Takashi Kizu, Osamu Nishiyama, Satoki Shichijo, Shunsuke Yoshii, Yoshiki Tsujii, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara,

<h4>Objectives</h4>Data on the long-term outcomes of endoscopic submucosal dissection (ESD) performed in elderly patients with early colorectal cancer (CRC) are limited. We analyzed the prognosis of elderly CRC patients, not only from the viewpoint of treatment curability but also from the patients' baseline physical condition assessed by several indexes.<h4>Methods</h4>A retrospective ... Read more >>

Dig Endosc (Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society)
[2021, :]

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White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice.

Sadatsugu Sakane, Hayato Hikita, Kumiko Shirai, Yuta Myojin, Youichi Sasaki, Shinnosuke Kudo, Kenji Fukumoto, Naoki Mizutani, Yuki Tahata, Yuki Makino, Ryoko Yamada, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Background & aims</h4>Although nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity, the role of adipose tissue in NAFLD is not well-understood. Because autophagy has been reported to be involved in the degradation of lipid droplets, we investigated the role of adipose tissue autophagy in the liver pathogenesis of ... Read more >>

Cell Mol Gastroenterol Hepatol (Cellular and molecular gastroenterology and hepatology)
[2021, :]

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Evidence-based clinical practice guidelines for liver cirrhosis 2020.

Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai, Hiroki Nishikawa, Yoichi Hiasa, Hisashi Hidaka, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike,

The first edition of the clinical practice guidelines for liver cirrhosis was published in 2010, and the second edition was published in 2015 by the Japanese Society of Gastroenterology (JSGE). The revised third edition was recently published in 2020. This version has become a joint guideline by the JSGE and ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2021, 51(7):725-749]

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Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation.

Takeshi Tamura, Takahiro Kodama, Katsuhiko Sato, Kazuhiro Murai, Teppei Yoshioka, Minoru Shigekawa, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hirofumi Akita, Hidetoshi Eguchi, Randy L Johnson, Hideki Yokoi, Masashi Mukoyama, Tomohide Tatsumi, Tetsuo Takehara,

The role of PI3K and Hippo signaling in chronic pancreatitis (CP) pathogenesis is unclear. Therefore, we assessed the involvement of these pathways in CP by examining the PI3K and Hippo signaling components PTEN and SAV1, respectively. We observed significant decreases in pancreatic PTEN and SAV1 levels in 2 murine CP ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(13):]

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Transcriptomics Identify Thrombospondin-2 as a Biomarker for NASH and Advanced Liver Fibrosis.

Kazuhiro Kozumi, Takahiro Kodama, Hiroki Murai, Sadatsugu Sakane, Olivier Govaere, Simon Cockell, Daisuke Motooka, Naruyasu Kakita, Yukinori Yamada, Yasuteru Kondo, Yuki Tahata, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Yoshihiro Kamada, Ann K Daly, Quentin M Anstee, Tomohide Tatsumi, Eiichi Morii, Tetsuo Takehara,

<h4>Background and aims</h4>NAFLD is the most common liver disease worldwide. NASH, the progressive form of NAFLD, and advanced fibrosis are associated with poor outcomes. We searched for their noninvasive biomarkers.<h4>Approach and results</h4>Global RNA sequencing of liver tissue from 98 patients with biopsy-proven NAFLD was performed. Unsupervised hierarchical clustering well distinguished ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, :]

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Sa571 EVALUATION OF MENTAL STATE AND CLINICAL SYMPTOMS OF CORONAVIRUS PANDEMIC IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Mizuki Tani, Shinichiro Shinzaki, Akiko Asakura, Taku Tashiro, Takahiro Amano, Yuriko Otake, Takeo Yoshihara, Shunsuke Yoshii, Yoshiki Tsujii, Yoshito Hayashi, Takahiro Inoue, Hideki Iijima, Tetsuo Takehara,

Gastroenterology (Gastroenterology)
[2021, 160(6):S-557-S-557]

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Clinical and Histopathological Features of Early Gastric Cancer With Unclear Lateral Demarcation

Kengo Nagai, Yoshito Hayashi, Ryotaro Uema, Takanori Inoue, Keiichi Kimura, Akihiko Sakatani, Shunsuke Yoshii, Yoshiki Tsujii, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara,

<h4>Background: </h4> Magnifying-endoscopy with narrow band imaging (M-NBI) is useful to determine lateral demarcation of early gastric cancers, but determining the lateral demarcation is sometimes difficult. Features related to the unclear lateral demarcation remain unknown. We evaluated the clinical and histopathological features of early gastric cancers with unclear lateral demarcation ... Read more >>

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Leucine-rich alpha-2 glycoprotein is a potential biomarker to monitor disease activity in inflammatory bowel disease receiving adalimumab: PLANET study.

Shinichiro Shinzaki, Katsuyoshi Matsuoka, Hiroki Tanaka, Fuminao Takeshima, Shingo Kato, Takehiro Torisu, Yuki Ohta, Kenji Watanabe, Shiro Nakamura, Naoki Yoshimura, Taku Kobayashi, Akiko Shiotani, Fumihito Hirai, Sakiko Hiraoka, Mamoru Watanabe, Minoru Matsuura, Shohei Nishimoto, Shinta Mizuno, Hideki Iijima, Tetsuo Takehara, Tetsuji Naka, Takanori Kanai, Takayuki Matsumoto,

<h4>Background</h4>This multicenter prospective study (UMIN000019958) aimed to evaluate the usefulness of serum leucin-rich alpha-2 glycoprotein (LRG) levels in monitoring disease activity in inflammatory bowel disease (IBD).<h4>Methods</h4>Patients with moderate-to-severe IBD initiated on adalimumab therapy were enrolled herein. Serum LRG, C-reactive protein (CRP), and fecal calprotectin (fCal) levels were measured at week ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2021, 56(6):560-569]

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Vascular Endothelial Growth Factor-A is an Immunohistochemical Biomarker for the Efficacy of Bevacizumab-containing Chemotherapy for Duodenal and Jejunal Adenocarcinoma

Takahiro Amano, Hideki Iijima, Shinichiro Shinzaki, Taku Tashiro, Shuko Iwatani, Mizuki Tani, Yuriko Otake, Takeo Yoshihara, Aya Sugimoto, Satoshi Egawa, Shinjiro Yamaguchi, Kazuo Kinoshita, Manabu Araki, Motohiro Hirao, Yuko Sakakibara, Satoshi Hiyama, Hiroyuki Ogawa, Koji Nagaike, Jun Murata, Masato Komori, Yorihide Okuda, Takashi Kizu, Yoshiki Tsujii, Yoshito Hayashi, Takahiro Inoue, Hidekazu Takahashi, Tsunekazu Mizushima, Eiichi Morii, Tetsuo Takehara,

<h4>Background: </h4> The efficacy and safety of bevacizumab-containing chemotherapy for patients with metastatic duodenal and jejunal adenocarcinoma (mDJA) are unclear. The present study aimed to evaluate the efficacy of bevacizumab and to explore immunohistochemical markers that can predict the efficacy of bevacizumab for patients with mDJA. <h4>Methods: </h4>: This multicentre ... Read more >>

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Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis.

Naoki Mizutani, Hayato Hikita, Yoshinobu Saito, Yuta Myojin, Katsuhiko Sato, Makiko Urabe, Tomohide Kurahashi, Yuto Shiode, Sadatsugu Sakane, Kazuhiro Murai, Yasutoshi Nozaki, Takahiro Kodama, Ryotaro Sakamori, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehara,

Grb2-associated binder 1 (Gab1) is an adaptor protein that is important for intracellular signal transduction by receptor tyrosine kinases that are receptors for various growth factors and plays an important role in rapid liver regeneration after partial hepatectomy and during acute hepatitis. On the other hand, mild liver regeneration is ... Read more >>

Am J Physiol Gastrointest Liver Physiol (American journal of physiology. Gastrointestinal and liver physiology)
[2021, 320(6):G958-G968]

Cited: 1 time

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Efficacy of Ramucirumab Versus Sorafenib as Subsequent Treatment for Hepatocellular Carcinoma.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Yuki Tahata, Kazuyoshi Ohkawa, Masahide Oshita, Shinji Tamura, Hideki Hagiwara, Eiji Mita, Takayuki Yakushijin, Masami Inada, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Background/aim</h4>The present study aimed to examine the therapeutic efficacy of ramucirumab compared with that of sorafenib as subsequent systemic therapy for patients with hepatocellular carcinoma (HCC) and serum α-fetoprotein (AFP) levels ≥400 ng/ml.<h4>Patients and methods</h4>In our prospectively registered, real-world cohort, 13 and 11 patients treated with ramucirumab or sorafenib, respectively, ... Read more >>

Anticancer Res (Anticancer research)
[2021, 41(4):2187-2192]

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Clinical course of hepatitis C virus-positive patients with decompensated liver cirrhosis in the era of direct-acting antiviral treatment.

Kazuki Maesaka, Ryotaro Sakamori, Ryoko Yamada, Yuki Tahata, Masahide Oshita, Hideki Hagiwara, Mitsuru Sakakibara, Shinji Tamura, Naoki Hiramatsu, Masami Inada, Sadaharu Iio, Toshifumi Ito, Takayuki Yakushijin, Yoshinori Doi, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>The aim of the present study was to investigate the clinical course in hepatitis C virus (HCV)-positive patients with decompensated liver cirrhosis after direct-acting antivirals (DAAs) have been used for HCV infection.<h4>Methods</h4>This multicenter study prospectively analyzed a registered cohort composed of 73 HCV-positive patients with decompensated cirrhosis who attended our ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2021, 51(5):517-527]

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Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis.

Ryotaro Sakamori, Ryoko Yamada, Kazuma Shinkai, Akira Doi, Yuki Tahata, Minoru Shigekawa, Takahiro Kodama, Hayato Hikita, Tomomi Yamada, Tomohide Tatsumi, Tetsuo Takehara,

Hepatitis C virus (HCV) can be eliminated by direct-acting antivirals in patients with decompensated liver cirrhosis. Although viral clearance in decompensated liver cirrhosis leads to improvement of the liver function and quality of life, changes in the skeletal muscle mass after sustained virologic response (SVR) in patients with decompensated liver ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2021, 60(5):745-750]

Cited: 1 time

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Use of a convolutional neural network for classifying microvessels of superficial esophageal squamous cell carcinomas.

Ryotaro Uema, Yoshito Hayashi, Taku Tashiro, Hirotsugu Saiki, Minoru Kato, Takahiro Amano, Mizuki Tani, Takeo Yoshihara, Takanori Inoue, Keiichi Kimura, Shuko Iwatani, Akihiko Sakatani, Shunsuke Yoshii, Yoshiki Tsujii, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara,

<h4>Background and aim</h4>The morphological diagnosis of microvessels on the surface of superficial esophageal squamous cell carcinomas using magnifying endoscopy with narrow-band imaging is widely used in clinical practice. Nevertheless, inconsistency, even among experts, remains a problem. We constructed a convolutional neural network-based computer-aided diagnosis system to classify the microvessels of ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, 36(8):2239-2246]

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Concomitant use of an immunomodulator with ustekinumab as an induction therapy for Crohn's disease: A systematic review and meta-analysis.

Takeo Yoshihara, Shinichiro Shinzaki, Takahiro Amano, Hideki Iijima, Tetsuo Takehara, Nagamu Inoue, Motoi Uchino, Motohiro Esaki, Taku Kobayashi, Masayuki Saruta, Ken Sugimoto, Shiro Nakamura, Keisuke Hata, Fumihito Hirai, Sakiko Hiraoka, Toshimitsu Fujii, Minoru Matsuura, Katsuyoshi Matsuoka, Kenji Watanabe, Hiroshi Nakase, Mamoru Watanabe,

<h4>Background and aim</h4>Ustekinumab (UST), a fully humanized monoclonal antibody against the p40 subunit of interleukin-12/23, is effective for the treatment of Crohn's disease (CD). The benefit of concomitant use of an immunomodulator (IM) with UST, however, is unclear. This study aimed to provide a systematic review and meta-analysis comparing the ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, 36(7):1744-1753]

Cited: 2 times

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Helicobacter pylori eradication prevents secondary gastric cancer in patients with mild-to-moderate atrophic gastritis.

Minoru Kato, Yoshito Hayashi, Tsutomu Nishida, Masahide Oshita, Fumihiko Nakanishi, Shinjiro Yamaguchi, Shinji Kitamura, Akihiro Nishihara, Tomofumi Akasaka, Hideharu Ogiyama, Masanori Nakahara, Takuya Yamada, Osamu Kishida, Masashi Yamamoto, Akinori Shimayoshi, Yoshiki Tsujii, Motohiko Kato, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara,

<h4>Background and aim</h4>Whether Helicobacter pylori eradication prevents metachronous recurrence after endoscopic resection (ER) of early gastric cancer remains controversial. This multicenter retrospective study aimed to evaluate the long-term (> 5 years) effects of H. pylori eradication by stratifying patients' baseline degrees of atrophic gastritis.<h4>Methods</h4>A total of 483 H. pylori-positive patients who had undergone ER ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, 36(8):2083-2090]

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Rebleeding in patients with delayed bleeding after endoscopic submucosal dissection for early gastric cancer.

Minami Hashimoto, Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Yohei Yabuuchi, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Mitsuhiro Fujishiro, Atsushi Masamune, Hiromasa Ohira, ,

<h4>Objectives</h4>Delayed bleeding is a major adverse event in endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Some patients may experience rebleeding after successful hemostasis for delayed bleeding, yet the details of rebleeding remain unclear. We aimed to clarify the frequency and risk factors of rebleeding.<h4>Methods</h4>Among 11,452 patients who underwent ... Read more >>

Dig Endosc (Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society)
[2021, :]

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Suppression of Autophagy Promotes Fibroblast Activation in P53-deficient Colorectal Cancer Cells

Takanori Inoue, Yoshito Hayashi, Yoshiki Tsujii, Shunsuke Yoshii, Akihiko Sakatani, Keiichi Kimura, Ryotaro Uema, Minoru Kato, Hirotsugu Saiki, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara,

Deficiency of p53 in cancer cells activates the transformation of normal tissue fibroblasts into carcinoma-associated fibroblasts; this promotes tumor progression through a variety of mechanisms in the tumor microenvironment. The role of autophagy in carcinoma-associated fibroblasts in tumor progression has not been elucidated. We aimed to clarify the significance of ... Read more >>

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