Full Text Journal Articles by
Author Terrence J Monks

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A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway.

Huong Nguyen, Jia Yi Koh, Hainan Li, Argel Islas-Robles, Sai Pranathi Meda Venkata, Jie-Mei Wang, Terrence J Monks,

Peripheral arterial disease (PAD) is one of the major complications of diabetes due to an impairment in angiogenesis. Since there is currently no drug with satisfactory efficacy to enhance blood vessel formation, discovering therapies to improve angiogenesis is critical. An imidazolinone metabolite of the metformin-methylglyoxal scavenging reaction, (E)-1,1-dimethyl-2-(5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl) guanidine (IMZ), ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21645]

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Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity.

Aram B Cholanians, Andy V Phan, Serrine S Lau, Terrence J Monks,

3, 4-Methylenedioxymethamphetamine (MDMA) is a hallucinogenic amphetamine derivative. The acute effects of MDMA are hyperthermia, hyperactivity, and behavioral changes, followed by long-term serotonergic neurotoxicity in rats and primates. However, the underlying mechanisms of MDMA neurotoxicity remain elusive. We reported that pretreatment of rats with Ro 4-1284, a reversible inhibitor of ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2019, 170(1):157-166]

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Toxicoproteomic Analysis of Poly(ADP-ribose)-associated Proteins Induced by Oxidative Stress in Human Proximal Tubule Cells.

Argel Islas-Robles, Deepthi Yedlapudi, Serrine S Lau, Terrence J Monks,

2,3,5-Tris-(glutathion-S-yl)hydroquinone (TGHQ) is a nephrotoxic and nephrocarcinogenic metabolite of hydroquinone. TGHQ generates ROS, causing DNA strand breaks, hyperactivation of PARP-1, increases in intracellular calcium ([Ca2+]i), and cell death. PARP-1 catalyzes the attachment of ADP-ribose polymers (PAR) to target proteins. In human kidney proximal tubule cells (HK-2), ROS-mediated PARP-1 hyperactivation and ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2019, :]

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Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.

Hainan Li, Megan O'Meara, Xiang Zhang, Kezhong Zhang, Berhane Seyoum, Zhengping Yi, Randal J Kaufman, Terrence J Monks, Jie-Mei Wang,

Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC dysfunction are not fully understood. Methylglyoxal (MGO) is one of the highly reactive dicarbonyl species formed during hyperglycemia. We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived ... Read more >>

Diabetes (Diabetes)
[2019, 68(6):1287-1302]

Cited: 4 times

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Cell-specific regulation of Nrf2 during ROS-Dependent cell death caused by 2,3,5-tris(glutathion-S-yl)hydroquinone (TGHQ).

Fengjiao Zhang, Frances M Munoz, Lanlan Sun, Shuya Zhang, Serrine S Lau, Terrence J Monks,

2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ), a potent nephrotoxic and nephroncarcinogenic metabolite of benzene and hydroquinone, retains the ability to redox cycle and create oxidative stress. We have previously detected that TGHQ induces ROS-dependent necrotic or apoptotic cell death in renal epithelial HK-2 and human leukemic HL-60 cells respectively. Herein, we sought to determine the ... Read more >>

Chem Biol Interact (Chemico-biological interactions)
[2019, 302:1-10]

Cited: 3 times

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All-trans-retinoic acid-mediated cytoprotection in LLC-PK1 renal epithelial cells is coupled to p-ERK activation in a ROS-independent manner.

Jessica M Sapiro, Terrence J Monks, Serrine S Lau,

Although all-<i>trans</i>-retinoic acid (ATRA) provides protection against a variety of conditions in vivo, particularly ischemia, the molecular mechanisms underpinning these effects remain unclear. The present studies were designed to assess potential mechanisms by which ATRA affords cytoprotection against renal toxicants in LLC-PK<sub>1</sub> cells. Pretreatment of LLC-PK<sub>1</sub> cells with ATRA (25 ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2017, 313(6):F1200-F1208]

Cited: 2 times

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MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes.

Hainan Li, Jenny Liu, Yihan Wang, Zhiyao Fu, Maik Hüttemann, Terrence J Monks, Alex F Chen, Jie-Mei Wang,

Bone marrow-derived progenitor cells (BMPCs) are potential candidates for autologous cell therapy in tissue repair and regeneration because of their high angiogenic potential. However, increased progenitor cell apoptosis in diabetes directly limits their success in the clinic. MicroRNAs are endogenous noncoding RNAs that regulate gene expression at the posttranscriptional level, ... Read more >>

Am J Physiol Endocrinol Metab (American journal of physiology. Endocrinology and metabolism)
[2017, 313(4):E391-E401]

Cited: 5 times

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From the Cover: ROS-Induced Store-Operated Ca2+ Entry Coupled to PARP-1 Hyperactivation Is Independent of PARG Activity in Necrotic Cell Death.

Frances M Munoz, Fengjiao Zhang, Argel Islas-Robles, Serrine S Lau, Terrence J Monks,

2,3,5-tris(Glutathion-S-yl)hydroquinone, a potent nephrotoxic and nephrocarcinogenic metabolite of benzene and hydroquinone, generates reactive oxygen species (ROS) causing DNA strand breaks and the subsequent activation of DNA repair enzymes, including poly(ADP-ribose) polymerase (PARP)-1. Under robust oxidative DNA damage, PARP-1 is hyperactivated, resulting in the depletion of NAD+ and ATP with accompanying ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2017, 158(2):444-453]

Cited: 5 times

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Exploration of early-life candidate biomarkers for childhood asthma using antibody arrays.

Haili Xu, Timothy Radabaugh, Zhenqiang Lu, Michael Galligan, Dean Billheimer, Donata Vercelli, Anne L Wright, Terrence J Monks, Marilyn Halonen, Serrine S Lau,

<h4>Background</h4>Proteomic approaches identifying biomarkers have been applied to asthma to only a very limited extent.<h4>Methods</h4>With an antibody array (RayBiotech, Norcross, GA, USA), the relative intensity and rank differences of 444 proteins were compared in 24 plasma samples obtained at age 3, 11 from children with and 12 without asthma diagnoses ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2016, 27(7):696-701]

Cited: 6 times

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Report of the 2014-2016 AACP Research and Graduate Affairs Committee.

Natalie D Eddington Chair, Jeffrey Aubé, Sudip K Das, Vicki L Ellingrod, Richard Hansen, S Suresh Madhavan, Terrence J Monks, Marilyn E Morris, Joan M Lakoski Staff Liaison,

Am J Pharm Educ (American journal of pharmaceutical education)
[2016, 80(9):S21]

Cited: 3 times

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From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration.

Aram B Cholanians, Andy V Phan, Eric J Ditzel, Todd D Camenisch, Serrine S Lau, Terrence J Monks,

Synucleinopathies, including Parkinson's disease (PD), are neurodegenerative diseases characterized by accumulation of α-synuclein (SYN), a small neuronal protein with prion like properties that plays a central role in PD pathogenesis. SYN can misfold and generate toxic oligomers/aggregates, which can be cytotoxic. Environmental arsenic (As)-containing pesticide use correlates with increased incidence ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2016, 153(2):271-281]

Cited: 11 times

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Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma.

Jennifer D Cohen, Matthew Labenski, Nicholas J Mastrandrea, Ryan D Canatsey, Terrence J Monks, Serrine S Lau,

Increased activity of B-Raf has been identified in approximately 7% of human cancers. Treatment of Eker rats (Tsc-2(EK/+) ), bearing a mutation in one allele of the tuberous sclerosis-2 (Tsc-2) gene, with the nephrocarcinogen 2,3,5-tris-(glutathion-S-yl) hydroquinone (TGHQ) results in loss of the wild-type allele of Tsc-2 in renal preneoplastic lesions ... Read more >>

Mol Carcinog (Molecular carcinogenesis)
[2016, 55(8):1243-1250]

Cited: 0 times

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Vesicular monoamine transporter 2 and the acute and long-term response to 3,4-(±)-methylenedioxymethamphetamine.

Lucina E Lizarraga, Aram B Cholanians, Andy V Phan, Joseph M Herndon, Serrine S Lau, Terrence J Monks,

3,4-(±)-Methylenedioxymethamphetamine (MDMA, Ecstasy) is a ring-substituted amphetamine derivative with potent psychostimulant properties. The neuropharmacological effects of MDMA are biphasic in nature, initially causing synaptic monoamine release, primarily of serotonin (5-HT). Conversely, the long-term effects of MDMA manifest as prolonged depletions in 5-HT, and reductions in 5-HT reuptake transporter (SERT), indicative ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2015, 143(1):209-219]

Cited: 4 times

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PARP-1 hyperactivation and reciprocal elevations in intracellular Ca2+ during ROS-induced nonapoptotic cell death.

Fengjiao Zhang, Ruiye Xie, Frances M Munoz, Serrine S Lau, Terrence J Monks,

The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of renal ischemia/reperfusion injury, and many other pathological conditions. DNA strand breaks caused by ROS lead to the activation of poly(ADP-ribose)polymerase-1 (PARP-1), the excessive activation of which can result in cell death. We have utilized a model ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2014, 140(1):118-134]

Cited: 15 times

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Catechol-o-methyltransferase and 3,4-({+/-})-methylenedioxymethamphetamine toxicity.

Joseph M Herndon, Aram B Cholanians, Lucina E Lizarraga, Serrine S Lau, Terrence J Monks,

Metabolism of 3,4-(±)-methylenedioxymethamphetamine (MDMA) is necessary to elicit its neurotoxic effects. Perturbations in phase I and phase II hepatic enzymes can alter the neurotoxic profile of systemically administered MDMA. In particular, catechol-O-methyltransferase (COMT) plays a critical role in determining the fraction of MDMA that is converted to potentially neurotoxic metabolites. ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2014, 139(1):162-173]

Cited: 1 time

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Serotonin reuptake transporter deficiency modulates the acute thermoregulatory and locomotor activity response to 3,4-(±)-methylenedioxymethamphetamine, and attenuates depletions in serotonin levels in SERT-KO rats.

Lucina E Lizarraga, Andy V Phan, Aram B Cholanians, Joseph M Herndon, Serrine S Lau, Terrence J Monks,

3,4-(±)-Methylenedioxymethamphetamine (MDMA) is a ring-substituted amphetamine derivative with potent psychostimulant properties. The neuropharmacological effects of MDMA are biphasic in nature, initially causing synaptic monoamine release, primarily of serotonin (5-HT), inducing thermogenesis and hyperactivity (5-HT syndrome). The long-term effects of MDMA manifest as a prolonged depletion in 5-HT, and structural damage ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2014, 139(2):421-431]

Cited: 9 times

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Glial cell response to 3,4-(+/-)-methylenedioxymethamphetamine and its metabolites.

Joseph M Herndon, Aram B Cholanians, Serrine S Lau, Terrence J Monks,

3,4-(±)-Methylenedioxymethamphetamine (MDMA) and 3,4-(±)-methylenedioxyamphetamine (MDA), a primary metabolite of MDMA, are phenylethylamine derivatives that cause serotonergic neurotoxicity. Although several phenylethylamine derivatives activate microglia, little is known about the effects of MDMA on glial cells, and evidence of MDMA-induced microglial activation remains ambiguous. We initially determined microglial occupancy status of the ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2014, 138(1):130-138]

Cited: 4 times

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Reactive intermediates: molecular and MS-based approaches to assess the functional significance of chemical-protein adducts.

Terrence J Monks, Serrine S Lau,

Biologically reactive intermediates formed as endogenous products of various metabolic processes are considered important factors in a variety of human diseases, including Parkinson's disease and other neurological disorders, diabetes and complications thereof, and other inflammatory-associated diseases. Chemical-induced toxicities are also frequently mediated via the bioactivation of relatively stable organic molecules ... Read more >>

Toxicol Pathol (Toxicologic pathology)
[2013, 41(2):315-321]

Cited: 4 times

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A dual role for poly(ADP-ribose) polymerase-1 during caspase-dependent apoptosis.

Fengjiao Zhang, Serrine S Lau, Terrence J Monks,

2,3,5-Tris(glutathion-S-yl)hydroquinone (TGHQ), a metabolite of benzene, catalyzes the generation of reactive oxygen species (ROS) and caspase-dependent apoptosis in human promyelocytic leukemia (HL-60) cells. We now report that TGHQ induces severe DNA damage, as evidenced by DNA ladder formation and H2AX phosphorylation. The subsequent activation of the DNA nick sensor enzyme, ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2012, 128(1):103-114]

Cited: 18 times

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ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

Jennifer D Cohen, Jaime M C Gard, Raymond B Nagle, Justin D Dietrich, Terrence J Monks, Serrine S Lau,

The mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase signaling cascades have been implicated in a number of human cancers. The tumor suppressor gene tuberous sclerosis-2 (Tsc-2) functions as a negative regulator of mTOR. Critical proteins in both pathways are activated following treatment of Eker rats (Tsc-2(EK/+)) with the ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2011, 124(1):75-87]

Cited: 13 times

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cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

Jennifer D Cohen, Kimberly Y Tham, Nicholas J Mastrandrea, Alfred C Gallegos, Terrence J Monks, Serrine S Lau,

The loss of tuberin, the tuberous sclerosis-2 (Tsc-2) gene product, is associated with cytoplasmic mislocalization of p27 in uterine leiomyomas derived from Eker rats (Tsc-2(EK/+)) and in human metastatic renal cell carcinoma tissue. Signaling associated with cytoplasmic mislocalization of p27 in renal cancer is relatively unknown. Renal tumors derived from ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2011, 122(2):361-371]

Cited: 7 times

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The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation.

Ashley A Fisher, Matthew T Labenski, Srinivas Malladi, John D Chapman, Shawn B Bratton, Terrence J Monks, Serrine S Lau,

Electrophile-mediated post-translational modifications (PTMs) are known to cause tissue toxicities and disease progression. These effects are mediated via site-specific modifications and structural disruptions associated with such modifications. 1,4-Benzoquinone (BQ) and its quinone-thioether metabolites are electrophiles that elicit their toxicity via protein arylation and the generation of reactive oxygen species. Site-specific ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2011, 122(1):64-72]

Cited: 7 times

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Introduction to the proceedings of the 8th international Symposium on Biological Reactive Intermediates.

Terrence J Monks, Rafael de la Torre,

Chem Biol Interact (Chemico-biological interactions)
[2011, 192(1-2):1-2]

Cited: 0 times

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The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis.

Fengjiao Zhang, Serrine S Lau, Terrence J Monks,

2,3,5-Tris(glutathion-S-yl)-hydroquinone (TGHQ), a metabolite of hydroquinone, is toxic to renal proximal tubule epithelial cells. TGHQ retains the ability to redox cycle and create an oxidative stress. To assist in elucidating the contribution of reactive oxygen species (ROS) to TGHQ-induced toxicity, we determined whether the antioxidant, N-acetyl-L-cysteine (NAC), could protect human ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2011, 120(1):87-97]

Cited: 55 times

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Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro.

Ashley A Fisher, Matthew T Labenski, Terrence J Monks, Serrine S Lau,

Biological reactive intermediates can be created via metabolism of xenobiotics during the process of chemical elimination. They can also be formed as by-products of cellular metabolism, which produces reactive oxygen and nitrogen species. These reactive intermediates tend to be electrophilic in nature, which enables them to interact with tissue macromolecules, ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2011, 691:303-316]

Cited: 0 times

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