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Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis.

Kristen M Krysko, Jennifer S Graves, Mary Rensel, Bianca Weinstock-Guttman, Alice Rutatangwa, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu S Goyal, Yolanda Harris, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To assess real-world effectiveness of initial treatment with newer compared to injectable disease-modifying therapies (DMTs) on disease activity in pediatric multiple sclerosis (MS) and clinically isolated syndrome (CIS). METHODS:This is a cohort study of children with MS/CIS followed at 12 clinics in the US Network of Pediatric MS Centers, who ... Read more >>

Ann. Neurol. (Annals of neurology)
[2020, :]

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Multiple Sclerosis in Children: Current and Emerging Concepts.

J Nicholas Brenton, Ryan Kammeyer, Lauren Gluck, Teri Schreiner, Naila Makhani,

Multiple sclerosis is being increasingly recognized and diagnosed in children. In the past several years, advances have been made in diagnosing multiple sclerosis in children, identifying new genetic and environmental risk factors, delineating underlying immunobiology, characterizing imaging findings, and implementing new treatment strategies. In this review, we discuss these advances. ... Read more >>

Semin Neurol (Seminars in neurology)
[2020, 40(2):192-200]

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Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study.

Kevin Messacar, Emily Spence-Davizon, Christina Osborne, Craig Press, Teri L Schreiner, Jan Martin, Ricka Messer, John Maloney, Alexis Burakoff, Meghan Barnes, Shannon Rogers, Adriana S Lopez, Janell Routh, Susan I Gerber, M Steven Oberste, W Allan Nix, Mark J Abzug, Kenneth L Tyler, Rachel Herlihy, Samuel R Dominguez,

BACKGROUND:In May, 2018, Children's Hospital Colorado noted an outbreak of enterovirus A71 (EV-A71) neurological disease. We aimed to characterise the clinical features of EV-A71 neurological disease during this outbreak. METHODS:In this retrospective observational cohort study, children (younger than 18 years) who presented to Children's Hospital Colorado (Aurora, CO, USA) between ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(2):230-239]

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Cognitive processing speed in pediatric-onset multiple sclerosis: Baseline characteristics of impairment and prediction of decline.

Asya I Wallach, Michael Waltz, T Charles Casper, Gregory Aaen, Anita Belman, Leslie Benson, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Yolanda Harris, Timothy E Lotze, Soe Mar, Manikum Moodley, Jayne M Ness, Mary Rensel, Moses Rodriguez, John W Rose, Teri Schreiner, Jan-Mendelt Tillema, Emmanuelle Waubant, Bianca Weinstock-Guttman, Leigh E Charvet, Lauren B Krupp,

BACKGROUND:Cognitive impairment occurs in approximately one-third of pediatric-onset multiple sclerosis (POMS) patients. The Symbol Digit Modalities Test (SDMT), a widely used cognitive screen in adults, has yet to be incorporated early into the standard care of POMS. OBJECTIVE:To screen for cognitive impairment early in the course of POMS and analyze ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, :1352458519891984]

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1889. Clinical Features Distinguishing Enterovirus A71 and Enterovirus D68-Associated Acute Flaccid Myelitis in Colorado, 2013–2018.

Kevin Messacar, Kevin Messacar, Emily Spence-Davizon, Christina Osborne, Craig Press, Teri Schreiner, Jan Martin, Ricka Messer, John Maloney, Alexis Burakoff, Meghan Barnes, Mark Abzug, Ken Tyler, Samuel Dominguez,

AbstractBackgroundSeveral enteroviruses (EVs), including EV-A71 and EV-D68, have been associated with acute flaccid myelitis (AFM). Clinical features distinguishing AFM presentations associated with specific EV types are not well described.MethodsEV-associated AFM was defined as any child presenting to Children’s Hospital Colorado in 2013–2018 who met the Council of State and Territorial ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S54-S55]

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Novel clinical features of glycine receptor antibody syndrome: A series of 17 cases.

Amanda L Piquet, Murtaza Khan, Judith E A Warner, Matthew P Wicklund, Jeffrey L Bennett, Maureen A Leehey, Lauren Seeberger, Teri L Schreiner, M Mateo Paz Soldan, Stacey L Clardy,

Objective:To describe novel clinical features of GlyRα1-IgG-positive patients. Methods:Patients with a positive serum GlyRα1-IgG were identified during a 2-year period from July 2016 to December 2018 at 2 academic centers and followed prospectively. All patients in this series were evaluated in the Neuroimmunology and Autoimmune Neurology clinics at the University ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(5):e592]

Cited: 1 time

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Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Emmanuelle Waubant, Brenda Banwell, Evangeline Wassmer, Maria-Pia Sormani, Maria-Pia Amato, Rogier Hintzen, Lauren Krupp, Kevin Rostásy, Silvia Tenembaum, Tanuja Chitnis, ,

OBJECTIVE:The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable timeframe, with a key focus on short- and long-term safety. METHODS:The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review ... Read more >>

Neurology (Neurology)
[2019, 92(22):e2538-e2549]

Cited: 1 time

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miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS.

Brooke Rhead, Xiaorong Shao, Jennifer S Graves, Tanuja Chitnis, Amy T Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Lauren Krupp, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Moses Rodriguez, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan S Candee, Mark Gorman, Leslie Benson, Soe Mar, Ilana Kahn, John Rose, T Charles Casper, Hong Quach, Diana Quach, Catherine Schaefer, Emmanuelle Waubant, Lisa F Barcellos, ,

Objective:Onset of multiple sclerosis (MS) occurs in childhood for approximately 5% of cases (pediatric MS, or ped-MS). Epigenetic influences are strongly implicated in MS pathogenesis in adults, including the contribution from microRNAs (miRNAs), small noncoding RNAs that affect gene expression by binding target gene mRNAs. Few studies have specifically examined ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(6):1053-1061]

Cited: 1 time

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Vitamin D genes influence MS relapses in children.

Jennifer S Graves, Lisa F Barcellos, Lauren Krupp, Anita Belman, Xiaorong Shao, Hong Quach, Janace Hart, Tanuja Chitnis, Bianca Weinstock-Guttman, Gregory Aaen, Leslie Benson, Mark Gorman, Benjamin Greenberg, Timothy Lotze, Mar Soe, Jayne Ness, Moses Rodriguez, John Rose, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, T Charles Casper, Emmanuelle Waubant,

OBJECTIVE:The aim of this study was to determine whether a vitamin D genetic risk score (vitDGRS) is associated with 25-hydroxyvitamin D (25(OH)D) level and multiple sclerosis (MS) relapses in children. METHODS:DNA samples were typed for single nucleotide polymorphisms (SNPs) from four genes previously identified to be associated with 25(OH)D levels. ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2019, :1352458519845842]

Cited: 1 time

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Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry.

Calvin Chi, Xiaorong Shao, Brooke Rhead, Edlin Gonzales, Jessica B Smith, Anny H Xiang, Jennifer Graves, Amy Waldman, Timothy Lotze, Teri Schreiner, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Jayne Ness, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Tanuja Chitnis, Soe Mar, Anita Belman, Theron Charles Casper, John Rose, Manikum Moodley, Mary Rensel, Moses Rodriguez, Benjamin Greenberg, Llana Kahn, Jennifer Rubin, Catherine Schaefer, Emmanuelle Waubant, Annette Langer-Gould, Lisa F Barcellos,

Multiple sclerosis (MS) is an autoimmune disease with high prevalence among populations of northern European ancestry. Past studies have shown that exposure to ultraviolet radiation could explain the difference in MS prevalence across the globe. In this study, we investigate whether the difference in MS prevalence could be explained by ... Read more >>

PLoS Genet. (PLoS genetics)
[2019, 15(1):e1007808]

Cited: 2 times

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Rituximab vs placebo induction prior to glatiramer acetate monotherapy in multiple sclerosis.

Justin M Honce, Kavita V Nair, Stefan Sillau, Brooke Valdez, Augusto Miravalle, Enrique Alvarez, Teri Schreiner, John R Corboy, Timothy L Vollmer,

OBJECTIVE:To examine whether rituximab induction followed by glatiramer acetate (GA) monotherapy is more effective than GA alone for the treatment of relapsing multiple sclerosis with active disease. METHODS:This was a single-center, double-blind, placebo-controlled study. Fifty-five participants were randomly assigned (1:1 ratio) to either rituximab (R-GA) or placebo (P-GA) induction, followed ... Read more >>

Neurology (Neurology)
[2019, 92(7):e723-e732]

Cited: 0 times

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Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis.

Gregory Aaen, Michael Waltz, Wendy Vargas, Naila Makhani, Jayne Ness, Yolanda Harris, T Charles Casper, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Jennifer Graves, Benjamin Greenberg, Timothy Lotze, Soe Mar, Jan-Mendelt Tillema, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Amy Waldman, Bianca Weinstock-Guttman, Anita Belman, Emmanuelle Waubant, Lauren Krupp,

Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2019, 34(3):148-152]

Cited: 0 times

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Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis.

Kevin Messacar, Stefan Sillau, Sarah E Hopkins, Catherine Otten, Molly Wilson-Murphy, Brian Wong, Jonathan D Santoro, Andrew Treister, Harlori K Bains, Alcy Torres, Luke Zabrocki, Julia R Glanternik, Amanda L Hurst, Jan A Martin, Teri Schreiner, Naila Makhani, Roberta L DeBiasi, Michael C Kruer, Adriana H Tremoulet, Keith Van Haren, Jay Desai, Leslie A Benson, Mark P Gorman, Mark J Abzug, Kenneth L Tyler, Samuel R Dominguez,

OBJECTIVE:To determine the safety, tolerability, and efficacy of fluoxetine for proven or presumptive enterovirus (EV) D68-associated acute flaccid myelitis (AFM). METHODS:A multicenter cohort study of US patients with AFM in 2015-2016 compared serious adverse events (SAEs), adverse effects, and outcomes between fluoxetine-treated patients and untreated controls. Fluoxetine was administered at ... Read more >>

Neurology (Neurology)
[2019, 92(18):e2118-e2126]

Cited: 5 times

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1901. Safety, Tolerability, and Efficacy of Fluoxetine as an Antiviral for Enterovirus D68 Associated Acute Flaccid Myelitis: A Retrospective Multicenter Cohort Study.

Kevin Messacar, Stefan Sillau, Sarah Hopkins, Catherine Otten, Molly Wilson-Murphy, Brian Wong, Jonathan Santoro, Andrew Treister, Harlori Tokhie, Alcy Torres, Luke Zabrocki, Julia Glanternik, Amanda L Hurst, Jan Martin, Teri Schreiner, Naila Makhani, Roberta DeBiasi, Michael Kruer, Adriana H Tremoulet, Keith Van Haren, Jay Desai, Leslie Benson, Mark Gorman, Mark Abzug, Kenneth Tyler, Samuel Dominguez,

AbstractBackgroundMost patients with enterovirus (EV) D68-associated acute flaccid myelitis (AFM) have long-term disability. No effective therapies have been identified. Fluoxetine is the only FDA-approved medication with antiviral activity against EV-D68. This study retrospectively analyzed the safety, tolerability, and efficacy of fluoxetine for EV-D68-associated AFM.MethodsA multicenter cohort study of US ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S546-S546]

Cited: 0 times

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Heterogeneity in association of remote herpesvirus infections and pediatric MS.

Bardia Nourbakhsh, Alice Rutatangwa, Michael Waltz, Mary Rensel, Manikum Moodley, Jennifer Graves, Theron Charles Casper, Amy Waldman, Anita Belman, Benjamin Greenberg, Manu Goyal, Yolanda Harris, Ilana Kahn, Timothy Lotze, Soe Mar, Teri Schreiner, Gregory Aaen, Janace Hart, Jayne Ness, Jennifer Rubin, Jan-Mendelt Tillema, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Meghan Candee, Bianca Weinstock-Guttman, Xiaorong Shao, Lisa Barcellos, Judith James, Emmanuelle Waubant, ,

Objective:While prior Epstein-Barr virus (EBV) infection has been consistently associated with subsequent risk of developing multiple sclerosis (MS), the association with other common herpesviruses has been more controversial. Our objectives were to determine whether remote infection with EBV and other common herpesviruses affect the susceptibility to pediatric MS and if ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(10):1222-1228]

Cited: 2 times

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Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US.

Kristen M Krysko, Jennifer Graves, Mary Rensel, Bianca Weinstock-Guttman, Gregory Aaen, Leslie Benson, Tanuja Chitnis, Mark Gorman, Manu Goyal, Lauren Krupp, Timothy Lotze, Soe Mar, Moses Rodriguez, John Rose, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

OBJECTIVE:To characterize the use and safety of newer disease-modifying therapies (DMTs) in children with multiple sclerosis (MS) and clinically isolated syndrome (CIS) treated under 18 years of age. METHODS:This is a cohort study including children with MS or CIS followed at 12 outpatient practices participating in the US Network of ... Read more >>

Neurology (Neurology)
[2018, 91(19):e1778-e1787]

Cited: 3 times

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Several household chemical exposures are associated with pediatric-onset multiple sclerosis.

Soe Mar, Shannon Liang, Michael Waltz, T Charles Casper, Manu Goyal, Benjamin Greenberg, Bianca Weinstock-Guttman, Moses Rodriguez, Gregory Aaen, Anita Belman, Lisa F Barcellos, John Rose, Mark Gorman, Leslie Benson, Meghan Candee, Tanjua Chitnis, Yolanda Harris, Ilana Kahn, Shelly Roalsted, Janace Hart, Timothy Lotze, Manikum Moodley, Jayne Ness, Mary Rensel, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Lauren Krupp, Jennifer S Graves, Emmanuelle Waubant, ,

Background:There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods:We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(12):1513-1521]

Cited: 1 time

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Correction to: Impact of an electronic monitoring device and behavioural feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.

E Ann Yeh, Stephanie A Grover, Victoria E Powell, Gulay Alper, Brenda L Banwell, Kim Edwards, Mark Gorman, Jennifer Graves, Timothy E Lotze, Jean K Mah, Lauren Mednick, Jayne Ness, Maya Obadia, Ruth Slater, Amy Waldman, Emmanuelle Waubant, Carolyn E Schwartz, ,

The clinicaltrials.gov identifying number for the article titled "Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial" is NCT02234713 (https://clinicaltrials.gov/ct2/show/NCT02234713). ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2018, 27(4):1117]

Cited: 0 times

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Early infectious exposures are not associated with increased risk of pediatric-onset multiple sclerosis.

Leena Suleiman, Emmanuelle Waubant, Gregory Aaen, Anita Belman, Leslie Benson, Meghan Candee, Tanuja Chitnis, Mark Gorman, Manu Goyal, Benjamin Greenberg, Yolanda Harris, Janace Hart, Ilana Kahn, Lauren Krupp, Timothy Lotze, Soe Mar, Manikum Moodley, Jayne Ness, Bardia Nourbakhsh, Mary Rensel, Moses Rodriguez, John Rose, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Bianca Weinstock-Guttman, T Charles Casper, Michael Waltz, Jennifer S Graves, ,

OBJECTIVE:We sought to determine if early infectious exposures such as daycare, early use of antibiotics, vaccinations and other germ exposures including pacifier use and playing on grass are associated with multiple sclerosis (MS) risk in children. METHODS:This was a case-control study of children with MS or clinically isolated syndrome (CIS) ... Read more >>

Mult Scler Relat Disord (Multiple Sclerosis and Related Disorders)
[2018, 22:103-107]

Cited: 0 times

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Attitudes, perceptions, and use of marijuana in youth with multiple sclerosis.

J Nicholas Brenton, Teri Schreiner, Krystle Karoscik, Meg Richter, Samantha Ferrante, Amy Waldman, Brenda Banwell,

Studies have shown a negative impact on cognition and brain volume in marijuana-using adult multiple sclerosis (MS) patients and healthy adolescents. Given that onset of MS during childhood and adolescence negatively impacts brain growth and the normal maturation of neuronal networks, the addition of marijuana exposure in these youth may ... Read more >>

J. Neurol. (Journal of neurology)
[2018, 265(2):417-423]

Cited: 1 time

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Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis.

Saeedeh Azary, Teri Schreiner, Jennifer Graves, Amy Waldman, Anita Belman, Bianca Weinstock Guttman, Gregory Aaen, Jan-Mendelt Tillema, Soe Mar, Janace Hart, Jayne Ness, Yolanda Harris, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, John Rose, Lisa F Barcellos, Tim Lotze, Suzan L Carmichael, Shelly Roalstad, Charles T Casper, Emmanuelle Waubant,

OBJECTIVE:The role of diet in multiple sclerosis (MS) course remains largely unknown. Children with MS have a higher relapse rate compared with MS in adults. Thus, studying the effect of diet on relapse rate in this age group is likely to provide more robust answers. METHODS:This is a multicentre study ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2018, 89(1):28-33]

Cited: 13 times

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Neurological Manifestations of Hospitalized Children with Influenza During the 2016–2017 Season.

Suchitra Rao, Kevin Messacar, Jan Martin, M Alex Ahern, Christina Osborne, Michelle Torok, Amanda Dempsey, Teri Schreiner, Samuel Dominguez,

AbstractBackgroundInfluenza A H1N1 and B are associated with neurological complications including seizures, encephalopathy and encephalitis. However, this season, when H3N2 was the predominant strain, many patients were admitted with neurological manifestations of influenza (NMI). The study objectives were to: 1) identify clinical characteristics of children with NMI and 2) compare demographics and clinical ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S693-S694]

Cited: 0 times

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Genetic risk factors for pediatric-onset multiple sclerosis.

Milena A Gianfrancesco, Pernilla Stridh, Xiaorong Shao, Brooke Rhead, Jennifer S Graves, Tanuja Chitnis, Amy Waldman, Timothy Lotze, Teri Schreiner, Anita Belman, Benjamin Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan M Tillema, Janace Hart, Stacy Caillier, Jayne Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Soe Mar, Ilana Kahn, John Rose, Shelly Roalstad, T Charles Casper, Ling Shen, Hong Quach, Diana Quach, Jan Hillert, Anna Hedstrom, Tomas Olsson, Ingrid Kockum, Lars Alfredsson, Catherine Schaefer, Lisa F Barcellos, Emmanuelle Waubant, ,

BACKGROUND:Strong evidence supports the role of both genetic and environmental factors in pediatric-onset multiple sclerosis (POMS) etiology. OBJECTIVE:We comprehensively investigated the association between established major histocompatibility complex (MHC) and non-MHC adult multiple sclerosis (MS)-associated variants and susceptibility to POMS. METHODS:Cases with onset <18 years (n = 569) and controls (n = 16,251) were included from ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(14):1825-1834]

Cited: 4 times

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Dietary factors and pediatric multiple sclerosis: A case-control study.

Julia Pakpoor, Brandon Seminatore, Jennifer S Graves, Teri Schreiner, Amy T Waldman, Timothy E Lotze, Anita Belman, Benjamin M Greenberg, Bianca Weinstock-Guttman, Gregory Aaen, Jan-Mendelt Tillema, Jamie C McDonald, Janace Hart, Jayne M Ness, Yolanda Harris, Jennifer Rubin, Meghan Candee, Lauren Krupp, Mark Gorman, Leslie Benson, Moses Rodriguez, Tanuja Chitnis, Soe Mar, Ilana Kahn, John Rose, Suzan L Carmichael, Shelly Roalstad, Michael Waltz, T Charles Casper, Emmanuelle Waubant, ,

BACKGROUND:The role of diet in multiple sclerosis (MS) is largely uncharacterized, particularly as it pertains to pediatric-onset disease. OBJECTIVE:To determine the association between dietary factors and MS in children. METHODS:Pediatric MS patients and controls were recruited from 16 US centers (MS or clinically isolated syndrome onset before age 18, <4 years ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(8):1067-1076]

Cited: 6 times

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Outcomes of Colorado children with acute flaccid myelitis at 1 year.

Jan A Martin, Kevin Messacar, Michele L Yang, John A Maloney, Jennifer Lindwall, Terri Carry, Patricia Kenyon, Stefan H Sillau, Joyce Oleszek, Kenneth L Tyler, Samuel R Dominguez, Teri L Schreiner,

OBJECTIVE:We describe long-term functional, neurodiagnostic, and psychosocial outcomes of a cohort of 12 children from Colorado diagnosed with acute flaccid myelitis (AFM) in 2014. METHODS:Children were assessed every 3 months for 1 year or until clinical resolution. Assessments included neurologic examination, MRI, EMG/nerve conduction studies (NCS), functional measures (Assisting Hand ... Read more >>

Neurology (Neurology)
[2017, 89(2):129-137]

Cited: 15 times

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