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Author Teresa Pellegrino

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Unveiling the Dynamical Assembly of Magnetic Nanocrystal Zig-Zag Chains via In Situ TEM Imaging in Liquid.

Milena P Arciniegas, Andrea Castelli, Rosaria Brescia, David Serantes, Sergiu Ruta, Ondrej Hovorka, Akira Satoh, Roy Chantrell, Teresa Pellegrino,

The controlled assembly of colloidal magnetic nanocrystals is key to many applications such as nanoelectronics, storage memory devices, and nanomedicine. Here, the motion and ordering of ferrimagnetic nanocubes in water via liquid-cell transmission electron microscopy is directly imaged in situ. Through the experimental analysis, combined with molecular dynamics simulations and ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(25):e1907419]

Cited: 0 times

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Novel synthesis of platinum complexes and their intracellular delivery to tumor cells by means of magnetic nanoparticles.

Alessandra Quarta, Manuel Amorín, María José Aldegunde, Laura Blasi, Andrea Ragusa, Simone Nitti, Giammarino Pugliese, Giuseppe Gigli, Juan R Granja, Teresa Pellegrino,

Platinum-based drugs are popular in clinics as chemotherapeutic agents to treat solid tumors. However, severe side effects such as nephro- and neurotoxicity impose strict dosage limitations that can lead to the development of drug resistance and tumor relapse. To overcome these issues Pt(iv) prodrugs and platinum delivery systems might represent ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(48):23482-23497]

Cited: 1 time

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Confining Iron Oxide Nanocubes inside Submicrometric Cavities as a Key Strategy To Preserve Magnetic Heat Losses in an Intracellular Environment.

Mikhail V Zyuzin, Marco Cassani, Markus J Barthel, Helena Gavilan, Niccolò Silvestri, Alberto Escudero, Alice Scarpellini, Federica Lucchesi, Francisco J Teran, Wolfgang J Parak, Teresa Pellegrino,

The design of magnetic nanostructures whose magnetic heating efficiency remains unaffected at the tumor site is a fundamental requirement to further advance magnetic hyperthermia in the clinic. This work demonstrates that the confinement of magnetic nanoparticles (NPs) into a sub-micrometer cavity is a key strategy to enable a certain degree ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2019, 11(45):41957-41971]

Cited: 1 time

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EXPRESS: Cardiac Sympathetic Dysfunction in Pulmonary Arterial Hypertension: Lesson from Left-sided Heart Failure.

Valentina Mercurio, Teresa Pellegrino, Giorgio Bosso, Giacomo Campi, Paolo Parrella, Valentina Piscopo, Carlo Gabriele Tocchetti, Paul Hassoun, Mario Petretta, Alberto Cuocolo, Domenico Bonaduce,

(Pulmonary circulation)
[2019, :2045894019868620]

Cited: 1 time

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Oil Core-PEG Shell Nanocarriers for In Vivo MRI Imaging.

Vincenzo Calcagno, Raffaele Vecchione, Vincenzo Quagliariello, Pasquina Marzola, Alice Busato, Pierangela Giustetto, Martina Profeta, Sara Gargiulo, Chiara Di Cicco, Hui Yu, Marco Cassani, Nicola Maurea, Marcello Mancini, Teresa Pellegrino, Paolo A Netti,

Oil-in-water emulsions represent a promising carrier for in vivo imaging because of the possibility to convey poorly water-soluble species. To promote accumulation at the tumor site and prolong circulation time, reduction of carrier size and surface PEGylation plays a fundamental role. In this work a novel, simple method to design ... Read more >>

Adv Healthc Mater (Advanced healthcare materials)
[2019, 8(3):e1801313]

Cited: 3 times

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Polymer Coating and Lipid Phases Regulate Semiconductor Nanorods' Interaction with Neuronal Membranes: A Modeling Approach.

Barbara Salis, Giammarino Pugliese, Teresa Pellegrino, Alberto Diaspro, Silvia Dante,

The interplay between nanoparticles (NPs) and cell membranes is extremely important with regard to using NPs in biology applications. With the aim of unraveling the dominating factors on the molecular scale, we have studied the interaction between polymer-coated semiconductor nanorods (NRs) made of cadmium selenium/cadmium sulfur and model lipid membranes. ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2019, 10(1):618-627]

Cited: 0 times

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Nanosystems Based on Magnetic Nanoparticles and Thermo- or pH-Responsive Polymers: An Update and Future Perspectives.

Binh T Mai, Soraia Fernandes, Preethi B Balakrishnan, Teresa Pellegrino,

Combining hard matter, like inorganic nanocrystals, and soft materials, like polymers, can generate multipurpose materials with a broader range of applications with respect to the individual building blocks. Given their unique properties at the nanoscale, magnetic nanoparticles (MNPs) have drawn a great deal of interest due to their potential use ... Read more >>

Acc. Chem. Res. (Accounts of chemical research)
[2018, 51(5):999-1013]

Cited: 10 times

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Dually responsive gold-iron oxide heterodimers: merging stimuli-responsive surface properties with intrinsic inorganic material features.

Hamilton Kakwere, Maria Elena Materia, Alberto Curcio, Mirko Prato, Ayyappan Sathya, Simone Nitti, Teresa Pellegrino,

We demonstrate a versatile approach for the preparation of dually responsive smart inorganic heterostructures (HSs) with the potential for exploitation in nanomedicine. We utilize Au-FexOy dimers as templates for generating smart inorganic HSs with a pH-responsive coating and a thermo-responsive coating attached to iron oxide and gold nanoparticles (NPs), respectively. ... Read more >>

Nanoscale (Nanoscale)
[2018, 10(8):3930-3944]

Cited: 2 times

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Star poly(ε-caprolactone)-based electrospun fibers as biocompatible scaffold for doxorubicin with prolonged drug release activity.

Preethi Bala Balakrishnan, Lorenza Gardella, Mahdi Forouharshad, Teresa Pellegrino, Orietta Monticelli,

In this work, a novel drug delivery system consisting of poly(ε-caprolactone) (PCL) electrospun fibers containing an ad-hoc-synthesized star polymer made up of a poly(amido-amine) (PAMAM) core and PCL branches (PAMAM-PCL) was developed. The latter system which was synthesized via the ring opening polymerization of ε-caprolactone, starting from a hydroxyl-terminated PAMAM ... Read more >>

Colloids Surf B Biointerfaces (Colloids and surfaces. B, Biointerfaces)
[2018, 161:488-496]

Cited: 3 times

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Prognostic role of FDG PET/CT in patients with differentiated thyroid cancer treated with 131-iodine empiric therapy.

Barbara Salvatore, Michele Klain, Emanuele Nicolai, Domenico D'Amico, Gianluca De Matteis, Marco Raddi, Rosa Fonti, Teresa Pellegrino, Giovanni Storto, Alberto Cuocolo, Leonardo Pace,

To assess the long-term prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg).Forty-nine patients with histological diagnosis of DTC (31 with papillary and 18 with follicular carcinoma) follow-up for a ... Read more >>

Medicine (Baltimore) (Medicine)
[2017, 96(42):e8344]

Cited: 1 time

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Integrated Imaging Characterization of Adrenal Adenoma: False-Positive Metaiodobenzylguanidine (MIBG) Findings of Adrenal Scintigraphy.

Serena Dell'Aversana, Milena Coppola, Umberto Balestrieri, Pier Paolo Mainenti, Carmen Pascale, Massimo Imbriaco, Vito Chianca, Valeria Romeo, Teresa Pellegrino, Ciro Mainolfi, Simone Maurea,

Background:Evaluation of a patient with melanoma in whom an adrenal mass was detected on CT and MR during follow-up and further characterized with PET-CT and MIBG scintigraphy. Case Report:In this case report, we describe a patient with melanoma in whom an adrenal mass was detected on CT and MRI during ... Read more >>

(Polish journal of radiology)
[2017, 82:422-425]

Cited: 0 times

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Cardiac sympathetic neuronal damage precedes myocardial fibrosis in patients with Anderson-Fabry disease.

Massimo Imbriaco, Teresa Pellegrino, Valentina Piscopo, Mario Petretta, Andrea Ponsiglione, Carmela Nappi, Marta Puglia, Serena Dell'Aversana, Eleonora Riccio, Letizia Spinelli, Antonio Pisani, Alberto Cuocolo,

Cardiac sympathetic denervation may be detectable in patients with Anderson-Fabry disease (AFD), suggesting its usefulness for early detection of the disease. However, the relationship between sympathetic neuronal damage measured by 123I-metaiodobenzylguanidine (MIBG) imaging with myocardial fibrosis on cardiac magnetic resonance (CMR) is still unclear.Cardiac sympathetic innervation was assessed by 123I-MIBG ... Read more >>

Eur. J. Nucl. Med. Mol. Imaging (European journal of nuclear medicine and molecular imaging)
[2017, 44(13):2266-2273]

Cited: 5 times

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Forced- and Self-Rotation of Magnetic Nanorods Assembly at the Cell Membrane: A Biomagnetic Torsion Pendulum.

François Mazuel, Samuel Mathieu, Riccardo Di Corato, Jean-Claude Bacri, Thierry Meylheuc, Teresa Pellegrino, Myriam Reffay, Claire Wilhelm,

In order to provide insight into how anisotropic nano-objects interact with living cell membranes, and possibly self-assemble, magnetic nanorods with an average size of around 100 nm × 1 µm are designed by assembling iron oxide nanocubes within a polymeric matrix under a magnetic field. The nano-bio interface at the ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2017, 13(31):]

Cited: 1 time

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Dumbbell-like [email protected] Nanocrystals: Synthesis, Characterization, and Catalytic Activity in CO Oxidation.

Sharif Najafishirtari, Tathiana Midori Kokumai, Sergio Marras, Priscila Destro, Mirko Prato, Alice Scarpellini, Rosaria Brescia, Aidin Lak, Teresa Pellegrino, Daniela Zanchet, Liberato Manna, Massimo Colombo,

We report the colloidal synthesis of dumbbell-like [email protected] nanocrystals ([email protected] NCs) and the study of their properties in the CO oxidation reaction. To this aim, the as-prepared NCs were deposited on γ-alumina and pretreated in an oxidizing environment to remove the organic ligands. A comparison of these NCs with bulk ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2016, 8(42):28624-28632]

Cited: 3 times

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Oil/water nano-emulsion loaded with cobalt ferrite oxide nanocubes for photo-acoustic and magnetic resonance dual imaging in cancer: in vitro and preclinical studies.

Raffaele Vecchione, Vincenzo Quagliariello, Pierangela Giustetto, Dominic Calabria, Ayyappan Sathya, Roberto Marotta, Martina Profeta, Simone Nitti, Niccolò Silvestri, Teresa Pellegrino, Rosario V Iaffaioli, Paolo Antonio Netti,

Dual imaging dramatically improves detection and early diagnosis of cancer. In this work we present an oil in water (O/W) nano-emulsion stabilized with lecithin and loaded with cobalt ferrite oxide (Co0.5Fe2.5O4) nanocubes for photo-acoustic and magnetic resonance dual imaging. The nanocarrier is responsive in in vitro photo-acoustic and magnetic resonance ... Read more >>

Nanomedicine (Nanomedicine : nanotechnology, biology, and medicine)
[2017, 13(1):275-286]

Cited: 7 times

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Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single-Endosome and Tissue Levels.

François Mazuel, Ana Espinosa, Nathalie Luciani, Myriam Reffay, Rémi Le Borgne, Laurence Motte, Karine Desboeufs, Aude Michel, Teresa Pellegrino, Yoann Lalatonne, Claire Wilhelm,

Quantitative studies of the long-term fate of iron oxide nanoparticles inside cells, a prerequisite for regenerative medicine applications, are hampered by the lack of suitable biological tissue models and analytical methods. Here, we propose stem-cell spheroids as a tissue model to track intracellular magnetic nanoparticle transformations during long-term tissue maturation. ... Read more >>

ACS Nano (ACS nano)
[2016, 10(8):7627-7638]

Cited: 38 times

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Sleep-disordered breathing, impaired cardiac adrenergic innervation and prognosis in heart failure.

Oriana Scala, Stefania Paolillo, Roberto Formisano, Teresa Pellegrino, Giuseppe Rengo, Paola Gargiulo, Fausto De Michele, Antonio Starace, Antonio Rapacciuolo, Valentina Parisi, Maria Prastaro, Valentina Piscopo, Santo Dellegrottaglie, Dario Bruzzese, Fabiana De Martino, Antonio Parente, Dario Leosco, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone-Filardi,

Unfavourable effects of sleep-disordered breathing (SDB) in heart failure (HF) are mainly mediated by impaired sympathetic activity. Few data are available on SDB and cardiac adrenergic impairment evaluated at myocardial level. The aim of the study was to assess the relationship between SDB, cardiac sympathetic innervation assessed by 123I-metaiodobenzylguanidine (123I-MIBG) ... Read more >>

Heart (Heart (British Cardiac Society))
[2016, 102(22):1813-1819]

Cited: 1 time

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PEGylated gold nanorods as optical trackers for biomedical applications: an in vivo and in vitro comparative study.

Gaser N Abdelrasoul, Raffaella Magrassi, Silvia Dante, Marta d'Amora, Marco Scotto d'Abbusco, Teresa Pellegrino, Alberto Diaspro,

Gold nanorods (AuNRs) are eligible for a variety of biological applications including cell imaging, sensing, and photothermal therapy thanks to their optical properties. The aim of this work is to show how AuNRs could be employed as non-photobleachable optical contrast agents for biomedical applications. In order to demonstrate the feasibility ... Read more >>

Nanotechnology (Nanotechnology)
[2016, 27(25):255101]

Cited: 5 times

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Impact of aging on cardiac sympathetic innervation measured by 123I-mIBG imaging in patients with systolic heart failure.

Giuseppe Rengo, Gennaro Pagano, Dino Franco Vitale, Roberto Formisano, Klara Komici, Laura Petraglia, Valentina Parisi, Grazia Daniela Femminella, Claudio de Lucia, Stefania Paolillo, Alessandro Cannavo, Emilio Attena, Teresa Pellegrino, Santo Dellegrottaglie, Alessia Memmi, Bruno Trimarco, Alberto Cuocolo, Pasquale Perrone Filardi, Dario Leosco, Nicola Ferrara,

Sympathetic nervous system (SNS) hyperactivity is a salient characteristic of chronic heart failure (HF) and contributes to the progression of the disease. Iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging has been successfully used to assess cardiac SNS activity in HF patients and to predict prognosis. Importantly, SNS hyperactivity characterizes also physiological ageing, and ... Read more >>

Eur. J. Nucl. Med. Mol. Imaging (European journal of nuclear medicine and molecular imaging)
[2016, 43(13):2392-2400]

Cited: 9 times

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Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia.

Maria F Casula, Erika Conca, Ioanna Bakaimi, Ayyappan Sathya, Maria Elena Materia, Alberto Casu, Andrea Falqui, Elisa Sogne, Teresa Pellegrino, Antonios G Kanaras,

A simple, one pot method to synthesize water-dispersible Mn doped iron oxide colloidal clusters constructed of nanoparticles arranged into secondary flower-like structures was developed. This method allows the successful incorporation and homogeneous distribution of Mn within the nanoparticle iron oxide clusters. The formed clusters retain the desired morphological and structural ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2016, 18(25):16848-16855]

Cited: 4 times

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Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure.

Valentina Parisi, Giuseppe Rengo, Pasquale Perrone-Filardi, Gennaro Pagano, Grazia Daniela Femminella, Stefania Paolillo, Laura Petraglia, Giuseppina Gambino, Aurelio Caruso, Maria Gabriella Grimaldi, Francesco Baldascino, Maria Nolano, Andrea Elia, Alessandro Cannavo, Antonio De Bellis, Enrico Coscioni, Teresa Pellegrino, Alberto Cuocolo, Nicola Ferrara, Dario Leosco,

It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function.The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure.In 110 patients with systolic heart failure, we evaluated the correlation between echocardiographic EAT thickness and ... Read more >>

Circ. Res. (Circulation research)
[2016, 118(8):1244-1253]

Cited: 19 times

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Duality of Iron Oxide Nanoparticles in Cancer Therapy: Amplification of Heating Efficiency by Magnetic Hyperthermia and Photothermal Bimodal Treatment.

Ana Espinosa, Riccardo Di Corato, Jelena Kolosnjaj-Tabi, Patrice Flaud, Teresa Pellegrino, Claire Wilhelm,

The pursuit of innovative, multifunctional, more efficient, and safer treatments is a major challenge in preclinical nanoparticle-mediated thermotherapeutic research. Here, we report that iron oxide nanoparticles have the dual capacity to act as both magnetic and photothermal agents. We further explore every key aspect of this magnetophotothermal approach, choosing iron ... Read more >>

ACS Nano (ACS nano)
[2016, 10(2):2436-2446]

Cited: 108 times

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Relationship between left ventricular diastolic function and myocardial sympathetic denervation measured by (123)I-meta-iodobenzylguanidine imaging in Anderson-Fabry disease.

Letizia Spinelli, Teresa Pellegrino, Antonio Pisani, Caterina Anna Giudice, Eleonora Riccio, Massimo Imbriaco, Marco Salvatore, Bruno Trimarco, Alberto Cuocolo,

Whether cardiac sympathetic nervous function abnormalities may be present in patients with Anderson-Fabry disease (AFD) remains unexplored. We investigated the relationship between left ventricular (LV) function and cardiac sympathetic nervous function in patients with AFD.Twenty-five patients (12 men, mean age 43 ± 13 years) with genetically proved AFD and preserved LV ejection fraction ... Read more >>

Eur. J. Nucl. Med. Mol. Imaging (European journal of nuclear medicine and molecular imaging)
[2016, 43(4):729-739]

Cited: 4 times

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Impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine indexes of cardiac sympathetic innervation.

Teresa Pellegrino, Valentina Piscopo, Antonio Boemio, Barbara Russo, Gianluca De Matteis, Sara Pellegrino, Sara Maria Delle Acque Giorgio, Manuela Amato, Mario Petretta, Alberto Cuocolo,

BACKGROUND:This study was designed to assess the impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine (MIBG) indexes of cardiac sympathetic innervation. METHODS:Forty-five patients with heart failure (HF) (38 men, age 58±15 years) underwent (123)I-MIBG cardiac imaging. Of these patients, 10 were obese [body mass index (BMI) ≥30 kg/m(2)]. Ten-minute planar ... Read more >>

(Quantitative imaging in medicine and surgery)
[2015, 5(6):822-828]

Cited: 4 times

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Myocardial 123I-metaiodobenzylguanidine scintigraphy in patients with homozygous and heterozygous parkin mutations.

Anna De Rosa, Teresa Pellegrino, Sabina Pappatà, Maria Teresa Pellecchia, Silvio Peluso, Francesco Saccà, Paolo Barone, Alberto Cuocolo, Giuseppe De Michele,

BACKGROUND:PARK2 is an autosomal recessive parkinsonism caused by parkin gene mutations. Several Parkinson's Disease (PD) cases harbor single parkin mutations, raising a debate about the pathogenic meaning of heterozygous mutations. Here, we evaluate cardiac autonomic innervation in patients with either two or one parkin mutations compared to patients with idiopathic ... Read more >>

J Nucl Cardiol (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology)
[2017, 24(1):103-107]

Cited: 1 time

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