Full Text Journal Articles by
Author Teresa Nichols

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Transcription of mouse Sp2 yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion.

Haifeng Yin, Teresa D Nichols, Jonathan M Horowitz,

The Sp-family of transcription factors is comprised by nine members, Sp1-9, that share a highly conserved DNA-binding domain. Sp2 is a poorly characterized member of this transcription factor family that is widely expressed in murine and human cell lines yet exhibits little DNA-binding or trans-activation activity in these settings. As ... Read more >>

Biochim. Biophys. Acta (Biochimica et biophysica acta)
[2010, 1799(7):520-531]

Cited: 5 times

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Sp2 is a maternally inherited transcription factor required for embryonic development.

Jianzhen Xie, Haifeng Yin, Teresa D Nichols, Jeffrey A Yoder, Jonathan M Horowitz,

The Sp family of transcription factors is required for the expression of cell cycle- and developmentally regulated genes, and the deregulated expression of a handful of family members is associated with human tumorigenesis. Sp2 is a relatively poorly characterized member of the Sp family that, although widely expressed, exhibits little ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(6):4153-4164]

Cited: 4 times

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Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.

Susan K Murphy, Zhiqing Huang, Yaqing Wen, Monique A Spillman, Regina S Whitaker, Lauren R Simel, Teresa D Nichols, Jeffrey R Marks, Andrew Berchuck,

Overexpression of the imprinted insulin-like growth factor-II (IGF2) is a prominent characteristic of gynecologic malignancies. The purpose of this study was to determine whether IGF2 loss of imprinting (LOI), aberrant H19 expression, and/or epigenetic deregulation of the IGF2/H19 imprinted domain contributes to elevated IGF2 expression in serous epithelial ovarian tumors. ... Read more >>

Mol. Cancer Res. (Molecular cancer research : MCR)
[2006, 4(4):283-292]

Cited: 63 times

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Sp2 localizes to subnuclear foci associated with the nuclear matrix.

K Scott Moorefield, Haifeng Yin, Teresa D Nichols, Christopher Cathcart, Steven O Simmons, Jonathan M Horowitz,

We have reported that extracts prepared from many human and mouse cell lines show little or no Sp2 DNA-binding activity and that Sp2 has little or no capacity to stimulate transcription of promoters that are activated by Sp1, Sp3, and Sp4. Using an array of chimeric Sp1/Sp2 proteins we showed ... Read more >>

Mol. Biol. Cell (Molecular biology of the cell)
[2006, 17(4):1711-1722]

Cited: 12 times

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