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Acute Bronchiolitis During The Covid-19 Pandemic.

Patricia Flores-Pérez, Nathalia Gerig, Mª Isabel Cabrera-López, José L de Unzueta-Roch, Teresa Del Rosal, Cristina Calvo, ,

<h4>Introduction</h4>The autumn and winter bronchiolitis epidemics have virtually disappeared in the first year of the COVID-19 pandemic.Our objectives were characterise bronchiolitis during fourth quarter of 2020 and the role played by SARS-CoV-2.<h4>Methods</h4>Prospective multi-centre study performed in Madrid (Spain) between October and December 2020 including all children admitted with acute bronchiolitis. ... Read more >>

Enferm Infecc Microbiol Clin (Engl Ed) (Enfermedades infecciosas y microbiologia clinica (English ed.))
[2021, :]

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The Role of Respiratory Viruses in Children with Ataxia-Telangiectasia.

Ana Méndez-Echevarría, María Belén Caminoa, Teresa Del Rosal, Inmaculada Casas, Francisco Pozo, Samuel Ignacio Pascual-Pascual, Mar García-Romero, Carmen Cámara, Cristina Calvo,

<h4>Background</h4>The impact of respiratory virus infection in patients diagnosed with ataxia-telangiectasia (A-T) has not been well studied.<h4>Methods</h4>A prospective case control study was performed at a National Reference Unit for Primary Immunodeficiency in Spain (from November 2018 to July 2019), including patients younger than 20 years. Symptom questionnaires and nasopharyngeal swabs ... Read more >>

Viruses (Viruses)
[2021, 13(5):]

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Preseptal Versus Orbital Cellulitis in Children: An Observational Study.

Javier Miranda-Barrios, Blanca Bravo-Queipo-de-Llano, Fernando Baquero-Artigao, María Granados-Fernandez, Susana Noval, Ignacio Rabanal, Ana Méndez-Echevarría, Teresa Del Rosal, Talía Sainz, Javier Aracil, Cristina Calvo,

<h4>Background</h4>Preseptal and orbital cellulitis are two types of infection surrounding the orbital septum with very different potential outcomes. Our aim was to describe key differential features of both conditions, laying special emphasis on diagnostic and therapeutic tools.<h4>Methods</h4>A retrospective review of patients admitted to a tertiary hospital over a 15-year period ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(11):969-974]

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Staphylococcus aureus Nasal Colonization in Spanish Children. The COSACO Nationwide Surveillance Study.

Teresa Del Rosal, Ana Méndez-Echevarría, Cesar Garcia-Vera, Luis Escosa-Garcia, Martin Agud, Fernando Chaves, Federico Román, José Gutierrez-Fernandez, Enrique Ruiz de Gopegui, Guillermo Ruiz-Carrascoso, Maria Del Carmen Ruiz-Gallego, Albert Bernet, Sara Maria Quevedo, Ana Maria Fernández-Verdugo, Jesús Díez-Sebastian, Cristina Calvo, ,

<h4>Objective</h4>To assess the prevalence and risk factors for <i>S. aureus</i> and methicillin-resistant <i>S. aureus</i> (MRSA) nasal colonization in Spanish children.<h4>Methods</h4>Cross-sectional study of patients <14 years from primary care centers all over Spain. Clinical data and nasal aspirates were collected from March to July 2018.<h4>Results</h4>A total of 1876 patients were enrolled. ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2020, 13:4643-4651]

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Characterization of methicillin‐resistant Staphylococcus aureus strains colonizing the nostrils of Spanish children

Federico Román, Ana Mendez‐Echevarria, Teresa Del Rosal, Cesar Garcia‐Vera, Luis Escosa‐Garcia, Martin Agud, Fernando Chaves, José Gutiérrez‐Fernández, Enrique Ruiz de Gopegui, Guillermo Ruiz‐Carrascoso, Maria del Carmen Ruiz‐Gallego, Albert Bernet, Sara Maria Quevedo, Ana Maria Fernández‐Verdugo, Talia Sainz, Cristina Calvo,

Abstract <h4>Objective</h4> To characterize the Staphylococcus aureus strains colonizing healthy Spanish children. <h4>Methods</h4> Between March and July 2018, 1876 Spanish children younger than 14 years attending primary healthcare centers were recruited from rural and urban areas. Staphylococcus aureus colonization of the anterior nostrils was analyzed. MecA and mecC genes, antibiotic susceptibility, ... Read more >>

Microbiologyopen (MicrobiologyOpen)
[2021, 10(5):]

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Outcome of Severe Bacterial Pneumonia in the Era of Pneumococcal Vaccination.

Teresa Del Rosal, María Belén Caminoa, Alba González-Guerrero, Iker Falces-Romero, María Pilar Romero-Gómez, Fernando Baquero-Artigao, Talía Sainz, Ana Méndez-Echevarría, Luis Escosa-García, Francisco Javier Aracil, Cristina Calvo,

<b>Introduction:</b> After the introduction of pneumococcal conjugate vaccines, community-acquired pneumonia (CAP) caused by <i>Streptococcus pneumoniae</i> has decreased whereas <i>Staphylococcus aureus</i> and <i>Streptococcus pyogenes</i> could be increasing. These bacteria have been associated with high rates of complications. <b>Aims:</b> (1) To describe the characteristics of pediatric bacterial CAP requiring hospitalization. (2) To ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:576519]

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Marked changes in innate immunity associated with a mild course of COVID-19 in identical twins with athymia and absent circulating T cells.

Argentina Colmenero-Velázquez, Gloria Esteso, Teresa Del Rosal, Ane Calvo Apalategui, Hugh Reyburn, Eduardo López-Granados,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, 147(2):567-568]

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A Bayesian Model to Predict COVID-19 Severity in Children.

Sara Domínguez-Rodríguez, Serena Villaverde, Francisco J Sanz-Santaeufemia, Carlos Grasa, Antoni Soriano-Arandes, Jesús Saavedra-Lozano, Victoria Fumadó, Cristina Epalza, Miquel Serna-Pascual, José A Alonso-Cadenas, Paula Rodríguez-Molino, Joan Pujol-Morro, David Aguilera-Alonso, Silvia Simó, Sara Villanueva-Medina, M Isabel Iglesias-Bouzas, M José Mellado, Blanca Herrero, Susana Melendo, Mercedes De la Torre, Teresa Del Rosal, Pere Soler-Palacin, Cristina Calvo, María Urretavizcaya-Martínez, Marta Pareja, Fátima Ara-Montojo, Yolanda Ruiz Del Prado, Nerea Gallego, Marta Illán Ramos, Elena Cobos, Alfredo Tagarro, Cinta Moraleda, ,

<h4>Background</h4>We aimed to identify risk factors causing critical disease in hospitalized children with COVID-19 and to build a predictive model to anticipate the probability of need for critical care.<h4>Methods</h4>We conducted a multicenter, prospective study of children with SARS-CoV-2 infection in 52 Spanish hospitals. The primary outcome was the need for ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(8):e287-e293]

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Septicemia and meningitis associated with Haemophilus influenzae type b vaccine failure.

Sara López López, Teresa Del Rosal, Susana Jiménez Bueno, Fernando Baquero-Artigao,

Enferm Infecc Microbiol Clin (Engl Ed) (Enfermedades infecciosas y microbiologia clinica (English ed.))
[2021, 39(8):417-418]

Cited: 0 times

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Acute bronchiolitis during the COVID-19 pandemic.

Patricia Flores-Pérez, Nathalia Gerig, Mª Isabel Cabrera-López, José L de Unzueta-Roch, Teresa Del Rosal, Cristina Calvo, ,

<h4>Introduction</h4>The autumn and winter bronchiolitis epidemics have virtually disappeared in the first year of the COVID-19 pandemic. Our objectives were characterised bronchiolitis during fourth quarter of 2020 and the role played by SARS-CoV-2.<h4>Methods</h4>Prospective multi-centre study performed in Madrid (Spain) between October and December 2020 including all children admitted with acute ... Read more >>

Enferm Infecc Microbiol Clin (Engl Ed) (Enfermedades infecciosas y microbiologia clinica (English ed.))
[2021, :]

Cited: 0 times

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Compassionate use of cefiderocol for VIM metallo-β-lactamase-producing Pseudomonas aeruginosa infection in a toddler with Burkitt lymphoma.

Carlos D Grasa, María Rosa Gómez-Gil, Sonsoles San Román Pacheco, Teresa Del Rosal, Francisco Moreno, Nathalia Gerig, Bárbara Ochoa Fernández, Cristina Calvo, Fernando Baquero-Artigao,

J Glob Antimicrob Resist (Journal of global antimicrobial resistance)
[2021, 26:91-92]

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Interferon-Gamma Release Assays Differentiate between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children.

Aina Martínez-Planas, Fernando Baquero-Artigao, Begoña Santiago, Clàudia Fortuny, Ana Méndez-Echevarría, Teresa Del Rosal, Matilde Bustillo-Alonso, Inés Gale, Carmelo Guerrero, Daniel Blázquez-Gamero, Anna Canet, Miguel Lillo, Olga Calavia, Esmeralda Núñez Cuadros, Lola Falcón-Neyra, Antoni Soriano-Arandes, Jakko Van Ingen, Marc Tebruegge, Antoni Noguera-Julian, ,

<h4>Objectives</h4>To assess the performance of interferon-gamma release assays (IGRAs) in the differential diagnosis between Mycobacterium avium complex (MAC) and tuberculosis (TB) in children affected with subacute/chronic submandibular/cervical lymphadenitis.<h4>Study design</h4>Multicenter observational study comparing children with microbiologically confirmed MAC lymphadenitis from the European NontuberculouS MycoBacterial Lymphadenitis in childrEn study with children with ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 236:211-218.e2]

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Prevalence of thrombotic complications in children with SARS-CoV-2.

David Aguilera-Alonso, Sara Murias, Amelia Martínez-de-Azagra Garde, Antoni Soriano-Arandes, Marta Pareja, Enrique Otheo, Cinta Moraleda, Alfredo Tagarro, Cristina Calvo, ,

Knowledge of thrombosis in children with SARS-CoV-2 is scarce. In this multicentre national cohort of children with SARS-CoV-2 involving 49 hospitals, 4 patients out of 537 infected children developed a thrombotic complication (prevalence of 0.7% (95% CI: 0.2% to 1.9%) out of the global cohort and 1.1% (95% CI: 0.3% ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2021, :]

Cited: 3 times

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SARS-CoV-2 infection in ambulatory and hospitalised Spanish children.

María de Ceano-Vivas, Irene Martín-Espín, Teresa Del Rosal, Marta Bueno-Barriocanal, Marta Plata-Gallardo, José Antonio Ruiz-Domínguez, Rosario López-López, Miguel Ángel Molina-Gutiérrez, Patricia Bote-Gascón, Isabel González-Bertolín, Paula García-Sánchez, Julia Martín-Sánchez, Begoña de Miguel-Lavisier, Talía Sainz, Fernando Baquero-Artigao, Ana Méndez-Echevarría, Cristina Calvo,

Arch Dis Child (Archives of disease in childhood)
[2020, 105(8):808-809]

Cited: 14 times

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Pneumonia in Hospitalized Children During SARS-CoV-2 Pandemic. Is it All COVID-19? Comparison Between COVID and Non-COVID Pneumonia.

Raquel Jimenez-García, Javier Nogueira, Azucena Retuerta-Oliva, Talía Sainz, Julia Cano-Fernández, Patricia Flores-Pérez, Ana Méndez-Echevarría, Enrique Villalobos-Pinto, Lourdes Calleja-Gero, Fancisco J Sanz-Santaeufemia, María P Romero, Teresa Del Rosal, Fernando Baquero-Artigao, Carlos Grasa, Cristina Calvo,

Our study describes more than 100 children hospitalized with pneumonia during lockdown in the first pandemic wave with only 20% attributable to SARS-CoV-2. The serologic study during follow-up only helped to detect 4%. Other etiologies were common. Older age, presence of headache, vomiting, lymphopenia and thrombopenia were associated with COVID-19 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(3):e111-e113]

Cited: 1 time

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Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population.

Serena Villaverde, Sara Domínguez-Rodríguez, Gema Sabrido, Conchita Pérez-Jorge, Marta Plata, María Pilar Romero, Carlos Daniel Grasa, Ana Belén Jiménez, Elena Heras, Antonio Broncano, María Del Mar Núñez, Marta Illán, Paloma Merino, Beatriz Soto, David Molina-Arana, Amanda Bermejo, Pablo Mendoza, Manuel Gijón, Begoña Pérez-Moneo, Cinta Moraleda, Alfredo Tagarro, ,

We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019-compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 232:287-289.e4]

Cited: 13 times

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Possible role of highly activated mucosal NK cells against viral respiratory infections in children undergoing haematopoietic stem cell transplantation.

Maria Vela, Teresa Del Rosal, Antonio Pérez-Martínez, Jaime Valentín, Inmaculada Casas, Francisco Pozo, Francisco Reinoso-Barbero, David Bueno, Dolores Corral, Ana Méndez-Echevarría, Yasmina Mozo, Cristina Calvo,

Infection is the leading cause of non-relapse-related mortality after allogeneic haematopoietic stem cell transplantation (HSCT). Altered functions of immune cells in nasal secretions may influence post HSCT susceptibility to viral respiratory infections. In this prospective study, we determined T and NK cell numbers together with NK activation status in nasopharyngeal ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18792]

Cited: 1 time

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Septicemia and meningitis associated with Haemophilus influenzae type b vaccine failure.

Sara López López, Teresa Del Rosal, Susana Jiménez Bueno, Fernando Baquero-Artigao,

Enferm Infecc Microbiol Clin (Engl Ed) (Enfermedades infecciosas y microbiologia clinica (English ed.))
[2020, :]

Cited: 0 times

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False-positive Results of Quantiferon-Tb-Gold Assay in Children.

Cristian Quintana-Ortega, Ana Mendez-Echevarria, Teresa Del Rosal, Miguel Gonzalez-Muñoz, Fernando Baquero-Artigao,

We present a pediatric case series describing false-positive QuantiFERON-TB Gold In-tube (QFT-GIT) assay (QIAGEN, Germany) results observed in a tertiary hospital in Spain (2013-2018). During the study period, 7 of 737 test results were considered false-positives: 4 children with chronic medical conditions, 1 Mycobacterium lentiflavum lymphadenitis, 1 infant born to ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(7):620-623]

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Gestational and congenital tuberculosis: An ongoing problem.

Paula Rodríguez-Molino, María de la Calle, Teresa Del Rosal, Fernando Baquero-Artigao,

Enferm Infecc Microbiol Clin (Engl Ed) (Enfermedades infecciosas y microbiologia clinica (English ed.))
[2020, 38(10):505-506]

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The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy.

Marta Benavides-Nieto, Ana Méndez-Echevarría, Teresa Del Rosal, María Luz García-García, Inmaculada Casas, Francisco Pozo, Olga de la Serna, Eduardo Lopez-Granados, Rebeca Rodriguez-Pena, Cristina Calvo,

BACKGROUND:The role of viruses in children with respiratory tract infections and humoral immunodeficiencies has hardly been studied. We have evaluated these infections in children with humoral immunodeficiencies who required immunoglobulin replacement therapy, considering their relationship with symptoms, lung function, bacterial co-infection, and outcomes. METHODS:We conducted a prospective case-control study during ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2019, 54(2):194-199]

Cited: 1 time

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Lung ultrasound for prediction of respiratory support in infants with acute bronchiolitis: A cohort study.

Mercedes Bueno-Campaña, Talía Sainz, Maria Alba, Teresa Del Rosal, Ana Mendez-Echevarría, Regina Echevarria, Alfredo Tagarro, Marta Ruperez-Lucas, Maria L Herrreros, Libertad Latorre, Cristina Calvo,

OBJECTIVE:Respiratory tract infections are among the most common causes of morbidity and mortality worldwide. Acute bronchiolitis (AB) is the leading cause of hospital admission among infants. Clinical scores have proven to be inaccurate in predicting prognosis. Our aim was to build a score based on findings of lung ultrasound (LU) ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2019, 54(6):873-880]

Cited: 7 times

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Linezolid-containing Treatment Regimens for Tuberculosis in Children.

Luis M Prieto, Begoña Santiago, Teresa Del Rosal, Begoña Carazo, Ana B Jiménez, Beatriz Pérez-Gorricho, Felipe Rubio, Alfredo Tagarro, Daniel Blázquez-Gamero, David Moreno-Pérez, María J Mellado, Fernando Baquero-Artigao, ,

BACKGROUND:In recent years, there is an increasing interest in the use of linezolid for the treatment of tuberculosis (TB). METHODS:Patients less than 18 years of age who received linezolid within the Spanish Pediatric TB Network from 2001 to 2016 were retrospectively included. Treatment characteristics, adverse events (AEs) and outcomes were ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(3):263-267]

Cited: 0 times

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Fatal Pneumocystis jirovecii and Cytomegalovirus Infections in an Infant With Normal TRECs Count: Pitfalls of Newborn Screening for Severe Combined Immunodeficiency.

Ana Mendez-Echevarria, Luis Ignacio Gonzalez-Granado, Luis M Allende, Beatriz De Felipe, Del Rosal Teresa, Cristina Calvo, Antonio Perez-Martinez, Ruiz-Garcia Raquel, Olaf Neth,

Newborn screening for severe combined immunodeficiency using T-cell receptor excision circles allows prompt diagnosis and initiation of supportive and curative therapy thereby reducing morbidity and mortality. However, profound combined immunodeficiencies with normal numbers of nonfunctional T cells will go undetected. We present a patient with calcium release-activated calcium channel gene ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(2):157-160]

Cited: 2 times

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18F-FDG PET/CT monitoring of non-tuberculous mycobacterial infection in a child with interleukin-12 receptor β-1 deficiency.

Ana Mendez-Echevarria, Sonia Rodado-Marina, Monica Coronado-Poggio, Teresa Del Rosal,

Infection (Infection)
[2019, 47(3):503-506]

Cited: 0 times

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