Full Text Journal Articles by
Author Teresa A Zimmers

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What's New in Shock, February 2021?

Linda E Sousse, Teresa A Zimmers,

Shock (Shock (Augusta, Ga.))
[2021, 55(2):143-146]

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Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform.

Ashok Narasimhan, Safi Shahda, Joshua K Kays, Susan M Perkins, Lijun Cheng, Katheryn N H Schloss, Daniel E I Schloss, Leonidas G Koniaris, Teresa A Zimmers,

Patients with pancreatic ductal adenocarcinoma (PDAC) suffer debilitating and deadly weight loss, known as cachexia. Development of therapies requires biomarkers to diagnose, and monitor cachexia; however, no such markers are in use. Via Somascan, we measured ~1300 plasma proteins in 30 patients with PDAC vs. 11 controls. We found 60 ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(12):]

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Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models.

Rachel A Caston, Fenil Shah, Colton L Starcher, Randall Wireman, Olivia Babb, Michelle Grimard, Jack McGeown, Lee Armstrong, Yan Tong, Roberto Pili, Joseph Rupert, Teresa A Zimmers, Adily N Elmi, Karen E Pollok, Edward A Motea, Mark R Kelley, Melissa L Fishel,

With a plethora of molecularly targeted agents under investigation in cancer, a clear need exists to understand which pathways can be targeted simultaneously with multiple agents to elicit a maximal killing effect on the tumour. Combination therapy provides the most promise in difficult to treat cancers such as pancreatic. Ref-1 ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, :]

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ACVR2B antagonism as a countermeasure to multi-organ perturbations in metastatic colorectal cancer cachexia.

Joshua R Huot, Fabrizio Pin, Ashok Narasimhan, Leah J Novinger, Austin S Keith, Teresa A Zimmers, Monte S Willis, Andrea Bonetto,

<h4>Background</h4>Advanced colorectal cancer (CRC) is often accompanied by the development of liver metastases, as well as cachexia, a multi-organ co-morbidity primarily affecting skeletal (SKM) and cardiac muscles. Activin receptor type 2B (ACVR2B) signalling is known to cause SKM wasting, and its inhibition restores SKM mass and prolongs survival in cancer. ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2020, 11(6):1779-1798]

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Sex Differences in Cancer Cachexia.

Xiaoling Zhong, Teresa A Zimmers,

<h4>Purpose of review</h4>Cachexia, a feature of cancer and other chronic diseases, is marked by progressive weight loss and skeletal muscle wasting. This review aims to highlight the sex differences in manifestations of cancer cachexia in patients, rodent models, and our current understanding of the potential mechanisms accounting for these differences.<h4>Recent ... Read more >>

Curr Osteoporos Rep (Current osteoporosis reports)
[2020, 18(6):646-654]

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Changes in Serum Myostatin Levels in Alcoholic Hepatitis Correlate with Improvement in MELD.

Hani Shamseddeen, Abhishek Madathanapalli, Vijay S Are, Vijay H Shah, Arun J Sanyal, Qing Tang, Tiebing Liang, Kayla Gelow, Teresa A Zimmers, Naga Chalasani, Archita P Desai,

<h4>Background</h4>Alcoholic hepatitis (AH) is a serious clinical syndrome often associated with muscle wasting. Myostatin, a member of the transforming growth factor-β superfamily, has been studied in diseases with muscle wasting; however, the role of myostatin in AH is unknown.<h4>Aims</h4>To investigate the association between myostatin, clinical variables, and outcomes in AH.<h4>Methods</h4>We ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2020, :]

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Pathological Responses of Cardiac Mitochondria to Burn Trauma.

Meijing Wang, Susan R Scott, Leonidas G Koniaris, Teresa A Zimmers,

Despite advances in treatment and care, burn trauma remains the fourth most common type of traumatic injury. Burn-induced cardiac failure is a key factor for patient mortality, especially during the initial post-burn period (the first 24 to 48 h). Mitochondria, among the most important subcellular organelles in cardiomyocytes, are a ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(18):]

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The Combination of Low Skeletal Muscle Mass and High Tumor Interleukin-6 Associates with Decreased Survival in Clear Cell Renal Cell Carcinoma.

Joshua K Kays, Leonidas G Koniaris, Caleb A Cooper, Roberto Pili, Guanglong Jiang, Yunlong Liu, Teresa A Zimmers,

Clear cell renal carcinoma (ccRCC) is frequently associated with cachexia which is itself associated with decreased survival and quality of life. We examined relationships among body phenotype, tumor gene expression, and survival. Demographic, clinical, computed tomography (CT) scans and tumor RNASeq for 217 ccRCC patients were acquired from the Cancer ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(6):]

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Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia.

Joshua R Huot, Leah J Novinger, Fabrizio Pin, Ashok Narasimhan, Teresa A Zimmers, Thomas M O'Connell, Andrea Bonetto,

Advanced colorectal cancer (CRC) is often accompanied by development of liver metastases (LMs) and skeletal muscle wasting (i.e., cachexia). Despite plaguing the majority of CRC patients, cachexia remains unresolved. By using mice injected with Colon-26 mouse tumors, either subcutaneously (s.c.; C26) or intrasplenically to mimic hepatic dissemination of cancer cells ... Read more >>

JCI Insight (JCI insight)
[2020, 5(9):]

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miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2.

Shatovisha Dey, Jason J Kwon, Sheng Liu, Gabriel A Hodge, Solaema Taleb, Teresa A Zimmers, Jun Wan, Janaiah Kota,

Pancreatic ductal adenocarcinoma (PDAC) is an intractable cancer with a dismal prognosis. miR-29a is commonly downregulated in PDAC; however, mechanisms for its loss and role still remain unclear. Here, we show that in PDAC, repression of miR-29a is directly mediated by MYC via promoter activity. RNA sequencing analysis, integrated with ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2020, 18(2):311-323]

Cited: 1 time

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Modelling survival.

Teresa A Zimmers, Leonidas G Koniaris,

A new mouse model of sepsis can reproduce the long-term muscle weakness seen in patients who survive this life-threatening illness. ... Read more >>

Elife (eLife)
[2019, 8:]

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Age- and sex-dependent role of osteocytic pannexin1 on bone and muscle mass and strength.

Alexandra Aguilar-Perez, Rafael Pacheco-Costa, Emily G Atkinson, Padmini Deosthale, Hannah M Davis, Alyson L Essex, Julian E Dilley, Leland Gomez, Joseph E Rupert, Teresa A Zimmers, Roger J Thompson, Matthew R Allen, Lilian I Plotkin,

Pannexins (Panxs), glycoproteins that oligomerize to form hemichannels on the cell membrane, are topologically similar to connexins, but do not form cell-to-cell gap junction channels. There are 3 members of the family, 1-3, with Panx1 being the most abundant. All Panxs are expressed in bone, but their role in bone ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):13903]

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Voluntary Wheel Running Has Beneficial Effects in a Rat Model of CKD-Mineral Bone Disorder (CKD-MBD).

Keith G Avin, Matthew R Allen, Neal X Chen, Shruthi Srinivasan, Kalisha D O'Neill, Ashley D Troutman, Garrison Mast, Elizabeth A Swallow, Mary Beth Brown, Joseph M Wallace, Teresa A Zimmers, Stuart J Warden, Sharon M Moe,

<h4>Background</h4>Reduced bone and muscle health in individuals with CKD contributes to their higher rates of morbidity and mortality.<h4>Methods</h4>We tested the hypothesis that voluntary wheel running would improve musculoskeletal health in a CKD rat model. Rats with spontaneous progressive cystic kidney disease (Cy/+ <sub>IU</sub>) and normal littermates (NL) were given access ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2019, 30(10):1898-1909]

Cited: 1 time

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The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy.

Xiaoling Zhong, Marianne Pons, Christophe Poirier, Yanlin Jiang, Jianguo Liu, George E Sandusky, Safi Shahda, Attila Nakeeb, C Max Schmidt, Michael G House, Eugene P Ceppa, Nicholas J Zyromski, Yunlong Liu, Guanglong Jiang, Marion E Couch, Leonidas G Koniaris, Teresa A Zimmers,

<h4>Background</h4>Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice.<h4>Methods</h4>Isoform-specific activin expression and activities were queried in human and murine tumours and PDAC models. Activin inhibition was by administration of soluble ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2019, 10(5):1083-1101]

Cited: 4 times

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What's New in Shock, July 2019?

Jennifer L Hartwell, Teresa A Zimmers,

Shock (Shock (Augusta, Ga.))
[2019, 52(1):1-4]

Cited: 0 times

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Multimodal Action of Mas Activation for Systemic Cancer Cachexia Therapy.

Joseph E Rupert, Leonidas G Koniaris, Teresa A Zimmers,

Cancer cachexia remains a largely intractable, deadly condition for patients with no approved, effective therapies. However, research progress over the past few decades demonstrates that cachexia is a disease with specific, targetable mechanisms. New work by Murphy and colleagues in this issue of <i>Cancer Research</i> suggests that activation of the ... Read more >>

Cancer Res (Cancer research)
[2019, 79(4):699-700]

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Resveratrol Improves Recovery and Survival of Diet-Induced Obese Mice Undergoing Extended Major (80%) Hepatectomy.

Xiaoling Jin, Teresa A Zimmers, Zongxiu Zhang, Leonidas G Koniaris,

<h4>Introduction</h4>Loss of hepatic epidermal growth factor receptor (EGFR) expression is a cause for the increased perioperative risk for complications and death in patients with obesity and fatty liver undergoing liver resection. Herein, we set out to identify agents that might increase EGFR expression and improve recovery for patients with fatty ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2019, 64(1):93-101]

Cited: 0 times

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Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia.

Fabrizio Pin, Rafael Barreto, Yukiko Kitase, Sumegha Mitra, Carlie E Erne, Leah J Novinger, Teresa A Zimmers, Marion E Couch, Lynda F Bonewald, Andrea Bonetto,

<h4>Background</h4>Cachexia frequently occurs in women with advanced ovarian cancer (OC), along with enhanced inflammation. Despite being responsible for one third of all cancer deaths, cachexia is generally under-studied in OC due to a limited number of pre-clinical animal models. We aimed to address this gap by characterizing the cachectic phenotype ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2018, 9(4):685-700]

Cited: 18 times

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Three cachexia phenotypes and the impact of fat-only loss on survival in FOLFIRINOX therapy for pancreatic cancer.

Joshua K Kays, Safi Shahda, Melissa Stanley, Teresa M Bell, Bert H O'Neill, Marc D Kohli, Marion E Couch, Leonidas G Koniaris, Teresa A Zimmers,

<h4>Background</h4>By the traditional definition of unintended weight loss, cachexia develops in ~80% of patients with pancreatic ductal adenocarcinoma (PDAC). Here, we measure the longitudinal body composition changes in patients with advanced PDAC undergoing 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin therapy.<h4>Methods</h4>We performed a retrospective review of 53 patients with advanced PDAC on ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2018, 9(4):673-684]

Cited: 17 times

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An Assessment of the Academic Impact of Shock Society Members.

Daniel P Milgrom, Leonidas G Koniaris, Nakul P Valsangkar, Neha Lad, Teresa M Bell, Brandon Wojcik, Teresa A Zimmers,

Professional society membership enhances career development and productivity by offering opportunities for networking and learning about recent advances in the field. The quality and contribution of such societies can be measured in part through the academic productivity, career status, and funding success rates of their members. Here, using Scopus, NIH ... Read more >>

Shock (Shock (Augusta, Ga.))
[2018, 49(5):508-513]

Cited: 1 time

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GDF11 induces kidney fibrosis, renal cell epithelial-to-mesenchymal transition, and kidney dysfunction and failure.

Marianne Pons, Leonidas G Koniaris, Sharon M Moe, Juan C Gutierrez, Aurora Esquela-Kerscher, Teresa A Zimmers,

BACKGROUND:GDF11 modulates embryonic patterning and kidney organogenesis. Herein, we sought to define GDF11 function in the adult kidney and in renal diseases. METHODS:In vitro renal cell lines, genetic, and murine in vivo renal injury models were examined. RESULTS:Among tissues tested, Gdf11 was highest in normal adult mouse kidney. Expression was ... Read more >>

Surgery (Surgery)
[2018, 164(2):262-273]

Cited: 4 times

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Sarcopenia is a Significant Predictor of Mortality After Abdominal Aortic Aneurysm Repair.

Joshua K Kays, Tiffany W Liang, Teresa A Zimmers, Daniel P Milgrom, Hamzah Abduljabar, Andrew Young, Bradford J Kim, Teresa M Bell, Andres Fajardo, Michael P Murphy, Leonidas G Koniaris,

<h4>Aims</h4>Repair of abdominal aortic aneurysms (AAA) decreases the incidence of rupture and death. In cancer patients, sarcopenia has been associated with increased surgical complications and mortality. The impact of sarcopenia on survival after AAA repair has yet to be described.<h4>Methods and results</h4>Patient demographic, laboratory, body composition measurements and survival data ... Read more >>

JCSM Clin Rep (JCSM clinical reports)
[2018, 3(1):]

Cited: 1 time

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Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naïve pancreatic cancer patients.

Erin E Talbert, Heather L Lewis, Matthew R Farren, Mitchell L Ramsey, Jeffery M Chakedis, Priyani Rajasekera, Ericka Haverick, Angela Sarna, Mark Bloomston, Timothy M Pawlik, Teresa A Zimmers, Gregory B Lesinski, Phil A Hart, Mary E Dillhoff, Carl R Schmidt, Denis C Guttridge,

<h4>Background</h4>Cancer-associated wasting, termed cancer cachexia, has a profound effect on the morbidity and mortality of cancer patients but remains difficult to recognize and diagnose. While increases in circulating levels of a number of inflammatory cytokines have been associated with cancer cachexia, these associations were generally made in patients with advanced ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2018, 9(2):358-368]

Cited: 12 times

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Meloxicam increases epidermal growth factor receptor expression improving survival after hepatic resection in diet-induced obese mice.

Xiaoling Jin, Teresa A Zimmers, Yanlin Jiang, Daniel P Milgrom, Zongxiu Zhang, Leonidas G Koniaris,

BACKGROUND:Patients with fatty liver have delayed regenerative responses, increased hepatocellular injury, and increased risk for perioperative mortality. Currently, no clinical therapy exists to prevent liver failure or improve regeneration in patients with fatty liver. Previously we demonstrated that obese mice have markedly reduced levels of epidermal growth factor receptor in ... Read more >>

Surgery (Surgery)
[2018, 163(6):1264-1271]

Cited: 1 time

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Erratum to: Exogenous GDF11 induces cardiac and skeletal muscle dysfunction and wasting.

Teresa A Zimmers, Yanlin Jiang, Meijing Wang, Tiffany W Liang, Joseph E Rupert, Ernie D Au, Francesco E Marino, Marion E Couch, Leonidas G Koniaris,

Basic Res Cardiol (Basic research in cardiology)
[2017, 112(5):53]

Cited: 5 times

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