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Author Tatsushi Onaka


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Stress adaptation by increasing the area of the cell membrane.

Tatsushi Onaka,

J. Physiol. (Lond.) (The Journal of physiology)
[2020, :]

Cited: 0 times

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Expression of hypothalamic feeding-related peptide genes and neuroendocrine responses in an experimental allergic encephalomyelitis rat model.

Kentaro Tanaka, Reiko Saito, Kenya Sanada, Haruki Nishimura, Kazuaki Nishimura, Satomi Sonoda, Hiromichi Ueno, Yasuhito Motojima, Takanori Matsuura, Mitsuhiro Yoshimura, Takashi Maruyama, Tatsushi Onaka, Yukiyo Yamamoto, Koichi Kusuhara, Yoichi Ueta,

Experimental allergic encephalomyelitis (EAE) is considered to be a useful animal model of human multiple sclerosis (MS). However, among the various symptoms of MS, the mechanisms contributing to inflammatory anorexia remain unclear. In the present study, we used an EAE rat model to examine changes in expression levels of hypothalamic ... Read more >>

Peptides (Peptides)
[2020, 129:170313]

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Acute Mono-Arthritis Activates the Neurohypophysial System and Hypothalamo-Pituitary Adrenal Axis in Rats.

Haruki Nishimura, Makoto Kawasaki, Takanori Matsuura, Hitoshi Suzuki, Yasuhito Motojima, Kazuhiko Baba, Hideo Ohnishi, Yoshiaki Yamanaka, Teruaki Fujitani, Mitsuhiro Yoshimura, Takashi Maruyama, Hiromichi Ueno, Satomi Sonoda, Kazuaki Nishimura, Kentarou Tanaka, Kenya Sanada, Tatsushi Onaka, Yoichi Ueta, Akinori Sakai,

Various types of acute/chronic nociceptive stimuli cause neuroendocrine responses such as activation of the hypothalamo-neurohypophysial [oxytocin (OXT) and arginine vasopressin (AVP)] system and hypothalamo-pituitary adrenal (HPA) axis. Chronic multiple-arthritis activates the OXT/AVP system, but the effects of acute mono-arthritis on the OXT/AVP system in the same animals has not been ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2020, 11:43]

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Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation.

Toshihiro Nakano, Kazuhiro Shiizaki, Yutaka Miura, Masahiro Matsui, Keisei Kosaki, Shoya Mori, Kunihiro Yamagata, Seiji Maeda, Takuya Kishi, Naoki Usui, Masahide Yoshida, Tatsushi Onaka, Hiroaki Mizukami, Ruri Kaneda, Kazunori Karasawa, Kosaku Nitta, Hiroshi Kurosu, Makoto Kuro-O,

Circulating levels of fibroblast growth factor-21 (FGF21) start increasing in patients with chronic kidney disease (CKD) since early stages during the cause of disease progression. FGF21 is a liver-derived hormone that induces responses to stress through acting on hypothalamus to activate the sympathetic nervous system and the hypothalamus-pituitary-adrenal endocrine axis. ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):19247]

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Visualization of a blue light transmission area in living animals using light-induced nuclear translocation of fluorescent proteins.

Ayumu Inutsuka, Norihiro Kimizuka, Natsuki Takanohashi, Hisashi Yakabu, Tatsushi Onaka,

Optical manipulations are widely used to analyze neuronal functions in vivo. Blue light is frequently used to activate channelrhodopsins or LOV domains, although the degrees of its absorption and scattering are higher than those of longer wavelength light. High spatial resolution of optical manipulation is easily achieved in vitro, while the light ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, 522(1):138-143]

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Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase-An Animal Model of Cystathioninuria.

Noriyuki Akahoshi, Hiroki Handa, Rintaro Takemoto, Shotaro Kamata, Masahide Yoshida, Tatsushi Onaka, Isao Ishii,

Elevated plasma homocysteine levels are considered as a risk factor for cardiovascular diseases as well as preeclampsia-a pregnancy disorder characterized by hypertension and proteinuria. We previously generated mice lacking cystathionine γ-lyase (Cth) as cystathioninuria models and found them to be with cystathioninemia/homocysteinemia. We investigated whether Cth-deficient (Cth-/-) pregnant mice display ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(14):]

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Role of oxytocin in the control of stress and food intake.

Tatsushi Onaka, Yuki Takayanagi,

Oxytocin neurones in the hypothalamus are activated by stressful stimuli and food intake. The oxytocin receptor is located in various brain regions, including the sensory information-processing cerebral cortex; the cognitive information-processing prefrontal cortex; reward-related regions such as the ventral tegmental areas, nucleus accumbens and raphe nucleus; stress-related areas such as ... Read more >>

J. Neuroendocrinol. (Journal of neuroendocrinology)
[2019, 31(3):e12700]

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Neuropathic Pain Up-Regulates Hypothalamo-Neurohypophysial and Hypothalamo-Spinal Oxytocinergic Pathways in Oxytocin-Monomeric Red Fluorescent Protein 1 Transgenic Rat.

Haruki Nishimura, Makoto Kawasaki, Hitoshi Suzuki, Takanori Matsuura, Yasuhito Motojima, Hideo Ohnishi, Yoshiaki Yamanaka, Mitsuhiro Yoshimura, Takashi Maruyama, Reiko Saito, Hiromichi Ueno, Satomi Sonoda, Kazuaki Nishimura, Tatsushi Onaka, Yoichi Ueta, Akinori Sakai,

Despite the high incidence of neuropathic pain, its mechanism remains unclear. Oxytocin (OXT) is an established endogenous polypeptide produced in the supraoptic nucleus (SON) and paraventricular nucleus (PVN) of the hypothalamus. OXT, which is synthesized by OXT neurons in the SON and the magnocellular part of the PVN (mPVN), is ... Read more >>

Neuroscience (Neuroscience)
[2019, 406:50-61]

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Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice.

Sho Matsui, Tsutomu Sasaki, Daisuke Kohno, Keisuke Yaku, Ayumu Inutsuka, Hiromi Yokota-Hashimoto, Osamu Kikuchi, Takayoshi Suga, Masaki Kobayashi, Akihiro Yamanaka, Akihiro Harada, Takashi Nakagawa, Tatsushi Onaka, Tadahiro Kitamura,

Diet affects health through ingested calories and macronutrients, and macronutrient balance affects health span. The mechanisms regulating macronutrient-based diet choices are poorly understood. Previous studies had shown that NAD-dependent deacetylase sirtuin-1 (SIRT1) in part influences the health-promoting effects of caloric restriction by boosting fat use in peripheral tissues. Here, we ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):4604]

Cited: 3 times

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Upregulation of hypothalamic arginine vasopressin by peripherally administered furosemide in transgenic rats expressing arginine vasopressin-enhanced green fluorescent protein.

Hiromichi Ueno, Mitsuhiro Yoshimura, Kentaro Tanaka, Haruki Nishimura, Kazuaki Nishimura, Satomi Sonoda, Yasuhito Motojima, Reiko Saito, Takashi Maruyama, Tetsu Miyamoto, Ryota Serino, Masahito Tamura, Tatsushi Onaka, Yutaka Otsuji, Yoichi Ueta,

Furosemide, which is used worldwide as a diuretic agent, inhibits sodium reabsorption in the Henle's loop, resulting in diuresis and natriuresis. Arginine vasopressin (AVP) is synthesized in the supraoptic nucleus (SON), paraventricular nucleus (PVN), and suprachiasmatic nucleus (SCN) of the hypothalamus. The synthesis AVP in the magnocellular neurons of SON ... Read more >>

J. Neuroendocrinol. (Journal of neuroendocrinology)
[2018, :e12603]

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Gene therapy for Glut1-deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter.

Sachie Nakamura, Shin-Ichi Muramatsu, Naomi Takino, Mika Ito, Eriko F Jimbo, Kuniko Shimazaki, Tatsushi Onaka, Sumio Ohtsuki, Tetsuya Terasaki, Takanori Yamagata, Hitoshi Osaka,

BACKGROUND:We generated an adeno-associated virus (AAV) vector in which the human SLC2A1 gene, encoding glucose transporter type 1 (GLUT1), was expressed under the human endogenous GLUT1 promoter (AAV-GLUT1). We examined whether AAV-GLUT1 administration could lead to functional improvement in GLUT1-deficient mice. METHODS:We extrapolated human endogenous GLUT1 promoter sequences from rat ... Read more >>

J Gene Med (The journal of gene medicine)
[2018, 20(4):e3013]

Cited: 2 times

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Oxytocin-Oxytocin Receptor Systems Facilitate Social Defeat Posture in Male Mice.

Naranbat Nasanbuyan, Masahide Yoshida, Yuki Takayanagi, Ayumu Inutsuka, Katsuhiko Nishimori, Akihiro Yamanaka, Tatsushi Onaka,

Social stress has deteriorating effects on various psychiatric diseases. In animal models, exposure to socially dominant conspecifics (i.e., social defeat stress) evokes a species-specific defeat posture via unknown mechanisms. Oxytocin neurons have been shown to be activated by stressful stimuli and to have prosocial and anxiolytic actions. The roles of ... Read more >>

Endocrinology (Endocrinology)
[2018, 159(2):763-775]

Cited: 2 times

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Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome.

Sachie Nakamura, Hitoshi Osaka, Shin-Ichi Muramatsu, Naomi Takino, Mika Ito, Shiho Aoki, Eriko F Jimbo, Kuniko Shimazaki, Tatsushi Onaka, Sumio Ohtsuki, Tetsuya Terasaki, Takanori Yamagata,

We generated an adeno-associated virus (AAV) vector in which the human SLC2A1 gene was expressed under the synapsin I promoter (AAV-hSLC2A1) and examined if AAV-hSLC2A1 administration can lead to functional improvement in GLUT1-deficient mice.AAV-hSLC2A1 was injected into heterozygous knock-out murine Glut1 (GLUT1+/-) mice intraperitoneally (systemic; 1.85 × 1011 vg/mouse) or intra-cerebroventricularly (local; 1.85 × 1010 vg/mouse). ... Read more >>

Mol Genet Metab Rep (Molecular genetics and metabolism reports)
[2017, 10:67-74]

Cited: 3 times

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Activation of Supraoptic Oxytocin Neurons by Secretin Facilitates Social Recognition.

Yuki Takayanagi, Masahide Yoshida, Akihide Takashima, Keiko Takanami, Shoma Yoshida, Katsuhiko Nishimori, Ichiko Nishijima, Hirotaka Sakamoto, Takanori Yamagata, Tatsushi Onaka,

Social recognition underlies social behavior in animals, and patients with psychiatric disorders associated with social deficits show abnormalities in social recognition. Oxytocin is implicated in social behavior and has received attention as an effective treatment for sociobehavioral deficits. Secretin receptor-deficient mice show deficits in social behavior. The relationship between oxytocin ... Read more >>

Biol. Psychiatry (Biological psychiatry)
[2017, 81(3):243-251]

Cited: 11 times

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Activation of hypothalamic oxytocin neurons following tactile stimuli in rats.

Shota Okabe, Masahide Yoshida, Yuki Takayanagi, Tatsushi Onaka,

Gentle touching or stroking has anxiolytic actions and contributes to the establishment of an intimate relationship between individuals. Oxytocin administration also has anxiolytic actions and facilitates social behaviors. In this study, we examined effects of stroking stimuli on activation of oxytocin neurons and emission of 50-kHz ultrasonic vocalizations, an index ... Read more >>

Neurosci. Lett. (Neuroscience letters)
[2015, 600:22-27]

Cited: 13 times

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Social evolution. Oxytocin-gaze positive loop and the coevolution of human-dog bonds.

Miho Nagasawa, Shouhei Mitsui, Shiori En, Nobuyo Ohtani, Mitsuaki Ohta, Yasuo Sakuma, Tatsushi Onaka, Kazutaka Mogi, Takefumi Kikusui,

Human-like modes of communication, including mutual gaze, in dogs may have been acquired during domestication with humans. We show that gazing behavior from dogs, but not wolves, increased urinary oxytocin concentrations in owners, which consequently facilitated owners' affiliation and increased oxytocin concentration in dogs. Further, nasally administered oxytocin increased gazing ... Read more >>

Science (Science (New York, N.Y.))
[2015, 348(6232):333-336]

Cited: 113 times

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Effects of a subconvulsive dose of kainic acid on the gene expressions of the arginine vasopressin, oxytocin and neuronal nitric oxide synthase in the rat hypothalamus.

Mitsuhiro Yoshimura, Jun-ichi Ohkubo, Hirofumi Hashimoto, Takanori Matsuura, Takashi Maruyama, Tatsushi Onaka, Hideaki Suzuki, Yoichi Ueta,

Arginine vasopressin (AVP) synthesis in the hypothalamo-neurohypophysial system (HNS) is up-regulated by kainic acid (KA)-induced seizure in rats. However, it remains unknown whether a subconvulsive dose of KA affects the HNS. Here we examined the effects of subcutaneous (s.c.) administration of a low dose of KA (4 mg/kg) on the ... Read more >>

Neurosci. Res. (Neuroscience research)
[2015, 99:62-68]

Cited: 2 times

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The medial amygdala-medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents.

Masahide Yoshida, Yuki Takayanagi, Tatsushi Onaka,

Fear responses play evolutionarily beneficial roles, although excessive fear memory can induce inappropriate fear expression observed in posttraumatic stress disorder, panic disorder, and phobia. To understand the neural machineries that underlie these disorders, it is important to clarify the neural pathways of fear responses. Contextual conditioned fear induces freezing behavior ... Read more >>

Endocrinology (Endocrinology)
[2014, 155(8):2996-3004]

Cited: 9 times

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Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice.

Keiko Ikeda, Shin'Ichiro Satake, Tatsushi Onaka, Hiroki Sugimoto, Naoki Takeda, Keiji Imoto, Kiyoshi Kawakami,

Dystonia is characterized by excessive involuntary and prolonged simultaneous contractions of both agonist and antagonist muscles. Although the basal ganglia have long been proposed as the primary region, recent studies indicated that the cerebellum also plays a key role in the expression of dystonia. One hereditary form of dystonia, rapid-onset ... Read more >>

J. Physiol. (Lond.) (The Journal of physiology)
[2013, 591(13):3433-3449]

Cited: 27 times

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Long-term administration of intranasal oxytocin is a safe and promising therapy for early adolescent boys with autism spectrum disorders.

Masaya Tachibana, Kuriko Kagitani-Shimono, Ikuko Mohri, Tomoka Yamamoto, Wakako Sanefuji, Ayumi Nakamura, Masako Oishi, Tadashi Kimura, Tatsushi Onaka, Keiichi Ozono, Masako Taniike,

OBJECTIVE: Oxytocin (OT) has been a candidate for the treatment of autism spectrum disorders (ASD), and the impact of intranasally delivered OT on ASD has been investigated. However, most previous studies were conducted by single-dose administration to adults; and, therefore, the long-term effect of nasal OT on ASD patients and ... Read more >>

J Child Adolesc Psychopharmacol (Journal of child and adolescent psychopharmacology)
[2013, 23(2):123-127]

Cited: 67 times

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Highly visible expression of an oxytocin-monomeric red fluorescent protein 1 fusion gene in the hypothalamus and posterior pituitary of transgenic rats.

Akiko Katoh, Hiroaki Fujihara, Toyoaki Ohbuchi, Tatsushi Onaka, Takashi Hashimoto, Mitsuhiro Kawata, Hideaki Suzuki, Yoichi Ueta,

We have generated rats bearing an oxytocin (OXT)-monomeric red fluorescent protein 1 (mRFP1) fusion transgene. The mRFP1 fluorescence was highly visible in ventral part of the supraoptic nucleus (SON) and the posterior pituitary in a whole mount. mRFP1 fluorescence in hypothalamic sections was also observed in the SON, the paraventricular ... Read more >>

Endocrinology (Endocrinology)
[2011, 152(7):2768-2774]

Cited: 32 times

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Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake.

Yuki Takayanagi, Tatsushi Onaka,

Subsequent to the isolation of the first recognized RFamide neuropeptide, FMRFamide, from the clam, a large number of these peptides have been identified. There are now five groups of RFamide peptides identified in mammals. RFamide peptides show diversity with respect to their N-terminal sequence and biological activity. RFamide peptides have ... Read more >>

FEBS J. (The FEBS journal)
[2010, 277(24):4998-5005]

Cited: 19 times

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Effects of RFamide-related peptide (RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats.

Maroot Kaewwongse, Yuki Takayanagi, Tatsushi Onaka,

RFamide-related peptides (RFRP-1 and RFRP-3) are localised in neurones of the dorsomedial hypothalamus in rats. The dorsomedial hypothalamus plays an essential role in neuroendocrine and behavioural stress responses. In the present study, we examined the role of RFRP in the control of neuroendocrine and behavioural responses in rats. Stressful stimuli ... Read more >>

J. Neuroendocrinol. (Journal of neuroendocrinology)
[2011, 23(1):20-27]

Cited: 31 times

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Impairment of social and emotional behaviors in Cadm1-knockout mice.

Yuki Takayanagi, Eriko Fujita, Zhiling Yu, Takanori Yamagata, Mariko Y Momoi, Takashi Momoi, Tatsushi Onaka,

Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, mediates synaptic cell adhesion. Missense mutations in the CADM1 gene have been identified in autism spectrum disorder (ASD) patients. In the present study, we examined emotional behaviors, social behaviors and motor performances in Cadm1-knockout (KO) mice. Cadm1-KO mice showed ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2010, 396(3):703-708]

Cited: 30 times

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Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis.

Natsu Yoshida, Yuko Maejima, Udval Sedbazar, Akihiko Ando, Hideharu Kurita, Boldbaatar Damdindorj, Eisuke Takano, Darambazar Gantulga, Yusaku Iwasaki, Tomoyuki Kurashina, Tatsushi Onaka, Katsuya Dezaki, Masanori Nakata, Masatomo Mori, Toshihiko Yada,

A recently discovered satiety molecule, nesfatin-1, is localized in neurons of the hypothalamus and brain stem and colocalized with stress-related substances, corticotropin-releasing hormone (CRH), oxytocin, proopiomelanocortin, noradrenaline (NA) and 5-hydroxytryptamine (5-HT). Intracerebroventricular (icv) administration of nesfatin-1 produces fear-related behaviors and potentiates stressor-induced increases in plasma adrenocorticotropic hormone (ACTH) and corticosterone ... Read more >>

Aging (Albany NY) (Aging)
[2010, 2(11):775-784]

Cited: 46 times

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