Full Text Journal Articles by
Author Tariq Ahmad

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Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure.

Catherine Mezzacappa, Neal G Ravindra, Cesar Caraballo, Fouad Chouairi, P Elliott Miller, John-Ross D Clarke, Jadry Gruen, Makoto Mori, Megan McCullough, Clancy Mullan, Arnar Geirsson, Joseph G Rogers, Mohammad Anwer, Nihar Desai, Tariq Ahmad,

<b>Importance: </b>Patient outcomes in heart failure clinical trials are generally better than those observed in real-world settings. This may be related to stricter inclusion and exclusion criteria in clinical trials.<br><br><b>Objective: </b>We study sought to characterize the clinical implications of differences between patients in clinical trials and those in a real-world ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0242928]

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Validating the positivity thresholds of drug-tolerant anti-infliximab and anti-adalimumab antibody assays.

Rachel Nice, Neil Chanchlani, Harry Green, Claire Bewshea, Tariq Ahmad, James R Goodhand, Timothy J McDonald, Mandy H Perry, Nicholas A Kennedy,

BACKGROUND:When used proactively, drug-tolerant anti-tumour necrosis factor (TNF) antibody assays provide early opportunity to suppress immunogenicity. AIM:To validate positivity thresholds of IDKmonitor drug-tolerant anti-infliximab and -adalimumab antibody assays. METHODS:We applied positivity thresholds, defined by testing sera from 498 anti-TNF naive healthy adults, from the Exeter Ten Thousand study to data ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, :]

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Root-cause analyses of missed opportunities for the diagnosis of colorectal cancer in patients with inflammatory bowel disease.

Claire Gordon, Desmond Chee, Ben Hamilton, Neel M Heerasing, Peter Hendy, Neil Chanchlani, Simeng Lin, Emma Wesley, Ian R Daniels, Nishanthi Silva, Melanie Osborne, Nicholas A Kennedy, James R Goodhand, Tariq Ahmad,

BACKGROUND:Colonoscopic surveillance in patients with inflammatory bowel disease (IBD) leads to earlier detection of colorectal cancer (CRC) and reduces CRC-associated mortality. However, it is limited by poor adherence in practice. AIM:To identify missed opportunities to detect IBD-associated CRC at our hospital METHODS: We undertook root-cause analyses to identify patients with ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, :]

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Conduct of Clinical Trials in the Era of COVID-19: JACC Scientific Expert Panel.

Mitchell A Psotka, William T Abraham, Mona Fiuzat, Gerasimos Filippatos, JoAnn Lindenfeld, Tariq Ahmad, Ankeet S Bhatt, Peter E Carson, John G F Cleland, G Michael Felker, James L Januzzi, Dalane W Kitzman, Eric S Leifer, Eldrin F Lewis, John J V McMurray, Robert J Mentz, Scott D Solomon, Norman Stockbridge, John R Teerlink, Muthiah Vaduganathan, Orly Vardeny, David J Whellan, Janet Wittes, Stefan D Anker, Christopher M O'Connor,

The coronavirus disease-2019 (COVID-19) pandemic has profoundly changed clinical care and research, including the conduct of clinical trials, and the clinical research ecosystem will need to adapt to this transformed environment. The Heart Failure Academic Research Consortium is a partnership between the Heart Failure Collaboratory and the Academic Research Consortium, composed of ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2020, 76(20):2368-2378]

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Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource.

Evangelos Stournaras, Wendi Qian, Apostolos Pappas, You Yi Hong, Rasha Shawky, , Tim Raine, Miles Parkes, ,

OBJECTIVE:Thiopurines are widely used as maintenance therapy in inflammatory bowel disease (IBD) but the evidence base for their use is sparse and their role increasingly questioned. Using the largest series reported to date, we assessed the long-term effectiveness of thiopurines in ulcerative colitis (UC) and Crohn's disease (CD), including their ... Read more >>

Gut (Gut)
[2020, :]

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Impact of Preoperative Lymphopenia on Survival Following Left Ventricular Assist Device Placement.

Kristin Stawiarski, Olayinka Agboola, Jiheum Park, Arnar Geirsson, Daniel Jacoby, Lavanya Bellumkonda, Tariq Ahmad, Josephine Chou, Forrester Lee, Abeel Mangi, Pramod Bonde,

Lymphopenia has been implicated in poor outcomes in the heart failure population. However, the prognostic implication of lymphopenia in left ventricular assist device (LVAD) patients is unknown. We examine the impact of lymphopenia on all-cause mortality in this population over a 24-month period post-implantation. A total of 170 patients between ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2020, :]

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Underpowered PANTS: A Response to the Conclusions of "Extended Analysis Identifies Drug-Specific Association of Two Distinct HLA Class II Haplotypes for Development of Immunogenicity to Adalimumab and Infliximab".

Aleksejs Sazonovs, Tariq Ahmad, Carl A Anderson,

Gastroenterology (Gastroenterology)
[2020, :]

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COVID-19 infections and outcomes in a live registry of heart failure patients across an integrated health care system.

César Caraballo, Megan McCullough, Michael A Fuery, Fouad Chouairi, Craig Keating, Neal G Ravindra, P Elliott Miller, Maricar Malinis, Nitu Kashyap, Allen Hsiao, F Perry Wilson, Jeptha P Curtis, Matthew Grant, Eric J Velazquez, Nihar R Desai, Tariq Ahmad,

BACKGROUND:Patients with comorbid conditions have a higher risk of mortality with SARS-CoV-2 (COVID-19) infection, but the impact on heart failure patients living near a disease hotspot is unknown. Therefore, we sought to characterize the prevalence and outcomes of COVID-19 in a live registry of heart failure patients across an integrated ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238829]

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Geographical affiliation with top 10 NIH-funded academic medical centers and differences between mortality from cardiovascular disease and cancer.

Suveen Angraal, César Caraballo, Peter Kahn, Ambika Bhatnagar, Bikramjot Singh, F Perry Wilson, Mona Fiuzat, Christopher M O'Connor, Larry A Allen, Nihar R Desai, Ronac Mamtani, Tariq Ahmad,

Community engagement and rapid translation of findings for the benefit of patients has been noted as a major criterion for NIH decisions regarding allocation of funds for research priorities. We aimed to examine whether the presence of top NIH-funded institutions resulted in a benefit on the cardiovascular and cancer mortality ... Read more >>

Am Heart J (American heart journal)
[2020, 230:54-58]

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Real-world Effectiveness of Tofacitinib for Moderate to Severe Ulcerative Colitis: A Multicentre UK Experience.

Sailish Honap, Desmond Chee, Thomas P Chapman, Mehul Patel, Alexandra J Kent, Shuvra Ray, Esha Sharma, James Kennedy, Sarah Cripps, Alissa Walsh, James R Goodhand, Tariq Ahmad, Jack Satsangi, Peter M Irving, Nicholas A Kennedy, ,

BACKGROUND:Tofacitinib is a partially selective Janus kinase inhibitor approved for the treatment of refractory moderate to severe ulcerative colitis [UC]. We sought to define the effectiveness and adverse effects of tofacitinib in a real-world cohort. METHODS:We conducted a retrospective observational cohort study of 134 patients with UC [64% male; median ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2020, 14(10):1385-1393]

Cited: 2 times

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Editorial: is pharmacogenetic testing for adverse effects to IBD treatments ready for roll-out?

Desmond Chee, James R Goodhand, Tariq Ahmad,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, 52(6):1076-1077]

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Increased Induction Infliximab Clearance Predicts Early Antidrug Antibody Detection.

Alexander Eser, Walter Reinisch, Stefan Schreiber, Tariq Ahmad, Suliman Boulos, Diane R Mould,

Treatment of patients with biologics such as infliximab may trigger development of antidrug antibodies, which are associated with faster drug clearance, reduced treatment efficacy, and increased risk of infusion-related reactions. The aim of this study was to identify predictors of baseline infliximab clearance and early antidrug antibody formation. Pharmacokinetic and ... Read more >>

J Clin Pharmacol (Journal of clinical pharmacology)
[2020, :]

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Evaluation of Case Volumes of a Heart Transplant Program and Short-term Outcomes After Changes in the United Network for Organ Sharing Donor Heart Allocation System.

Makoto Mori, Lynn Wilson, Ayyaz Ali, Tariq Ahmad, Muhammad Anwer, Daniel Jacoby, Arnar Geirsson, Harlan M Krumholz,

Importance:Institution-level strategic changes may be associated with heart transplant volume and outcomes. Objective:To describe changes in practice that markedly increased heart transplant volume at a single center, as well as associated patient characteristics and outcomes. Design, Setting, and Participants:A pre-post cohort study was conducted of 107 patients who underwent heart ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(9):e2017513]

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Comparison of Mortality and Readmission in Non-Ischemic Versus Ischemic Cardiomyopathy After Implantable Cardioverter-Defibrillator Implantation.

Angela Y Higgins, Jenny Bjerre, Craig S Parzynski, Karl E Minges, Tariq Ahmad, Nihar R Desai, Alan Enriquez, Erica S Spatz, Daniel J Friedman, Jeptha P Curtis, Mark A Hlatky, James V Freeman,

Data is lacking on the contemporary risk of death and readmission following implantable cardioverter-defibrillator (ICD) implantation in patients with non-ischemic cardiomyopathies (NICM) compared with ischemic cardiomyopathies (ICM) in a large nationally representative cohort. We performed a retrospective cohort study using the National Cardiovascular Data Registry ICD Registry linked with Medicare ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2020, 133:116-125]

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Use and outcomes of wearable cardioverter-defibrillators in a large integrated academic health system.

Peter A Kahn, Jadry Gruen, Alex Thomas, Tariq Ahmad, Nihar R Desai,

Am Heart J (American heart journal)
[2020, 226:232-234]

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Quadruple Therapy Is the New Standard of Care for HFrEF.

Tariq Ahmad, Nihar R Desai,

JACC Heart Fail (JACC. Heart failure)
[2020, 8(10):819-821]

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A Global, Prospective, Observational Study Measuring Disease Burden and Suffering in Patients with Ulcerative Colitis Using the Pictorial Representation of Illness and Self-Measure Tool.

Subrata Ghosh, Tom Sensky, Francesc Casellas, Louis-Charles Rioux, Tariq Ahmad, Juan R Márquez, Tomas Vanasek, Irina Gubonina, Orhan Sezgin, Sandro Ardizzone, Kristina Kligys, Joel Petersson, Yasuo Suzuki, Laurent Peyrin-Biroulet,

BACKGROUND:The understanding the Impact of ulcerative COlitis aNd Its assoCiated disease burden on patients study [ICONIC] was a 2-year, global, prospective, observational study evaluating the cumulative burden of ulcerative colitis [UC] using the Pictorial Representation of Illness and Self-Measure [PRISM] tool that is validated to measure suffering, but not previously ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2020, :]

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Transition to Advanced Therapies in Elderly Patients Supported by Extracorporeal Membrane Oxygenation Therapy.

Fouad Chouairi, Saraschandra Vallabhajosyula, Clancy Mullan, Makoto Mori, Arnar Geirsson, Nihar R Desai, Tariq Ahmad, P Elliott Miller,

BACKGROUND:Although the use of extracorporeal membrane oxygenation (ECMO) continues to increase, very little is known about how age influences the transition to definitive advanced therapies. METHODS:Using the National Inpatient Sample database from 2008 to 2017, we analyzed patients supported by ECMO for cardiogenic shock and separated patients into 2 age ... Read more >>

J Card Fail (Journal of cardiac failure)
[2020, :]

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Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study.

Harry D Green, Robin N Beaumont, Andrew R Wood, Benjamin Hamilton, Samuel E Jones, James R Goodhand, Nicholas A Kennedy, Tariq Ahmad, Hanieh Yaghootkar, Michael N Weedon, Timothy M Frayling, Jessica Tyrrell,

BACKGROUND:Gastro-oesophageal reflux disease (GORD) is associated with multiple risk factors but determining causality is difficult. We used a genetic approach [Mendelian randomization (MR)] to identify potential causal modifiable risk factors for GORD. METHODS:We used data from 451 097 European participants in the UK Biobank and defined GORD using hospital-defined ICD10 and ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2020, 49(4):1270-1281]

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Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure.

Jadry Gruen, Cesar Caraballo, P Elliott Miller, Megan McCullough, Catherine Mezzacappa, Neal Ravindra, Clancy W Mullan, Samuel W Reinhardt, Makoto Mori, Eric Velazquez, Arnar Geirsson, Tariq Ahmad, Nihar R Desai,

OBJECTIVES:This study sought to use INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) results to evaluate sex differences in the use and clinical outcomes of left ventricular assist devices (LVAD). BACKGROUND:Despite a similar incidence of heart failure in men and women, prior studies have highlighted potential underuse of LVADs in ... Read more >>

JACC Heart Fail (JACC. Heart failure)
[2020, 8(9):770-779]

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Quality improvement project identifies factors associated with delay in IBD diagnosis.

Gareth J Walker, Simeng Lin, Neil Chanchlani, Amanda Thomas, Peter Hendy, Neel Heerasing, Lucy Moore, Harry D Green, Desmond Chee, Claire Bewshea, Joseph Mays, Nicholas A Kennedy, Tariq Ahmad, James R Goodhand,

BACKGROUND:Delay in the diagnosis of inflammatory bowel disease (IBD) is common and contemporary UK studies are lacking. AIM:To determine factors associated with, and the consequences of, a prolonged time to diagnosis in IBD. METHODS:This quality improvement study included 304 adults with a new IBD diagnosis made between January 2014 and ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, 52(3):471-480]

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Clinical features and genetic risk of demyelination following anti-TNF treatment.

Simeng Lin, Harry D Green, Peter Hendy, Neel M Heerasing, Neil Chanchlani, Benjamin Hamilton, Gareth J Walker, Graham A Heap, Jeremy Hobart, Roswell J Martin, Alasdair J Coles, Mark S Silverberg, Peter M Irving, Guy Chung-Faye, Eli Silber, Fraser Cummings, Ellina Lytvyak, Vibeke Andersen, Andrew R Wood, Jessica Tyrrell, Robin N Beaumont, Michael N Weedon, Nicholas A Kennedy, Alexander Spiers, Timothy Harrower, James R Goodhand, Tariq Ahmad, ,

BACKGROUND:Anti-TNF exposure has been linked to demyelination events. We sought to describe the clinical features of demyelination events following anti-TNF treatment and test whether affected patients were genetically predisposed to multiple sclerosis (MS). METHODS:We conducted a case-control study to describe the clinical features of demyelination events following anti-TNF. We compared ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2020, :]

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Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial.

Mona Fiuzat, Justin Ezekowitz, Wendimagegn Alemayehu, Cynthia M Westerhout, Marco Sbolli, Dario Cani, David J Whellan, Tariq Ahmad, Kirkwood Adams, Ileana L Piña, Chetan B Patel, Kevin J Anstrom, Lawton S Cooper, Daniel Mark, Eric S Leifer, G Michael Felker, James L Januzzi, Christopher M O'Connor,

Importance:Despite evidence that guideline-directed medical therapy (GDMT) improves outcomes in patients with heart failure (HF) and reduced ejection fraction, many patients are undertreated. The Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment (GUIDE-IT) trial tested whether a strategy of using target concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) to guide optimization ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2020, 5(7):757-764]

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Psychiatric Comorbidity and Outcomes After Left Ventricular Assist Device Implantation for End-Stage Heart Failure.

Clancy Mullan, Cesar Caraballo, Neal G Ravindra, P Elliott Miller, Megan McCullough, Kelly Brown, Tsung Wai Aw, Jadry Gruen, John-Ross D Clarke, Eric J Velazquez, Arnar Geirsson, Makoto Mori, Nihar R Desai, Tariq Ahmad,

BACKGROUND:Psychiatric comorbidities play a key role in patient selection for left ventricular assist devices (LVADs), but their impact on clinical outcomes is unknown. OBJECTIVES:The goal of this study was to examine the clinical impact of psychiatric illness on outcomes in patients receiving LVADs for end-stage heart failure (HF). METHODS:The study ... Read more >>

JACC Heart Fail (JACC. Heart failure)
[2020, 8(7):569-577]

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Zinc supplementation improves markers of glucose homeostasis in thalassaemia.

Ellen B Fung, Tariq Ahmad, David W Killilea, Rahim Hussain, Ashutosh Lal,

Br J Haematol (British journal of haematology)
[2020, 190(3):e162-e166]

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