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Promising modulation of self-assembled Ge-rich QDs by ultra-heavy phosphorus doping.

Ningning Zhang, Peizong Chen, Kun Peng, Lijian Zhang, Tao Liu, Jia Yan, Zuimin Jiang, Zhenyang Zhong,

Self-assembled Ge-rich quantum dots (QDs) can not only act as a prototype model for the fundamental studies of heteroepitaxial growth but also have great potential in optoelectronic devices for telecommunication and monolithic optical-electronic integrated circuits. Here, we report the unique features of Ge-rich QDs ultra-heavily doped with phosphorus (P) and ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(24):13137-13144]

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Rational design of minimum CRISPR guide RNA by site-specific Cas9-RNA conjugation.

Xinyu Ling, Xiaoqin Gao, Liying Chang, Heqi Chen, Xiaomeng Shi, Tao Liu,

The CRISPR-Cas9 system enables facile and efficient genome engineering in living cells and organisms. We report a Cas9-RNA conjugation strategy to afford minimal crRNA containing only the guide sequence for the target gene, which may simplify and reduce the cost for large-scale and high-throughput crRNA synthesis and lead to new ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(54):7515-7518]

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Enriched environment enhances histone acetylation of NMDA receptor in the hippocampus and improves cognitive dysfunction in aged mice.

Xin Wang, Zhao-Xiang Meng, Ying-Zhu Chen, Yu-Ping Li, Hong-Yu Zhou, Man Yang, Ting-Ting Zhao, Yu-Lai Gong, Yi Wu, Tao Liu,

The mechanisms of age-associated memory impairment may be associated with glutamate receptor function and chromatin modification. To observe the effect of an enriched environment on the cognitive function of mice with age-associated memory impairment, 3-month-old C57BL/6 male mice ("young" mice) were raised in a standard environment, while 24-month-old C57BL/6 male ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(12):2327-2334]

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Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?

Ai-Mei Liu, Bo-Li Chen, Ling-Tai Yu, Tao Liu, Ling-Ling Shi, Pan-Pan Yu, Yi-Bo Qu, Kwok-Fai So, Li-Bing Zhou,

Multiple types of stem cells have been proposed for the treatment of spinal cord injury, but their comparative information remains elusive. In this study, a rat model of T10 contusion spinal cord injury was established by the impactor method. Human umbilical cord-derived mesenchymal stem cells (UCMSCs) or human adipose tissue-derived ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(12):2306-2317]

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Risk factors associated with COVID-19 infection: a retrospective cohort study based on contacts tracing.

Tao Liu, Wenjia Liang, Haojie Zhong, Jianfeng He, Zihui Chen, Guanhao He, Tie Song, Shaowei Chen, Ping Wang, Jialing Li, Yunhua Lan, Mingji Cheng, Jinxu Huang, Jiwei Niu, Liang Xia, Jianpeng Xiao, Jianxiong Hu, Lifeng Lin, Qiong Huang, Zuhua Rong, Aiping Deng, Weilin Zeng, Jiansen Li, Xing Li, Xiaohua Tan, Min Kang, Lingchuan Guo, Zhihua Zhu, Dexin Gong, Guimin Chen, Moran Dong, Wenjun Ma,

This study aimed to estimate the attack rates, and identify the risk factors of COVID-19 infection. Based on a retrospective cohort study, we investigated 11,580 contacts of COVID-19 cases in Guangdong Province from 10 January to 15 March 2020. All contacts were tested by RT-PCR to detect their infection of ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1546-1553]

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Metagenomics for taxonomy profiling: tools and approaches.

Mukesh Kumar Awasthi, B Ravindran, Surendra Sarsaiya, Hongyu Chen, Steven Wainaina, Ekta Singh, Tao Liu, Sunil Kumar, Ashok Pandey, Lal Singh, Zengqiang Zhang,

The study of metagenomics is an emerging field that identifies the total genetic materials in an organism along with the set of all genetic materials like deoxyribonucleic acid and ribose nucleic acid, which play a key role with the maintenance of cellular functions. The best part of this technology is ... Read more >>

Bioengineered (Bioengineered)
[2020, 11(1):356-374]

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Spin crossover and photomagnetic behaviors in one-dimensional looped coordination polymers.

Xiao-Peng Sun, Tao Liu, Zi-Shuo Yao, Jun Tao,

Three one-dimensional looped coordination polymers with the formula of [Fe(dpds)2{C(CN)3}2]·dpds (1, dpds = 4,4'-dipyridyl disulfide), [Fe(dpds)2(NCBH3)2] (2) and [Fe(dpds)2(NCSe)2]·3.5H2O (3) have been synthesized and characterized by single-crystal X-ray crystallography, Mössbauer spectroscopy and magnetic measurements. The spin-crossover (SCO) behaviors of these compounds depend significantly on axial ligands: compound 1 exhibited thermal-induced ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(25):9243-9249]

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Does Pedicle Screw Fixation Assisted by O-Arm Navigation Perform Better Than Fluoroscopy-guided Technique in Thoracolumbar Fractures in Percutaneous Surgery?: A Retrospective Cohort Study.

Jianhua Lu, Weikai Chen, Hao Liu, Huilin Yang, Tao Liu,

STUDY DESIGN:A retrospective cohort study. OBJECTIVE:To evaluate the effect of O-arm navigation in percutaneous surgeries for thoracolumbar fracture in comparison to the use of conventional fluoroscopic technique. SUMMARY OF BACKGROUND DATA:O-arm navigation is a progressive surgical tool, with extensive research papers reporting its effects. Whereas, there were not many papers ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, 33(6):247-253]

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Automated Coupling of Nanodroplet Sample Preparation with Liquid Chromatography-Mass Spectrometry for High-Throughput Single-Cell Proteomics.

Sarah M Williams, Andrey V Liyu, Chia-Feng Tsai, Ronald J Moore, Daniel J Orton, William B Chrisler, Matthew J Gaffrey, Tao Liu, Richard D Smith, Ryan T Kelly, Ljiljana Paša-Tolić, Ying Zhu,

Single-cell proteomics can provide critical biological insight into the cellular heterogeneity that is masked by bulk-scale analysis. We have developed a nanoPOTS (nanodroplet processing in one pot for trace samples) platform and demonstrated its broad applicability for single-cell proteomics. However, because of nanoliter-scale sample volumes, the nanoPOTS platform is not ... Read more >>

Anal. Chem. (Analytical chemistry)
[2020, :]

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A novel separation-sensing membrane performing precise real-time serum analysis during blood drawing.

Zhenyu Chu, Wei Zhang, Qiannan You, Xiaoyue Yao, Tao Liu, Gongping Liu, Guangru Zhang, Xiaoping Gu, Zhengliang Ma, Wanqin Jin,

Dynamic and on-site analysis of serum from human blood is crucial particularly for making decisions during clinical surgery and emergency treatments. However, state-of-the-art blood assay methods can only collect single or discrete data of physiological analytes, remaining great challenge in online report of dynamic fluctuation of key analytes. Here we ... Read more >>

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, :]

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Scoring systems for predicting mortality for severe patients with COVID-19.

Yufeng Shang, Tao Liu, Yongchang Wei, Jingfeng Li, Liang Shao, Minghui Liu, Yongxi Zhang, Zhigang Zhao, Haibo Xu, Zhiyong Peng, Fuling Zhou, Xinghuan Wang,

BackgroundCoronavirus disease 2019 (COVID-19) has been widely spread and caused tens of thousands of deaths, especially in patients with severe COVID-19. This analysis aimed to explore risk factors for mortality of severe COVID-19, and establish a scoring system to predict in-hospital deaths.MethodsPatients with COVID-19 were retrospectively analyzed and clinical characteristics ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[0, :]

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The Vibrio cholerae cytotoxin MakA induces noncanonical autophagy resulting in the spatial inhibition of canonical autophagy

Dale Corkery, Aftab Nadeem, Kyaw Min Aung, Ahmed Hassan, Tao Liu, Ramón Cervantes-Rivera, Alf Håkon Lystad, Hui Wang, Karina Persson, Andrea Puhar, Anne Simonsen, Bernt Eric Uhlin, Sun Nyunt Wai, Yao-Wen Wu,

Abstract Autophagy plays an essential role in the defence against many microbial pathogens as a regulator of both innate and adaptive immunity. Among some pathogens, sophisticated mechanisms have evolved that promote their ability to evade or subvert host autophagy. Here, we describe a novel mechanism of autophagy subversion mediated by ... Read more >>

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Therapeutic Effect of Berberine on Insomnia Rats by ErbB Signaling Pathway.

Qingquan Wang, Xiaojuan Ren, Xingping Zhang, Guanying Wang, Hongxia Xu, Ning Deng, Tao Liu, Zhipeng Peng,

BACKGROUND Insomnia seriously affects people's health and quality of life. Short-term use of Western drugs may also be harmful. Traditional Chinese medicine has been widely used to treat diseases in world. Therefore, this paper aims to study the therapeutic effect of berberine based on the insomnious rat model. MATERIAL AND ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e921831]

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β-Asarone Exerts Antioxidative Effects on H2O2-Stimulated PC12 Cells by Activating Nrf2/HO-1 Pathway.

Xinxin Hei, Miao Xie, Jingqian Xu, Jinjin Li, Tao Liu,

Oxidative stress-mediated neuron damage is considered an important contributor to the pathogenesis and development of neurodegenerative diseases. Although β-asarone is widely known for its neuroprotective pharmacological properties, the exact mechanism of β-asarone against oxidative stress has not been fully elucidated. The aim of the present study was to investigate underlying ... Read more >>

Neurochem. Res. (Neurochemical research)
[2020, :]

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Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma.

Michael A Gillette, Shankha Satpathy, Song Cao, Saravana M Dhanasekaran, Suhas V Vasaikar, Karsten Krug, Francesca Petralia, Yize Li, Wen-Wei Liang, Boris Reva, Azra Krek, Jiayi Ji, Xiaoyu Song, Wenke Liu, Runyu Hong, Lijun Yao, Lili Blumenberg, Sara R Savage, Michael C Wendl, Bo Wen, Kai Li, Lauren C Tang, Melanie A MacMullan, Shayan C Avanessian, M Harry Kane, Chelsea J Newton, MacIntosh Cornwell, Ramani B Kothadia, Weiping Ma, Seungyeul Yoo, Rahul Mannan, Pankaj Vats, Chandan Kumar-Sinha, Emily A Kawaler, Tatiana Omelchenko, Antonio Colaprico, Yifat Geffen, Yosef E Maruvka, Felipe da Veiga Leprevost, Maciej Wiznerowicz, Zeynep H Gümüş, Rajwanth R Veluswamy, Galen Hostetter, David I Heiman, Matthew A Wyczalkowski, Tara Hiltke, Mehdi Mesri, Christopher R Kinsinger, Emily S Boja, Gilbert S Omenn, Arul M Chinnaiyan, Henry Rodriguez, Qing Kay Li, Scott D Jewell, Mathangi Thiagarajan, Gad Getz, Bing Zhang, David Fenyö, Kelly V Ruggles, Marcin P Cieslik, Ana I Robles, Karl R Clauser, Ramaswamy Govindan, Pei Wang, Alexey I Nesvizhskii, Li Ding, D R Mani, Steven A Carr, ,

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics. Multi-omics clustering revealed four subgroups defined by key driver mutations, country, and gender. Proteomic ... Read more >>

Cell (Cell)
[2020, 182(1):200-225.e35]

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Spin crossover and structural phase transition in homochiral and heterochiral Fe[(pybox)2]2+ complexes.

Wan-Qing Gao, Yin-Shan Meng, Chun-Hua Liu, Yao Pan, Tao Liu, Yuan-Yuan Zhu,

Spin crossover and structural phase transition in three pairs of homochiral and heterochiral [Fe(pybox)2]2+ diastereomers were investigated through magnetic and crystallographic studies. Herein, we show that the spin transition properties of these compounds are strongly related to the homochiral or heterochiral assembly of the ligands and structural phase transition. Our ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(19):6323-6327]

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Changes in thyroid hormone related proteins and gene expression induced by polychlorinated biphenyls and halogen flame retardants exposure of children in a Chinese e-waste recycling area.

Ling-Chuan Guo, Tao Liu, Ying Yang, Shengbing Yu, Yanhong Gao, Weixiong Huang, Jianpeng Xiao, Wenjun Ma, Shannon Rutherford, Yonghui Zhang,

Polychlorinated biphenyls (PCBs) and halogen flame retardants (HFRs) are major pollutants in e-waste recycling area. High internal exposure levels of PCBs and HFRs are harmful to human thyroid hormone (TH) equilibrium. To examine their disrupting effects on TH, we conducted a study on children (n = 114) of an e-waste recycling and ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 742:140597]

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Conformation-Tuning Effect of Asymmetric Small Molecule Acceptors on Molecular Packing, Interaction, and Photovoltaic Performance.

Zhenghui Luo, Ruijie Ma, Yiqun Xiao, Tao Liu, Huiliang Sun, Mengyao Su, Qing Guo, Guanghao Li, Wei Gao, Yuzhong Chen, Yang Zou, Xugang Guo, Maojie Zhang, Xinhui Lu, He Yan, Chuluo Yang,

Understanding the conformation effect on molecular packing, miscibility, and photovoltaic performance is important to open a new avenue for small-molecule acceptor (SMA) design. Herein, two novel acceptor-(donor-acceptor1-donor)-acceptor (A-DA1D-A)-type asymmetric SMAs are developed, namely C-shaped BDTP-4F and S-shaped BTDTP-4F. The BDTP-4F-based polymer solar cells (PSCs) with PM6 as donor, yields a ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, :e2001942]

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The Relationship Between Ambient Temperature and FPG, A Series of Cross-Sectional Studies in Guangdong Province, China

Jiali Luo, Guanhao He, Yanjun Xu, Zihui Chen, Xiaojun Xu, Shaowei Chen, Jianxiong Hu, Guiyuan Ji, Tao Liu, Weilin Zeng, Xing Li, Jianpeng Xiao, Lingchuan Guo, Wenjun Ma,

Abstract Background: There existed evidence that the incidence and glycemic control rate of T2DM have seasonal variation, which can be attributed to the effect of temperature on FPG. The present study aimed to examine the associations between short-term ambient temperature exposure and FPG among different populations and calculate temperature-FPG association ... Read more >>

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Domino Synthetic Strategy for Tetrahydrothiopyran Derivatives from Benzaldehydes, 2-Acetylfuran/2-Acetylthiophene, and Sodium Sulfide.

Dongdong Chen, Weixia Du, Xufeng Yang, Tao Liu,

A novel domino reaction from benzaldehydes and 2-acetylfuran/2-acetylthiophene with sodium sulfide was developed to synthesize a series of tetrahydrothiopyran (THTP) derivatives. The reaction proceeded well to construct a tetrahydrothiopyran ring and five new bonds in one step. A mechanism is proposed, involving a stepwise Aldol/double Michael addition/Aldol (AMMA) reaction cascade. ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2020, :]

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Disrupted brain network dynamics and cognitive functions in methamphetamine use disorder: insights from EEG microstates.

Tianzhen Chen, Hang Su, Na Zhong, Haoye Tan, Xiaotong Li, Yiran Meng, Chunmei Duan, Congbin Zhang, Juwang Bao, Ding Xu, Weidong Song, Jixue Zou, Tao Liu, Qingqing Zhan, Haifeng Jiang, Min Zhao,

BACKGROUND:Dysfunction in brain network dynamics has been found to correlate with many psychiatric disorders. However, there is limited research regarding resting electroencephalogram (EEG) brain network and its association with cognitive process for patients with methamphetamine use disorder (MUD). This study aimed at using EEG microstate analysis to determine whether brain ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):334]

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Distinct Roles of Ag(I) and Cu(II) as Cocatalysts in Achieving Positional-Selective C-H Alkenylation of Isoxazoles: A Theoretical Investigation.

Jing Zhang, Lingli Han, Siwei Bi, Tao Liu,

For C-H alkenylation of aryl-substituted diarylisoxazoles, one mode is N-directed C-H alkenylation and the other is C-H alkenylation in the isoxazole ring. In this study, selective C-H alkenylations of 3,5-diarylisoxazoles have been investigated theoretically with the aid of density functional theory (DFT) calculations. With Cp*RhIII as the catalyst, the N-directed ... Read more >>

J. Org. Chem. (The Journal of organic chemistry)
[2020, 85(13):8387-8396]

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Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy.

Na Yu, Tao Liu, Xi Zhang, Ningqiang Gong, Tianjiao Ji, Jing Chen, Xing-Jie Liang, Daniel S Kohane, Shutao Guo,

The use of glycoside prodrugs is a promising strategy for developing new targeted medicines for chemotherapy. However, the in vivo utility of such prodrugs is hindered by insufficient activation and the lack of convenient synthetic methods. We have developed an innovative strategy for synthesizing ketal glycoside prodrugs that are unique ... Read more >>

Nano Lett. (Nano letters)
[2020, 20(7):5465-5472]

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Different intervention strategies toward live poultry markets against avian influenza A (H7N9) virus: model-based assessment

Guanghu Zhu, Min Kang, Xueli Wei, Tian Tang, Tao Liu, Jianpeng Xiao, Tie Song, Wenjun Ma,

Background: Different interventions targeting live poultry markets (LPMs) have been applied in China for controlling the avian influenza A (H7N9), including LPM closure and "1110" policy (i.e., daily cleaning, weekly disinfection, monthly rest day, zero poultry stock overnight). However, the effects of these interventions have not been comprehensively assessed. Methods: ... Read more >>

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Phenylethanol Glycosides Protect Myocardial Hypertrophy Induced by Abdominal Aortic Constriction via ECE-1 Demethylation Inhibition and PI3K/PKB/eNOS Pathway Enhancement.

Qiong-Ling Fan, Jia-Wei Wang, Shi-Lei Zhang, Tao Liu, Jun Zhao, Shu-Ping You,

Phenylethanol glycosides (CPhGs) are the core material basis of pharmacological activity in Cistanche tubulosa and have a variety of pharmacological effects. However, it is unclear whether CPhGs have an ameliorative effect on pressure overload-induced myocardial hypertrophy. In this study, male SD rats weighing (200 ± 20) g were established cardiac hypertrophy models ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2020, 2020:2957094]

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