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Author Tanja Gerlza

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Single domain shark VNAR antibodies neutralize SARS-CoV-2 infection in vitro.

Aziz Gauhar, Cyril V Privezentzev, Mykhaylo Demydchuk, Tanja Gerlza, Julia Rieger, Andreas J Kungl, Frank S Walsh, J Lynn Rutkowski, Pawel Stocki,

Single domain shark variable domain of new antigen receptor (VNAR) antibodies can offer a viable alternative to conventional Ig-based monoclonal antibodies in treating COVID-19 disease during the current pandemic. Here we report the identification of neutralizing single domain VNAR antibodies selected against the severe acute respiratory syndrome coronavirus 2 spike ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21970]

Cited: 0 times

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Isolation and Characterization of Heparan Sulfate from Human Lung Tissues.

Rupert Derler, Nikola Kitic, Tanja Gerlza, Andreas J Kungl,

Glycosaminoglycans are a class of linear, highly negatively charged, <i>O</i>-linked polysaccharides that are involved in many (patho)physiological processes. In vitro experimental investigations of such processes typically involve porcine-derived heparan sulfate (HS). Structural information about human, particularly organ-specific heparan sulfate, and how it compares with HS from other organisms, is very ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(18):]

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Development of Molecules Antagonizing Heparan Sulfate Proteoglycans.

Tanja Gerlza, Christina Trojacher, Nikola Kitic, Tiziana Adage, Andreas J Kungl,

Heparan sulfate proteoglycans (HSPGs) occur in almost every tissue of the human body and consist of a protein core, with covalently attached glycosaminoglycan polysaccharide chains. These glycosaminoglycans are characterized by their polyanionic nature, due to sulfate and carboxyl groups, which are distributed along the chain. These chains can be modified ... Read more >>

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2021, 47(3):316-332]

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Glycosaminoglycans located on neutrophils and monocytes impact on CXCL8- and CCL2-induced cell migration.

Tanja Gerlza, Margareta Nagele, Zala Mihalic, Christina Trojacher, Andreas Kungl,

The role of glycosaminoglycans on the surface of immune cells has so far been less studied compared to their participation in inflammatory responses as members of the endothelium and the extracellular matrix. In this study we have therefore investigated if glycosaminoglycans on immune cells act in concert with GPC receptors ... Read more >>

Cytokine (Cytokine)
[2021, 142:155503]

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Designing an improved T-cell mobilising CXCL10 mutant through enhanced GAG binding affinity.

Tanja Gerlza, Michael Nagele, Martha Gschwandtner, Sophie Winkler, Andreas Kungl,

The chemokine CXCL10 is released by a plethora of cells, including immune and metastatic cancer cells, following stimulation with interferon-gamma. It acts via its GPC receptor on T-cells attracting them to various target tissues. Glycosaminoglycans (GAGs) are regarded as co-receptors of chemokines, which enable the establishment of a chemotactic gradient ... Read more >>

Protein Eng Des Sel (Protein engineering, design & selection : PEDS)
[2019, 32(8):367-373]

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Anti-inflammatory effects of the GAG-binding CXCL9(74-103) peptide in dinitrofluorobenzene-induced contact hypersensitivity in mice.

Vincent Vanheule, Helena Crijns, Fariba Poosti, Pieter Ruytinx, Nele Berghmans, Tanja Gerlza, Isabelle Ronsse, Noëmie Pörtner, Patrick Matthys, Andreas J Kungl, Ghislain Opdenakker, Sofie Struyf, Paul Proost,

<h4>Background</h4>To recruit leucocytes to an inflammatory site, chemokine binding to glycosaminoglycans (GAGs) is critical. Therefore, strategies to interfere with this interaction, aiming at the production of anti-inflammatory agents, were developed. These include production of modified chemokines without affinity for G protein-coupled receptors but with enhanced affinity for GAGs. Such modified ... Read more >>

Clin Exp Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2018, 48(10):1333-1344]

Cited: 2 times

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Glycosaminoglycans are important mediators of neutrophilic inflammation in vivo.

Martha Gschwandtner, Elisabeth Strutzmann, Mauro M Teixeira, Hans J Anders, Maria Diedrichs-Möhring, Tanja Gerlza, Gerhild Wildner, Remo C Russo, Tiziana Adage, Andreas J Kungl,

The pro-inflammatory chemokine interleukin-8 (CXCL8) exerts its function by establishing a chemotactic gradient in infected or damaged tissues to guide neutrophil granulocytes to the site of inflammation via its G protein-coupled receptors (GPCRs) CXCR1 and CXCR2 located on neutrophils. Endothelial glycosaminoglycans (GAGs) have been proposed to support the chemotactic gradient ... Read more >>

Cytokine (Cytokine)
[2017, 91:65-73]

Cited: 9 times

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Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation.

Martha Gschwandtner, Anna Maria Piccinini, Tanja Gerlza, Tiziana Adage, Andreas J Kungl,

Multiple Sclerosis, a chronic inflammatory demyelinating disease of the central nervous system, involves an increased expression of monocyte chemotactic protein 1 MCP1-/CCL2. For exerting its chemotactic effects, chemokine binding to glycosaminoglycans (GAGs) is required and therefore this interaction represents a potential target for therapeutic intervention. We have designed an anti-inflammatory ... Read more >>

Neurosci Lett (Neuroscience letters)
[2016, 626:164-173]

Cited: 9 times

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Preparation and Characterization of Glycosaminoglycan Chemokine Coreceptors.

Nikola Kitic, Martha Gschwandtner, Rupert Derler, Tanja Gerlza, Andreas J Kungl,

Interactions between chemokines and glycosaminoglycans (GAGs) are crucial for the physiological and pathophysiological activities of chemokines. GAGs are therefore commonly designated as chemokine coreceptors which are deeply involved in the chemokine-signaling network. Studying the interaction of chemokines with GAGs is therefore a major prerequisite to fully understand the biological function ... Read more >>

Methods Enzymol (Methods in enzymology)
[2016, 570:517-538]

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Designing a mutant CCL2-HSA chimera with high glycosaminoglycan-binding affinity and selectivity.

Tanja Gerlza, Sophie Winkler, Aid Atlic, Christina Zankl, Viktoria Konya, Nikola Kitic, Elisabeth Strutzmann, Kerstin Knebl, Tiziana Adage, Akos Heinemann, Roland Weis, Andreas J Kungl,

Chemokines like CCL2 mediate leukocyte migration to inflammatory sites by binding to G-protein coupled receptors on the target cell as well as to glycosaminoglycans (GAGs) on the endothelium of the inflamed tissue. We have recently shown that the dominant-negative Met-CCL2 mutant Y13A/S21K/Q23R with improved GAG binding affinity is highly bio-active ... Read more >>

Protein Eng Des Sel (Protein engineering, design & selection : PEDS)
[2015, 28(8):231-240]

Cited: 4 times

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A combinatorial approach to biophysically characterise chemokine-glycan binding affinities for drug development.

Tanja Gerlza, Bianca Hecher, Dalibor Jeremic, Thomas Fuchs, Martha Gschwandtner, Angelika Falsone, Bernd Gesslbauer, Andreas J Kungl,

Chemokine binding to glycosaminoglycans (GAGs) is recognised to be an important step in inflammation and other pathological disorders like tumor growth and metastasis. Although different ways and strategies to interfere with these interactions are being pursued, no major breakthrough in the development of glycan-targeting drugs has been reported so far. ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2014, 19(7):10618-10634]

Cited: 18 times

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Targeting glycosaminoglycans in the lung by an engineered CXCL8 as a novel therapeutic approach to lung inflammation.

Tiziana Adage, Viktoria Konya, Corinna Weber, Elisabeth Strutzmann, Thomas Fuchs, Christina Zankl, Tanja Gerlza, Dalibor Jeremic, Akos Heinemann, Andreas J Kungl,

It is broadly recognized that chemokine-activated neutrophils play a crucial role in the inflammation and disruption of lung tissue observed in several acute and chronic lung diseases. Since glycosaminoglycan side chains of proteoglycans act as chemokine co-receptors in inflammation, we have used a CXCL8-based dominant-negative mutant, dnCXCL8, to displace neutrophil-related ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2015, 748:83-92]

Cited: 8 times

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The effect of the decoy molecule PA401 on CXCL8 levels in bronchoalveolar lavage fluid of patients with cystic fibrosis.

Oliver J McElvaney, Niamh O'Reilly, Michelle White, Noreen Lacey, Kerstin Pohl, Tanja Gerlza, David A Bergin, Hilary Kerr, Cormac McCarthy, M Emmet O'Brien, Tiziana Adage, Andreas J Kungl, Emer P Reeves, Noel G McElvaney,

<h4>Background</h4>The chemokine interleukin-8 (CXCL8) is a key mediator of inflammation in airways of patients with cystic fibrosis (CF). Glycosaminoglycans (GAGs) possess the ability to influence the chemokine profile of the CF lung by binding CXCL8 and protecting it from proteolytic degradation. CXCL8 is maintained in an active state by this ... Read more >>

Mol Immunol (Molecular immunology)
[2015, 63(2):550-558]

Cited: 10 times

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Designing CXCL8-based decoy proteins with strong anti-inflammatory activity in vivo.

Angelika Falsone, Veronica Wabitsch, Elena Geretti, Heide Potzinger, Tanja Gerlza, James Robinson, Tiziana Adage, Mauro M Teixeira, Andreas J Kungl,

IL (interleukin)-8 [CXCL8 (CXC chemokine ligand 8)] exerts its role in inflammation by triggering neutrophils via its specific GPCRs (G-protein-coupled receptors), CXCR1 (CXC chemokine receptor 1) and CXCR2, for which additional binding to endothelial HS-GAGs (heparan sulphate-glycosaminoglycans) is required. We present here a novel approach for blocking the CXCL8-related inflammatory ... Read more >>

Biosci Rep (Bioscience reports)
[2013, 33(5):]

Cited: 13 times

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Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma.

Alexander J A Deutsch, Elisabeth Steinbauer, Nicole A Hofmann, Dirk Strunk, Tanja Gerlza, Christine Beham-Schmid, Helmut Schaider, Peter Neumeister,

Chemokine receptors have a crucial role in the development and progression of lymphoid neoplasms. To determine the chemokine receptor expression profile in gastric mucosa-associated lymphoid tissue (MALT) lymphoma, we performed an expression analysis of 19 chemokine receptors at mRNA levels by using real-time RT-PCR, as well as of five chemokine ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2013, 26(2):182-194]

Cited: 33 times

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Chlamydia psittaci Infection in nongastrointestinal extranodal MALT lymphomas and their precursor lesions.

Ariane Aigelsreiter, Tanja Gerlza, Alexander J A Deutsch, Eva Leitner, Christine Beham-Schmid, Alfred Beham, Helmut Popper, Nicole Borel, Andreas Pospischil, Markus Raderer, Harald H Kessler, Peter Neumeister,

Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) are associated with various infectious pathogens. We analyzed the presence of Chlamydia psittaci, Chlamydia pneumoniae, and Chlamydia trachomatis DNA in 47 nongastrointestinal and 14 gastrointestinal MALT lymphomas, 37 nonmalignant control samples, and 27 autoimmune precursor lesions by polymerase chain reaction amplification ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2011, 135(1):70-75]

Cited: 18 times

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