Full Text Journal Articles by
Author Tanja Bruun

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Assaying Chlamydia pneumoniae Persistence in Monocyte-Derived Macrophages Identifies Dibenzocyclooctadiene Lignans as Phenotypic Switchers.

Eveliina Taavitsainen, Maarit Kortesoja, Tanja Bruun, Niklas G Johansson, Leena Hanski,

Antibiotic-tolerant persister bacteria involve frequent treatment failures, relapsing infections and the need for extended antibiotic treatment. The virulence of an intracellular human pathogen C. pneumoniae is tightly linked to its propensity for persistence and means for its chemosensitization are urgently needed. In the current work, persistence of C. pneumoniae clinical ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(2):]

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Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators.

Mikael Jumppanen, Sini M Kinnunen, Mika J Välimäki, Virpi Talman, Samuli Auno, Tanja Bruun, Gustav Boije Af Gennäs, Henri Xhaard, Ingo B Aumüller, Heikki Ruskoaho, Jari Yli-Kauhaluoma,

Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the GATA4-NKX2-5 transcriptional synergy. Here, the chemical space around the molecular structure of 1 was explored by synthesizing and characterizing 220 ... Read more >>

J. Med. Chem. (Journal of medicinal chemistry)
[2019, 62(17):8284-8310]

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Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives.

Chinmay Bhat, Polina Ilina, Irene Tilli, Manuela Voráčová, Tanja Bruun, Victoria Barba, Nives Hribernik, Katja-Emilia Lillsunde, Eero Mäki-Lohiluoma, Tobias Rüffer, Heinrich Lang, Jari Yli-Kauhaluoma, Paula Kiuru, Päivi Tammela,

The first total synthesis of the marine bromotyrosine purpurealidin I (1) using trifluoroacetoxy protection group and its dimethylated analog (29) is reported along with 16 simplified bromotyrosine derivatives lacking the tyramine moiety. Their cytotoxicity was evaluated against the human malignant melanoma cell line (A-375) and normal skin fibroblast cells (Hs27) ... Read more >>

Mar Drugs (Marine drugs)
[2018, 16(12):]

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