Full Text Journal Articles by
Author Tamer M Ibrahim

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Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity.

Souraya A Domiati, Khaled H Abd El Galil, Mohammed A S Abourehab, Tamer M Ibrahim, Hanan M Ragab,

A structure-guided modelling approach using COX-2 as a template was used to investigate the effect of replacing the chloro atom located at the chlorophenyl ring of amide-linked bipyrazole moieties, aiming at attaining better anti-inflammatory effect with a good safety profile. Bromo, fluoro, nitro, and methyl groups were revealed to be ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2022, 37(1):2179-2190]

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Investigation of the anti-inflammatory and analgesic activities of promising pyrazole derivative.

Adnan A Bekhit, Sherry N Nasralla, Eman J El-Agroudy, Nahla Hamouda, Ahmed Abd El-Fattah, Salma A Bekhit, Kikuko Amagase, Tamer M Ibrahim,

The development of new COX-2 inhibitors with analgesic and anti-inflammatory efficacy as well as minimal gastrointestinal, renal and cardiovascular toxicity, is of vital importance to patients suffering from chronic course pain and inflammatory conditions. This study aims at evaluating the therapeutic activity and adverse drug reactions associated with the use ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2022, 168:106080]

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