Full Text Journal Articles by
Author Talmage Broadbent

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Thyroid eye disease presenting with superior rectus/levator complex enlargement.

Yao Wang, Pradeep Mettu, Talmage Broadbent, Phillip Radke, Kevin Firl, J Banks Shepherd, Steven M Couch, Angeline Nguyen, Amanda D Henderson, Timothy McCulley, Collin M McClelland, Ali Mokhtarzadeh, Michael S Lee, James A Garrity, Andrew R Harrison,

Purpose: To describe the demographic and clinical characteristics of patients with thyroid eye disease (TED) who present with predominate superior rectus/levator complex involvement.Methods: A multi-institutional retrospective review was performed to identify patients with TED who presented with superior isolated or predominate rectus/levator involvement. Baseline and subsequent visits were reviewed to ... Read more >>

Orbit (Orbit (Amsterdam, Netherlands))
[2020, 39(1):5-12]

Cited: 0 times

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Primary Epithelioid Sarcoma of Orbit: A Case Report and Review of the Literature.

Erin A Kaya, Talmage J Broadbent, Cheddhi J Thomas, Aaron E Wagner, Steve H Thatcher, Wayne T Lamoreaux, Robert K Fairbanks, Christopher M Lee,

Epithelioid sarcoma is a rare high-grade malignancy identified by Enzinger in 1970. It accounts for 1% of all reported soft tissue sarcomas and presents most commonly in distal upper extremities in young adults with a male predominance. At this time, there are only 5 previously reported cases of primary epithelioid ... Read more >>

Case Rep Oncol Med (Case reports in oncological medicine)
[2018, 2018:3989716]

Cited: 0 times

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Erotic asphyxiation: May have you seeing double.

Caroline S Halbach, Andrew R Harrison, Talmage J Broadbent, Ali Mokhtarzadeh,

Purpose:If not recognized and treated promptly, nontraumatic orbital subperiosteal hemorrhage (NTSOH) can have serious sequelae including compressive optic neuropathy and permanent vision loss. The following case establishes erotic asphyxiation as a cause of NTSOH. Observations:A 29 year-old patient presented with diplopia and periorbital edema and ecchymosis. Complete ophthalmologic exam showed ... Read more >>

Am J Ophthalmol Case Rep (American journal of ophthalmology case reports)
[2019, 13:99-101]

Cited: 0 times

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Minimally invasive brow lifting techniques.

Talmage Broadbent, Ali Mokhktarzadeh, Andrew Harrison,

PURPOSE OF REVIEW:Aesthetic concerns about upper eyelid and brow position are very common in ophthalmic practice. Management of brow descent and devolumization requires an approach customized to each patient taking into consideration preoperative examination and patient desires. This article will review several minimally invasive techniques that can be used to ... Read more >>

Curr Opin Ophthalmol (Current opinion in ophthalmology)
[2017, 28(5):539-543]

Cited: 2 times

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A Survey of Current Blepharospasm Treatment Patterns Among Oculoplastic Surgeons.

Talmage J Broadbent, Ralph E Wesley, Louise A Mawn,

To determine the current practice pattern of ASOPRS members injecting onabotulinumtoxinA for Blepharospasm.An invitation to participate in a web-based, anonymous survey was sent to current members of American Society of Ophthalmic Plastic and Reconstructive Surgeons (ASOPRS) via e-mail. The survey consisted of 9 questions and used the Research Electronic Data ... Read more >>

Ophthalmic Plast Reconstr Surg (Ophthalmic plastic and reconstructive surgery)
[2016, 32(1):24-27]

Cited: 3 times

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Socioeconomic and Ethnic Disparities in Periocular Cutaneous Malignancies.

Talmage Broadbent, Brian Bingham, Louise A Mawn,

Cutaneous malignancies make up the majority of periocular tumors diagnosed and treated by ophthalmologists. In this review, we examine literature regarding ethnic and socioeconomic disparities in incidence and clinical outcomes of the three most common cutaneous periocular tumors: basal cell carcinoma, squamous cell carcinoma, and melanoma. In all three tumor ... Read more >>

Semin Ophthalmol (Seminars in ophthalmology)
[2016, 31(4):317-324]

Cited: 1 time

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DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC.

Kunal Rai, Sharmistha Sarkar, Talmage J Broadbent, Matthew Voas, Kenneth F Grossmann, Lincoln D Nadauld, Somaye Dehghanizadeh, Fanuel T Hagos, Yumei Li, Rachel K Toth, Stephanie Chidester, Timothy M Bahr, W Evan Johnson, Brad Sklow, Randall Burt, Bradley R Cairns, David A Jones,

Although genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system and the concomitant hypomethylation of key intestinal cell fating genes. Notably, this hypomethylation maintained zebrafish intestinal cells ... Read more >>

Cell (Cell)
[2010, 142(6):930-942]

Cited: 52 times

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New perspectives on APC control of cell fate and proliferation in colorectal cancer.

Reid A Phelps, Talmage J Broadbent, Diana M Stafforini, David A Jones,

Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Considerable evidence for this model has come from mouse models of Apc truncation where nuclear beta-catenin is detectable soon after loss of Apc. However, examination of tumors from familial adenomatous ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2009, 8(16):2549-2556]

Cited: 49 times

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A two-step model for colon adenoma initiation and progression caused by APC loss.

Reid A Phelps, Stephanie Chidester, Somaye Dehghanizadeh, Jason Phelps, Imelda T Sandoval, Kunal Rai, Talmage Broadbent, Sharmistha Sarkar, Randall W Burt, David A Jones,

Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Using zebrafish and human cells, we show that homozygous loss of APC causes failed intestinal cell differentiation but that this occurs in the absence of nuclear beta-catenin and increased intestinal ... Read more >>

Cell (Cell)
[2009, 137(4):623-634]

Cited: 166 times

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Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development.

Lincoln D Nadauld, Stephanie Chidester, Dawne N Shelton, Kunal Rai, Talmage Broadbent, Imelda T Sandoval, Peter W Peterson, Elizabeth J Manos, Chris M Ireland, H Joseph Yost, David A Jones,

Congenital hypertrophy/hyperplasia of the retinal pigmented epithelium is an ocular lesion found in patients harboring mutations in the adenomatous polyposis coli (APC) tumor suppressor gene. We report that Apc-deficient zebrafish display developmental abnormalities of both the lens and retina. Injection of dominant-negative Lef reduced Wnt signaling in the lens but ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2006, 103(36):13409-13414]

Cited: 25 times

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Prevention of toxin-induced intestinal ion and fluid secretion by a small-molecule CFTR inhibitor.

Jay R Thiagarajah, Talmage Broadbent, Emily Hsieh, Alan S Verkman,

BACKGROUND & AIMS:The cystic fibrosis transmembrane conductance regulator (CFTR) provides an important apical route for Cl(-) secretion across intestinal epithelia. A thiazolidinone-type CFTR blocker (CFTR(inh)-172) reduced cholera toxin-induced fluid accumulation in mouse intestinal loops. Here, we characterize the efficacy and pharmacodynamics of CFTR(inh)-172 in blocking cAMP and cGMP induced Cl(-)/fluid ... Read more >>

Gastroenterology (Gastroenterology)
[2004, 126(2):511-519]

Cited: 82 times

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