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Author Taketo Otsuka

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Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

<h4>Background</h4>Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018.<h4>Study design</h4>To determine whether EV-D68 was responsible for ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):6-10]

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Novel scoring system for differentiating parechovirus-A3 and enterovirus infection in neonates and young infants.

Ryohei Izumita, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Nobutaka Kitamura, Kohei Akazawa, Akihiko Saitoh,

BACKGROUND:Parechovirus-A3 (PeV-A3) and the enteroviruses (EVs) are the most common viral pathogens responsible for sepsis and meningoencephalitis in neonates and young infants; however, differences in the clinical presentations of two infections are not well described. OBJECTIVES:To describe the clinical presentations of PeV-A3- and EVs-related diseases and develop a novel scoring ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2020, 124:104256]

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Intrafamilial Transmission of Parechovirus A and Enteroviruses in Neonates and Young Infants.

Ryohei Izumita, Kazuki Deuchi, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

<h4>Background</h4>Parechovirus A (PeV-A) is an important cause of sepsis and meningoencephalitis in neonates and young infants. Thus, identifying the source of PeV-A is essential for prevention; however, little is known regarding the spread of PeV-A among family members of PeV-A-infected neonates and young infants.<h4>Methods</h4>In this prospective study, we evaluated stool ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, 8(6):501-506]

Cited: 2 times

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2585. Changing Epidemiological Profile of Infantile Parechovirus-A3 Infection in Japan

Yuta Aizawa, Ryohei Izumita, Takayuki Yamanaka, Rie Habuka, Tatsuki Ikuse, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

Abstract <h4>Background</h4> Parechovirus-A3 (PeV-A3) causes severe disease, including sepsis and meningoencephalitis in young infants. The first case of PeV-A3 was reported in Japan in 1999 and, although epidemics have been reported every 2 to 3 years in more than 20 countries, no major epidemic has occurred in Japan since 2014. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S898-S899]

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2635. Outbreak of Enterovirus D68 Among Children in Japan and Simultaneous Circulation of Clade B3 in Europe.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

AbstractBackgroundEnterovirus D68 (EV-D68) is a re-emerging, high-morbidity pathogen that causes severe respiratory infection and acute flaccid myelitis in children. EV-D68 is phylogenetically divided into 4 major groups—clade A through D—and each clade has subclades defined by genetic variant. Outbreaks of all strains have been reported in more than 10 countries. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S920-S921]

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Efficacy and safety of cold forceps polypectomy utilizing the jumbo cup: a prospective study.

Hiroshi Hasegawa, Shigeki Bamba, Kenichiro Takahashi, Masaki Murata, Taketo Otsuka, Hiroshi Matsumoto, Takehide Fujimoto, Rie Osak, Hirotsugu Imaeda, Atsushi Nishida, Hiromitsu Ban, Ayano Sonoda, Osamu Inatomi, Masaya Sasaki, Mitsushige Sugimoto, Akira Andoh,

<h4>Background/aims</h4>There are few prospective studies on cold forceps polypectomy (CFP) using jumbo cup forceps. Therefore, we examined patients with diminutive polyps (5 mm or smaller) treated with CFP using jumbo cup forceps to achieve an adenoma-free colon and also assessed the safety of the procedure and the recurrence rate of ... Read more >>

Intest Res (Intestinal research)
[2019, 17(2):265-272]

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Successful Helicobacter pylori eradication therapy improves symptoms of chronic constipation.

Masaki Murata, Mitsushige Sugimoto, Taketo Otsuka, Atsushi Nishida, Osamu Inatomi, Shigeki Bamba, Akira Andoh,

<h4>Backgrounds and aims</h4>Constipation is one of the most common gastrointestinal functional disorders. Recently, the gut microbiota has been implicated in the development of constipation. Helicobacter pylori infection is considered to be a possible factor influencing the gut microbiota profile. Here, we investigated the effect of H. pylori eradication therapy on symptoms ... Read more >>

Helicobacter (Helicobacter)
[2018, 23(6):e12543]

Cited: 1 time

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Usefulness of the clip-flap method of endoscopic submucosal dissection: A randomized controlled trial.

Hiromitsu Ban, Mitsushige Sugimoto, Taketo Otsuka, Masaki Murata, Toshiro Nakata, Hiroshi Hasegawa, Osamu Inatomi, Shigeki Bamba, Akira Andoh,

<h4>Aim</h4>To prospectively investigate the efficacy and safety of clip-flap assisted endoscopic submucosal dissection (ESD) for gastric tumors.<h4>Methods</h4>From May 2015 to October 2016, we enrolled 104 patients with gastric cancer or adenoma scheduled for ESD at Shiga University of Medical Science Hospital. We randomized patients into two subgroups using the minimization ... Read more >>

World J Gastroenterol (World journal of gastroenterology)
[2018, 24(35):4077-4085]

Cited: 3 times

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Severity of gastric mucosal atrophy affects the healing speed of post-endoscopic submucosal dissection ulcers.

Taketo Otsuka, Mitsushige Sugimoto, Hiromitsu Ban, Toshiro Nakata, Masaki Murata, Atsushi Nishida, Osamu Inatomi, Shigeki Bamba, Akira Andoh,

AIM:To investigate factors associated with the healing of endoscopic submucosal dissection (ESD)-induced ulcers. METHODS:We enrolled 132 patients with gastric tumors scheduled for ESD. Following ESD, patients were treated with daily lansoprazole 30 mg or vonoprazan 20 mg. Ulcer size was endoscopically measured on the day after ESD and at 4 ... Read more >>

World J Gastrointest Endosc (World journal of gastrointestinal endoscopy)
[2018, 10(5):83-92]

Cited: 2 times

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Cap polyposis refractory to Helicobacter pylori eradication treated with endoscopic submucosal dissection.

Masaki Murata, Mitsushige Sugimoto, Hiromitsu Ban, Taketo Otsuka, Toshiro Nakata, Masahide Fukuda, Osamu Inatomi, Shigeki Bamba, Ryoji Kushima, Akira Andoh,

Cap polyposis is a rare intestinal disorder. Characteristic endoscopic findings are multiple inflammatory polypoid lesions covered by caps of fibrous purulent exudate. Although a specific treatment has not been established, some studies have suggested that eradication therapy for Helicobacter pylori (H. pylori) is effective. We report a case of a ... Read more >>

World J Gastrointest Endosc (World journal of gastrointestinal endoscopy)
[2017, 9(10):529-534]

Cited: 0 times

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Can We Distinguish between Human Parechovirus Type 3 and Enteroviruses Infection in Neonates and Young Infants Based on their Clinical and Laboratory Findings?

Ryohei Izumita, Yuta Aizawa, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

AbstractBackgroundHuman parechovirus type 3 (HPeV3) and enteroviruses (EVs) are the major viral pathogens causing severe diseases in neonates and young infants. Although two infections typically occur in summer, and initial clinical presentations are similar, differences in clinical and laboratory characteristics of HPeV3- and EV- infections are not well described.MethodsFrom January ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S693-S693]

Cited: 0 times

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Subcutaneous chest wall abscess as a complication of BCG vaccination.

Taketo Otsuka, Ryosuke Hosokai, Toru Watanabe, Naruhiko Ishiwada, Akihiko Saitoh,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2017, 59(11):1206-1208]

Cited: 0 times

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Haemophilus influenzae peritonitis in a girl on automated peritoneal dialysis: Case report and review of the literature.

Taketo Otsuka, Hiroya Hasegawa, Takeshi Yamada, Utako Kaneko, Akihiko Saitoh,

<i>Haemophilus influenzae</i> is a rare cause of peritonitis in patients on peritoneal dialysis (PD). We report a case of peritonitis due to non-typeable <i>H. influenzae</i> in a 5-year-old girl on automated PD. The patient was successfully treated with intraperitoneal cefepime and cefazolin. The isolate was multilocus sequence type 3 and ... Read more >>

IDCases (IDCases)
[2017, 9:47-49]

Cited: 0 times

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Efficacy of the Kyoto Classification of Gastritis in Identifying Patients at High Risk for Gastric Cancer.

Mitsushige Sugimoto, Hiromitsu Ban, Hitomi Ichikawa, Shu Sahara, Taketo Otsuka, Osamu Inatomi, Shigeki Bamba, Takahisa Furuta, Akira Andoh,

Objective The Kyoto gastritis classification categorizes the endoscopic characteristics of Helicobacter pylori (H. pylori) infection-associated gastritis and identifies patterns associated with a high risk of gastric cancer. We investigated its efficacy, comparing scores in patients with H. pylori-associated gastritis and with gastric cancer. Methods A total of 1,200 patients with ... Read more >>

Intern Med (Internal medicine (Tokyo, Japan))
[2017, 56(6):579-586]

Cited: 23 times

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Influence of potassium-competitive acid blocker on the gut microbiome of Helicobacter pylori-negative healthy individuals.

Taketo Otsuka, Mitsushige Sugimoto, Ryo Inoue, Masashi Ohno, Hiromitsu Ban, Atsushi Nishida, Osamu Inatomi, Shunsuke Takahashi, Yuji Naito, Akira Andoh,

Gut (Gut)
[2017, 66(9):1723-1725]

Cited: 13 times

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Antimicrobial activity of antisense peptide-peptide nucleic acid conjugates against non-typeable Haemophilus influenzae in planktonic and biofilm forms.

Taketo Otsuka, Aimee L Brauer, Charmaine Kirkham, Erin K Sully, Melinda M Pettigrew, Yong Kong, Bruce L Geller, Timothy F Murphy,

<h4>Background</h4>Antisense peptide nucleic acids (PNAs) are synthetic polymers that mimic DNA/RNA and inhibit bacterial gene expression in a sequence-specific manner.<h4>Methods</h4>To assess activity against non-typeable Haemophilus influenzae (NTHi), we designed six PNA-peptides that target acpP, encoding an acyl carrier protein. MICs and minimum biofilm eradication concentrations (MBECs) were determined. Resistant strains ... Read more >>

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2017, 72(1):137-144]

Cited: 5 times

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Successful Combined Treatment for Atrophic Thyroiditis With Growth Hormone Deficiency.

Taketo Otsuka, Naoya Tajima, Keisuke Nagasaki, Minoru Okazaki,

Glob Pediatr Health (Global pediatric health)
[2016, 3:2333794X16670082]

Cited: 0 times

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Four-times-daily Dosing of Rabeprazole with Sitafloxacin, High-Dose Amoxicillin, or Both for Metronidazole-Resistant Infection with Helicobacter pylori in Japan.

Mitsushige Sugimoto, Shu Sahara, Hitomi Ichikawa, Takuma Kagami, Hiromitsu Ban, Taketo Otsuka, Akira Andoh, Takahisa Furuta,

<h4>Background</h4>The bacterial resistance of Helicobacter pylori to antimicrobial agents such as clarithromycin and metronidazole has been increasing worldwide, leading to the failure of eradication treatment. Here, we present an eradication regimen consisting of four-times-daily dosing (q.i.d.) of rabeprazole with potent acid inhibition.<h4>Aim</h4>To investigate the efficacy of eradication therapy with rabeprazole ... Read more >>

Helicobacter (Helicobacter)
[2017, 22(1):]

Cited: 5 times

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Influenza Virus Shedding in Laninamivir-Treated Children upon Returning to School.

Hiroki Kondo, Yugo Shobugawa, Akinobu Hibino, Ren Yagami, Clyde Dapat, Minoru Okazaki, Taketo Otsuka, Koyata Fujii, Mohd Rohaizat Hassan, Reiko Saito,

The current School Health and Safety Act in Japan states that children with influenza infection should stay home until day 6(th) after symptoms onset. This was an amendment of a previous version recommending school return on day 3 after defervescence. Here, we investigated the duration of fever and virus shedding ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2016, 238(2):113-121]

Cited: 6 times

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The Vaccine Candidate Substrate Binding Protein SBP2 Plays a Key Role in Arginine Uptake, Which Is Required for Growth of Moraxella catarrhalis.

Taketo Otsuka, Charmaine Kirkham, Aimee Brauer, Mary Koszelak-Rosenblum, Michael G Malkowski, Timothy F Murphy,

Moraxella catarrhalis is an exclusively human pathogen that is an important cause of otitis media in children and lower respiratory tract infections in adults with chronic obstructive pulmonary disease. A vaccine to prevent M. catarrhalis infections would have an enormous global impact in reducing morbidity resulting from these infections. Substrate ... Read more >>

Infect Immun (Infection and immunity)
[2016, 84(2):432-438]

Cited: 7 times

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Substrate binding protein SBP2 of a putative ABC transporter as a novel vaccine antigen of Moraxella catarrhalis.

Taketo Otsuka, Charmaine Kirkham, Antoinette Johnson, Megan M Jones, Timothy F Murphy,

Moraxella catarrhalis is a common respiratory tract pathogen that causes otitis media in children and infections in adults with chronic obstructive pulmonary disease. Since the introduction of the pneumococcal conjugate vaccines with/without protein D of nontypeable Haemophilus influenzae, M. catarrhalis has become a high-priority pathogen in otitis media. For the ... Read more >>

Infect Immun (Infection and immunity)
[2014, 82(8):3503-3512]

Cited: 11 times

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Reply: To PMID 23411622.

Taketo Otsuka, ,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2014, 33(2):228-229]

Cited: 0 times

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Molecular epidemiology and serogroup 6 capsular gene evolution of pneumococcal carriage in a Japanese birth cohort study.

Taketo Otsuka, Bin Chang, Akihito Wada, Minoru Okazaki,

Antibiotic resistance in Streptococcus pneumoniae is a major concern worldwide. However, it is unclear whether resistance is associated with only a few highly prevalent clones or numerous and diverse clones. We monitored 349 healthy children and obtained nasopharyngeal cultures at five time points coinciding with health check-ups (4, 7, 10, ... Read more >>

J Med Microbiol (Journal of medical microbiology)
[2013, 62(Pt 12):1868-1875]

Cited: 1 time

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Individual risk factors associated with nasopharyngeal colonization with Streptococcus pneumoniae and Haemophilus influenzae: a Japanese birth cohort study.

Taketo Otsuka, Bin Chang, Takatoshi Shirai, Atsushi Iwaya, Akihito Wada, Noboru Yamanaka, Minoru Okazaki, ,

<h4>Background</h4>The first step in a bacterial disease is the establishment of nasopharyngeal carriage.<h4>Methods</h4>We conducted a birth cohort study to identify factors associated with colonization in healthy children and evaluate the serotype distributions and resistances of Streptococcus pneumoniae/Haemophilus influenzae. Nasopharyngeal cultures were obtained from 349 subjects at 5 time points coinciding ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2013, 32(7):709-714]

Cited: 15 times

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Incidence survey of acute otitis media in children in Sado Island, Japan--Sado Otitis Media Study (SADOMS).

Taketo Otsuka, Osamu Kitami, Kouji Kondo, Hisayuki Ota, Shinsuke Oshima, Akio Tsuchiya, Takatoshi Shirai, Koyata Fujii, Michihide Nakamure, Yasuhiro Shoji, Hisano Nakamura, Yasuko Masuda, Kenichi Komiyama, Kazunaga Yoshida, Yukio Ishikawa, Atsushi Iwaya, Sugata Takahashi, Minoru Okazaki, Muneki Hotomi, Noboru Yamanaka,

<h4>Background</h4>Acute otitis media (AOM) is one of the most common forms of bacterial infection and cause for clinic visits in children. The incidence of AOM was 0.9-1.2 episodes per person-year during the first 2 years of life in previous reports conducted before 2000. The aim of this study was to ... Read more >>

PLoS One (PloS one)
[2013, 8(7):e68711]

Cited: 13 times

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