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Author Takehiko Saito

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Highly Pathogenic Avian Influenza A(H5N8) Virus Clade 2.3.4.4b, Western Siberia, Russia, 2020.

Ivan Sobolev, Kirill Sharshov, Nikita Dubovitskiy, Olga Kurskaya, Alexander Alekseev, Sergey Leonov, Yuriy Yushkov, Victor Irza, Andrey Komissarov, Artem Fadeev, Daria Danilenko, Junki Mine, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito, Alexander Shestopalov,

Two variants of highly pathogenic avian influenza A(H5N8) virus were detected in dead poultry in Western Siberia, Russia, during August and September 2020. One variant was represented by viruses of clade 2.3.4.4b and the other by a novel reassortant between clade 2.3.4.4b and Eurasian low pathogenicity avian influenza viruses circulating ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):2224-2227]

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First Outbreak of an H5N8 Highly Pathogenic Avian Influenza Virus on a Chicken Farm in Japan in 2020.

Saki Sakuma, Yuko Uchida, Momoyo Kajita, Taichiro Tanikawa, Junki Mine, Ryota Tsunekuni, Takehiko Saito,

On 5 November 2020, a confirmed outbreak due to an H5N8 highly pathogenic avian influenza virus (HPAIV) occurred at an egg-hen farm in Kagawa prefecture (western Japan). This virus, A/chicken/Kagawa/11C/2020 (Kagawa11C2020), was the first HPAI poultry isolate in Japan in 2020 and had multiple basic amino acids-a motif conferring high ... Read more >>

Viruses (Viruses)
[2021, 13(3):]

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Genetic Characterization of Influenza A Viruses in Japanese Swine in 2015 to 2019.

Junki Mine, Yuko Uchida, Nobuhiro Takemae, Takehiko Saito,

To assess the current status of influenza A viruses of swine (IAVs-S) throughout Japan and to investigate how these viruses persisted and evolve on pig farms, we genetically characterized IAVs-S isolated during 2015 to 2019. Nasal swab samples collected through active surveillance and lung tissue samples collected for diagnosis yielded ... Read more >>

J Virol (Journal of virology)
[2020, 94(14):]

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Characterization of a novel reassortant H7N3 highly pathogenic avian influenza virus isolated from a poultry meat product taken on a passenger flight to Japan.

Akihiro Shibata, Rieko Harada, Masatoshi Okamatsu, Keita Matsuno, Tomoko Arita, Yasushi Suzuki, Masayuki Shirakura, Takato Odagiri, Nobuhiro Takemae, Yuko Uchida, Takehiko Saito, Yoshihiro Sakoda, Hiroyuki Osaka,

A new reassortant H7N3 avian influenza virus (AIV) was isolated from a duck meat product that was illegally taken on board a passenger flight from China to Japan in March 2018. Sequencing analysis revealed that the H7N3 isolate, A/duck/Japan/AQ-HE30-1/2018 (Dk/HE30-1) (H7N3), was a reassortant highly pathogenic avian influenza virus (HPAIV) ... Read more >>

J Vet Med Sci (The Journal of veterinary medical science)
[2019, 81(3):444-448]

Cited: 6 times

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Epidemic of influenza A(H1N1)pdm09 analyzed by full genome sequences and the first case of oseltamivir-resistant strain in Myanmar 2017.

Su Mon Kyaw Win, Reiko Saito, Nay Chi Win, Di Ja Lasham, Yadanar Kyaw, Nay Lin, Khin Nyo Thein, Irina Chon, Takashi Odagiri, Win Thein, Latt Latt Kyaw, Ommar Swe Tin, Akihiko Saitoh, Tsutomu Tamura, Chika Hirokawa, Yuko Uchida, Takehiko Saito, Shinji Watanabe, Takato Odagiri, Kazuhiro Kamata, Hidekazu Osada, Clyde Dapat, Hisami Watanabe, Htay Htay Tin,

A community outbreak of human influenza A(H1N1)pdm09 virus strains was observed in Myanmar in 2017. We investigated the circulation patterns, antigenicity, and drug resistance of 2017 influenza A(H1N1)pdm09 viruses from Myanmar and characterized the full genome of influenza virus strains in Myanmar from in-patients and out-patients to assess the pathogenicity ... Read more >>

PLoS One (PloS one)
[2020, 15(3):e0229601]

Cited: 2 times

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Improvement of a recombinant avian avulavirus serotype 10 vectored vaccine by the addition of untranslated regions.

Ryota Tsunekuni, Taichiro Tanikawa, Takaaki Nakaya, Takehiko Saito,

<h4>Background</h4>We have previously developed a recombinant avian avulavirus serotype 10 (rAAvV-10/HA) expressing the hemagglutinin (HA) gene of a highly pathogenic avian influenza virus (HPAIV) as an emergency vaccine for poultry. rAAvV-10/HA can overcome the activity of the anti-AAvV-1 (Newcastle disease virus) antibody acquired by commercial chickens upon routine vaccination. Most ... Read more >>

Vaccine (Vaccine)
[2020, 38(4):822-829]

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A novel H7N3 reassortant originating from the zoonotic H7N9 highly pathogenic avian influenza viruses that has adapted to ducks.

Momoko Nakayama, Yuko Uchida, Akihiro Shibata, Yoshifumi Kobayashi, Junki Mine, Nobuhiro Takemae, Ryota Tsunekuni, Taichiro Tanikawa, Rieko Harada, Hiroyuki Osaka, Takehiko Saito,

The first human case of zoonotic H7N9 avian influenza virus (AIV) infection was reported in March 2013 in China. This virus continues to circulate in poultry in China while mutating to highly pathogenic AIVs (HPAIVs). Through monitoring at airports in Japan, a novel H7N3 reassortant of the zoonotic H7N9 HPAIVs, ... Read more >>

Transbound Emerg Dis (Transboundary and emerging diseases)
[2019, 66(6):2342-2352]

Cited: 3 times

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Isolation of highly pathogenic H5N6 avian influenza virus in Southern Vietnam with genetic similarity to those infecting humans in China.

Ryota Tsunekuni, Kasumi Sudo, Phuong Thanh Nguyen, Bach Duc Luu, Thai Duy Phuong, Tran Minh Tan, Tung Nguyen, Junki Mine, Momoko Nakayama, Taichiro Tanikawa, Kirill Sharshov, Nobuhiro Takemae, Takehiko Saito,

Since 2013, H5N6 highly pathogenic avian influenza viruses (HPAIVs) have been responsible for outbreaks in poultry and wild birds around Asia. H5N6 HPAIV is also a public concern due to sporadic human infections being reported in China. In the current study, we isolated an H5N6 HPAIV strain (A/Muscovy duck/Long An/AI470/2018; ... Read more >>

Transbound Emerg Dis (Transboundary and emerging diseases)
[2019, 66(6):2209-2217]

Cited: 3 times

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Phylogeographic evidence for the inter- and intracontinental dissemination of avian influenza viruses via migration flyways.

Junki Mine, Yuko Uchida, Kirill Sharshov, Ivan Sobolev, Alexander Shestopalov, Takehiko Saito,

Genetically related highly pathogenic avian influenza viruses (HPAIVs) of H5N6 subtype caused outbreaks simultaneously in East Asia and Europe-geographically distinct regions-during winter 2017-2018. This situation prompted us to consider whether the application of phylogeographic analysis to a particular gene segment of AIVs could provide clues for understanding how AIV had ... Read more >>

PLoS One (PloS one)
[2019, 14(6):e0218506]

Cited: 3 times

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Genetics and pathogenicity of H5N6 highly pathogenic avian influenza viruses isolated from wild birds and a chicken in Japan during winter 2017-2018.

Junki Mine, Yuko Uchida, Momoko Nakayama, Taichiro Tanikawa, Ryota Tsunekuni, Kirill Sharshov, Nobuhiro Takemae, Ivan Sobolev, Alexander Shestpalov, Takehiko Saito,

An H5N6 highly pathogenic avian influenza virus (HPAIV) outbreak occurred in poultry in Japan during January 2018, and H5N6 HPAIVs killed several wild birds in 3 prefectures during Winter 2017-2018. Time-measured phylogenetic analyses demonstrated that the Hemagglutinin (HA) and internal genes of these isolates were genetically similar to clade 2.3.4.4.B ... Read more >>

Virology (Virology)
[2019, 533:1-11]

Cited: 4 times

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Pathogenicity of two novel human-origin H7N9 highly pathogenic avian influenza viruses in chickens and ducks.

Taichiro Tanikawa, Yuko Uchida, Nobuhiro Takemae, Ryota Tsunekuni, Junki Mine, Ming-Tsan Liu, Ji-Rong Yang, Masayuki Shirakura, Shinji Watanabe, Takato Odagiri, Takehiko Saito,

Human infection by low-pathogenic avian influenza viruses of the H7N9 subtype was first reported in March 2013 in China. Subsequently, these viruses caused five outbreaks through September 2017. In the fifth outbreak, H7N9 virus possessing a multiple basic amino acid insertion in the cleavage site of hemagglutinin emerged and caused ... Read more >>

Arch Virol (Archives of virology)
[2019, 164(2):535-545]

Cited: 0 times

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Comparative pathogenicity of H5N6 subtype highly pathogenic avian influenza viruses in chicken, Pekin duck and Muscovy duck.

Yuko Uchida, Junki Mine, Nobuhiro Takemae, Taichiro Tanikawa, Ryota Tsunekuni, Takehiko Saito,

In Japan during the 2016-2017 winter season, clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIVs) of the H5N6 subtype caused 12 outbreaks in chicken and Muscovy duck farms. These viruses have been circulating in Vietnam and China since 2014. In this study, we evaluated the susceptibility of chicken, Pekin duck ... Read more >>

Transbound Emerg Dis (Transboundary and emerging diseases)
[2019, 66(3):1227-1251]

Cited: 8 times

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Phylogeographic analysis of human influenza A and B viruses in Myanmar, 2010-2015.

Khin Thu Zar Htwe, Clyde Dapat, Yugo Shobugawa, Takashi Odagiri, Akinobu Hibino, Hiroki Kondo, Ren Yagami, Takehiko Saito, Nobuhiro Takemae, Tsutomu Tamura, Hisami Watanabe, Yadanar Kyaw, Nay Lin, Yi Yi Myint, Htay Htay Tin, Win Thein, Latt Latt Kyaw, Pan Ei Soe, Makoto Naito, Hassan Zaraket, Hiroshi Suzuki, Takashi Abe, Reiko Saito,

We investigated the circulation patterns of human influenza A and B viruses in Myanmar between 2010 and 2015 by analyzing full HA genes. Upper respiratory tract specimens were collected from patients with symptoms of influenza-like illness. A total of 2,860 respiratory samples were screened by influenza rapid diagnostic test, of ... Read more >>

PLoS One (PloS one)
[2019, 14(1):e0210550]

Cited: 3 times

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Genetic and antigenic dynamics of influenza A viruses of swine on pig farms in Thailand.

Junki Mine, Haruka Abe, Sujira Parchariyanon, Prakit Boonpornprasert, Namfon Ubonyaem, Bandit Nuansrichay, Nobuhiro Takemae, Taichiro Tanikawa, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito,

Surveillance studies of influenza A virus of swine (IAV-S) have accumulated information regarding IAVs-S circulating in Thailand, but how IAVs-S evolve within a farm remains unclear. In the present study, we isolated 82 A(H1N1)pdm09 and 87 H3N2 viruses from four farms from 2011 through 2017. We then phylogenetically and antigenically ... Read more >>

Arch Virol (Archives of virology)
[2019, 164(2):457-472]

Cited: 5 times

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Neuraminidase inhibitor susceptibility and evolutionary analysis of human influenza B isolates from three Asian countries during 2012-2015.

Akinobu Hibino, Elie Massaad, Hiroki Kondo, Reiko Saito, Takashi Odagiri, Nobuhiro Takemae, Ryota Tsunekuni, Takehiko Saito, , Yadanar Kyaw, Nay Lin, Yi Yi Myint, Htay Htay Tin, Nguyen Le Khanh Hang, Le Quynh Mai, Ren Yagami, Yugo Shobugawa, Tommy Lam, Hassan Zaraket,

Influenza B viruses of both the Yamagata and the Victoria lineages are implicated in a large proportion of the morbidity and mortality associated with influenza outbreaks. In this study, we characterized the full genomes of 53 influenza B viruses isolated during 2012-2015 in three Asian countries: Japan, Myanmar, and Vietnam. ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2018, 62:27-33]

Cited: 0 times

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Kinetic profiles of photocurrents in cells expressing two types of channelrhodopsin genes.

Yoshito Watanabe, Eriko Sugano, Kitako Tabata, Taku Ozaki, Takehiko Saito, Makoto Tamai, Hiroshi Tomita,

Channelrhodopsin-2 (ChR2), a light-activated cation-selective ion channel, has been widely used as a tool in optogenetic research. ChR2 is specifically sensitive to wavelengths less than 550 nm. One of the methods to expand the sensitivity of a channelrhodopsin to a wider range of wavelengths is to express another channelrhodopsin in the ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2018, 496(3):814-819]

Cited: 1 time

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Reactivity and sensitivity of commercially available influenza rapid diagnostic tests in Japan.

Yuko Sakai-Tagawa, Seiya Yamayoshi, Chiharu Kawakami, Mai Q Le, Yuko Uchida, Takehiko Saito, Chairul A Nidom, Ira Humaira, Kathy Toohey-Kurth, Abdel-Satar Arafa, Ming-Tsan Liu, Yuelong Shu, Yoshihiro Kawaoka,

Seasonal influenza virus routinely causes epidemic infections throughout the world. Sporadic infections by H5N1, H5N6, and H7N9 viruses are also reported. To treat patients suffering from such viral infections, broadly reactive and highly sensitive influenza rapid diagnostic tests (IRDTs) are required. Here, we examined the reactivity and sensitivity of 25 ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):14483]

Cited: 4 times

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Spatial transmission of H5N6 highly pathogenic avian influenza viruses among wild birds in Ibaraki Prefecture, Japan, 2016-2017.

Ryota Tsunekuni, Yuji Yaguchi, Yuki Kashima, Kaoru Yamashita, Nobuhiro Takemae, Junki Mine, Taichiro Tanikawa, Yuko Uchida, Takehiko Saito,

From 29 November 2016 to 24 January 2017, sixty-three cases of H5N6 highly pathogenic avian influenza virus (HPAIV) infections were detected in wild birds in Ibaraki Prefecture, Japan. Here, we analyzed the genetic, temporal, and geographic correlations of these 63 HPAIVs to elucidate their dissemination throughout the prefecture. Full-genome sequence ... Read more >>

Arch Virol (Archives of virology)
[2018, 163(5):1195-1207]

Cited: 5 times

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Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016-2017.

Nobuhiro Takemae, Ryota Tsunekuni, Kirill Sharshov, Taichiro Tanikawa, Yuko Uchida, Hiroshi Ito, Kosuke Soda, Tatsufumi Usui, Ivan Sobolev, Alexander Shestopalov, Tsuyoshi Yamaguchi, Junki Mine, Toshihiro Ito, Takehiko Saito,

To elucidate the evolutionary pathway, we sequenced the entire genomes of 89 H5N6 highly pathogenic avian influenza viruses (HPAIVs) isolated in Japan during winter 2016-2017 and 117 AIV/HPAIVs isolated in Japan and Russia. Phylogenetic analysis showed that at least 5 distinct genotypes of H5N6 HPAIVs affected poultry and wild birds ... Read more >>

Virology (Virology)
[2017, 512:8-20]

Cited: 18 times

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Recombinant Avian Paramyxovirus Serotypes 2, 6, and 10 as Vaccine Vectors for Highly Pathogenic Avian Influenza in Chickens with Antibodies Against Newcastle Disease Virus.

Ryota Tsunekuni, Hirokazu Hikono, Taichiro Tanikawa, Riho Kurata, Takaaki Nakaya, Takehiko Saito,

Recombinant Newcastle disease virus (rNDV) expressing the hemagglutinin of highly pathogenic avian influenza virus (HPAIV HA) induces protective immunity against HPAIV in chickens. However, the efficacy of rNDV vectors is hampered when chickens are pre-immune to NDV, and most commercial chickens are routinely vaccinated against NDV. We recently showed that ... Read more >>

Avian Dis (Avian diseases)
[2017, 61(3):296-306]

Cited: 4 times

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Replication of a low-pathogenic avian influenza virus is enhanced by chicken ubiquitin-specific protease 18.

Taichiro Tanikawa, Yuko Uchida, Takehiko Saito,

Previous research revealed the induction of chicken USP18 (chUSP18) in the lungs of chickens infected with highly pathogenic avian influenza viruses (HPAIVs). This activity was correlated with the degree of pathogenicity of the viruses to chickens. As mammalian ubiquitin-specific protease (USP18) is known to remove type I interferon (IFN I)-inducible ... Read more >>

J Gen Virol (The Journal of general virology)
[2017, 98(9):2235-2247]

Cited: 3 times

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Characterization of Highly Pathogenic Avian Influenza Virus A(H5N6), Japan, November 2016.

Masatoshi Okamatsu, Makoto Ozawa, Kosuke Soda, Hiroki Takakuwa, Atsushi Haga, Takahiro Hiono, Aya Matsuu, Yuko Uchida, Ritsuko Iwata, Keita Matsuno, Masakazu Kuwahara, Toshiyo Yabuta, Tatsufumi Usui, Hiroshi Ito, Manabu Onuma, Yoshihiro Sakoda, Takehiko Saito, Koichi Otsuki, Toshihiro Ito, Hiroshi Kida,

Highly pathogenic avian influenza viruses (HPAIVs) A(H5N6) were concurrently introduced into several distant regions of Japan in November 2016. These viruses were classified into the genetic clade 2.3.4.4c and were genetically closely related to H5N6 HPAIVs recently isolated in South Korea and China. In addition, these HPAIVs showed further antigenic ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2017, 23(4):691-695]

Cited: 23 times

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[The 44th Scientific Meeting: Perspectives of Internal Medicine: Virology for Physician ∼Recent Advance in Viral Infection and Treatment∼: 2. Important Newly Emerging Viral Infection: 3) Avian Influenza].

Takehiko Saito,

Nihon Naika Gakkai Zasshi (Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine)
[2017, 106(3):415-421]

Cited: 0 times

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Influenza A Viruses of Swine (IAV-S) in Vietnam from 2010 to 2015: Multiple Introductions of A(H1N1)pdm09 Viruses into the Pig Population and Diversifying Genetic Constellations of Enzootic IAV-S.

Nobuhiro Takemae, Michiyo Harada, Phuong Thanh Nguyen, Tung Nguyen, Tien Ngoc Nguyen, Thanh Long To, Tho Dang Nguyen, Vu Phong Pham, Vu Tri Le, Hoa Thi Do, Hung Van Vo, Quang Vinh Tin Le, Tan Minh Tran, Thanh Duy Nguyen, Phuong Duy Thai, Dang Hoang Nguyen, Anh Quynh Thi Le, Diep Thi Nguyen, Yuko Uchida, Takehiko Saito,

Active surveillance of influenza A viruses of swine (IAV-S) involving 262 farms and 10 slaughterhouses in seven provinces in northern and southern Vietnam from 2010 to 2015 yielded 388 isolates from 32 farms; these viruses were classified into H1N1, H1N2, and H3N2 subtypes. Whole-genome sequencing followed by phylogenetic analysis revealed ... Read more >>

J Virol (Journal of virology)
[2017, 91(1):]

Cited: 6 times

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Initiation and regulation of immune responses to immunization with whole inactivated vaccines prepared from two genetically and antigenically distinct lineages of Egyptian influenza A virus subtype H5N1.

Ahmed Samy, Mona I El-Enbaawy, Ahmed A El-Sanousi, Soad A Nasef, Hirokazu Hikono, Takehiko Saito,

Following the introduction of highly pathogenic avian influenza (HPAI) virus subtype H5N1, the Egyptian government implemented a massive poultry vaccination campaign as the cornerstone of its policies to control the virus. The efficacy of vaccination has been evaluated primarily by measuring titers of antibodies inhibiting the hemagglutinating activity of the ... Read more >>

Arch Virol (Archives of virology)
[2016, 161(10):2797-2806]

Cited: 2 times

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