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Author Takayuki Yamanaka

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Outbreak of Enterovirus D68 Among Children in Japan-Worldwide Circulation of Enterovirus D68 Clade B3 in 2018.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

<h4>Background</h4>Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred in the United States in 2014. We experienced an accumulation of pediatric cases with asthma-like respiratory illness in Niigata, Japan, in 2018.<h4>Study design</h4>To determine whether EV-D68 was responsible for ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):6-10]

Cited: 0 times

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CTX-M group gene distribution of extended spectrum beta-lactamase-producing Enterobacteriaceae at a Japanese Children's hospital.

Takayuki Yamanaka, Hanako Funakoshi, Kazue Kinoshita, Chinami Iwashita, Yuho Horikoshi,

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae have spread globally as one of the most common multidrug resistant organisms. Although a wide variety of ESBL genes were known in each geographical region, few reports existed on the distribution of ESBL genes in Japanese children. To clarify the distribution of ESBL genes, we investigated ... Read more >>

J Infect Chemother (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2020, 26(9):1005-1007]

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Hemorrhagic colitis can be a life-threatening side effect of oseltamivir.

Yuki Abe, Shinya Tsukano, Yukie Izumita, Takayuki Yamanaka,

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(5):634-635]

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Parechovirus-A3 encephalitis presenting with focal seizure mimicking herpes simplex virus infection.

Sakiko Arai, Takayuki Yamanaka, Masashi Kasai, Tetsuhiro Fukuyama, Yuta Aizawa, Ko Matsui, Masanori Sato, Hiroko Matsui, Akihiko Saitoh,

BACKGROUND:Febrile neonates and young infants presenting with seizure require immediate evaluation and treatment. Herein we experienced two young infants with parechovirus-A3 (PeV-A3) encephalitis, initially presented with focal seizure suspecting herpes simplex virus (HSV) encephalitis. CASES:We have experienced 2 infantile cases, initially presented with focal seizure. At presentation, HSV encephalitis was ... Read more >>

J Infect Chemother (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2020, 26(7):736-740]

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2635. Outbreak of Enterovirus D68 Among Children in Japan and Simultaneous Circulation of Clade B3 in Europe.

Tatsuki Ikuse, Yuta Aizawa, Takayuki Yamanaka, Rie Habuka, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

AbstractBackgroundEnterovirus D68 (EV-D68) is a re-emerging, high-morbidity pathogen that causes severe respiratory infection and acute flaccid myelitis in children. EV-D68 is phylogenetically divided into 4 major groups—clade A through D—and each clade has subclades defined by genetic variant. Outbreaks of all strains have been reported in more than 10 countries. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S920-S921]

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Manifestation of coronary subclavian steal phenomenon using reactive hyperemia in the ipsilateral forearm.

Takako Iino, Takayuki Yamanaka, Wakana Sato, Kenji Iino, Hiroyuki Watanabe,

Coronary subclavian steal syndrome (CSSS) is a coronary steal phenomenon secondary to subclavian artery stenosis in patients who have undergone coronary bypass surgery with the internal thoracic artery. Most commonly, CSSS is diagnosed angiographically. Our case emphasizes that stress ultrasound assessment using reactive hyperemia in the ipsilateral arm elicits a ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2019, 36(10):1956-1958]

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2585. Changing Epidemiological Profile of Infantile Parechovirus-A3 Infection in Japan

Yuta Aizawa, Ryohei Izumita, Takayuki Yamanaka, Rie Habuka, Tatsuki Ikuse, Kanako Watanabe, Taketo Otsuka, Akihiko Saitoh,

Abstract <h4>Background</h4> Parechovirus-A3 (PeV-A3) causes severe disease, including sepsis and meningoencephalitis in young infants. The first case of PeV-A3 was reported in Japan in 1999 and, although epidemics have been reported every 2 to 3 years in more than 20 countries, no major epidemic has occurred in Japan since 2014. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S898-S899]

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Research and drug development activities in rare diseases: differences between Japan and Europe regarding influence of prevalence.

Hirokuni Mizoguchi, Takayuki Yamanaka, Shingo Kano,

Orphan drug legislation has contributed enormously to promote drug development for rare diseases but further effective and sustainable approaches are required. This study focused on the difference of rare disease prevalence between Japan and Europe, classified the rare diseases comprehensively using cluster analysis and analyzed the influence of prevalence on ... Read more >>

Drug Discov Today (Drug discovery today)
[2016, 21(10):1681-1689]

Cited: 0 times

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Mapping lifecycle management activities for blockbuster drugs in Japan based on drug approvals and patent term extensions.

Takayuki Yamanaka, Shingo Kano,

Drug lifecycle management (LCM), which entails acquiring drug approvals and patent protections, contributes to maximizing drug discovery investment returns. In a previous survey, a comparative analysis between Japan and the USA indicated that a unique patent term extension system has an important role in Japanese drug LCM. Therefore, in this ... Read more >>

Drug Discov Today (Drug discovery today)
[2016, 21(2):306-314]

Cited: 1 time

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Strategic balance of drug lifecycle management options differs between domestic and foreign companies in Japan.

Takayuki Yamanaka, Shingo Kano,

<h4>Introduction</h4>Drug approvals and patent protections are critical in drug lifecycle management (LCM) in order to maximize drug discovery investment returns.<h4>Area covered</h4>We analyzed drug LCM activities implemented by 10 top companies in Japan, focusing on drug approvals and patent term extensions.<h4>Expert opinion</h4>Foreign companies acquired numerous drug approvals primarily for new molecular ... Read more >>

Expert Opin Ther Pat (Expert opinion on therapeutic patents)
[2016, 26(4):497-503]

Cited: 1 time

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Patent term extension systems differentiate Japanese and US drug lifecycle management.

Takayuki Yamanaka, Shingo Kano,

Drug lifecycle management (LCM) contributes to maximizing drug discovery investment returns. After initial drug approval, additional approvals can be sought for novel indications and formulations to extend product marketability. Patents provide additional barriers to entry and patent term extension systems facilitate extension of these. Several aspects of the US and ... Read more >>

Drug Discov Today (Drug discovery today)
[2016, 21(1):111-117]

Cited: 2 times

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Asymptomatic children might transmit human parechovirus type 3 to neonates and young infants.

Yuta Aizawa, Takayuki Yamanaka, Kanako Watanabe, Tomohiro Oishi, Akihiko Saitoh,

<h4>Background</h4>Human parechovirus type 3 (HPeV3) epidemics occur worldwide and can lead to severe disease in neonates and young infants. Little is known about the source of HPeV3 infection.<h4>Objectives</h4>To investigate the source of HPeV3 infection and the role of asymptomatic children in the families of infected children.<h4>Study design</h4>During a 2014 HPeV3 ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2015, 70:105-108]

Cited: 11 times

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Novel approach for chirp and output power compensation applied to a 40-Gbit/s EADFB laser integrated with a short SOA.

Wataru Kobayashi, Masakazu Arai, Takeshi Fujisawa, Tomonari Sato, Toshio Ito, Koichi Hasebe, Shigeru Kanazawa, Yuta Ueda, Takayuki Yamanaka, Hiroaki Sanjoh,

We propose a novel approach for simultaneously controlling the chirp and increasing the output power of an EADFB laser by monolithically integrating a short-cavity SOA. We achieved a 40-Gbit/s 5-km SMF transmission at a wavelength of 1.55 μm by using an EADFB SOA with a lower power consumption than a ... Read more >>

Opt Express (Optics express)
[2015, 23(7):9533-9542]

Cited: 1 time

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Ultracompact, 160-Gbit/s transmitter optical subassembly based on 40-Gbit/s × 4 monolithically integrated light source.

Takeshi Fujisawa, Toshio Itoh, Shigeru Kanazawa, Kiyoto Takahata, Yuta Ueda, Ryuzo Iga, Hiroaki Sanjo, Takayuki Yamanaka, Masaki Kotoku, Hiroyuki Ishii,

The first ultracompact transmitter optical subassembly for long-distance, beyond-100-Gbit/s data communication systems based on a monolithically integrated light source is developed. The light source consists of four InGaAlAs-based electroabsorption modulator integrated DFB lasers (EADFB lasers) and their optical multiplexer and these components are monolithically integrated on one chip, resulting in ... Read more >>

Opt Express (Optics express)
[2013, 21(1):182-189]

Cited: 2 times

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Coding exons function as tissue-specific enhancers of nearby genes.

Ramon Y Birnbaum, E Josephine Clowney, Orly Agamy, Mee J Kim, Jingjing Zhao, Takayuki Yamanaka, Zachary Pappalardo, Shoa L Clarke, Aaron M Wenger, Loan Nguyen, Fiorella Gurrieri, David B Everman, Charles E Schwartz, Ohad S Birk, Gill Bejerano, Stavros Lomvardas, Nadav Ahituv,

Enhancers are essential gene regulatory elements whose alteration can lead to morphological differences between species, developmental abnormalities, and human disease. Current strategies to identify enhancers focus primarily on noncoding sequences and tend to exclude protein coding sequences. Here, we analyzed 25 available ChIP-seq data sets that identify enhancers in an ... Read more >>

Genome Res (Genome research)
[2012, 22(6):1059-1068]

Cited: 93 times

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Effective permittivities with exact second-order accuracy at inclined dielectric interface for the two-dimensional finite-difference time-domain method.

Takuo Hirono, Yuzo Yoshikuni, Takayuki Yamanaka,

Accuracy degradation at a dielectric interface in simulations using the finite-difference time-domain method can be prevented by assigning suitable effective permittivities at the nodes in the vicinity of the interface. The effective permittivities with exact second-order accuracy at the interface inclined to the Yee-lattice axis are analytically derived for what ... Read more >>

Appl Opt (Applied optics)
[2010, 49(7):1080-1096]

Cited: 1 time

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Common behavioral influences of the ErbB1 ligands transforming growth factor alpha and epiregulin administered to mouse neonates.

Noriko Tsuda, Makoto Mizuno, Takayuki Yamanaka, Toshi Komurasaki, Makoto Yoshimoto, Hiroyuki Nawa,

Ligands for epidermal growth factor (EGF) receptor (ErbB1), such as EGF, transforming growth factor alpha (TGFalpha), and epiregulin, are enriched in body fluids and blood and regulate development of various peripheral organs. It remains however how such circulating polypeptide growth factors influence brain development and function. Here, we performed peripheral ... Read more >>

Brain Dev (Brain & development)
[2008, 30(8):533-543]

Cited: 10 times

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Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.

Takayuki Yamanaka, Masao Uchida, Takefumi Doi,

Hepatitis C Virus (HCV) has been identified as the major causative agent of non-A, non-B hepatitis. Core protein is not only a capsid protein of HCV but also a regulator of cellular functions, and plays an important role in the pathogenesis of HCV. Core protein is produced as an innate ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2002, 294(3):521-527]

Cited: 22 times

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Hepatitis C virus core protein binds to a C-terminal region of NS5B RNA polymerase.

Masao Uchida, Nobumasa Hino, Takayuki Yamanaka, Hitomi Fukushima, Takeshi Imanishi, Yasutoshi Uchiyama, Tatsuhiko Kodama, Takefumi Doi,

Hepatitis C virus (HCV) NS5B has been shown to exhibit RNA-dependent RNA polymerase activity for its viral RNA replication. In this study, we demonstrated the formation of a complex between NS5B and the core protein (NS5B-core protein complex) in mammalian cells, as determined by indirect immunofluorescence and immunoprecipitation analyses. The ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2002, 22(4):297-306]

Cited: 10 times

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Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression.

Takayuki Yamanaka, Tatsuhiko Kodama, Takefumi Doi,

Hepatitis C Virus (HCV) is a single stranded RNA virus causing non-A and non-B hepatitis. Core protein is a viral capsid protein that plays an important role in the pathogenesis of HCV. The companion report revealed that an innate form (amino acids [a.a.] 1-191) regulated subcellular localization of a mature ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2002, 294(3):528-534]

Cited: 42 times

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