Full Text Journal Articles by
Author Takamasa Nukui

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Cerebrospinal fluid ATP as a potential biomarker in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS).

Takamasa Nukui, Atsushi Matsui, Hideki Niimi, Mamoru Yamamoto, Noriyuki Matsuda, Jin-Lan Piao, Kyo Noguchi, Isao Kitajima, Yuji Nakatsuji,

Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is caused by defective oxidative phosphorylation in the cerebral parenchyma, cerebral blood vessels, and leptomeningeal tissue. Although increased blood and cerebrospinal fluid (CSF) lactate level has been used as a diagnostic biomarker in patients with MELAS, no biomarkers reflecting disease activity exist. ... Read more >>

Mitochondrion (Mitochondrion)
[2020, 50:145-148]

Cited: 0 times

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[A case of clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) associated with infectious endocarditis caused by Staphylococcus aureus].

Ryoko Anada, Takamasa Nukui, Tomohiro Hayashi, Hirofumi Konishi, Nobuhiro Dougu, Yuji Nakatsuji,

A 17-year-old woman was admitted to our hospital because of a high fever, consciousness disturbance, and delirious behavior. Methicillin susceptible Staphylococcus aureus (MSSA) infection was confirmed by blood culture. Transthoracic echocardiogram showed no abnormality at first. Diffusion-weighted brain MRI showed a high intensity lesion in the middle portion of the ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2019, 59(10):666-668]

Cited: 0 times

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Effects of Transcranial Direct Current Stimulation (tDCS) Over the Frontal Polar Area on Motor and Executive Functions in Parkinson's Disease; A Pilot Study.

Koji Ishikuro, Nobuhiro Dougu, Takamasa Nukui, Mamoru Yamamoto, Yuji Nakatsuji, Satoshi Kuroda, Isao Matsushita, Hiroshi Nishimaru, Mariana F P Araujo, Hisao Nishijo,

Parkinson's disease (PD) is a neurodegenerative disorder with motor and non-motor symptoms due to degeneration of dopaminergic neurons. The current pharmacological treatments induce complications associated with long-term use. However, current stimulation techniques for PD treatment, such as deep brain stimulation (DBS), are too invasive. In this context, non-invasive brain stimulation ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2018, 10:231]

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[A case of acute disseminated encephalomyelitis concomitant with polyneuropathy associated with anti-lactosylceramide antibody].

Tomohiro Hayashi, Takamasa Nukui, Shutaro Takashima, Yuji Nakatsuji, Sayuri Shima, Tatsuro Mutoh,

We report a case of acute disseminated encephalomyelitis (ADEM) concomitant with polyneuropathy associated with anti-lactosylceramide antibody. A 68-year-old man was admitted to our hospital with ophthalmoparesis, bulbar palsy, tetraplegia after suffering from upper respiratory infection and headache. Subsequently, he developed respiratory failure requiring mechanical ventilation. Fluid-attenuated inversion recovery (FLAIR) MRI ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2018, 58(5):297-301]

Cited: 1 time

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Nivolumab-induced acute demyelinating polyradiculoneuropathy mimicking Guillain-Barré syndrome.

Takamasa Nukui, Yurika Nakayama, Mamoru Yamamoto, Yoshiharu Taguchi, Nobuhiro Dougu, Hirofumi Konishi, Tomohiro Hayashi, Yuji Nakatsuji,

J. Neurol. Sci. (Journal of the neurological sciences)
[2018, 390:115-116]

Cited: 2 times

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[A case of neurolymphomatosis presented as cauda equine syndrome accompanied with M-proteinemia].

Hirofumi Konishi, Yoshiharu Taguchi, Mamoru Yamamoto, Takamasa Nukui, Nobuhiro Dougu, Yuji Nakatsuji,

A 63-year-old man developed a syndrome of cauda equine, with the numbness which is a left lower extremity from the left buttocks, weakness of left leg, and a dysfunction of bladder and bowel. Enhanced MRI revealed the enhancement of lower cauda equine, and a nerve conduction test revealed decreased F-wave ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2018, 58(4):223-228]

Cited: 0 times

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[A case of neuro-Sweet disease showing the close association between disease activity and levels of soluble IL-2 receptor].

Takamasa Nukui, Shutaro Takashima, Yoshiharu Taguchi, Nobuhiro Dougu, Hirofumi Konishi, Kortaro Tanaka,

A 76-year-old man was admitted to our hospital presenting with fever, redness and pain in both the periocular regions, and disturbance of consciousness. He had neck stiffness, and cerebrospinal fluid analysis suggested aseptic meningoencephalitis. Laboratory tests showed increased levels of C-reactive protein, soluble IL-2 receptor (sIL-2R) and MPO-ANCA. Magnetic resonance ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2014, 54(11):876-881]

Cited: 1 time

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Study of hemostatic biomarkers in acute ischemic stroke by clinical subtype.

Koji Hirano, Shutaro Takashima, Nobuhiro Dougu, Yoshiharu Taguchi, Takamasa Nukui, Hirohumi Konishi, Shigeo Toyoda, Isao Kitajima, Kortaro Tanaka,

BACKGROUND: We studied the usefulness of hemostatic biomarkers in assessing the pathology of thrombus formation, subtype diagnosis, prognosis in the acute phase of cerebral infarction, and differences between various hemostatic biomarkers. METHODS: Our study included 69 patients with acute cerebral infarction who had been hospitalized within 2 days of stroke ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2012, 21(5):404-410]

Cited: 16 times

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Reversible "brain atrophy" in anti-NMDA receptor encephalitis.

Yoshiharu Taguchi, Shutaro Takashima, Takamasa Nukui, Kortaro Tanaka,

Intern. Med. (Internal medicine (Tokyo, Japan))
[2011, 50(21):2697]

Cited: 6 times

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Hypersalivation in a patient with anti-NMDAR encephalitis with ovarian teratoma.

Yoshiharu Taguchi, Shutaro Takashima, Takamasa Nukui, Kortaro Tanaka,

Intern. Med. (Internal medicine (Tokyo, Japan))
[2010, 49(8):803-804]

Cited: 3 times

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[Case of branch atheromatous disease presenting capsular warning syndrome].

Yoshiharu Taguchi, Shutaro Takashima, Takamasa Nukui, Nobuhiro Dougu, Shigeo Toyoda, Kortaro Tanaka,

We report a case of branch atheromatous disease (BAD) presenting capsular warning syndrome, who subsequently showed a complete recovery by the combination therapy as described below. A 54-year-old man with untreated hypertension was admitted to our hospital because of dysarthria and right hemiplegia. The NIHSS on admission was 12 points, ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2010, 50(5):320-324]

Cited: 4 times

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S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes.

Takamasa Nukui, Ritsuko Ehama, Masakiyo Sakaguchi, Hiroyuki Sonegawa, Chika Katagiri, Toshihiko Hibino, Nam-Ho Huh,

S100A8 and S100A9 are known to be up-regulated in hyperproliferative and psoriatic epidermis, but their function in epidermal keratinocytes remains largely unknown. Here we show that (1) S100A8 and S100A9 are secreted by cultured normal human keratinocytes (NHK) in a cytokine-dependent manner, (2) when applied to NHK, recombinant S100A8/A9 (a ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2008, 104(2):453-464]

Cited: 46 times

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Involvement of deterioration in S100C/A11-mediated pathway in resistance of human squamous cancer cell lines to TGFbeta-induced growth suppression.

Hiroyuki Sonegawa, Takamasa Nukui, Dai-Wei Li, Mikiro Takaishi, Masakiyo Sakaguchi, Nam-Ho Huh,

Recently, we demonstrated that S100C/A11 comprises an essential pathway for growth suppression by TGFbeta in normal human keratinocytes. Nuclear transfer of S100C/A11 was a hallmark of the activation of the process. In the present study, we examined the possible deterioration in the pathway in human squamous cancer cell lines, focusing ... Read more >>

J. Mol. Med. (Journal of molecular medicine (Berlin, Germany))
[2007, 85(7):753-762]

Cited: 3 times

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Bifurcated converging pathways for high Ca2+- and TGFbeta-induced inhibition of growth of normal human keratinocytes.

Masakiyo Sakaguchi, Hiroyuki Sonegawa, Takamasa Nukui, Yoshihiko Sakaguchi, Masahiro Miyazaki, Masayoshi Namba, Nam-Ho Huh,

Growth suppression of normal human keratinocytes by high Ca2+ or TGFbeta was shown to be mediated by p21WAF1/CIP1 and Sp1 [Pardali, K., et al. (2000) J. Biol. Chem. 275, 29244-29256; Santini, M. P., Talora, C., Seki, T., Bolgan, L. & Dotto, G. P. (2001) Proc. Nat. Acad. Sci. USA 98, ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2005, 102(39):13921-13926]

Cited: 22 times

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Targeted disruption of transcriptional regulatory function of p53 by a novel efficient method for introducing a decoy oligonucleotide into nuclei.

Masakiyo Sakaguchi, Takamasa Nukui, Hiroyuki Sonegawa, Hitoshi Murata, Junichiro Futami, Hidenori Yamada, Nam-ho Huh,

Decoy oligonucleotides have been used for functional sequestering of transcription factors. Efficient introduction into cells is a prerequisite for the oligonucleotides to exert their blocking function. Lipofection is the most widely used technique for that purpose because of its convenience and relatively high efficiency. However, the transduction efficiency of lipofection ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2005, 33(9):e88]

Cited: 6 times

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