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Author Ta Ching Chen

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Application of deep learning image assessment software VeriSee™ for diabetic retinopathy screening.

Yi-Ting Hsieh, Lee-Ming Chuang, Yi-Der Jiang, Tien-Jyun Chang, Chung-May Yang, Chang-Hao Yang, Li-Wei Chan, Tzu-Yun Kao, Ta-Ching Chen, Hsuan-Chieh Lin, Chin-Han Tsai, Mingke Chen,

PURPOSE:To develop a deep learning image assessment software VeriSee™ and to validate its accuracy in grading the severity of diabetic retinopathy (DR). METHODS:Diabetic patients who underwent single-field, nonmydriatic, 45-degree color retinal fundus photography at National Taiwan University Hospital between July 2007 and June 2017 were retrospectively recruited. A total of ... Read more >>

J. Formos. Med. Assoc. (Journal of the Formosan Medical Association = Taiwan yi zhi)
[2020, :]

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Optic neuritis at the nexus of peripheral autoimmunity and central nervous system demyelination: a nationwide cohort study

Wei-Sheng Lin, Ho-Min Chen, Chih-Chao Yang, Ta-Ching Chen, Jou-Wei Lin, Wang-Tso Lee,

Abstract Background Long-term course of optic neuritis is heterogeneous and varies across populations. We aim to investigate immune-related determinants that predict conversion of optic neuritis (ON) to multiple sclerosis (MS) or neuromyelitis optica (NMO) in a nationwide cohort. Methods We conducted the population-based cohort study using data ... Read more >>

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Polybenzyl Glutamate Biocompatible Scaffold Promotes the Efficiency of Retinal Differentiation toward Retinal Ganglion Cell Lineage from Human-Induced Pluripotent Stem Cells.

Ta-Ching Chen, Pin-Yi She, Dong Feng Chen, Jui-Hsien Lu, Chang-Hao Yang, Ding-Siang Huang, Pao-Yang Chen, Chen-Yu Lu, Kin-Sang Cho, Hsin-Fu Chen, Wei-Fang Su,

Optic neuropathy is one of the leading causes of irreversible blindness caused by retinal ganglion cell (RGC) degeneration. The development of induced pluripotent stem cell (iPSC)-based therapy opens a therapeutic window for RGC degeneration, and tissue engineering may further promote the efficiency of differentiation process of iPSCs. The present study ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(1):]

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Clinical Course and Treatment Response of Neuromyelitis Optica Spectrum Disease: An 8-Year Experience.

Chao-Wen Lin, I-Hung Lin, Ta-Ching Chen, Jieh-Ren Jou, Lin-Chung Woung,

PURPOSE:To report the clinical course and treatment response in a cohort of patients with neuromyelitis optica spectrum disorder (NMOSD) from a single referral center in Taiwan. DESIGN:Case series. METHODS:All NMOSD patients who received treatment and follow-up checks at National Taiwan University Hospital for at least 2 years between January 2008 ... Read more >>

Asia Pac J Ophthalmol (Phila) (Asia-Pacific journal of ophthalmology (Philadelphia, Pa.))
[2019, 8(3):206-210]

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Update on ocular myasthenia gravis in Taiwan.

Chao-Wen Lin, Ta-Ching Chen, Jieh-Ren Jou, Lin-Chung Woung,

Myasthenia gravis (MG) is an autoimmune disease involving the neuromuscular junction. Autoantibodies to the acetylcholine receptor or, less frequently, to muscle-specific kinase, attack against the postsynaptic junctional proteins, resulting in fluctuating and variable weakness of muscles. Extraocular, levator palpebrae superioris, and orbicularis oculi muscles are particularly susceptible. The majority of ... Read more >>

Taiwan J Ophthalmol (Taiwan journal of ophthalmology)
[2018, 8(2):67-73]

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Vitreomacular Changes after Intravitreal Gas Injection for Idiopathic Impending or Early Macular Hole: An Optical Coherence Tomography Study.

Teck-Boon Tew, Ta-Ching Chen, Chang-Hao Yang, Chung-May Yang,

To study the early changes of vitreomacular microstructure by optical coherence tomography (OCT) after intravitreal gas injection for the treatment of idiopathic impending or early full-thickness macular hole (FTMH).A retrospective, interventional case series.A total of 21 eyes were included. In the impending macular hole, 8/8 achieved vitreomacular traction (VMT) release, ... Read more >>

Ophthalmologica (Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde)
[2018, 239(1):1-10]

Cited: 0 times

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Vascular hypoperfusion in acute optic neuritis is a potentially new neurovascular model for demyelinating diseases.

Ta-Ching Chen, Chao-Yuan Yeh, Chao-Wen Lin, Chung-May Yang, Chang-Hao Yang, I-Hung Lin, Pao-Yang Chen, Jung-Yu Cheng, Fung-Rong Hu,

Optic neuritis is highly correlated with multiple sclerosis and is a major cause of acute visual loss and long-term neuronal degeneration. Primary cerebral hypoperfusion has been reported in brain demyelinating diseases. This study investigated whether peripapillary perfusion is changed in patients with acute optic neuritis (AON).This three-year cohort study was ... Read more >>

PLoS ONE (PloS one)
[2017, 12(9):e0184927]

Cited: 2 times

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Surgical result of pterygium extended removal followed by fibrin glue-assisted amniotic membrane transplantation.

Hsin-Yu Liu, Yuh-Fang Chen, Ta-Ching Chen, Po-Ting Yeh, Fung-Rong Hu, Wei-Li Chen,

To report the recurrence rate and cosmetic results of conjunctival wound edge and caruncle, and complications after pterygium extended removal followed by fibrin glue-assisted amniotic membrane transplantation.A prospective interventional cohort study enrolled 57 (58 eyes) patients undergoing pterygium extended removal followed by fibrin glue-assisted amniotic membrane transplantation. All patients received ... Read more >>

J. Formos. Med. Assoc. (Journal of the Formosan Medical Association = Taiwan yi zhi)
[2017, 116(1):10-17]

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The effect of resveratrol on protecting corneal epithelial cells from cytotoxicity caused by moxifloxacin and benzalkonium chloride.

Tzu-Yun Tsai, Ta-Ching Chen, I-Jong Wang, Chao-Yuan Yeh, Ming-Jai Su, Ruey-Hua Chen, Tzu-Hsun Tsai, Fung-Rong Hu,

PURPOSE: Moxifloxacin (MOX), a fourth generation fluoroquinolone (FQ), has a wide antibacterial spectrum, but may show cytotoxicity characterized by high productions of reactive oxygen species (ROS). This study investigated the protective role of a common antioxidant agent, resveratrol (trans-3,5,4'-trihydroxystilbene), against the cytotoxicity caused by MOX. METHODS: Experiments were performed with ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2015, 56(3):1575-1584]

Cited: 6 times

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Macular retinal detachment associated with intrachoroidal cavitation in myopic patients.

Ta-Ching Chen, Chang-Hao Yang, Jen-Pin Sun, Muh-Shy Chen, Chung-May Yang,

To investigate the clinical characteristics and treatment outcomes of macular retinal detachment (MRD) associated with intrachoroidal cavitation (ICC) in myopic patients.In this retrospective, consecutive, interventional case series, five patients with ICC and associated MRD were enrolled from January 2005 to December 2012. Basic ocular characteristics and clinical appearances of their ... Read more >>

Graefes Arch. Clin. Exp. Ophthalmol. (Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie)
[2015, 253(9):1437-1446]

Cited: 1 time

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Long-term outcome of foveolar internal limiting membrane nonpeeling for myopic traction maculopathy.

Tzyy-Chang Ho, Chung-May Yang, Jen-Shang Huang, Chang-Hao Yang, Po-Ting Yeh, Ta-Ching Chen, Allen Ho, Muh-Shy Chen,

PURPOSE: To investigate the long-term results of a novel technique to preserve the foveolar cone without peeling off the foveolar internal limiting membrane (ILM) during myopic traction maculopathy surgery. METHODS: Nineteen patients (19 eyes) were retrospectively studied and divided into 2 groups by the extent of ILM peeled and followed ... Read more >>

Retina (Philadelphia, Pa.) (Retina (Philadelphia, Pa.))
[2014, 34(9):1833-1840]

Cited: 4 times

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Recurrence of corneal neovascularization associated with lipid deposition after subconjunctival injection of bevacizumab.

Hsiao-Sang Chu, Ta-Ching Chen, Fung-Rong Hu, Wei-Li Chen,

PURPOSE: To report 7 cases of recurrent corneal neovascularization (NV) and lipid deposition after subconjunctival injection of bevacizumab for the treatment of corneal NV-induced lipid keratopathy. METHODS: We conducted a prospective interventional case series that included 20 eyes of chronic lipid keratopathy that received bevacizumab injection for the treatment of ... Read more >>

Cornea (Cornea)
[2013, 32(11):1446-1453]

Cited: 5 times

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Intravitreal expansile gas in the treatment of early macular hole: reappraisal.

Ta-Ching Chen, Chang-Hao Yang, Chung-May Yang,

PURPOSE: To study the effects of intravitreal injection (IVI) of expansile gas for early macular holes (EMH). METHODS: Prospective interventional case series. Twelve eyes of 12 patients with EMH (stage 2) underwent IVI of perfluoropropane 0.2 ml followed by 5 days' facedown positioning. RESULTS: Six cases (50%) achieved vitreous-macula separation. ... Read more >>

Ophthalmologica (Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde)
[2012, 228(3):159-166]

Cited: 6 times

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Long-term evaluation of refractive status and optical components in eyes of children born prematurely.

Ta-Ching Chen, Tzu-Hsun Tsai, Yung-Feng Shih, Po-Ting Yeh, Chang-Hao Yang, Fu-Chang Hu, Luke Long-Kuang Lin, Chung-May Yang,

PURPOSE: To evaluate the refractive status and optical components in school age children born prematurely and to examine the risk factors associated with refractive errors. METHODS: The participants were a cohort of children aged 7 to 9 years with gestational age less than 35 weeks or birth weight less than ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2010, 51(12):6140-6148]

Cited: 37 times

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Formation of idiopathic macular hole-reappraisal.

Po-Ting Yeh, Ta-Ching Chen, Chang-Hao Yang, Tzyy-Chang Ho, Muh-Shy Chen, Jen-Shang Huang, Chung-May Yang,

The study is intended to examine the development of macular hole in idiopathic conditions.A 2-year case file of optical coherence tomography (OCT) with the initial diagnosis of idiopathic impending hole (IH) or lamellar hole (LH) was reviewed. All cases of IH or LH were sequentially examined for more than 9 ... Read more >>

Graefes Arch. Clin. Exp. Ophthalmol. (Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie)
[2010, 248(6):793-798]

Cited: 11 times

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