Full Text Journal Articles by
Author T Walsh

Advertisement

Find full text journal articles






Isolation and characterization of novel reassortant mammalian orthoreovirus from pigs in the United States.

Liping Wang, Yan Li, Timothy Walsh, Zhenyu Shen, Yonghai Li, Nirmalendu Deb Nath, Jinhwa Lee, Baoliang Zheng, Ying Tao, Clinton R Paden, Krista Queen, Shuping Zhang, Suxiang Tong, Wenjun Ma,

Mammalian orthoreovirus (MRV) infects multiple mammalian species including humans. A United States Midwest swine farm with approximately one thousand 3-month-old pigs experienced an event, in which more than 300 pigs showed neurological signs, like "down and peddling", with approximately 40% mortality. A novel MRV was isolated from the diseased pigs. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):1137-1147]

Cited: 0 times

View full text PDF listing >>



Prevalence and risk analysis of mobile colistin resistance and extended-spectrum β-lactamase genes carriage in pet dogs and their owners: a population based cross-sectional study.

Lei Lei, Yongqiang Wang, Junjia He, Chang Cai, Qingzhi Liu, Dawei Yang, Zhiyu Zou, Lingyu Shi, Jianqin Jia, Yang Wang, Timothy R Walsh, Jianzhong Shen, Yougang Zhong,

Mobile colistin resistance gene <i>mcr-1</i> and extended-spectrum <i>β</i>-lactamase gene <i>bla</i> <sub>CTX-M</sub> are highly prevalent in human - and pet-derived bacteria. Isolation of identical strains of <i>mcr-1</i>-positive <i>Escherichia coli</i> (MCRPEC) or <i>bla</i> <sub>CTX-M</sub>-positive <i>E. coli</i> (CTX-MPEC) from pets and humans highlighted the potential for co-colonization of antibiotic-resistant bacteria which can be ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):242-251]

Cited: 1 time

View full text PDF listing >>



Advertisement

Randomised Controlled Trial of Intravenous Nafamostat Mesylate in COVID Pneumonitis: Phase 1b/2a Experimental Study to Investigate Safety, Pharmacokinetics and Pharmacodynamics

Tom Michael Quinn, Erin Gaughan, Annya Bruce, Jean Antonelli, Richard O'Connor, Feng Li, Sarah McNamara, Oliver Koch, Claire MacKintosh, David Dockrell, Timothy Walsh, Kevin Blyth, Colin Church, Jürgen Schwarze, Cecilia Boz, Asta Valanciute, Matthew Burgess, Philip Emanuel, Bethany Mills, Giulia Rinaldi, Gareth Hardisty, Ross Mills, Emily Findlay, Sunny Jabball, Andrew Duncan, Sinéad Plant, Adam Marshall, Irene Young, Kay Russell, Emma Scholefield, Alastair Nimmo, Islom Nazarov, Grant Churchill, James McCullagh, Kourosh Ebrahimi, Colin Ferrett, Kate Templeton, Steve Rannard, Andrew Owen, Anne Moore, Keith Finlayson, Manu Shankar-Hari, John Norrie, Richard Parker, Ahsan Akram, Daniel Anthony, James Dear, Nik Hirani, Kev Dhaliwal,

Background: Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including safety data. One such drug is Nafamostat Mesylate.<br><br>Methods: We present the findings of a phase Ib/II open label, platform randomised controlled trial of intravenous Nafamostat in hospitalised patients with ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Tuning Materials-Binding Peptide Sequences toward Gold- and Silver-Binding Selectivity with Bayesian Optimization.

Zak E Hughes, Michelle A Nguyen, Jialei Wang, Yang Liu, Mark T Swihart, Matthias Poloczek, Peter I Frazier, Marc R Knecht, Tiffany R Walsh,

Peptide sequence engineering can potentially deliver materials-selective binding capabilities, which would be highly attractive in numerous biotic and abiotic nanomaterials applications. However, the number of known materials-selective peptide sequences is small, and identification of new sequences is laborious and haphazard. Previous attempts have sought to use machine learning and other ... Read more >>

ACS Nano (ACS nano)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Platelet generation from circulating megakaryocytes is triggered in the lung vasculature

Xiaojuan Zhao, Dominic Alibhai, Tony Walsh, Nathalie Tarassova, Semra Birol, Christopher Williams, Chris Neil, Elizabeth Aitken, Amie Waller, Jose Ballester-Beltran, Peter Gunning, Edna Hardeman, Ejaife Agbani, Ingeborg Hers, Cedric Ghevaert, Alastair Poole,

Platelets, small hemostatic blood cells, are derived from megakaryocytes, although the generation process is not clear. Only small numbers of platelets have been produced in systems outside the body, where bone marrow and lung are proposed as sites of platelet generation. Here we show that perfusion of megakaryocytes ex vivo ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

, Lise J Estcourt, Alexis F Turgeon, Zoe K McQuilten, Bryan J McVerry, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Donald M Arnold, Abigail Beane, Philippe Bégin, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Janet E Birchall, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Meredith Buxton, Jeannie L Callum, Michaël Chassé, Allen C Cheng, Matthew E Cove, James Daly, Lennie Derde, Michelle A Detry, Menno De Jong, Amy Evans, Dean A Fergusson, Matthew Fish, Mark Fitzgerald, Claire Foley, Herman Goossens, Anthony C Gordon, Iain B Gosbell, Cameron Green, Rashan Haniffa, Heli Harvala, Alisa M Higgins, Thomas E Hills, Veronica C Hoad, Christopher Horvat, David T Huang, Cara L Hudson, Nao Ichihara, Emma Laing, Abigail A Lamikanra, François Lamontagne, Patrick R Lawler, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Sheila MacLennan, John Marshall, Daniel F McAuley, John F McDyer, Anna McGlothlin, Shay McGuinness, Gail Miflin, Stephanie Montgomery, Paul R Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Jane C Parker, Nicole Priddee, Damian F J Purcell, Luis F Reyes, Peter Richardson, Nancy Robitaille, Kathryn M Rowan, Jennifer Rynne, Hiroki Saito, Marlene Santos, Christina T Saunders, Ary Serpa Neto, Christopher W Seymour, Jon A Silversides, Alan A Tinmouth, Darrell J Triulzi, Anne M Turner, Frank van de Veerdonk, Timothy S Walsh, Erica M Wood, Scott Berry, Roger J Lewis, David K Menon, Colin McArthur, Ryan Zarychanski, Derek C Angus, Steve A Webb, David J Roberts, Manu Shankar-Hari,

<h4>Importance</h4>The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.<h4>Objective</h4>To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.<h4>Design, setting, and participants</h4>The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or ... Read more >>

JAMA (JAMA)
[2021, 326(17):1690-1702]

Cited: 0 times

View full text PDF listing >>



Real-World Impact of the Accelerate PhenoTest ® BC Kit on patients with bloodstream infections in IOAS (Improving Outcomes and Antimicrobial Stewardship): A Quasi-Experimental Multicenter Study.

Amira A Bhalodi, Shawn H MacVane, Bradley Ford, Dilek Ince, Patrick M Kinn, Kelly M Percival, Derek N Bremmer, Dustin R Carr, Thomas L Walsh, Micah M Bhatti, Samuel A Shelburne, Romney M Humphries, Kaleb Wolfe, Eric R Rosenbaum, Ryan K Dare, Johann Kolev, Meghan Madhusudhan, Michael A Ben-Aderet, Margie A Morgan,

<h4>Background</h4>Bloodstream infections (BSI) are a leading cause of morbidity and mortality in hospitalized patients. The IOAS (Improving Outcomes and Antimicrobial Stewardship) study seeks to evaluate the impact of the Accelerate PhenoTest® BC Kit (AXDX) on antimicrobial use and clinical outcomes in BSIs.<h4>Methods</h4>This multicenter, quasi-experimental study compared clinical and antimicrobial stewardship ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Diagnosing Ventilator-Associated Pneumonia (VAP) In UK NHS ICUs: The Perceived Value And Role of A Novel Optical Technology

William Stephen Jones, Jana Suklan, Amanda Winter, Kile Green, Tom Craven, Annya Bruce, Joanne Mair, Kev Dhaliwal, Tim Walsh, John Simpson, Sara Graziadio, Joy Allen,

<h4>Background: </h4> Diagnosing ventilator-associated pneumonia (VAP) in an intensive care unit (ICU) is a complex process. Our aim was to collect, evaluate and represent the information relating to current clinical practice for the diagnosis of VAP in UK NHS ICUs, and to explore the potential value and role of a ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Implementation of School-Based COVID-19 Testing Programs in Underserved Populations.

Emily E Haroz, Luther G Kalb, Jason G Newland, Jennifer L Goldman, Dana Keener Mast, Linda K Ko, Ryan Grass, Parth Shah, Tyler Walsh, Jennifer E Schuster,

Pediatrics (Pediatrics)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study.

Emma A Hurst, Richard J Mellanby, Ian Handel, David M Griffith, Adriano G Rossi, Timothy S Walsh, Manu Shankar-Hari, Jake Dunning, Natalie Z Homer, Scott G Denham, Kerri Devine, Paul A Holloway, Shona C Moore, Ryan S Thwaites, Romit J Samanta, Charlotte Summers, Hayley E Hardwick, Wilna Oosthuyzen, Lance Turtle, Malcolm G Semple, Peter J M Openshaw, J Kenneth Baillie, Clark D Russell, ,

<h4>Objectives</h4>The steroid hormone vitamin D has roles in immunomodulation and bone health. Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy vitamin D (25(OH)D) measurements in hospitalised people with COVID-19 and influenza A and in survivors of critical illness to test the hypotheses that vitamin D insufficiency scales ... Read more >>

BMJ Open (BMJ open)
[2021, 11(10):e055435]

Cited: 0 times

View full text PDF listing >>



Omics-based ecosurveillance uncovers the influence of estuarine macrophytes on sediment microbial function and metabolic redundancy in a tropical ecosystem.

Rohan M Shah, Sarah Stephenson, Joseph Crosswell, Daniel Gorman, Katie E Hillyer, Enzo A Palombo, Oliver A H Jones, Stephen Cook, Levente Bodrossy, Jodie van de Kamp, Thomas K Walsh, Andrew Bissett, Andrew D L Steven, David J Beale,

Vertical zonation within estuarine ecosystems can strongly influence microbial diversity and function by regulating competition, predation, and environmental stability. The degree to which microbial communities exhibit horizontal patterns through an estuary has received comparatively less attention. Here, we take a multi-omics ecosurveillance approach to study environmental gradients created by the ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, :151175]

Cited: 0 times

View full text PDF listing >>



Predicting the unpredictable: how dynamic COVID-19 policies and restrictions challenge model forecasts

Farah Houdroge, Anna Palmer, Dominic Delport, Tom Walsh, Sherrie Kelly, Samuel Hainsworth, Romesh Abeysuriya, Robyn Stuart, Cliff Kerr, Paul Coplan, David Wilson, Nick Scott,

<h4>Introduction: </h4> To retrospectively assess the accuracy of a mathematical modelling study that projected the rate of COVID-19 diagnoses for 72 locations worldwide in 2021, and to identify predictors of model accuracy. Methods Between June and August 2020, an agent-based model was used to project rates of COVID-19 infection ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Health and Economic Benefits of Achieving Contraceptive and Maternal Health Targets in Small Island Developing States in the Pacific and Caribbean

Sherrie Kelly, Tom Walsh, Dominic Delport, Debra ten Brink, Rowan Martin-Hughes, Caroline Homer, Jennifer Butler, Olanike Adedeji, Davide De Beni, Federica Maurizio, Howard Friedman, Doretta Di Marco, Federico Tobar, Pilar de la Corte Molina, Andre Richards, Nick Scott,

Background: Reducing unmet need for modern contraception and expanding access to quality maternal health (MH) services are priorities for improving women’s health and economic empowerment including in Small Island Developing States in the Pacific and Caribbean. We estimated health benefits and return-on-investment for contraceptive and MH interventions to help ensure ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



In Vitro User Assessment of a Novel Wound Protection and Specimen Extraction System for Laparoscopic Procedures Involving Morcellation.

Adriana Olaru, Mohammad F Khan, Tom Walsh, Donal Brennan, Ronan A Cahill,

<h4>Introduction</h4>The risk of unknowingly disseminating leiomyosarcoma by morcellation in women undergoing laparoscopic hysterectomy has massively impacted gynaecological practice. Here, we present the results of an in vitro assessment of a novel protection system developed to mitigate this hazard.<h4>Methods</h4>The Tissue Containment System for Manual Morcellation (Guardenia™, Advanced Surgical Concepts, Wicklow, Ireland) ... Read more >>

Surg Technol Int (Surgical technology international)
[2021, 39:]

Cited: 0 times

View full text PDF listing >>



Adenovirus viremia after in vivo T-cell depleted allo-transplant in adults: low lymphocyte counts are associated with uncontrolled viremia and fatal outcomes.

Ok-Kyong Chaekal, Rosemary Soave, Zhengming Chen, Tsiporah Shore, Sebastian Mayer, Adrienne Phillips, Jing Mei Hsu, Alexandra Gomez-Arteaga, Hanna Rennert, Alex Drelick, Nina Orfali, Thomas J Walsh, Catherine B Small, Rosy Priya L Kodiyanplakkal, Markus Plate, Michael J Satlin, Koen van Besien,

The incidence of adenovirus viremia and the role of screening in preventing adenovirus disease in adult transplant recipients are not well defined. Between January 2017 and May 2020, 262 allogeneic transplants were performed using <i>in vivo</i> T-cell depletion. Adenovirus viremia was found in 59 patients for a cumulative incidence of 10% ... Read more >>

Leuk Lymphoma (Leukemia & lymphoma)
[2021, :1-8]

Cited: 0 times

View full text PDF listing >>



Enamel Caries Detection and Diagnosis: An Analysis of Systematic Reviews.

T Walsh, R Macey, D Ricketts, A Carrasco Labra, H Worthington, A J Sutton, S Freeman, A M Glenny, P Riley, J Clarkson, E Cerullo,

Detection and diagnosis of caries-typically undertaken through a visual-tactile examination, often with supporting radiographic investigations-is commonly regarded as being broadly effective at detecting caries that has progressed into dentine and reached a threshold where restoration is necessary. With earlier detection comes an opportunity to stabilize disease or even remineralize the ... Read more >>

J Dent Res (Journal of dental research)
[2021, :220345211042795]

Cited: 0 times

View full text PDF listing >>



Predicting the unpredictable: how dynamic COVID-19 policies and restrictions challenge model forecasts

Farah Houdroge, Anna Palmer, Dominic Delport, Tom Walsh, Sherrie Kelly, Samuel Hainsworth, Romesh Abeysuriya, Robyn Stuart, Cliff Kerr, Paul Coplan, David Wilson, Nick Scott,

<h4>Introduction</h4> To retrospectively assess the accuracy of a mathematical modelling study that projected the rate of COVID-19 diagnoses for 72 locations worldwide in 2021, and to identify predictors of model accuracy. <h4>Methods</h4> Between June and August 2020, an agent-based model was used to project rates of COVID-19 infection incidence and ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Expansion of KPC-producing Enterobacterales in four large hospitals in Hanoi, Vietnam.

Tran Dieu Linh, Nguyen Hoai Thu, Keigo Shibayama, Masato Suzuki, LayMint Yoshida, Pham Duy Thai, Dang Duc Anh, Tran Nhu Duong, Hong Son Trinh, Vu Phuong Thom, Luu Thi Vu Nga, Nguyen Thi Kim Phuong, Bui Thanh Thuyet, Timothy R Walsh, Le Viet Thanh, Anne-Laure Bañuls, H Rogier van Doorn, Tran Van Anh, Tran Huy Hoang,

<h4>Objectives</h4>The incidence of carbapenem resistance among nosocomial Gram-negative bacteria in Vietnam is high and increasing, including among Enterobacterales. In this study, we assessed the presence of one of the main carbapenemase genes, bla<sub>KPC</sub>, among carbapenem-resistant Enterobacterales (CRE) from four large hospitals in Hanoi, Vietnam, between 2010 and 2015, and described ... Read more >>

J Glob Antimicrob Resist (Journal of global antimicrobial resistance)
[2021, 27:200-211]

Cited: 0 times

View full text PDF listing >>



A role for arthropods as vectors of multidrug-resistant Enterobacterales in surgical site infections from South Asia.

Brekhna Hassan, Muhammad Ijaz, Asadullah Khan, Kirsty Sands, Georgios-Ion Serfas, Liam Clayfield, Maisra Mohammed El-Bouseary, Giulia Lai, Edward Portal, Afifah Khan, William J Watkins, Julian Parkhill, Timothy R Walsh,

Understanding how multidrug-resistant Enterobacterales (MDRE) are transmitted in low- and middle-income countries (LMICs) is critical for implementing robust policies to curb the increasing burden of antimicrobial resistance (AMR). Here, we analysed samples from surgical site infections (SSIs), hospital surfaces (HSs) and arthropods (summer and winter 2016) to investigate the incidence ... Read more >>

Nat Microbiol (Nature microbiology)
[2021, 6(10):1259-1270]

Cited: 0 times

View full text PDF listing >>



Multifunctional Thermoresponsive Microcarriers for High-Throughput Cell Culture and Enzyme-Free Cell Harvesting.

Seyed Mohammad Hossein Dabiri, Ehsan Samiei, Shahla Shojaei, Lucas Karperien, Bardia Khun Jush, Tavia Walsh, Maryam Jahanshahi, Sadegh Hassanpour, David Hamdi, Amir Seyfoori, Samad Ahadian, Ali Khademhosseini, Mohsen Akbari,

An effective treatment of human diseases using regenerative medicine and cell therapy approaches requires a large number of cells. Cultivation of cells on microcarriers is a promising approach due to the high surface-to-volume ratios that these microcarriers offer. Here, multifunctional temperature-responsive microcarriers (cytoGel) made of an interpenetrating hydrogel network composed ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2021, 17(44):e2103192]

Cited: 0 times

View full text PDF listing >>



Colonization With Fluoroquinolone-Resistant Enterobacterales Decreases the Effectiveness of Fluoroquinolone Prophylaxis in Hematopoietic Cell Transplant Recipients.

Michael J Satlin, Liang Chen, Claire Douglass, Michael Hovan, Emily Davidson, Rosemary Soave, Marisa La Spina, Alexandra Gomez-Arteaga, Koen van Besien, Sebastian Mayer, Adrienne Phillips, Jing-Mei Hsu, Rianna Malherbe, Catherine B Small, Stephen G Jenkins, Lars F Westblade, Barry N Kreiswirth, Thomas J Walsh,

<h4>Background</h4>Levofloxacin prophylaxis is recommended to prevent gram-negative bloodstream infections (BSIs) in patients with prolonged chemotherapy-induced neutropenia. However, increasing fluoroquinolone resistance may decrease the effectiveness of this approach.<h4>Methods</h4>We assessed the prevalence of colonization with fluoroquinolone-resistant Enterobacterales (FQRE) among patients admitted for hematopoietic cell transplantation (HCT) from November 2016 to August 2019 ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 73(7):1257-1265]

Cited: 1 time

View full text PDF listing >>



Controlling the Orientation and Viscoelasticity of Materials-Binding Peptides on Hexagonal Boron Nitride Using Fatty Acids.

Nermina Brljak, Marc R Knecht, Tiffany R Walsh,

The adsorption of materials-binding peptides to technologically relevant 2D nanosheets of <i>h</i>-BN could be transformative for both property modulation and materials applications. To enhance binding, integration of non-natural functionalities into the biomolecule could prove to be important. However, very little is understood regarding the impact of these biomolecular structural alterations ... Read more >>

J Phys Chem B (The journal of physical chemistry. B)
[2021, 125(37):10621-10628]

Cited: 0 times

View full text PDF listing >>



Restoring fertility in yeast hybrids: Breeding and quantitative genetics of beneficial traits.

Samina Naseeb, Federico Visinoni, Yue Hu, Alex J Hinks Roberts, Agnieszka Maslowska, Thomas Walsh, Katherine A Smart, Edward J Louis, Daniela Delneri,

Hybrids between species can harbor a combination of beneficial traits from each parent and may exhibit hybrid vigor, more readily adapting to new harsher environments. Interspecies hybrids are also sterile and therefore an evolutionary dead end unless fertility is restored, usually via auto-polyploidisation events. In the <i>Saccharomyces</i> genus, hybrids are ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

Cited: 0 times

View full text PDF listing >>



Genetic Heterogeneity and Core Clinical Features of NOG-Related-Symphalangism Spectrum Disorder.

Ryan J Carlson, Alicia Quesnel, Dawson Wells, Zippora Brownstein, Dror Gilony, Suleyman Gulsuner, Kathleen A Leppig, Karen B Avraham, Mary-Claire King, Tom Walsh, Jay Rubinstein,

<h4>Objectives</h4>To better distinguish NOG-related-symphalangism spectrum disorder (NOG-SSD) from chromosomal 17q22 microdeletion syndromes and to inform surgical considerations in stapes surgery for patients with NOG-SSD.<h4>Background</h4>Mutations in NOG cause a variety of skeletal syndromes that often include conductive hearing loss. Several microdeletions of chromosome 17q22 lead to severe syndromes with clinical characteristics ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(8):e1143-e1151]

Cited: 0 times

View full text PDF listing >>



Transgastric Drainage for Esophageal Injuries: A Dynamic Strategy for a Heterogenous Patient Cohort.

Patrick A Boland, Asila Abdelatif, Brian Gilmartin, Mayilone Arumugasamy, Thomas N Walsh,

<h4>Background</h4>Esophageal injury is a rare but potentially lethal surgical emergency. It is associated with significant morbidity and mortality because of mediastinal contamination and difficulty of access. Surgery in such septic patients exacts a heavy physiological price, mandating consideration of more conservative measures. We review our experience with transgastric drainage for ... Read more >>

Surg Laparosc Endosc Percutan Tech (Surgical laparoscopy, endoscopy & percutaneous techniques)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

1.3155 s