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A Multicentered Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended-Spectrum Beta-Lactamase Producing Enterobacterales Infections in Children.

Latania K Logan, Jared R Rispens, Rachel L Medernach, T Nicholas Domitrovic, Andrea M Hujer, Steven H Marshall, Susan D Rudin, Nadia K Qureshi, Xiaotian Zheng, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales-(Ent) infections are increasing in pediatrics. Before CTX-M ESBL emerged, the most common infection-associated ESBL genes were TEM and SHV-type ESBLs. We sought to define the current epidemiology of Ent infections in children due to blaTEM and blaSHV (TEM-SHV-Ent).<h4>Methods</h4>A retrospective case-control analysis of children with TEM-SHV-Ent infections ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):39-43]

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A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli.

Joel A Goldberg, Ha Nguyen, Vijay Kumar, Elizabeth J Spencer, Denton Hoyer, Emma K Marshall, Anna Cmolik, Margaret O'Shea, Steven H Marshall, Andrea M Hujer, Kristine M Hujer, Susan D Rudin, T Nicholas Domitrovic, Christopher R Bethel, Krisztina M Papp-Wallace, Latania K Logan, Federico Perez, Michael R Jacobs, David van Duin, Barry M Kreiswirth, Robert A Bonomo, Mark S Plummer, Focco van den Akker,

Treatment of multidrug-resistant Gram-negative bacterial pathogens represents a critical clinical need. Here, we report a novel γ-lactam pyrazolidinone that targets penicillin-binding proteins (PBPs) and incorporates a siderophore moiety to facilitate uptake into the periplasm. The MIC values of γ-lactam YU253434, 1, are reported along with the finding that 1 is ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2020, 63(11):5990-6002]

Cited: 1 time

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ARGONAUT II Study of the In Vitro Activity of Plazomicin against Carbapenemase-Producing Klebsiella pneumoniae.

Michael R Jacobs, Caryn E Good, Andrea M Hujer, Ayman M Abdelhamed, Daniel D Rhoads, Kristine M Hujer, Susan D Rudin, T Nicholas Domitrovic, Lynn E Connolly, Kevin M Krause, Robin Patel, Cesar A Arias, Barry N Kreiswirth, Laura J Rojas, Roshan D'Souza, Richard C White, Lauren M Brinkac, Kevin Nguyen, Indresh Singh, Derrick E Fouts, David van Duin, Robert A Bonomo, ,

Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2020, 64(5):]

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Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study.

David van Duin, Cesar A Arias, Lauren Komarow, Liang Chen, Blake M Hanson, Gregory Weston, Eric Cober, Omai B Garner, Jesse T Jacob, Michael J Satlin, Bettina C Fries, Julia Garcia-Diaz, Yohei Doi, Sorabh Dhar, Keith S Kaye, Michelle Earley, Andrea M Hujer, Kristine M Hujer, T Nicholas Domitrovic, William C Shropshire, An Dinh, Claudia Manca, Courtney L Luterbach, Minggui Wang, David L Paterson, Ritu Banerjee, Robin Patel, Scott Evans, Carol Hill, Rebekka Arias, Henry F Chambers, Vance G Fowler, Barry N Kreiswirth, Robert A Bonomo, ,

<h4>Background</h4>Carbapenem-resistant Enterobacterales (CRE) are a global threat. We aimed to describe the clinical and molecular characteristics of Centers for Disease Control and Prevention (CDC)-defined CRE in the USA.<h4>Methods</h4>CRACKLE-2 is a prospective, multicentre, cohort study. Patients hospitalised in 49 US hospitals, with clinical cultures positive for CDC-defined CRE between April 30, ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(6):731-741]

Cited: 2 times

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594. A Multi-Centered Study of the Clinical and Molecular Epidemiology of AmpC Cephalosporinase-Producing (AmpC) Enterobacteriaceae (Ent) Infections in Children

Rachel L Medernach, T Nicholas Domitrovic, Karen C Hayani, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Jared R Rispens, Xiaotian Zheng, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

Abstract Background AmpC producing Ent are an important cause of multidrug-resistant (MDR) infections in pediatrics. Since most AmpC Ent studies have been conducted in adults, we characterized the molecular epidemiology of AmpC Ent strains with transmissible resistance and identified factors associated with AmpC Ent infections in children. Methods A case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S280-S280]

Cited: 0 times

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Antibiotic Resistance in Enterobacteriaceae from Surface Waters in Urban Brazil Highlights the Risks of Poor Sanitation.

Patricia S Bartley, T Nicholas Domitrovic, Vanessa T Moretto, Cleiton S Santos, Rafael Ponce-Terashima, Mitermayer G Reis, Lucio M Barbosa, Ronald E Blanton, Robert A Bonomo, Federico Perez,

Surface waters are an unappreciated reservoir of antimicrobial resistance (AMR). Poor sanitation brings different species of environmental bacteria into contact, facilitating horizontal gene transfer. To investigate the role of surface waters as potential reservoirs of AMR, we studied the point prevalence of fecal contamination, AMR genes, and Enterobacteriaceae in an ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2019, 100(6):1369-1377]

Cited: 2 times

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Community Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, Jared R Rispens, Steven H Marshall, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Sreenivas Konda, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Fluoroquinolones are uncommonly prescribed in children, yet pediatric multidrug resistant (MDR) enterobacteriaceae (Ent) infections often reveal fluoroquinolone resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children.<h4>Methods</h4>A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children with third-generation ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(6):595-599]

Cited: 2 times

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Rapid Molecular Diagnostics to Inform Empiric Use of Ceftazidime/Avibactam and Ceftolozane/Tazobactam Against Pseudomonas aeruginosa: PRIMERS IV.

Scott R Evans, Thuy Tien T Tran, Andrea M Hujer, Carol B Hill, Kristine M Hujer, Jose R Mediavilla, Claudia Manca, T Nicholas Domitrovic, Federico Perez, Michael Farmer, Kelsey M Pitzer, Brigid M Wilson, Barry N Kreiswirth, Robin Patel, Michael R Jacobs, Liang Chen, Vance G Fowler, Henry F Chambers, Robert A Bonomo, ,

<h4>Background</h4>Overcoming β-lactam resistance in pathogens such as Pseudomonas aeruginosa is a major clinical challenge. Rapid molecular diagnostics (RMDs) have the potential to inform selection of empiric therapy in patients infected by P. aeruginosa.<h4>Methods</h4>In this study, we used a heterogeneous collection of 197 P. aeruginosa that included multidrug-resistant isolates to determine ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 68(11):1823-1830]

Cited: 8 times

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A Multi-Centered Case-Case-Control Study of Factors Associated With Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Infections in Children and Young Adults.

Latania K Logan, David C Nguyen, Felicia A Scaggs Huang, Nadia K Qureshi, Angella Charnot-Katsikas, Allison H Bartlett, Xiaotian Zheng, Andrea M Hujer, T Nicholas Domitrovic, Steven H Marshall, Robert A Bonomo, Robert A Weinstein,

<h4>Background</h4>Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae (KPC-CRE) are multidrug-resistant organisms causing morbidity and mortality worldwide. KPC-CRE prevalence is increasing in pediatric populations, though multi-centered data are lacking. Identifying risk factors for KPC-CRE infection in children and classifying genotypes is a priority in this vulnerable population.<h4>Methods</h4>A case-case-control study of patients (0-22 years) ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(5):490-495]

Cited: 3 times

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The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, T Nicholas Domitrovic, Jared R Rispens, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Xiaotian Zheng, Sreenivas Konda, Robert A Weinstein, Robert A Bonomo,

<h4>Introduction</h4>The pandemic of extended-spectrum beta-lactamase-(ESBL)-producing Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent).<h4>Methods</h4>A retrospective matched case-control analysis of children with CTX-M-9-grp-Ent infections who received medical care at three Chicago area ... Read more >>

Infect Dis Ther (Infectious diseases and therapy)
[2019, 8(2):243-254]

Cited: 2 times

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2336. Resistance Mechanisms and Factors Associated With CTX-M-9 Group Extended-Spectrum β-Lactamase (ESBL)-Producing Infections in Children.

Rachel L Medernach, T Nicholas Domitrovic, Jared R Rispens, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Xiaotian Zheng, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

AbstractBackgroundThere is an increasing incidence of extended-spectrum β-lactamase (ESBL) producing infections in children. However, most studies focus only on CTX-M-1 group (CTX-M-15). We sought to define the epidemiology of the CTX-M-9 group (CTX-M-9) producing infections in children to devise more effective treatment and prevention strategies.MethodsA case–control study of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S694-S694]

Cited: 0 times

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ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases.

Michael R Jacobs, Ayman M Abdelhamed, Caryn E Good, Daniel D Rhoads, Kristine M Hujer, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Sandra S Richter, David van Duin, Barry N Kreiswirth, Chris Greco, Derrick E Fouts, Robert A Bonomo,

The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant <i>Acinetobacter baumannii</i> complex, <i>Stenotrophomonas maltophilia</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacteriaceae</i> strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC<sub>90</sub>s against <i>A. baumannii</i>, <i>S. maltophilia</i>, and <i>P. ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2019, 63(1):]

Cited: 12 times

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The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

Courtney L Luterbach, Ashley Boshe, Heather I Henderson, Eric Cober, Sandra S Richter, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Andrea M Hujer, Kristine M Hujer, Susan D Rudin, T Nicholas Domitrovic, Yohei Doi, Keith S Kaye, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin,

In the Consortium on Resistance Against Carbapenems in <i>Klebsiella</i> and other <i>Enterobacteriaceae</i> (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant <i>Enterobacteriaceae</i> (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(1):ofy351]

Cited: 1 time

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1348. In vitro Activity of Plazomicin, a Next-Generation Aminoglycoside, Against Carbapenemase-Producing Klebsiella pneumoniae

Michael R Jacobs, Caryn E Good, Ayman M Abdelhamed, Daniel D Rhoads, Kristine M Hujer, Andrea M Hujer, Susan D Rudin, T Nicholas Domitrovic, Lynn Connolly, Kevin M Krause, Sandra S Richter, David Van Duin, Barry N Kreiswirth, Robert A Bonomo, Antibiotic Resistance Leadership Group,

Abstract <h4>Background</h4> Plazomicin is a next-generation aminoglycoside with in vitro activity against multidrug-resistant Gram-negative species, including carbapenem-resistant isolates. The Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE) is a federally funded, prospective multicenter consortium of 20 hospitals from nine US healthcare systems to track carbapenem-resistant Enterobacteriaceae. <h4>Methods</h4> ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S412-S413]

Cited: 0 times

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Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae.

Anubhav Kanwar, Steven H Marshall, Federico Perez, Myreen Tomas, Michael R Jacobs, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Laura J Rojas, Barry N Kreiswirth, Liang Chen, Miguel Quinones-Mateu, David van Duin, Robert A Bonomo, ,

We report the emergence of colistin resistance in <i>Klebsiella pneumoniae</i> carbapenemase (KPC)-producing <i>Klebsiella pneumoniae</i> after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the <i>mgrB</i> gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(4):ofy054]

Cited: 0 times

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Evaluation of Sensititre Broth Microdilution Plate for determining the susceptibility of carbapenem-resistant Klebsiella pneumoniae to polymyxins.

Sandra S Richter, James Karichu, Joshua Otiso, Hillary Van Heule, George Keller, Eric Cober, Laura J Rojas, Andrea M Hujer, Kristine M Hujer, Steve Marshall, Frederico Perez, Susan D Rudin, T Nicholas Domitrovic, Keith S Kaye, Robert Salata, David van Duin, Robert A Bonomo,

Colistin and polymyxin B MICs were determined for 106 carbapenem-resistant Klebsiella pneumoniae (CR-Kp) isolates using Sensititre Research Use Only GNX2F plates (Thermo Fisher) and compared to CLSI broth macrodilution (BMD) as the reference method. For colistin, EUCAST breakpoints were applied and testing of isolates with very major (VM) errors was ... Read more >>

Diagn Microbiol Infect Dis (Diagnostic microbiology and infectious disease)
[2018, 91(1):89-92]

Cited: 3 times

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Nosocomial Outbreak of Extensively Drug-Resistant Acinetobacter baumannii Isolates Containing blaOXA-237 Carried on a Plasmid.

Andrea M Hujer, Paul G Higgins, Susan D Rudin, Genevieve L Buser, Steven H Marshall, Kyriaki Xanthopoulou, Harald Seifert, Laura J Rojas, T Nicholas Domitrovic, P Maureen Cassidy, Margaret C Cunningham, Robert Vega, Jon P Furuno, Christopher D Pfeiffer, Zintars G Beldavs, Meredith S Wright, Michael R Jacobs, Mark D Adams, Robert A Bonomo,

Carbapenem antibiotics are among the mainstays for treating infections caused by <i>Acinetobacter baumannii</i>, especially in the Northwest United States, where carbapenem-resistant <i>A. baumannii</i> remains relatively rare. However, between June 2012 and October 2014, an outbreak of carbapenem-resistant <i>A. baumannii</i> occurred in 16 patients from five health care facilities in the ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2017, 61(11):]

Cited: 5 times

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A Multicenter Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended- Spectrum β-Lactamase producing (ESBL) () Infections in Children.

Jared R Rispens, Rachel L Medernach, Andrea M Hujer, T Nicholas Domitrovic, Steven H Marshall, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Mary K Hayden, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

AbstractBackgroundESBL infections are increasingly prevalent in the pediatric population; however, most ESBL studies have focused on adults and/or CTX-M-type strains. We sought to characterize the molecular epidemiology of ESBL strains and to identify factors associated with TEM- and SHV-type ESBL (TEMSHV ) infections in children.MethodsA case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S679-S679]

Cited: 0 times

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Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis.

Travis B Nielsen, Paul Pantapalangkoor, Brian M Luna, Kevin W Bruhn, Jun Yan, Ken Dekitani, Sarah Hsieh, Brandon Yeshoua, Bryan Pascual, Evgeny Vinogradov, Kristine M Hujer, T Nicholas Domitrovic, Robert A Bonomo, Thomas A Russo, Magda Lesczcyniecka, Thomas Schneider, Brad Spellberg,

<h4>Background</h4>Extremely drug-resistant (XDR) Acinetobacter baumannii is one of the most commonly encountered, highly resistant pathogens requiring novel therapeutic interventions.<h4>Methods</h4>We developed C8, a monoclonal antibody (mAb), by immunizing mice with sublethal inocula of a hypervirulent XDR clinical isolate.<h4>Results</h4>C8 targets capsular carbohydrate on the bacterial surface, enhancing opsonophagocytosis. Treating with a single ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2017, 216(4):489-501]

Cited: 17 times

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A Prospective Observational Study of the Epidemiology, Management, and Outcomes of Skin and Soft Tissue Infections Due to Carbapenem-Resistant Enterobacteriaceae.

Oryan Henig, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Steve Marshall, Susan D Rudin, T Nicholas Domitrovic, Andrea M Hujer, Kristine M Hujer, Yohei Doi, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin, Keith S Kaye, ,

<h4>Background</h4>This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant <i>Enterobacteriaceae</i> (CRE).<h4>Methods</h4>Patients from the Consortium on Resistance Against Carbapenem in <i>Klebsiella</i> and Other <i>Enterobacteriaceae</i> (CRACKLE-1) from December 24, 2011 to October 1, 2014 with wound cultures positive ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(3):ofx157]

Cited: 3 times

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NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas.

Laura J Rojas, Andrea M Hujer, Susan D Rudin, Meredith S Wright, T Nicholas Domitrovic, Steven H Marshall, Kristine M Hujer, Sandra S Richter, Eric Cober, Federico Perez, Mark D Adams, David van Duin, Robert A Bonomo,

Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant <i>Klebsiella pneumoniae</i> ST147 isolate harboring <i>bla</i><sub>NDM-5</sub> and <i>bla</i><sub>OXA-181</sub> from a young man who underwent abdominal surgery in India. <i>bla</i><sub>NDM-5</sub> was located on an IncFII plasmid of ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2017, 61(7):]

Cited: 18 times

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A cold hard menace: A contaminated ice machine as a potential source for transmission of carbapenem-resistant Acinetobacter baumannii.

Anubhav Kanwar, T Nicholas Domitrovic, Sreelatha Koganti, Peter Fuldauer, Jennifer L Cadnum, Robert A Bonomo, Curtis J Donskey,

During an investigation of potential sources of transmission of multidrug-resistant gram-negative bacilli on a spinal cord injury unit, we recovered genetically related carbapenem-resistant Acinetobacter baumannii isolates from the stool of 3 patients, the hands of a nurse, and an ice machine water outlet spout and drain. Our findings suggest that ... Read more >>

Am J Infect Control (American journal of infection control)
[2017, 45(11):1273-1275]

Cited: 2 times

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Correction for Evans et al., "Informing Antibiotic Treatment Decisions: Evaluating Rapid Molecular Diagnostics To Identify Susceptibility and Resistance to Carbapenems against Acinetobacter spp. in PRIMERS III".

Scott R Evans, Andrea M Hujer, Hongyu Jiang, Carol B Hill, Kristine M Hujer, Jose R Mediavilla, Claudia Manca, Thuy Tien T Tran, T Nicholas Domitrovic, Paul G Higgins, Harald Seifert, Barry N Kreiswirth, Robin Patel, Michael R Jacobs, Liang Chen, Rangarajan Sampath, Thomas Hall, Christine Marzan, Vance G Fowler, Henry F Chambers, Robert A Bonomo,

J Clin Microbiol (Journal of clinical microbiology)
[2017, 55(6):1970]

Cited: 0 times

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A Multicenter Case-Case–control Study of Factors Associated with Klebsiella pneumoniae Carbapenemase (KPC)-Producing Enterobacteriaceae (KPC-CRE) Infections in Children

David C Nguyen, Felicia Scaggs-Huang, Angella Charnot-Katsikas, Allison H Bartlett, Xiaotian Zheng, Nadia K Qureshi, Andrea M Hujer, T Nicholas Domitrovic, Robert A Bonomo, Robert A Weinstein, Latania K Logan,

Abstract <h4>Background</h4> KPC-CRE are multidrug-resistant organisms (MDRO) associated with morbidity and mortality worldwide. KPC-CRE infection prevalence is increasing in the pediatric population; however, multi-centered pediatric data are lacking. We sought to identify factors for KPC-CRE infections in children and to classify genotypes of infecting strains. <h4>Methods</h4> We conducted a case–case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S680-S680]

Cited: 0 times

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Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.

Laura J Rojas, Madiha Salim, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Steve Marshall, Susan D Rudin, T Nicholas Domitrovic, Andrea M Hujer, Kristine M Hujer, Yohei Doi, Keith S Kaye, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin, ,

<h4>Background</h4>Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp). Increasing use of colistin has led to resistance to this cationic antimicrobial peptide.<h4>Methods</h4>A cohort nested within the Consortium on Resistance against Carbapenems in Klebsiella pneumoniae (CRACKLE) was constructed of patients with infection, or colonization ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 64(6):711-718]

Cited: 49 times

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