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Diversity of hepatocellular carcinoma clones bearing hematopoietic malignancies-related chromosomal translocation.

Romain Parent, Marie-Laure Plissonnier, Brigitte Bancel, Wan-Li Liao, Sylvie Rumin, Remal Asaad, Marianne Till, Damien Sanlaville, Fabien Zoulim, Christian Trépo, Marie-Jeanne Marion,

Interpatient heterogeneity of hepatocellular carcinoma has been in-depth addressed. Intrapatient heterogeneity is less known. Four clones were freshly isolated from an Edmondson grade I HCV-associated hepatocellular carcinoma. Biochemical approaches, functional assays and cytogenetics were used. Albumin inducibility was uncoupled from canonical cytokeratin profiles, suggesting pathological combinations of hepatospecific and biliary ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2014, 115(4):666-677]

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