Full Text Journal Articles by
Author Sylvain Loric

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Combinatory therapy targeting mitochondrial oxidative phosphorylation improves efficacy of IDH mutant inhibitors in acute myeloid leukemia

Lucille Stuani, Marie Sabatier, Feng Wang, Nathalie Poupin, Claudie Bosc, Estelle Saland, Florence Castelli, Lara Gales, Camille Montersino, Emeline Boet, Evgenia Turtoi, Tony Kaoma, Thomas Farge, Nicolas Broin, Clément Larrue, Natalia Baran, Marc Conti, Sylvain Loric, Pierre-Luc Mouchel, Mathilde Gotanègre, Cédric Cassan, Laurent Fernando, Guillaume Cognet, Aliki Zavoriti, Mohsen Hosseini, Héléna Boutzen, Kiyomi Morita, Andrew Futreal, Emeline Chu-Van, Laurent Le Cam, Martin Carroll, Mary Selak, Norbert Vey, Claire Calmettes, Arnaud Pigneux, Audrey Bidet, Rémy Castellano, Francois Fenaille, Andrei Turtoi, Guillaume Cazals, Pierre Bories, Yves Gibon, Brandon Nicolay, Sébastien Ronseaux, Joe Marszalek, Courtney DiNardo, Marina Konopleva, Yves Collette, Laetitia Linares, Floriant Bellvert, Fabien Jourdan, Koichi Takahashi, Christian Récher, Jean-Charles Portais, Jean-Emmanuel Sarry,

Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, BCL-2 dependence and susceptibility to mitochondrial inhibitors in cancer cells. Here we show that high sensitivity to mitochondrial oxidative phosphorylation (OxPHOS) inhibitors is due to an enhanced mitochondrial oxidative ... Read more >>

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Relevance of total PSA and free PSA prescriptions.

Pierre-Jean Lamy, Jean-Paul Brouillet, Laurent Bermont, Guy Fouillet, Sylvain Loric,

The total PSA testing has been frequently criticized for its effectiveness in the early detection of prostate cancer. These widely resumed in and out of the medical community have led to a decrease in prescriptions. Recommendations against the use of PSA for screening have been issued in France and in ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2018, 76(6):659-663]

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[The level of evidence for the use of biomarkers in the early detection of prostate cancer].

Pierre-Jean Lamy, Anne-Sophie Gauchez, Laurent Salomon, Margaret Haugh, Jocelyn Ceraline, Yvonne Fulla, Agnès Georges, Stéphane Larré, Sylvain Loric, Elisabeth Luporsi, Pierre-Marie Martin, Catherine Mazerolles, Vincent Molinié, Pierre Mongiat-Artus, Jacques Piffret, François Thuillier, Paul Perrin, Xavier Rebillard, ,

To systematically review the evidence for the use of PSA and other biomarkers in the early detection of prostate cancer, we searched PubMed for clinical trials and studies assessing PSA and other biomarkers in the early detection of prostate cancer, published between 2000 and May 2013 that included >200 subjects. ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2016, 74(2):227-232]

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Score Predicting Acute Chest Syndrome During Vaso-occlusive Crises in Adult Sickle-cell Disease Patients.

Pablo Bartolucci, Anoosha Habibi, Mehdi Khellaf, Françoise Roudot-Thoraval, Giovanna Melica, Anne-Sophie Lascaux, Stéphane Moutereau, Sylvain Loric, Orianne Wagner-Ballon, Jugurtha Berkenou, Aline Santin, Marc Michel, Bertrand Renaud, Yves Lévy, Frédéric Galactéros, Bertrand Godeau,

Vaso-occlusive crisis (VOC), hallmark of sickle-cell disease (SCD), is the first cause of patients' Emergency-Room admissions and hospitalizations. Acute chest syndrome (ACS), a life-threatening complication, can occur during VOC, be fatal and prolong hospitalization. No predictive factor identifies VOC patients who will develop secondary ACS.This prospective, monocenter, observational study on ... Read more >>

EBioMedicine (EBioMedicine)
[2016, 10:305-311]

Cited: 5 times

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Six Months of Hydroxyurea Reduces Albuminuria in Patients with Sickle Cell Disease.

Pablo Bartolucci, Anoosha Habibi, Thomas Stehlé, Gaetana Di Liberto, Marie Georgine Rakotoson, Justine Gellen-Dautremer, Sylvain Loric, Stéphane Moutereau, Dil Sahali, Orianne Wagner-Ballon, Philippe Remy, Philippe Lang, Philippe Grimbert, Etienne Audureau, Bertrand Godeau, Frédéric Galacteros, Vincent Audard,

The earliest symptom of glomerular injury in patients with sickle cell disease (SCD) is microalbuminuria. The effect of hydroxyurea (HU) on urine albumin-to-creatinine ratio (ACR) is unclear and should be determined, because increasing numbers of patients with SCD take this drug to improve red blood cell function. In this cohort ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2016, 27(6):1847-1853]

Cited: 28 times

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[Early biological detection of prostate cancer: which test to use?].

Pierre-Jean Lamy, ,

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2015, 73 Suppl 1:29-30]

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Haematological determinants of cardiac involvement in adults with sickle cell disease.

Thibaud Damy, Diane Bodez, Anoosha Habibi, Aziz Guellich, Stéphane Rappeneau, Jocelyn Inamo, Soulef Guendouz, Justine Gellen-Dautremer, Serge Pissard, Sylvain Loric, Orianne Wagner-Ballon, Bertrand Godeau, Serge Adnot, Jean-Luc Dubois-Randé, Luc Hittinger, Frédéric Galactéros, Pablo Bartolucci,

Cardiac involvement is common in sickle cell disease (SCD). Studies are needed to establish haematological determinants of this involvement and prognostic markers. The aim of the study was to identify haematological factors associated with cardiac involvement in SCD and their impact on prognosis.This longitudinal observational study was performed on 1780 ... Read more >>

Eur. Heart J. (European heart journal)
[2016, 37(14):1158-1167]

Cited: 22 times

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Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea.

Marie Georgine Rakotoson, Gaetana Di Liberto, Etienne Audureau, Anoosha Habibi, Christine Fauroux, Sanam Khorgami, Anne Hulin, Sylvain Loric, France Noizat-Pirenne, Frédéric Galacteros, Pablo Bartolucci,

Dense red blood cells (DRBCs) are associated with chronic clinical manifestations of sickle-cell-disease (SCD). Hydroxyurea (HU) decreases the percent (%) DRBCs, thereby improving its therapeutic benefits, especially the prevention of SCD clinical complications, but parameters influencing %DRBCs remain unknown. The purpose of this study was to determine predictive biological parameters ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2015, 10:57]

Cited: 5 times

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Evidence of estrone-sulfate uptake modification in young and middle-aged rat prostate.

Frank Giton, Nanor Sirab, Grégory Franck, Marianne Gervais, Fabien Schmidlin, Tauhid Ali, Yves Allory, Alexandre de la Taille, Francis Vacherot, Sylvain Loric, Jean Fiet,

High plasma exposure to estrogens is often associated with prostate cancer. Reducing this phenomenon may present therapeutic benefits. The involvement of estrone sulphate (E1S), the most abundant circulating estrogen in men, has been partially studied in this age-related pathology. To investigate the consequences of plasma E1S overload on blood and ... Read more >>

J Steroid Biochem Mol Biol (The Journal of steroid biochemistry and molecular biology)
[2015, 152:89-100]

Cited: 8 times

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First evidence of subclinical renal tubular injury during sickle-cell crisis.

Vincent Audard, Stéphane Moutereau, Gaetana Vandemelebrouck, Anoosha Habibi, Mehdi Khellaf, Philippe Grimbert, Yves Levy, Sylvain Loric, Bertrand Renaud, Philippe Lang, Bertrand Godeau, Frédéric Galactéros, Pablo Bartolucci,

BACKGROUND: The pathophysiologic mechanisms classically involved in sickle-cell nephropathy include endothelial dysfunction and vascular occlusion. Arguments demonstrating that ischemia-reperfusion injury-related kidney damage might coincide with vaso-occlusive crisis (VOC) are lacking. METHODS: In this prospective study, we sought to determine whether tubular cells and glomerular permeability might be altered during VOC. ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2014, 9:67]

Cited: 9 times

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Role of natriuretic peptide to predict cardiac abnormalities in patients with hereditary transthyretin amyloidosis.

Thibaud Damy, Jean-François Deux, Stéphane Moutereau, Soulef Guendouz, Dania Mohty, Stéphane Rappeneau, Aziz Guellich, Luc Hittinger, Sylvain Loric, Jean-Pascal Lefaucheur, Violaine Plante-Bordeneuve,

BACKGROUND: Familial amyloid polyneuropathy (FAP) mainly targets the peripheral nervous system and heart. Early noninvasive detection of cardiac impairment is critical for therapeutic management. AIM: To assess if amino-terminal pro-brain natriuretic peptide (NT-proBNP) or troponin T (cTnT) can predict echocardiographic left-ventricle (LV) impairment in FAP. METHODS: Thirty-six asymptomatic carriers and ... Read more >>

Amyloid (Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis)
[2013, 20(4):212-220]

Cited: 17 times

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Prevention of contrast-induced nephropathy by N-acetylcysteine in critically ill patients: different definitions, different results.

Benjamin G Chousterman, Lila Bouadma, Stephane Moutereau, Sylvain Loric, Antonio Alvarez-Gonzalez, Armand Mekontso-Dessap, Jean-Pierre Laissy, Alain Rahmouni, Sandrine Katsahian, Laurent Brochard, Frédérique Schortgen,

PURPOSE: The use of N-acetylcysteine (NAC) for preventing contrast induced nephropathy (CIN) is debated in the intensive care unit. NAC may alter the concentration of serum creatinine and interfere with CIN diagnosis. The effectiveness of NAC was evaluated with a special attention on its specific effect on creatinine levels compared ... Read more >>

J Crit Care (Journal of critical care)
[2013, 28(5):701-709]

Cited: 8 times

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Androgens regulate Hedgehog signalling and proliferation in androgen-dependent prostate cells.

Nanor Sirab, Stéphane Terry, Frank Giton, Josselin Caradec, Mihelaiti Chimingqi, Stéphane Moutereau, Francis Vacherot, Alexandre de la Taille, Jean-Claude Kouyoumdjian, Sylvain Loric,

Prostate cancer (PCa) is androgen sensitive in its development and progression to metastatic disease. Hedgehog (Hh) pathway activation is important in the initiation and growth of various carcinomas including PCa. We and others have observed aberrations of Hh pathway during the progression of PCa to the castration-resistant state. The involvement ... Read more >>

Int. J. Cancer (International journal of cancer)
[2012, 131(6):1297-1306]

Cited: 14 times

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The value of urinary prostate cancer gene 3 (PCA3) scores in predicting pathological features at radical prostatectomy.

Xavier Durand, Evanguelos Xylinas, Camelia Radulescu, Rachel Haus-Cheymol, Stephane Moutereau, Gillaume Ploussard, Aurelien Forgues, Grégoire Robert, Francis Vacherot, Sylvain Loric, Yves Allory, Alain Ruffion, Alexandre de la Taille,

UNLABELLED: Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? PCA3 scores correlate to numerous histoprognostic factors, specifically tumour volume and positive surgical margins. These results may have a clinical impact in the near future on the selection ... Read more >>

BJU Int. (BJU international)
[2012, 110(1):43-49]

Cited: 33 times

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A bias in quantitative RT-PCR limit of detection is induced by the use of cancer cell lines in the molecular detection of circulating tumor cells.

Justine Prost à la Denise, Anne-France Dekairelle, Cédric Desbene, Stéphane Moutereau, Richard Douard, Michel Devanlay, Pascal Eschwege, Jean-Luc Gala, Sylvain Loric,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2011, 49(6):1073-1075]

Cited: 0 times

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Improved neopterin ELISA kit: a good compromise between HPLC results and clinical practice.

Stéphane Moutereau, Najia Ech Chad, Michel Devanlay, Liliane Esmilaire, Sylvain Loric,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2011, 49(3):553-554]

Cited: 1 time

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Prostate cancer antigen 3 score accurately predicts tumour volume and might help in selecting prostate cancer patients for active surveillance.

Guillaume Ploussard, Xavier Durand, Evanguelos Xylinas, Stéphane Moutereau, Camélia Radulescu, Aurélien Forgue, Nathalie Nicolaiew, Stéphane Terry, Yves Allory, Sylvain Loric, Laurent Salomon, Francis Vacherot, Alexandre de la Taille,

BACKGROUND: The optimal selection of prostate cancer (PCa) patients for active surveillance (AS) is currently being debated. OBJECTIVE: To assess the impact of urinary prostate cancer antigen 3 (PCA3) score as an AS criterion instead of and in addition to the current criteria. DESIGN, SETTING, AND PARTICIPANTS: We prospectively studied ... Read more >>

Eur. Urol. (European urology)
[2011, 59(3):422-429]

Cited: 77 times

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Renoprotective potency of amifostine in rat renal ischaemia-reperfusion.

Mohammed Koussai Chok, Marc Conti, Abdelhamid Almolki, Sophie Ferlicot, Sylvain Loric, Antoine Dürrbach, Gérard Benoît, Stéphane Droupy, Pascal Eschwège,

Kidneys from haemodynamically unstable donors may suffer from renal ischaemia-reperfusion (RIR) injury. RIR is associated with reactive oxygen species production that induces inflammation and activates the arachidonic acid (AA) pathway which converts AA into prostaglandin E(2). Amifostine was investigated for its renoprotective potential in RIR.The effect of amifostine (25 mg/kg  ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2010, 25(12):3845-3851]

Cited: 10 times

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Renoprotective potency of heme oxygenase-1 induction in rat renal ischemia-reperfusion.

Mohammed Koussai Chok, Sophie Ferlicot, Marc Conti, Abdelhamid Almolki, Antoine Dürrbach, Sylvain Loric, Gérard Benoît, Stéphane Droupy, Pascal Eschwège,

PURPOSE:Renal injury caused by ischemia-reperfusion (IR) can lead to acute renal failure or delayed graft function. Renal ischemia-reperfusion (RIR) induces inflammatory disorders via activation of arachidonic acid metabolism into prostaglandin E(2) (PGE(2)). Two inducible enzymes, COX-2 and microsomal prostaglandin E synthase (mPGES), regulate PGE(2) production. Heme oxygenase-1 (HO-1) is a ... Read more >>

Inflamm Allergy Drug Targets (Inflammation & allergy drug targets)
[2009, 8(4):252-259]

Cited: 19 times

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Should kidney tubular markers be adjusted for urine creatinine? The example of urinary cystatin C.

Marc Conti, Stéphane Moutereau, Liliane Esmilaire, Cédric Desbene, Karim Lallali, Michel Devanlay, Antoine Durrbach, Philippe Manivet, Pascal Eschwège, Sylvain Loric,

Evaluation of specific urinary markers with respect to urine creatinine (uCreat) is common. However, as uCreat is a function of both glomerular filtration and tubular secretion, using uCreat for specific tubular markers, suggests that glomerular function is normal, and there is no tubular secretion. Thus, adjusting values of any tubular ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2009, 47(12):1553-1556]

Cited: 7 times

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Elucidation of the natural artemisinin decomposition route upon iron interaction: a fine electronic redistribution promotes reactivity.

Wichit Nosoongnoen, Jaturong Pratuangdejkul, Korbtham Sathirakul, Alexandre Jacob, Marc Conti, Sylvain Loric, Jean-Marie Launay, Philippe Manivet,

The conformational analysis of artemisinin by molecular dynamics and quantum chemistry calculations revealed the existence of seven energy minima with specific interconversion pathways. Among the seven conformers, only , and were able to undergo bond rearrangements upon Fe(2+) interaction. These rearrangements were due to a peculiar puckering of the trioxane ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2008, 10(33):5083-5093]

Cited: 4 times

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Estrone sulfate (E1S), a prognosis marker for tumor aggressiveness in prostate cancer (PCa).

Frank Giton, Alexandre de la Taille, Yves Allory, Hervé Galons, Francis Vacherot, Pascale Soyeux, Claude Clément Abbou, Sylvain Loric, Olivier Cussenot, Jean-Pierre Raynaud, Jean Fiet,

Seeking insight into the possible role of estrogens in prostate cancer (PCa) evolution, we assayed serum E2, estrone (E1), and estrone sulfate (E1S) in 349 PCa and 100 benign prostatic hyperplasia (BPH) patients, and in 208 control subjects in the same age range (50-74 years). E1 (pmol/L+/-S.D.) and E1S (nmol/L+/-S.D.) ... Read more >>

J. Steroid Biochem. Mol. Biol. (The Journal of steroid biochemistry and molecular biology)
[2008, 109(1-2):158-167]

Cited: 15 times

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Fetuin-A is an independent predictor of death after ST-elevation myocardial infarction.

Pascal Lim, Jean-Phillipe Collet, Stéphane Moutereau, Nathalie Guigui, Laurens Mitchell-Heggs, Sylvain Loric, Magy Bernard, Said Benhamed, Gilles Montalescot, Jean-Luc Dubois Randé, Pascal Guéret,

BACKGROUND:Fetuin-A inhibits inflammation and has a protective effect against myocardial ischemia. Its deficiency has been found to be associated with cardiovascular death in patients with end-stage renal failure disease. We investigated the association between plasma fetuin-A and clinical outcome after ST-elevation acute myocardial infarction (STEMI). METHODS:We measured fetuin-A in 284 ... Read more >>

Clin. Chem. (Clinical chemistry)
[2007, 53(10):1835-1840]

Cited: 31 times

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Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer.

Richard Douard, Stéphane Moutereau, Pascal Pernet, Mihelaiti Chimingqi, Yves Allory, Philippe Manivet, Marc Conti, Michel Vaubourdolle, Paul-Henri Cugnenc, Sylvain Loric,

The Hedgehog (Hh) gene family is known to regulate development of stem cells. In addition, activation is responsible for the induction of GLI1 proto-oncogene and subsequent cellular proliferation. Sonic Hedgehog (SHh), one of the Hh family members promotes carcinogenesis in airway and pancreatic epithelia, is expressed in colonic stem cells. ... Read more >>

Surgery (Surgery)
[2006, 139(5):665-670]

Cited: 79 times

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Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay.

Richard Douard, Philippe Wind, Jean-Patrick Sales, Bruno Landi, Anne Berger, Joseph Benichou, François Gayral, Sylvain Loric, Paul-Henri Cugnenc,

BACKGROUND: The criteria commonly used for prognosis of colorectal cancer remain histoprognostic and are based on primarily TNM classification. The lack of discrimination of purely histoprognostic criteria is evidenced by the development of different outcomes in similarly staged patients. The aim of this work was to study the long-term prognostic ... Read more >>

Surgery (Surgery)
[2006, 139(4):556-562]

Cited: 7 times

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