Full Text Journal Articles by
Author Syed Ali Raza Naqvi

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Antihypertensive and Antihyperlipidemic Activity of Aqueous Methanolic Extract of Rauwolfia Serpentina in Albino Rats.

Syed Muhammad Ali Shah, Syed Ali Raza Naqvi, Naveed Munir, Sohaib Zafar, Muhammad Akram, Jaweria Nisar,

Rauwolfia serpentina has a wide range of therapeutic effects so this study was planned to explore the antihypertensive and antihyperlipidemic therapeutic responses of R serpentina doses using albino rats by measuring the blood pressure, biochemical parameters, and histological architecture of liver and kidney tissues. Thirty albino rats were divided into ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820942077]

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Synthesis, evaluation of thymidine phosphorylase and angiogenic inhibitory potential of ciprofloxacin analogues: Repositioning of ciprofloxacin from antibiotic to future anticancer drugs.

Sohail Anjum Shahzad, Ayesha Sarfraz, Muhammad Yar, Zulfiqar Ali Khan, Syed Ali Raza Naqvi, Sadia Naz, Nazeer Ahmad Khan, Umar Farooq, Razia Batool, Muhammad Ali,

Over expression of thymidine phosphorylase (TP) in various human tumors compared to normal healthy tissue is associated with progression of cancer and proliferation. The 2-deoxy-d-ribose is the final product of thymidine phosphorylase (TP) catalyzed reaction. Both TP and 2-deoxy-d-ribose are known to promote unwanted angiogenesis in cancerous cells. Discovery of ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 100:103876]

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Design and syntheses of 7-nitro-2-aryl-4H-benzo[d][1,3]oxazin-4-ones as potent anticancer and antioxidant agents.

Ayesha Bari, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Syed Ali Raza Naqvi, Shakeel Ahmad Khan, Hira Amjad, Ahsan Iqbal, Muhammad Yar,

A group of new nitro substituted benzoxazinones (3a-k) were synthesized from easily available 4-nitroanthranilic acid. All the synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. Anti-proliferative and pro-apoptotic potential of all the synthesized compounds (3a-k) was evaluated by MTT and Hoechst 33258 staining ... Read more >>

J Mol Struct (Journal of molecular structure)
[2020, 1214:128252]

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Development of 99mTc-SDP-choline SPECT radiopharmaceutical for imaging of cerebrovascular diseases.

Rashid Rasheed, Syed Ali Raza Naqvi, Rida Siraj, Nosheen Aslam, Muhammad Waqas Nasir, Ali Abbas, Muhammad Yaseen, Abdul Qaddus, Samina Roohi,

Cerebrovascular diseases are known as serious public health problem worldwide, which can be addressed more precisely through molecular imaging of non-functional brain cells. CDP-choline is an active cerebrovascular chemotherapeutic agent that can be used for diagnosis of cerebrovascular diseases post radiolabeling with γ-emitter radioisotopes. In this study we developed 99mTc ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(1(Supplementary)):241-244]

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Antimicrobial and Antihypercholesterolemic Activities of Pulicaria gnaphalodes.

Syed Ali Raza Naqvi, Syed Muhammad Ali Shah, Laiba Kanwal, Muhammad Saeed, Atta-Ul-Haq, Jaweria Nisar, Zonaira Nisar, Muhammad Akram,

Multidrug resistance has increased globally in the communities. Bacterial infections associated with health care have weakened the existing antimicrobial therapy and demand the search for alternative therapies. In the present investigation, the medicinal plant Pulicaria gnaphalodes from Quetta, Pakistan, has been screened for antimicrobial potential. In vitro antimicrobial efficacy of ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(1):1559325820904858]

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Purification and modification of Cordia myxa gum to enhance its nutraceutical attribute as binding agent.

Muhammad Farrukh Tahir, Shazia Anwer Bukhari, Fozia Anjum, Muhammad Qasim, Haseeb Anwar, Syed Ali Raza Naqvi,

The aim of the present study was to purify, hydrolyze and modify the Cordia myxa gum to document its binder potential in pharmaceutical tablets formulation. The hydrolysis and modification was carried out to remove impurities, roughness, increase thermal stability and to improve the functional properties of biopolymers. Physiochemical properties such ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(5(Supplementary)):2245-2250]

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225Ac Prostate-Specific Membrane Antigen Posttherapy α Imaging: Comparing 2 and 3 Photopeaks.

Sharjeel Usmani, Rashid Rasheed, Fareeda Al Kandari, Fahad Marafi, Syed Ali Raza Naqvi,

Ac-based PSMA-targeted therapy has emerged as promising agent for the treatment of metastatic castration-resistant prostate cancer. Posttherapy image is used for tracer localization and dosimetry. Prior 2 photopeaks of 440 and 218 KeV were reported for posttherapy imaging. Our study of gamma ray spectrum, phantom, and clinical images show that ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2019, 44(5):401-403]

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Optimization of Radiation Exposure in 18F-Sodium Fluoride Positron Emission Tomography-Computed Tomography in Bone Imaging: Quo Vadis.

Rashid Rasheed, Sharjeel Usmani, Syed Ali Raza Naqvi, Fareeda Alkandari, Fahad A Marafi, Saqib Rasheed,

Indian J Nucl Med (Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India)
[2019, 34(2):157-159]

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Technetium-99m labeled Ibuprofen: Development and biological evaluation using sterile inflammation induced animal models.

Naeem-Ul-Haq Khan, Syed Ali Raza Naqvi, Hamza Sohail, Samina Roohi, Muhammad Asghar Jamal,

In this study we are presenting the development of technetium-99m (99mTc) labeled ibuprofen for the imaging of aseptic inflammation. 99mTc-Ibuprofen complex was developed by optimizing the radiolabeling conditions such as reaction time, ligand and reducing agent concentration, pH, reaction time and temperature. Following the addition of 600 µg of ibuprofen, 4 µg ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2019, 46(3):3093-3100]

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5-Endo-dig cyclizations in organic syntheses.

Muhammad Aamir Sajid, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Syed Ali Raza Naqvi, Muhammad Usman,

The favorability of ring closure reactions as per Baldwin rules has gained immense importance recently. This is evident from the current literature such as research articles, reviews, and books that have been published in this area. This review covers the recent applications of 5-endo-dig cyclization in organic synthesis focusing in ... Read more >>

Mol Divers (Molecular diversity)
[2020, 24(1):295-317]

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Detection of Paracetamol as substrate of the gut microbiome.

Imran Mukhtar, Haseeb Anwar, Ghulam Hussain, Azhar Rasul, Syed Ali Raza Naqvi, Muhammad Naeem Faisal, Imtiaz Mustafa, Saima Malik, Arslan Shaukat, Osman Asghar Mirza, Muhammad Umar Sohail,

Gut microbiome, a new organ; represent targets to alter pharmacokinetics of orally administered drugs. Recently, in vitro trials endorsed the idea that orally administered drugs interact and some of their quantity may be taken up by normal microbiome during transit through gut. Such transport mechanisms in microbiome may compete for ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(2 (Supplementary)):751-757]

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Alpha Therapy with 225Actinium Labeled Prostate Specific Membrane Antigen: Reporting New Photopeak of 78 Kilo-electron Volts for Better Image Statistics.

Rashid Rasheed, Sharjeel Usmani, Syed Ali Raza Naqvi, Fareeda Alkandari, Fahad Marafi,

(Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India)
[2019, 34(1):76-77]

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Magneto-Priming Improved Nutraceutical Potential and Antimicrobial Activity of Momordica charantia L. Without Affecting Nutritive Value.

Shazia Anwer Bukhari, Nabila Farah, Ghulam Mustafa, Saqib Mahmood, Syed Ali Raza Naqvi,

The need for some economic strategies for increased growth and nutraceuticals of medicinal plants is well acknowledged now. It was hypothesized that external magnetic field treatment (MFT) of seeds affecting internal magnet of cells may affect growth and metabolism. In this study, seeds were subjected to pre-sowing magnetic field (50 mT ... Read more >>

Appl Biochem Biotechnol (Applied biochemistry and biotechnology)
[2019, 188(3):878-892]

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Enzymatic degradation study of 111In-labeled minigastrin peptides using cathepsin B enzyme and AR42J cancer cell line for the development of neuroendocrine tumor imaging radiopharmaceuticals.

Syed Ali Raza Naqvi, Muhammad Yameen, Zaib Hussain, Sadia Asim, Muhammad Usman, Naeemul Haq Khan, Khizar Abbas,

Neuroendocrine tumors (NET) are the rare tumors which often impose graveyard threat. These tumors are characterized by the over expression of various G-protein coupled receptors including cholecystokinin (CCK) receptors-1 and 2 (A or B). Minigastrin peptides are being investigated for theranostic purposes of CCK-2 receptor positive NET. The minigastrin analogue ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(6 (Supplementary):2585-2589]

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Susceptibility of 99mTc-Ciprofloxacin for Common Infection Causing Bacterial Strains Isolated from Clinical Samples: an In Vitro and In Vivo Study.

Syed Ali Raza Naqvi, Samina Roohi, Hassina Sabir, Sohail Anjum Shahzad, Aysha Aziz, Rashid Rasheed,

99mTc-ciprofloxacin scintigraphy is useful in the detection of gram-positive and gram-negative bacterial infections and also for differentiating the infection from aseptic inflammation. However, due to growing bacterial resistance to antibiotics, the 99mTc-ciprofloxacin no longer can be effective in broad-spectrum infection imaging as it is gradually losing specificity. In this study, ... Read more >>

Appl Biochem Biotechnol (Applied biochemistry and biotechnology)
[2019, 188(2):424-435]

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Identification of 1,2,4-triazoles as new thymidine phosphorylase inhibitors: Future anti-tumor drugs.

Sohail Anjum Shahzad, Muhammad Yar, Zulfiqar Ali Khan, Lubna Shahzadi, Syed Ali Raza Naqvi, Adeem Mahmood, Sami Ullah, Ahson Jabbar Shaikh, Tauqir Ali Sherazi, Adebayo Tajudeen Bale, Jędrzej Kukułowicz, Marek Bajda,

Thymidine phosphorylase (TP) is over expressed in several solid tumors and its inhibition can offer unique target suitable for drug discovery in cancer. A series of 1,2,4-triazoles 3a-3l has been synthesized in good yields and subsequently inhibitory potential of synthesized triazoles 3a-3l against thymidine phosphorylase enzyme was evaluated. Out of ... Read more >>

Bioorg. Chem. (Bioorganic chemistry)
[2019, 85:209-220]

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Technetium-99m radiolabeling and biological study of epirubicin for in vivo imaging of multi-drug-resistant Staphylococcus aureus infections via single photon emission computed tomography.

N U H Khan, Syed Ali Raza Naqvi, Samina Roohi, Tauqir A Sherazi, Zulfiqar Ali Khan, Ameer Fawad Zahoor,

The development of functional imaging is a promising strategy for diagnosis and treatment of infectious and cancerous diseases. In this study, epirubicin was developed as a [99m Tc]-labeled radiopharmaceutical for the imaging of multi-drug-resistant Staphylococcus aureus infections. The labeling was carried out using sodium pertechnetate (Na99m TcO4 ; ~370 MBq). The ... Read more >>

Chem Biol Drug Des (Chemical biology & drug design)
[2019, 93(2):154-162]

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Phenolic acid profiling and antiglycation studies of leaf and fruit extracts of tyrosine primed Momordica charantia seeds for possible treatment of diabetes mellitus.

Nabila Farah, Shazia Anwer Bukhari, Muhammad Ali, Syed Ali-Raza Naqvi, Saqib Mahmood,

The increasing risk of variety of fatal diseases including diabetes mellitus is imposing serious challenge to chemist, biologists and clinicians. Due to the side effects of the chemotherapy, worldwide it is thinking that phyto-medicine are more effective to cope continuously increasing risk of fatal diseases without any side effect. Seed ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(6 (Supplementary):2667-2672]

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Synthetic applications and methodology development of Chan-Lam coupling: a review.

Iqra Munir, Ameer Fawad Zahoor, Nasir Rasool, Syed Ali Raza Naqvi, Khalid Mahmood Zia, Raheel Ahmad,

Chan-Lam coupling is one of the most popular and easy methods to perform arylation of amines (N-arylations). This cross-coupling is generally performed by reacting aryl boronate derivatives with a variety of substrates involving nitrogen containing functional groups such as amines, amides, ureas, hydrazine, carbamates. This article summarizes the synthetic applications ... Read more >>

Mol Divers (Molecular diversity)
[2019, 23(1):215-259]

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177Lu-DOTA-coupled minigastrin peptides: promising theranostic agents in neuroendocrine cancers.

Syed Faheem Askari Rizvi, Syed Ali Raza Naqvi, Samina Roohi, Tauqir A Sherazi, Rashid Rasheed,

Treatment with radionuclide labeled regulatory peptides is a promising tool in the management of patients with inoperable receptor positive neuroendocrine tumors. Peptide receptor lutetium-177 radionuclide therapy currently has gained ample attention due to high specific accumulation of regulatory peptides at tumor cell surface and promising characteristics of β- and γ-energy ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2018, 45(6):1759-1767]

Cited: 1 time

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Post interferon therapy decreases male fertility through gonadotoxic effect.

Shazia Anwer Bukhari, Muhammad Masood Ahmed, Fozia Anjum, Haseeb Anwar, Syed Ali Raza Naqvi, Tauseef Zahra, Uzma Batool,

Prevalence of hepatitis C virus (HCV) has been seen in more than 15% of Pakistani population. For the treatment of this infection, only two medicines, interferon, and ribavirin were approved in 1998. The concerned physicians evaluate side effects of these two antiviral drugs only during the treatment period. The long-term ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1565-1570]

Cited: 2 times

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Nucleophilic ring opening reactions of aziridines.

Rabia Akhtar, Syed Ali Raza Naqvi, Ameer Fawad Zahoor, Sameera Saleem,

Aziridine ring opening reactions have gained tremendous importance in the synthesis of nitrogen containing biologically active molecules. During recent years, a great effort has been put forward by scientists toward unique bond construction methodologies via ring opening of aziridines. In this regard, a wide range of chiral metal- and organo-catalyzed ... Read more >>

Mol. Divers. (Molecular diversity)
[2018, 22(2):447-501]

Cited: 2 times

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Ciprofloxacin: from infection therapy to molecular imaging.

Syed Ali Raza Naqvi, Samina Roohi, Anam Iqbal, Tauqir A Sherazi, Ameer Fawad Zahoor, Muhammad Imran,

Diagnosis of deep-seated bacterial infection remains a serious medical challenge. The situation is becoming more severe with the increasing prevalence of bacteria that are resistant to multiple antibiotic classes. Early efforts to develop imaging agents for infection, such as technetium-99m (99mTc) labeled leukocytes, were encouraging, but they failed to differentiate ... Read more >>

Mol. Biol. Rep. (Molecular biology reports)
[2018, 45(5):1457-1468]

Cited: 4 times

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Evaluation of 99mTc-sulfadiazine as Bacillus microorganisms infection imaging agent using animal model.

Muhammad Tauqeer Ahmed, Muhammad Yameen, Bushra Munir, Sadia Asim, Muhammad Usman, Syed Ali Raza Naqvi, Jawad Akhtar Hussain Gillani, Rashid Rasheed, Muhammad Adeel Shahzad,

Bacterial infection is one of the vital sources of morbidity and mortality. The development of single photon emission computed tomography (SPECT) radiotracer agents using antibiotics, for targeting in-vivo bacteria, helps in antibiotic dose calibration, targeted infection therapy and reduction in mortality rate. The aim of this study was to appraised ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2018, 31(4(Supplementary)):1495-1499]

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Radiosynthesis and Biodistribution of 99mTc-Metronidazole as an Escherichia coli Infection Imaging Radiopharmaceutical.

Anam Iqbal, Syed Ali Raza Naqvi, Rashid Rasheed, Asim Mansha, Matloob Ahmad, Ameer Fawad Zahoor,

Bacterial infection poses life-threatening challenge to humanity and stimulates to the researchers for developing better diagnostic and therapeutic agents complying with existing theranostic techniques. Nuclear medicine technique helps to visualize hard-to-diagnose deep-seated bacterial infections using radionuclide-labeled tracer agents. Metronidazole is an antiprotozoal antibiotic that serves as a preeminent anaerobic chemotherapeutic ... Read more >>

Appl Biochem Biotechnol (Applied biochemistry and biotechnology)
[2018, 185(1):127-139]

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