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Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19 Infection.

Haripal Kashyap, R N Seshendra Kumar, Srishti Gautam, Arvind Gupta, Swati Gupta, Prashant K Tiwari,

Indian J Pediatr (Indian journal of pediatrics)
[2021, :]

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Clinical characterization and Genomic analysis of COVID-19 breakthrough infections during second wave in different states of India

Nivedita Gupta, Harmanmeet Kaur, Pragya Yadav, Labanya Mukhopadhyay, Rima Sahay, Abhinendra Kumar, Dimpal Nyayanit, Anita Shete, Savita Patil, Triparna Majumdar, Salaj Rana, Swati Gupta, Jitender Narayan, Neetu Vijay, Pradip Barde, Gita Natrajan, Amurtha Kumari, Manasa Kumari, Debasis Biswas, Jyoti Iravane, Sharmila Raut, Shanta Dutta, Sulochana Devi, Purnima Barua, Piyali Gupta, Biswa Borkakoty, Deepjyoti Kalita, Kanwardeep Dhingra, Bashir Fomda, Yash Joshi, Kapil Goyal, Reena John, Ashok, Rahul Dhodapkar, Priyanka Pandit, Sarada Devi, Manisha Dudhmal, Deepa Kinariwala, Neeta Khandelwal, Yogendra Kumar Tiwari, PK Khatri, Anjali Gupta, Himanshu Khatri, Bharti Malhotra, Mythily Nagasundaram, Lalit Dar, Nazira Sheikh, Neeraj Aggarwal, Priya Abraham,

During March to June 2021 India has experienced a deadly second wave of COVID-19 with an increased number of post-vaccination breakthrough infections reported across the country. To understand the possible reason of these breakthroughs we collected 677 clinical samples (throat swab/ nasal swabs) of individuals who had received two doses ... Read more >>

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Checkerboard Analysis To Evaluate Synergistic Combinations of Existing Antifungal Drugs and Propylene Glycol Monocaprylate in Isolates from Recalcitrant Tinea Corporis and Cruris Patients Harboring Squalene Epoxidase Gene Mutation.

Kabir Sardana, Aastha Gupta, Suresh Sadhasivam, R K Gautam, Ananta Khurana, Swamini Saini, Swati Gupta, Shamik Ghosh,

Recalcitrant dermatophytic infections of the glabrous skin (tinea corporis/cruris/faciei) pose a huge challenge to health care systems. Combinations of oral and topical drugs may potentially improve cure rates, but the same has never been objectively assessed for this condition in laboratory or clinical studies. The present study was undertaken with ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2021, 65(8):e0032121]

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Antimicrobial resistance in Shigella species: Our five years (2015-2019) experience in a tertiary care center in north India.

Neelam Taneja, Jutang Babat Ain Tiewsoh, Swati Gupta, Balvinder Mohan, Ritu Verma, Pinky Shankar, Chandradeo Narayan, Vivek Kumar Yadav, Muralidharan Jayashree, Surjit Singh,

<h4>Purpose</h4>Shigella is the second leading cause of diarrhoeal mortality especially in children <5 years of age in African and Asian countries. Rapid changes are occurring in the epidemiology of shigellosis and Shigella are increasingly becoming highly drug resistant. To determine the serogroup distribution and antimicrobial resistance of Shigella isolated at ... Read more >>

Indian J Med Microbiol (Indian journal of medical microbiology)
[2021, :]

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Inhibition of Plasmodium falciparum Lysyl-tRNA Synthetase via a Piperidine-Ring Scaffold Inspired Cladosporin Analogues.

Palak Babbar, Mizuki Sato, Yogavel Manickam, Siddhartha Mishra, Karl Harlos, Swati Gupta, Suhel Parvez, Haruhisa Kikuchi, Amit Sharma,

Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) represents a promising therapeutic anti-malarial target. Cladosporin was identified as a selective and potent PfKRS inhibitor but lacks metabolic stability. Here, we report chemical synthesis, biological evaluation and structural characterization of analogues where the tetrahydropyran (THP) frame of cladosporin is replaced with the piperidine ring ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2021, 22(14):2468-2477]

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Non-Motor Symptoms of Parkinson's Disease: The Neurobiology of Early Psychiatric and Cognitive Dysfunction.

Ayan Hussein, Christopher A Guevara, Pamela Del Valle, Swati Gupta, Deanna L Benson, George W Huntley,

Parkinson's disease (PD) is a progressive neurodegenerative disorder that has been recognized for over 200 years by its clinically dominant motor system impairment. There are prominent non-motor symptoms as well, and among these, psychiatric symptoms of depression and anxiety and cognitive impairment are common and can appear earlier than motor ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211011979]

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Leaves and Roots of Micropropagated Plants Adopt Different Pathways for Withanolide Biosynthesis in Withania Coagulans: A Comparative Transcriptome Study

Swati Gupta, Manoj Kumar Bohra, Kalpna sharma, Sumita Kachhwaha, Shanker Lal Kothari, Rohit Jain,

Withania coagulans (Stocks) Dunal commonly known as paneerbandh due to its milk coagulating properties, is a widely used medicinal herb, and micropropagated plants of the plant to produce some novel withanolides. Trasncscriptome sequencing of leaves and roots of micropropagated plants of W. coagulans assembled total 8.08 and 6.35 GB of ... Read more >>

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Spontaneous subcapital femoral neck fracture complicating osteonecrosis of femoral head.

Sumit Arora, Manoj Kumar, Yasim Khan, Nitish Bansal, Swati Gupta, Jatin Talwar, Vinod Kumar, Lalit Maini,

Spontaneous subcapital fracture (SSF) of femoral neck in pre-existent osteonecrosis of femoral head (ONFH) is a rare presentation. Only a few cases have been reported so far and majority of them have been reported to have unilateral hip involvement. We retrospectively reviewed clinical-radiological data of 10 patients (12 hips) with ... Read more >>

Acta Orthop Belg (Acta orthopaedica Belgica)
[2021, 87(1):25-34]

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Ebola virus outbreak preparedness plan for developing Nations: Lessons learnt from affected countries.

Swati Gupta, Nivedita Gupta, Pragya Yadav, Deepak Patil,

<h4>Background</h4>Ebola virus (EBOV); a public health emergency of international concern,is known to pose threat of global outbreaks. EBOV has spread in African continent and due to unchecked international travel, importation of cases has been reported in different countries. In this alarming scenario, developing countries need to evaluate and upgrade their ... Read more >>

J Infect Public Health (Journal of infection and public health)
[2021, 14(3):293-305]

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State-of-the-art equipment for rapid and accurate diagnosis of COVID-19

Navchetan Awasthi, Swati Gupta, Amritanjali Kiran, Rohit Pardasani,

The World Health Organization (WHO) declared COVID-19 as a pandemic worldwide. Containment of this pandemic requires the diagnosis of the disease at an early stage. Extensive accessibility to accurate and rapid testing procedures is the need of the hour to control SARS-CoV-2 virus infection and to check the amount of ... Read more >>

(Biomedical Engineering Tools for Management for Patients with COVID-19)
[2021, :19-40]

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Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries.

Moses Badio, Edouard Lhomme, Mark Kieh, Abdoul Habib Beavogui, Stephen B Kennedy, Seydou Doumbia, Bailah Leigh, Samba O Sow, Alpha Diallo, Daniela Fusco, Matthew Kirchoff, Monique Termote, Renaud Vatrinet, Deborah Wentworth, Helène Esperou, H Clifford Lane, Jerome Pierson, Deborah Watson-Jones, Céline Roy, Eric D'Ortenzio, Brian Greenwood, Genevieve Chêne, Laura Richert, James D Neaton, Yazdan Yazdanpanah, ,

<h4>Introduction</h4>The Ebola virus disease (EVD) outbreak in 2014-2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine. Multiple questions regarding the safety, immunogenicity, and efficacy of EVD vaccines remain unanswered. To address ... Read more >>

Trials (Trials)
[2021, 22(1):86]

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2020 White Paper on Recent Issues in Bioanalysis: Vaccine Assay Validation, qPCR Assay Validation, QC for CAR-T Flow Cytometry, NAb Assay Harmonization and ELISpot Validation (Part 3 - Recommendations on Immunogenicity Assay Strategies, NAb Assays, Biosimilars and FDA/EMA Immunogenicity Guidance/Guideline, Gene & Cell Therapy and Vaccine Assays).

Bart Corsaro, Tong-Yuan Yang, Rocio Murphy, Ivo Sonderegger, Andrew Exley, Sylvie Bertholet, Naveen Dakappagari, Francis Dessy, Fabio Garofolo, Lisa Kierstead, Holger Koch, Ghanashyam Sarikonda, Natasha Savoie, Richard Siggers, Therese Solstad, Yanmei Lu, Mark Milton, Jean-Claude Marshall, Jason DelCarpini, Boris Gorovits, Swati Gupta, Lynne Jesaitis, John Kamerud, Arno Kromminga, Anna Ma, Jim McNally, Haoheng Yan, Bonnie Wu, Daniela Verthelyi, Susan Kirshner, Joao Pedras-Vasconcelos, Manoj Rajadhyaksha, Roland F Staack, Elana Cherry, Isabelle Cludts, Madeleine Dahlbäck, George R Gunn, Akiko Ishii-Watabe, Vibha Jawa, Robert Kubiak, Michael Partridge, Marco Petrillo, Samuel O Pine, Johann Poetzl, Sam Song, Chris Stebbins, Yuling Wu, Lucia Zhang, Sumit Kar, Meina Liang, Mohsen Rajabi Abhari, Becky Schweighardt, Kay Stubenrauch, Yuanxin Xu,

The 14<sup>th</sup> edition of the Workshop on Recent Issues in Bioanalysis (14<sup>th</sup> WRIB) was held virtually on June 15-29, 2020 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations, and regulatory agencies worldwide. The 14<sup>th</sup> WRIB included three Main Workshops, seven Specialized Workshops that ... Read more >>

Bioanalysis (Bioanalysis)
[2021, 13(6):415-463]

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Andrographolide Mitigates Unfolded Protein Response Pathway and Apoptosis Involved in Chikungunya Virus Infection.

Swati Gupta, Kamla Prasad Mishra, Bhuvnesh Kumar, Shashi Bala Singh, Lilly Ganju,

<h4>Background</h4>Chikungunya virus (CHIKV) is an arthropod-borne RNA virus which induces host Endoplasmic Reticulum (ER) stress by accumulating unfolded or misfolded proteins. ER stress activates the unfolded protein response (UPR) pathway to enable proper protein folding and maintain cellular homeostasis. There is no approved drug or vaccine available for CHIKV treatment, ... Read more >>

Comb Chem High Throughput Screen (Combinatorial chemistry & high throughput screening)
[2021, 24(6):849-859]

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The non-adrenergic imidazoline-1 receptor protein Nischarin is a key regulator of astrocyte glutamate uptake

Swati Gupta, Narges Bazargani, James Drew, Souvik Modi, Hélène Marie, David Attwell, Josef Kittler,

<h4>Summary</h4> Astrocytic GLT-1 is the main glutamate transporter involved in glutamate buffering in the brain, pivotal for glutamate removal at excitatory synapses to terminate neurotransmission and for preventing excitotoxicity. We show here that the surface expression and function of GLT-1 can be rapidly modulated through the interaction of its N-terminus ... Read more >>

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Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis.

Ritu Mishra, Swati Gupta,

<h4>Background</h4>Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in ... Read more >>

Curr Pharm Des (Current pharmaceutical design)
[2020, :]

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Guided Endodontic Access in a Maxillary Molar Using a Dynamic Navigation System.

Omid Dianat, Swati Gupta, Jeffery B Price, Behzad Mostoufi,

The treatment of calcified root canals is challenging in endodontic practice. A 63-year-old man was referred to the postgraduate endodontic clinic at the University of Maryland School of Dentistry, Baltimore, MD, for the treatment of tooth #3. Because of the patient's history of head and neck radiation and the high ... Read more >>

J Endod (Journal of endodontics)
[2021, 47(4):658-662]

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Additive Effect of Platelet Rich Fibrin with Coronally Advanced Flap Procedure in Root Coverage of Miller's Class I and II Recession Defects-A PRISMA Compliant Systematic Review and Meta-Analysis.

Saurav Panda, Anurag Satpathy, Abhaya Chandra Das, Manoj Kumar, Lora Mishra, Swati Gupta, Gunjan Srivastava, Monika Lukomska-Szymanska, Silvio Taschieri, Massimo Del Fabbro,

<h4>Aim</h4>This systematic review and meta-analysis aims to assess the additive effect of leukocyte and platelet-rich fibrin (L-PRF) on coronally advanced flap (CAF) procedures in root coverage of Miller's class I and II gingival recession defects. Review methodology: A comprehensive search in MEDLINE (PubMed), Scopus and CENTRAL (the Cochrane Central Register ... Read more >>

Materials (Basel) (Materials (Basel, Switzerland))
[2020, 13(19):]

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Electric Shock-Induced Vertebral Fracture: A Case Report and Literature Review with Special Emphasis on Fracture Morphology.

Sumit Arora, Yasim Khan, Tarun Suri, Swati Gupta,

<h4>Case</h4>A 35-year-old man suffered electric injury with 220 V alternating current when he was connecting electric wires at approximately 5 feet height and accidentally touched a live wire. He was diagnosed to have fracture involving superior and inferior endplates of L2 vertebral body without involvement of posterior elements. He, subsequently, ... Read more >>

JBJS Case Connect (JBJS case connector)
[2020, 10(4):e2000143]

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Assessment of Bone Quality Using Radiogrammetric Parameters of Proximal Humerus in India: Defining the Osteoporotic Fracture Risk Limit Value and its Reliability.

Sonali Jain, Sumit Arora, Swati Gupta, Siddharth Sharma, Nitish Bansal, Shashi Ranjan,

<h4>Background</h4>World health organization (WHO) has defined osteoporosis clinically on the basis of bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry (DXA) scan and the presence of fractures. This facility is expensive and not readily available in majority of the centers in India. The authors have attempted to study defined ... Read more >>

Indian J Orthop (Indian journal of orthopaedics)
[2020, 54(Suppl 2):307-315]

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Electrocuted Hip: Late Consequences of Electrical Shock Injuries of Orthopaedic Relevance: A Case Report and Review of Literature.

Yasim Khan, Sumit Arora, Swati Gupta, Nidhi Mahajan, Sumit Sural, Anil Dhal,

<h4>Case</h4>A 43-year-old man suffered household electric shock from 220 V alternating current when he accidently touched a live wire with his left hand. Subsequently, he was diagnosed to have osteonecrosis of the left femoral head and underwent total hip arthroplasty.<h4>Conclusion</h4>We suggest that the electric current could have thrombosed the terminal ... Read more >>

JBJS Case Connect (JBJS case connector)
[2020, 10(3):e1900632]

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Andrographolide attenuates complete freund's adjuvant induced arthritis via suppression of inflammatory mediators and pro-inflammatory cytokines.

Swati Gupta, K P Mishra, Bhuvnesh Kumar, S B Singh, Lilly Ganju,

<h4>Ethnopharmacological relevance</h4>Traditional plant-derived medicines have enabled the mankind in curing the wide spectrum of diseases throughout the ages. Andrographis paniculata (Burm.f.) Nees, is one of the traditional plant used as a folk medicine for the management of inflammation, arthritis, viral-bacterial infections and other ailments in India, China, Malaysia and other ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 261:113022]

Cited: 2 times

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Revisiting blood agar for the isolation of Neisseria gonorrhoeae.

Sunil Sethi, Shreya Singh, Surinder Singh Banga, Neha Jain, Swati Gupta, Nandita Sharma, Hemant Chaudhry, Sakshi Malhotra, Tarun Narang,

Indian J Sex Transm Dis AIDS (Indian journal of sexually transmitted diseases and AIDS)
[2020, 41(2):221-222]

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Efficacy and Safety of VB-1953 Topical Gel in Non-Responder Acne Patients with Clindamycin-Resistant Cutibacterium acnes.

Rohit Batra, Suresh Sadhasivam, Swamini Saini, Swati Gupta, Rahul Kumar Singh Bisen, Mau Sinha, Shamik Ghosh, Shilpi Jain,

<h4>Background and objectives</h4>The emergence of resistant strains of Cutibacterium acnes can limit the efficacy of currently approved antibiotics for acne. VB-1953 is a next-generation antibiotic that exerts a bactericidal effect on resistant C. acnes. In this study, we investigated the safety, tolerability, and efficacy of VB-1953 topical gel in patients ... Read more >>

Drugs R D (Drugs in R&D)
[2020, 20(2):95-104]

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Oral manifestation of Waardenburg syndrome: a case report and review of the literature.

Rohan Jagtap, Ambika Srivastava, Aniket Jadhav, Swati Gupta,

Waardenburg syndrome is a rare autosomal dominant genetic disorder of neural crest cell migration. It is characterized by congenital sensorineural hearing loss, heterochromia iridis, depigmentation of hair and skin, and increased intercanthal distance. It is subdivided into four subtypes with I and II being most common. These subtypes are categorized ... Read more >>

BJR Case Rep (BJR case reports)
[2020, 6(4):20200071]

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Biomarkers Associated with Beneficial PD-1 Checkpoint Blockade in Non-Small Cell Lung Cancer (NSCLC) Identified Using High-Plex Digital Spatial Profiling.

Jon Zugazagoitia, Swati Gupta, Yuting Liu, Kit Fuhrman, Scott Gettinger, Roy S Herbst, Kurt A Schalper, David L Rimm,

<h4>Purpose</h4>Only a minority of patients with advanced non-small cell lung cancer (NSCLC) truly benefits from single-agent PD-1 checkpoint blockade, and more robust predictive biomarkers are needed.<h4>Experimental design</h4>We assessed tumor samples from 67 immunotherapy-treated NSCLC cases represented in a tissue microarray, 53 of whom had pretreatment samples and received monotherapy. Using ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(16):4360-4368]

Cited: 5 times

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