Full Text Journal Articles by
Author Swantje Mindorf

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International multicenter examination of MOG antibody assays.

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan, Jessica Sagen, James P Fryer, John Mills, Bianca Teegen, Swantje Mindorf, Nora Ritter, Ulrike Krummrei, Winfried Stöcker, Juliane Eggert, Eoin P Flanagan, Melanie Ramberger, Harald Hegen, Kevin Rostasy, Thomas Berger, Maria Isabel Leite, Jacqueline Palace, Sarosh R Irani, Russell C Dale, Christian Probst, Monika Probst, Fabienne Brilot, Sean J Pittock, Patrick Waters,

OBJECTIVE:To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG and MOG-IgM) from 5 international centers. METHODS:The following samples were analyzed: MOG-IgG clearly positive sera (n = 39), MOG-IgG low positive sera (n = 39), borderline negative sera (n = 13), ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(2):]

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An international multicenter examination of MOG antibody assays

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan, Jessica Sagen, Jim Fryer, John Mills, Bianca Tegen, Swantje Mindorf, Nora Ritter, Ulrike Krummrei, Winfried Stocker, Juliane Eggert, Eoin Flanagan, Melanie Ramberger, Harald Hegen, Kevin Rostasy, Thomas Berger, Isabel Leite, Jacqueline Palace, Sarosh Irani, Russell Dale, Christian Probst, Monika Probst, Fabienne Brilot, Sean Pittock, Patrick Waters,

Objectives: To compare the reproducibility of 11 antibody assays for IgG and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG, MOG-IgM) from five international centers. Methods: The following samples were analyzed: MOG-IgG clearly positive sera (n=39), MOG-IgG low positive sera (n=39), borderline negative sera (n=13), clearly negative sera (n=40), and healthy ... Read more >>

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Antibodies against neural antigens in patients with acute stroke: joint results of three independent cohort studies.

Georg Royl, Tsafack Judicael Fokou, Rittika Chunder, Rakad Isa, Thomas F Münte, Klaus-Peter Wandinger, Markus Schwaninger, Oliver Herrmann, José Manuel Valdueza, Jan Brocke, Martin Willkomm, Dietrich Willemsen, Gerd U Auffarth, Swantje Mindorf, Britta Brix, Angel Chamorro, Anna Planas, Xabier Urra,

BACKGROUND AND PURPOSE:Ischemic stroke (IS) and hemorrhagic stroke (HemS) typically lead to a breakdown of the blood-brain barrier with neural antigen presentation. This presentation could potentially generate destructive auto-immune responses. Pre-existing antineuronal and antiglial antibodies (AA), predominantly NMDA receptor antibodies, have been reported in patients with stroke. This article summarizes ... Read more >>

J. Neurol. (Journal of neurology)
[2019, 266(11):2772-2779]

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GABAA receptor autoimmunity: A multicenter experience.

Kevin O'Connor, Patrick Waters, Lars Komorowski, Anastasia Zekeridou, Chu-Yueh Guo, Victor C Mgbachi, Christian Probst, Swantje Mindorf, Bianca Teegen, Jeffrey M Gelfand, Michael D Geschwind, Vanda Lennon, Sean J Pittock, Andrew McKeon,

Objective:We sought to validate methods for detection and confirmation of GABAA receptor (R)-IgG and clinically characterize seropositive cases. Methods:Archived serum and CSF specimens (185 total) suspected to harbor GABAAR-IgG were evaluated by indirect immunofluorescence assay (IFA). Twenty-six specimens from 19 patients appeared suspicious for GABAAR-IgG positivity by IFA, based on ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(3):e552]

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Routine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus.

Swantje Mindorf, Inga M Dettmann, Stine Krüger, Tarek Fuhrmann, Kristin Rentzsch, Ingolf Karl, Christian Probst, Lars Komorowski, Kai Fechner, Nina van Beek, Susanne Lemcke, Susanne Lemcke, Miklós Sárdy, Christine Bangert, Sandrine Benoit, Takashi Hashimoto, Detlef Zillikens, Hendri H Pas, Marcel F Jonkman, Winfried Stöcker, Enno Schmidt, ,

Autoantibodies against the 3 desmocollin (Dsc; Dsc1-Dsc3) isoforms have been described in different pemphigus variants. Here, we developed state-of-the-art detection systems for serum anti-Dsc1, Dsc2 and Dsc1 IgG and IgA. These assays were applied in 5 different cohorts including pemphigus vulgaris (PV) patients with compatible direct immunofluorescence (IF) microscopy but ... Read more >>

Exp. Dermatol. (Experimental dermatology)
[2017, 26(12):1267-1270]

Cited: 8 times

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Autoantibodies against "rods and rings"-related IMPDH2 in hepatitis C genotype 1 and DAA therapy in a "real life" cohort.

Werner Dammermann, Susanne Polywka, Inga Dettmann, Swantje Mindorf, Lars Komorowski, Malte Wehmeyer, Julian Schulze Zur Wiesch, Winfried Stöcker, Stefan Lüth,

Autoantibodies against inosine-5'-monophosphate-dehydrogenase-2 (IMPDH2; "rods and rings" pattern) develop in chronic hepatitis C (CHC) patients under treatment with peg-interferon (IFN) and ribavirin (RBV), an inhibitor of IMPDH2. We investigated the influence of the alternative therapy with direct-acting antivirals (DAA)/ribavirin on anti-IMPDH2 autoantibody generation and the use of anti-IMPDH2 development as ... Read more >>

Med. Microbiol. Immunol. (Medical microbiology and immunology)
[2017, 206(5):379-382]

Cited: 1 time

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Autoantibodies against glutamate receptor δ2 after allogenic stem cell transplantation.

Ramona Miske, Stefanie Hahn, Thorsten Rosenkranz, Matthias Müller, Inga M Dettmann, Swantje Mindorf, Yvonne Denno, Stefanie Brakopp, Madeleine Scharf, Bianca Teegen, Christian Probst, Nico Melzer, Hans-Michael Meinck, Christoph Terborg, Winfried Stöcker, Lars Komorowski,

To report on a Caucasian patient who developed steroid-responsive transverse myelitis, graft vs host disease of the gut, and anti-GluRδ2 after allogenic stem cell transplantation.Histoimmunoprecipitation (HIP) with the patient's serum and cryosections of rat and porcine cerebellum followed by mass spectrometry was used to identify the autoantigen. Correct identification was ... Read more >>

(Neurology® Neuroimmunology & Neuroinflammation)
[2016, 3(4):e255]

Cited: 2 times

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Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration.

Ramona Miske, Catharina C Gross, Madeleine Scharf, Kristin S Golombeck, Marvin Hartwig, Urvashi Bhatia, Andreas Schulte-Mecklenbeck, Kathrin Bönte, Christine Strippel, Ludger Schöls, Matthis Synofzik, Hubertus Lohmann, Inga Madeleine Dettmann, Michael Deppe, Swantje Mindorf, Tobias Warnecke, Yvonne Denno, Bianca Teegen, Christian Probst, Stefanie Brakopp, Klaus-Peter Wandinger, Heinz Wiendl, Winfried Stöcker, Sven G Meuth, Lars Komorowski, Nico Melzer,

To report on a novel neuronal target antigen in 3 patients with autoimmune cerebellar degeneration.Three patients with subacute to chronic cerebellar ataxia and controls underwent detailed clinical and neuropsychological assessment together with quantitative high-resolution structural MRI. Sera and CSF were subjected to comprehensive autoantibody screening by indirect immunofluorescence assay (IFA) ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2017, 4(1):e307]

Cited: 6 times

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Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies.

Bethan Lang, Mateusz Makuch, Teresa Moloney, Inga Dettmann, Swantje Mindorf, Christian Probst, Winfried Stoecker, Camilla Buckley, Charles R Newton, M Isabel Leite, Paul Maddison, Lars Komorowski, Jane Adcock, Angela Vincent, Patrick Waters, Sarosh R Irani,

Autoantibodies against the extracellular domains of the voltage-gated potassium channel (VGKC) complex proteins, leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-2 (CASPR2), are found in patients with limbic encephalitis, faciobrachial dystonic seizures, Morvan's syndrome and neuromyotonia. However, in routine testing, VGKC complex antibodies without LGI1 or CASPR2 reactivities (double-negative) are more ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2017, 88(4):353-361]

Cited: 22 times

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An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy.

Elion Hoxha, Laurence H Beck, Thorsten Wiech, Nicola M Tomas, Christian Probst, Swantje Mindorf, Catherine Meyer-Schwesinger, Gunther Zahner, Phillip R Stahl, Ruth Schöpper, Ulf Panzer, Sigrid Harendza, Udo Helmchen, David J Salant, Rolf A K Stahl,

Thrombospondin type 1 domain-containing 7A (THSD7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major antigen phospholipase A2 receptor 1 (PLA2R1). The prevalence of THSD7A-Ab-positive patients is unknown, and it is unclear whether the clinical presentation differs between patients positive for PLA2R1-Ab or THSD7A-Ab. We ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2017, 28(2):520-531]

Cited: 33 times

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Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis.

Sebastian Torben Jendrek, Daniel Gotthardt, Thomas Nitzsche, Laila Widmann, Tobias Korf, Maike Anna Michaels, Karl-Heinz Weiss, Evaggelia Liaskou, Mette Vesterhus, Tom Hemming Karlsen, Swantje Mindorf, Peter Schemmer, Florian Bär, Bianca Teegen, Torsten Schröder, Marc Ehlers, Christoph Matthias Hammers, Lars Komorowski, Hendrik Lehnert, Klaus Fellermann, Stefanie Derer, Johannes Roksund Hov, Christian Sina,

Pancreatic autoantibodies (PABs), comprising antibodies against glycoprotein 2 (anti-GP2), are typically associated with complicated phenotypes in Crohn's disease, but have also been observed with variable frequencies in patients with UC. In a previous study, we observed a high frequency of primary sclerosing cholangitis (PSC) in patients with anti-GP2-positive UC. We ... Read more >>

Gut (Gut)
[2017, 66(1):137-144]

Cited: 12 times

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