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Author Sven Mahner

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tRNAGlyGCC-Derived Internal Fragment (i-tRF-GlyGCC) in Ovarian Cancer Treatment Outcome and Progression.

Konstantina Panoutsopoulou, Tobias Dreyer, Julia Dorn, Eva Obermayr, Sven Mahner, Toon van Gorp, Ioana Braicu, Robert Zeillinger, Viktor Magdolen, Margaritis Avgeris, Andreas Scorilas,

Epithelial ovarian cancer (EOC) remains a highly-lethal gynecological malignancy, characterized by frequent recurrence, chemotherapy resistance and poor 5-year survival. Identifying novel predictive molecular markers remains an overdue challenge in the disease's clinical management. Herein, in silico analysis of TCGA-OV highlighted the tRNA-derived internal fragment (i-tRF-GlyGCC) among the most abundant tRFs ... Read more >>

Cancers (Basel) (Cancers)
[2021, 14(1):]

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Effects of intralipid infusions on anti-trophoblast antibody (ATAb)-activities in patients with recurrent pregnancy loss: An observational report.

Nina Rogenhofer, Sven Mahner, Yumiko Lindgard von Hasselbach, Christian J Thaler,

<h4>Problem</h4>Some studies suggest intravenous intralipid infusions (IVIL) to be effective in the treatment of immune-mediated pregnancy failure. To this date it remains to be established, how IVIL might protect pregnancy and therefore a specific subgroup of RPL patients that might benefit from IVIL has not been defined. Anti-trophoblast antibodies (ATAb) ... Read more >>

Am J Reprod Immunol (American journal of reproductive immunology (New York, N.Y. : 1989))
[2021, :e13506]

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Factors Influencing the In Vitro Maturation (IVM) of Human Oocyte.

Huixia Yang, Thomas Kolben, Sarah Meister, Corinna Paul, Julia van Dorp, Sibel Eren, Christina Kuhn, Martina Rahmeh, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt,

In vitro maturation (IVM) of oocytes is a promising assisted reproductive technology (ART) deemed as a simple and safe procedure. It is mainly used in patients with impaired oocyte maturation and in fertility preservation for women facing the risk of losing fertility. However, to date, it is still not widely ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(12):]

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Distress in hospitalized cancer patients: Associations with personality traits, clinical and psychosocial characteristics.

Theresia Pichler, Birgitt Marten-Mittag, Kerstin Hermelink, Eva Telzerow, Tamara Frank, Ulrike Ackermann, Claus Belka, Stephanie E Combs, Christian Gratzke, Jürgen Gschwend, Nadia Harbeck, Volker Heinemann, Kathleen Herkommer, Marion Kiechle, Sven Mahner, Steffi Pigorsch, Josefine Rauch, Christian Stief, Friederike Mumm, Pia Heußner, Peter Herschbach, Andreas Dinkel,

<h4>Objective</h4>To improve allocation of psychosocial care and to provide patient-oriented support offers, identification of determinants of elevated distress is needed. So far, there is a lack of evidence investigating the interplay between individual disposition and current clinical and psychosocial determinants of distress in the inpatient setting.<h4>Methods</h4>In this cross-sectional study, we ... Read more >>

Psychooncology (Psycho-oncology)
[2021, :]

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Epigenetic changes occur in placentas of spontaneous and recurrent miscarriages.

Sarah Meister, Isabel Kellner, Susanne Beyer, Stefanie Corradini, Christian Schulz, Nina Rogenhofer, Lucia Keilmann, Theresa Maria Kolben, Sven Mahner, Mirjana Kessler, Udo Jeschke, Thomas Kolben,

<h4>Background</h4>In contrast to genetic abnormalities which are well known to be responsible for around 50 % of human miscarriages, there is very few data about epigenetic alterations in spontaneous and recurrent miscarriages (SM, RM). The aim of this study was to analyze the histone modification marks H3K9ac and H3K4me3 in ... Read more >>

J Reprod Immunol (Journal of reproductive immunology)
[2021, 149:103466]

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The role of resveratrol, Sirtuin1 and RXRα as prognostic markers in ovarian cancer.

Fangfang Chen, Thomas Kolben, Sarah Meister, Bastian Czogalla, Theresa M Kolben, Anna Hester, Alexander Burges, Fabian Trillsch, Elisa Schmoeckel, Doris Mayr, Artur Mayerhofer, Sven Mahner, Udo Jeschke, Susanne Beyer,

<h4>Objective</h4>Ovarian cancer is the most lethal gynecologic cancer. Resveratrol (RSV) is known to alter metabolism in cancer. It affects the nuclear retinoid-X-receptor (RXR), which implies a modulating effect of RXR to gynaecologic cancers. Furthermore, RSV targets Sirtuin1 (Sirt1), a histone deacetylase.<h4>Study design</h4>123 tissue samples of patients with serous or mucinous ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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Association of a Combined Cancer Exhaustion Score with Circulating Tumor Cells and Outcome in Ovarian Cancer-A Study of the OVCAD Consortium.

Eva Obermayr, Elena Ioana Braicu, Stephan Polterauer, Liselore Loverix, Nicole Concin, Linn Woelber, Sven Mahner, Jalid Sehouli, Toon Van Gorp, Ignace Vergote, Robert Zeillinger, Stefanie Aust,

We investigated the prognostic role of systemic characteristics for cancer exhaustion and the presence of circulating tumor cells (CTCs) in primary epithelial ovarian cancer (EOC) patients. We included 185 patients in this multicenter study with a median follow-up time of 10.25 years. Albumin, c-reactive protein (CRP) and the kynurenine to ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(23):]

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Regulation of Epigenetic Modifications in the Placenta during Preeclampsia: PPARγ Influences H3K4me3 and H3K9ac in Extravillous Trophoblast Cells.

Sarah Meister, Laura Hahn, Susanne Beyer, Corinna Paul, Sophie Mitter, Christina Kuhn, Viktoria von Schönfeldt, Stefanie Corradini, Kritika Sudan, Christian Schulz, Theresa Maria Kolben, Sven Mahner, Udo Jeschke, Thomas Kolben,

The aim of this study was to analyze the expression of peroxisome proliferator-activated receptor γ (PPARγ) and retinoid X receptor α (RxRα), a binding heterodimer playing a pivotal role in the successful trophoblast invasion, in the placental tissue of preeclamptic patients. Furthermore, we aimed to characterize a possible interaction between ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(22):]

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Adjuvant radiotherapy and local recurrence in vulvar cancer - a subset analysis of the AGO-CaRE-1 study.

Linn Woelber, Katharina Prieske, Christine Zu Eulenburg, Stefanie Corradini, Cordula Petersen, Mareike Bommert, Thomas Blankenstein, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias W Beckmann, Alexander Mustea, Sven Mahner, Anna Jaeger,

<h4>Background</h4>The impact of adjuvant radiotherapy (RT) to the vulva with regard to prognosis and local recurrence in patients with vulvar squamous cell cancer (VSCC) is poorly described.<h4>Patients and methods</h4>In the AGO-CaRE-1 study 1618 patients with primary VSCC FIGO stage ≥ IB, treated between 1998-2008, were documented. In this retrospective subanalysis, ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2022, 164(1):68-75]

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Role of FoxP3-positive regulatory T-cells in regressive and progressive cervical dysplasia.

Aurelia Vattai, Nadine Kremer, Sarah Meister, Susanne Beyer, Lucia Keilmann, Anna Hester, Mina Temelkov, Helene Heidegger, Elisa Schmoeckel, Mirjana Kessler, Sven Mahner, Udo Jeschke, Linda Hertlein, Thomas Kolben,

<h4>Purpose</h4>Forkhead Box Protein 3 (FoxP3) is known as a key mediator in the immunosuppressive function of regulatory T-cells (Tregs). The aim of our study was to investigate whether FoxP3-positive Tregs have the potential to act as an independent predictor in progression as well as in regression of cervical intraepithelial neoplasia, ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2021, :]

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COVID-19 vaccination in patients with breast cancer and gynecological malignancies: A German perspective.

Marie Forster, Rachel Wuerstlein, Alexander Koenig, Niklas Amann, Susanne Beyer, Till Kaltofen, Tom Degenhardt, Alexander Burges, Fabian Trillsch, Sven Mahner, Nadia Harbeck, Anca Chelariu-Raicu,

<h4>Introduction</h4>The side effects of systemic cancer therapy and the lack of clinical data on safety and efficacy of COVID-19 vaccination in cancer patients cause uncertainty among the patients about whether to get vaccinated or not. Here, we evaluated attitude towards and effects of COVID-19 vaccination in patients with breast and ... Read more >>

Breast (Breast (Edinburgh, Scotland))
[2021, 60:214-222]

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The role of Interleukin-18 in recurrent early pregnancy loss.

Sanja Löb, Beate Ochmann, Zhi Ma, Theresa Vilsmaier, Christina Kuhn, Elisa Schmoeckel, Saskia-Laureen Herbert, Thomas Kolben, Achim Wöckel, Sven Mahner, Udo Jeschke,

<h4>Background</h4>A successful pregnancy is a unique and complex immunological state. Cytokines seem to be crucial for the implementation of a tolerogenic environment at the feto-maternal interphase towards the semi-allogenic fetus. Importantly, the switch from a Th1- to a Th2 cytokine profile might play a key role. Interestingly, Interleukin-18 (IL-18) can ... Read more >>

J Reprod Immunol (Journal of reproductive immunology)
[2021, 148:103432]

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Actin Beta-Like 2 as a New Mediator of Proliferation and Migration in Epithelial Ovarian Cancer.

Nicole Elisabeth Topalov, Doris Mayr, Clemens Scherer, Anca Chelariu-Raicu, Susanne Beyer, Anna Hester, Fabian Kraus, Mingjun Zheng, Till Kaltofen, Thomas Kolben, Alexander Burges, Sven Mahner, Fabian Trillsch, Udo Jeschke, Bastian Czogalla,

The impact of Actin beta-like 2 (ACTBL2), a novel described actin isoform, on epithelial ovarian cancer (EOC) biology has not been investigated so far. In this study, we analyzed the prognostic and functional significance of ACTBL2 and its regulatory element Nuclear factor of activated T-cells 5 (NFAT5). The expression of ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:713026]

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The role of E-Cadherin expression in primary site of breast cancer.

Nora Karsten, Thomas Kolben, Sven Mahner, Susanne Beyer, Sarah Meister, Christina Kuhn, Elisa Schmoeckel, Rachel Wuerstlein, Nadia Harbeck, Nina Ditsch, Udo Jeschke, Klaus Friese, Theresa Maria Kolben,

<h4>Purpose</h4>The tumour's ability to metastasize is the major cause for fatal outcomes in cancer diseases. In breast cancer, aberrant E-Cadherin expression has been linked to invasiveness and poor prognosis.<h4>Method</h4>We assessed expression of E-Cadherin by immunohistochemistry in primary tumour tissue from 125 female breast cancer patients. Staining intensities were analysed using ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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The Platelet-Activating Factor Receptor's Association with the Outcome of Ovarian Cancer Patients and Its Experimental Inhibition by Rupatadine.

Eileen Deuster, Ivi Hysenaj, Maja Kahaly, Elisa Schmoeckel, Doris Mayr, Susanne Beyer, Thomas Kolben, Anna Hester, Fabian Kraus, Anca Chelariu-Raicu, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla,

The platelet-activating factor receptor (PAFR) and its ligand (PAF) are important inflammatory mediators that are overexpressed in ovarian cancer. The receptor is an important player in ovarian cancer development. In this study, we aimed to evaluate the prognostic value of PAFR in epithelial ovarian cancer (EOC) and the potential use ... Read more >>

Cells (Cells)
[2021, 10(9):]

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Changes in gynecologic and breast cancer diagnoses during the first wave of the COVID-19 pandemic: analysis from a tertiary academic gyneco-oncological center in Germany.

Till Kaltofen, Friederike Hagemann, Nadia Harbeck, Rachel Wuerstlein, Bernd Peter Kost, Alexander Burges, Sven Mahner, Fabian Trillsch,

<h4>Purpose</h4>With the beginning of 2021, the world has been suffering from the COVID-19 pandemic for more than 1 year. More and more, we are able to evaluate side effects of the pandemic in the healthcare sector. A negative impact on cancer diagnoses is one of them. Careful observation of trends ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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Correction to: Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer.

Wanting Shao, Christina Kuhn, Doris Mayr, Nina Ditsch, Magdalena Kailuwait, Verena Wolf, Nadia Harbeck, Sven Mahner, Udo Jeschke, Vincent Cavaillès, Sophie Sixou,

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2021, 147(9):2545-2546]

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Prostaglandin E2 Receptor 4 (EP4) Affects Trophoblast Functions via Activating the cAMP-PKA-pCREB Signaling Pathway at the Maternal-Fetal Interface in Unexplained Recurrent Miscarriage.

Lin Peng, Anca Chelariu-Raicu, Yao Ye, Zhi Ma, Huixia Yang, Hellen Ishikawa-Ankerhold, Martina Rahmeh, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt,

Implantation consists of a complex process based on coordinated crosstalk between the endometrium and trophoblast. Furthermore, it is known that the microenvironment of this fetal-maternal interface plays an important role in the development of extravillous trophoblast cells. This is mainly due to the fact that tissues mediate embryonic signaling biologicals, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(17):]

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Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer.

Tilman L R Vogelsang, Aurelia Vattai, Elisa Schmoeckel, Till Kaltofen, Anca Chelariu-Raicu, Mingjun Zheng, Sven Mahner, Doris Mayr, Udo Jeschke, Fabian Trillsch,

Trace amine-associated receptor 1 (TAAR1) is a G<sub>αs</sub>- protein coupled receptor that plays an important role in the regulation of the immune system and neurotransmission in the CNS. In ovarian cancer cell lines, stimulation of TAAR1 via 3-iodothyronamine (T<sub>1</sub>AM) reduces cell viability and induces cell death and DNA damage. Aim ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(16):]

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Prognosis of Patients With Early Breast Cancer Receiving 5 Years vs 2 Years of Adjuvant Bisphosphonate Treatment: A Phase 3 Randomized Clinical Trial.

Thomas W P Friedl, Tanja Fehm, Volkmar Müller, Werner Lichtenegger, Jens Blohmer, Ralf Lorenz, Helmut Forstbauer, Visnja Fink, Inga Bekes, Jens Huober, Julia Jückstock, Andreas Schneeweiss, Hans Tesch, Sven Mahner, Sara Y Brucker, Georg Heinrich, Lothar Häberle, Peter A Fasching, Matthias W Beckmann, Robert E Coleman, Wolfgang Janni, Brigitte Rack,

<h4>Importance</h4>Bisphosphonate treatment in patients with early breast cancer has become part of care, but the optimal treatment duration is still unclear.<h4>Objective</h4>To compare 2 vs 5 years of zoledronate treatment following adjuvant chemotherapy in patients with early breast cancer.<h4>Design, setting, and participants</h4>The SUCCESS A phase 3 multicenter randomized open-label clinical trial ... Read more >>

JAMA Oncol (JAMA oncology)
[2021, 7(8):1149-1157]

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Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development.

Tabea L Bauer, Katrin Collmar, Till Kaltofen, Ann-Katrin Loeffler, Lorena Decker, Jan Mueller, Sabine Pinter, Stephan A Eisler, Sven Mahner, Patricia Fraungruber, Stefan Kommoss, Annette Staebler, Lewis Francis, R Steven Conlan, Johannes Zuber, Udo Jeschke, Fabian Trillsch, Philipp Rathert,

Epithelial ovarian cancer (EOC) is the most lethal disease of the female reproductive tract, and although most patients respond to the initial treatment with platinum (cPt)-based compounds, relapse is very common. We investigated the role of epigenetic changes in cPt-sensitive and -resistant EOC cell lines and found distinct differences in ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(15):]

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Cytoplasmic Localization of RXRα Determines Outcome in Breast Cancer.

Alaleh Zati Zehni, Falk Batz, Vincent Cavaillès, Sophie Sixou, Till Kaltofen, Simon Keckstein, Helene Hildegard Heidegger, Nina Ditsch, Sven Mahner, Udo Jeschke, Theresa Vilsmaier,

The aim of this retrospective study was to assess the prognostic value of cytoplasmic versus nuclear RXRα expression in breast cancer (BC) tissue samples and to correlate the results with clinicopathological parameters. In 319 BC patients, the expression of RXRα was evaluated via immunohistochemistry. Prognosis-determining aspects were calculated through uni- ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(15):]

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Seasonal Dynamic of Cholecalciferol (D3) And Anti-Muellerian Hormone (AMH) With Impact On Ovarian Response And IVF/ICSI

Nina Rogenhofer, Udo Jeschke, Viktoria von Schönfeldt, Sven Mahner, Christian Thaler,

<h4>Objective: </h4> Recent studies revealed intriguing associations between cholecalciferol ( D3) and reproductive functions. Seasonal changes of D3 concentrations are well known, however they are not always considered in the context of reproductive functions. In this study, we analysed D3 serum concentration in IVF/ICSI patients with respect to seasonal 3-month ... Read more >>

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Diagnostic workup for endometrioid borderline ovarian tumors (eBOT) requires histopathological evaluation of the uterus.

Juliane Reichenbach, Elisa Schmoeckel, Sven Mahner, Fabian Trillsch,

<h4>Background</h4>For young borderline ovarian tumor (BOT) patients, preservation of the uterus was incorporated as an accepted option into treatment guidelines. For the endometrioid subtype (eBOT) however, adequate histological evaluation is challenging and might be associated with synchronous endometrial disorders or misinterpreted as spread from uterine primaries.<h4>Case presentation</h4>We report the cases ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2021, 14(1):89]

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Changes in Stem Cell Regulation and Epithelial Organisation during Carcinogenesis and Disease Progression in Gynaecological Malignancies.

Paula Cunnea, Christina Fotopoulou, Jennifer Ploski, Fabian Trillsch, Sven Mahner, Mirjana Kessler,

Gynaecological malignancies represent a heterogeneous group of neoplasms with vastly different aetiology, risk factors, molecular drivers, and disease outcomes. From HPV-driven cervical cancer where early screening and molecular diagnostics efficiently reduced the number of advanced-stage diagnosis, prevalent and relatively well-treated endometrial cancers, to highly aggressive and mostly lethal high-grade serous ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(13):]

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