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Author Sven Mahner

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Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group.

Fabian Trillsch, Sven Mahner, Bastian Czogalla, Miriam Rottmann, Radoslav Chekerov, Elena Ioana Braicu, Gülten Oskay-Öczelik, Pauline Wimberger, Rolf Richter, Jalid Sehouli,

<h4>Objective</h4>Patients with platinum-resistant ovarian cancer (PROC) have a high need for reliable prognostic markers. Since significance of primary platinum resistance (PPR) versus secondary platinum resistance (SPR) was identified for patients receiving anti-angiogenic therapy, it has not been confirmed for chemotherapy only.<h4>Methods</h4>PROC patients from 3 prospective trials of the NOGGO study ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e37]

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Breast adipose tissue macrophages (BATMs) have a stronger correlation with breast cancer survival than breast tumor stroma macrophages (BTSMs).

Lili Lin, Christina Kuhn, Nina Ditsch, Thomas Kolben, Bastian Czogalla, Susanne Beyer, Fabian Trillsch, Elisa Schmoeckel, Doris Mayr, Sven Mahner, Udo Jeschke, Anna Hester,

<h4>Background</h4>An abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the breast and has also been identified as an independent indicator of poor survival in BC. This study aims ... Read more >>

Breast Cancer Res (Breast cancer research : BCR)
[2021, 23(1):45]

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Nuclear receptor corepressor (NCoR) is a positive prognosticator for cervical cancer.

Daniel Beilner, Christina Kuhn, Bernd P Kost, Theresa Vilsmaier, Aurelia Vattai, Till Kaltofen, Sven Mahner, Elisa Schmoeckel, Christian Dannecker, Julia Jückstock, Doris Mayr, Udo Jeschke, Helene Hildegard Heidegger,

<h4>Purpose</h4>Enzymes with epigenetic functions play an essential part in development of cancer. However, the significance of epigenetic changes in cervical carcinoma as a prognostic factor has not been fully investigated. Nuclear receptor corepressor (NCoR) presents itself as a potentially important element for epigenetic modification and as a potential prognostic aspect ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, :]

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Efficacy and safety of tisotumab vedotin in previously treated recurrent or metastatic cervical cancer (innovaTV 204/GOG-3023/ENGOT-cx6): a multicentre, open-label, single-arm, phase 2 study.

Robert L Coleman, Domenica Lorusso, Christine Gennigens, Antonio González-Martín, Leslie Randall, David Cibula, Bente Lund, Linn Woelber, Sandro Pignata, Frederic Forget, Andrés Redondo, Signe Diness Vindeløv, Menghui Chen, Jeffrey R Harris, Margaret Smith, Leonardo Viana Nicacio, Melinda S L Teng, Annouschka Laenen, Reshma Rangwala, Luis Manso, Mansoor Mirza, Bradley J Monk, Ignace Vergote, ,

<h4>Background</h4>Few effective second-line treatments exist for women with recurrent or metastatic cervical cancer. Accordingly, we aimed to evaluate the efficacy and safety of tisotumab vedotin, a tissue factor-directed antibody-drug conjugate, in this patient population.<h4>Methods</h4>This multicentre, open-label, single-arm, phase 2 study was done across 35 academic centres, hospitals, and community practices ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, :]

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EP4 as a Negative Prognostic Factor in Patients with Vulvar Cancer.

Anna Buchholz, Aurelia Vattai, Sophie Fürst, Theresa Vilsmaier, Christina Kuhn, Elisa Schmoeckel, Doris Mayr, Christian Dannecker, Sven Mahner, Udo Jeschke, Helene H Heidegger,

New prognostic factors and targeted therapies are urgently needed to improve therapeutic outcomes in vulvar cancer patients and to reduce therapy related morbidity. Previous studies demonstrated the important role of prostaglandin receptors in inflammation and carcinogenesis in a variety of tumor entities. In this study, we aimed to investigate the ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

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Combined COX-2/PPARγ Expression as Independent Negative Prognosticator for Vulvar Cancer Patients.

Nadine Ansorge, Christian Dannecker, Udo Jeschke, Elisa Schmoeckel, Doris Mayr, Helene H Heidegger, Aurelia Vattai, Maximiliane Burgmann, Bastian Czogalla, Sven Mahner, Sophie Fuerst,

Vulvar cancer incidence numbers have been rising steadily over the past decades. Especially the number of young patients with vulvar cancer increased recently. Therefore, the need to identify new prognostic factors for vulvar carcinoma is more apparent. Cyclooxygenase-2 (COX-2) has long been an object of scientific interest in the context ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(3):]

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Role of Pelvic Lymph Node Resection in Vulvar Squamous Cell Cancer: A Subset Analysis of the AGO-CaRE-1 Study.

Linn Woelber, Mareike Bommert, Philipp Harter, Katharina Prieske, Christine Zu Eulenburg, Julia Jueckstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias Beckmann, Alexander Mustea, Werner Meier, Sven Mahner, Anna Jaeger,

<h4>Background</h4>As the population at risk for pelvic nodal involvement remains poorly described, the role of pelvic lymphadenectomy (LAE) in vulvar squamous cell cancer (VSCC) has been a matter of discussion for decades.<h4>Methods</h4>In the AGO-CaRE-1 study, 1618 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB or higher primary ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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The G-Protein-Coupled Estrogen Receptor (GPER) Regulates Trimethylation of Histone H3 at Lysine 4 and Represses Migration and Proliferation of Ovarian Cancer Cells In Vitro.

Nan Han, Sabine Heublein, Udo Jeschke, Christina Kuhn, Anna Hester, Bastian Czogalla, Sven Mahner, Miriam Rottmann, Doris Mayr, Elisa Schmoeckel, Fabian Trillsch,

Histone H3 lysine 4 trimethylation (H3K4me3) is one of the most recognized epigenetic regulators of transcriptional activity representing, an epigenetic modification of Histone H3. Previous reports have suggested that the broad H3K4me3 domain can be considered as an epigenetic signature for tumor-suppressor genes in human cells. G-protein-coupled estrogen receptor (GPER), ... Read more >>

Cells (Cells)
[2021, 10(3):]

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Immunogenomic Identification for Predicting the Prognosis of Cervical Cancer Patients.

Qun Wang, Aurelia Vattai, Theresa Vilsmaier, Till Kaltofen, Alexander Steger, Doris Mayr, Sven Mahner, Udo Jeschke, Helene Hildegard Heidegger,

Cervical cancer is primarily caused by the infection of high-risk human papillomavirus (hrHPV). Moreover, tumor immune microenvironment plays a significant role in the tumorigenesis of cervical cancer. Therefore, it is necessary to comprehensively identify predictive biomarkers from immunogenomics associated with cervical cancer prognosis. The Cancer Genome Atlas (TCGA) public database ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(5):]

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Integrin α2β1 Represents a Prognostic and Predictive Biomarker in Primary Ovarian Cancer.

Katharina Dötzer, Friederike Schlüter, Franz Edler von Koch, Christine E Brambs, Sabine Anthuber, Sergio Frangini, Bastian Czogalla, Alexander Burges, Jens Werner, Sven Mahner, Barbara Mayer,

Currently, the same first-line chemotherapy is administered to almost all patients suffering from primary ovarian cancer. The high recurrence rate emphasizes the need for precise drug treatment in primary ovarian cancer. Being crucial in ovarian cancer progression and chemotherapeutic resistance, integrins became promising therapeutic targets. To evaluate its prognostic and ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(3):]

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EP4 as a Negative Prognostic Factor in Patients with Vulvar Cancer

Anna Buchholz, Aurelia Vattai, Sophie Fürst, Theresa Vilsmaier, Christina Kuhn, Elisa Schmoeckel, Doris Mayr, Christian Dannecker, Sven Mahner, Udo Jeschke, Helene H. Heidegger,

<h4>Simple Summary</h4> Within this study we investigated the expression of EP4 in vulvar cancer, its correlation with clinic-pathological parameters, its association with overall survival, and the effect oft EP4 antagonism on vulvar cancer cells, aiming to find a prognostic and potentially targetable marker in vulvar cancer. Cox regression revealed EP4 ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

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Age, treatment and prognosis of patients with squamous cell vulvar cancer (VSCC) - analysis of the AGO-CaRE-1 study.

Katharina Prieske, Linn Woelber, Mustafa Zelal Muallem, Christine Eulenburg, Julia Kathrin Jueckstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias Beckmann, Alexander Mustea, Werner Meier, Philipp Harter, Pauline Wimberger, Jalid Sehouli, Sven Mahner,

<h4>Background</h4>Despite an increasing incidence with simultaneous decreasing age of onset, vulvar squamous cell carcinoma (VSCC) is still a disease that mainly effects the elderly population. Data on the association of age with prognosis and treatment patterns in VSCC are sparse.<h4>Methods</h4>This is an analysis of the AGO-CaRE-1 cohort. Patients with VSCC ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, :]

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First Evidence for a Role of Siglec-8 in Breast Cancer.

Anna Trebo, Nina Ditsch, Tom Degenhardt, Christina Kuhn, Martina Rahmeh, Elisa Schmoeckel, Doris Mayr, Bastian Czogalla, Thomas Kolben, Sarah Meister, Sven Mahner, Udo Jeschke, Anna Hester,

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are involved in various immune cell-mediated diseases. Their role in cancer is poorly investigated, and research focusses on Siglec-expression on immune cells interacting with tumor cells. This study evaluates the role of Siglec-8 in breast cancer (BC). Siglec-8 expression was analyzed immunohistochemically on 235 primary ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(4):]

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Epigenetic modification via H3K4me3 and H3K9ac in human placenta is reduced in preeclampsia.

Sarah Meister, Laura Hahn, Susanne Beyer, Christina Kuhn, Magdalena Jegen, Viktoria von Schönfeldt, Stefanie Corradini, Christian Schulz, Theresa Maria Kolben, Anna Hester, Tamara Appelt, Sven Mahner, Udo Jeschke, Thomas Kolben,

<h4>Backround</h4>Alterations of DNA accessibility and chromatin structure are associated with diseases. We aimed to investigate epigenetic modifications in preeclampsia (PE), a pregnancy-associated hypertonic disease. Specifically, we addressed histone modification proteins H3K9ac (acetylated lysine 9 of the histone H3) and H3K4me3 (trimethylated lysine 4 of the histone H3) in PE.<h4>Methods</h4>We analyzed ... Read more >>

J Reprod Immunol (Journal of reproductive immunology)
[2021, 145:103287]

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G Protein-Coupled Estrogen Receptor Correlates With Dkk2 Expression and Has Prognostic Impact in Ovarian Cancer Patients.

Patricia Fraungruber, Till Kaltofen, Sabine Heublein, Christina Kuhn, Doris Mayr, Alexander Burges, Sven Mahner, Philipp Rathert, Udo Jeschke, Fabian Trillsch,

<h4>Purpose</h4>Wnt pathway modulator Dickkopf 2 (Dkk2) and signaling of the G protein-coupled estrogen receptor (GPER) seem to have essential functions in numerous cancer types. For epithelial ovarian cancer (EOC), it has not been proven if either Dkk2 or the GPER on its own have an independent impact on overall survival ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2021, 12:564002]

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Diagnostic Workup for Endometrioid Borderline Ovarian Tumors (eBOT) Requires Histopathological Evaluation of the Uterus

Juliane Reichenbach, Elisa Schmoeckel, Sven Mahner, Fabian Trillsch,

<h4>Background: </h4> For young borderline ovarian tumor (BOT) patients, preservation of the uterus was incorporated as an accepted option into treatment guidelines. For the endometrioid subtype (eBOT) however, adequate histological evaluation is challenging and might be associated with synchronous endometrial disorders or misinterpreted as spread from uterine primaries. Case presentationWe ... Read more >>

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Impact of clinical factors and surgical outcome on long-term survival in high-grade serous ovarian cancer: a multicenter analysis.

Joanna Baum, Elena Ioana Braicu, Oliver Hunsicker, Ignace Vergote, Nicole Concin, Els Van Nieuwenhuysen, Aarne Feldheiser, Patriciu Achimas-Cadariu, Silvia Darb-Esfahani, Astrid Berger, Bogdan Fetica, Sven Mahner, Andrea Papadia, Linn Wölber, Maria Luisa Gasparri, Adriaan Vanderstichele, Pierluigi Benedetti Panici, Michael D Mueller, Ilary Ruscito, Hannah Woopen, Jalid Sehouli,

<h4>Introduction</h4>Long-term survivors of ovarian cancer are a unique group of patients in whom prognostic factors for long-term survival have been poorly described. Such factors may provide information for a more personalized therapeutic approach. The objective of this study is to determine further characteristics of long-term survivors with high-grade serous ovarian ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, :]

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Interleukin-1 beta is significantly upregulated in the decidua of spontaneous and recurrent miscarriage placentas.

Sanja Löb, Niklas Amann, Christina Kuhn, Elisa Schmoeckel, Achim Wöckel, Alaleh Zati Zehni, Till Kaltofen, Simon Keckstein, Jan-Niclas Mumm, Sarah Meister, Thomas Kolben, Sven Mahner, Udo Jeschke, Theresa Vilsmaier,

<h4>Background</h4>Pregnancy is an extraordinarily complex immunological process. For successful pregnancy maintenance the maternal immune system must adapt to and tolerate the semi-allogenic fetus at the fetomaternal interface of the placenta. This balance is regulated by cytokines with a predominant T helper 2 (Th-2) system and a suppressed inflammatory T helper ... Read more >>

J Reprod Immunol (Journal of reproductive immunology)
[2021, 144:103283]

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p53 and p16 expression profiles in vulvar cancer: a translational analysis by the Arbeitsgemeinschaft Gynäkologische Onkologie Chemo and Radiotherapy in Epithelial Vulvar Cancer study group.

Linn Woelber, Katharina Prieske, Christine Eulenburg, Leticia Oliveira-Ferrer, Nikolaus de Gregorio, Ruediger Klapdor, Matthias Kalder, Iona Braicu, Sophie Fuerst, Maximilian Klar, Hans-Georg Strauss, Matthias Beckmann, Werner Meier, Atanas Ignatov, Alexander Mustea, Julia Jueckstock, Georg Schmidt, Dirk Bauerschlag, Martin Hellriegel, Ulrich Canzler, Karl Ulrich Petry, Stefan Kommoss, Peer Hantschmann, Martin Heubner, Sven Mahner, Eike Burandt,

<h4>Background</h4>There are 2 known pathways for tumorigenesis of vulvar squamous cell carcinoma-a human papillomavirus-dependent pathway characterized by p16 overexpression and a human papillomavirus-independent pathway linked to lichen sclerosus, characterized by TP53 mutation. A correlation of human papillomavirus dependency with a favorable prognosis has been proposed.<h4>Objective</h4>The objective of the study was ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

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The Prognostic Impact of Retinoid X Receptor and Thyroid Hormone Receptor alpha in Unifocal vs. Multifocal/Multicentric Breast Cancer.

Alaleh Zati Zehni, Falk Batz, Aurelia Vattai, Till Kaltofen, Svenja Schrader, Sven-Niclas Jacob, Jan-Niclas Mumm, Helene Hildegard Heidegger, Nina Ditsch, Sven Mahner, Udo Jeschke, Theresa Vilsmaier,

The aim of this study was to assess the prognostic value of the steroid hormone receptor expression, counting the retinoid X receptor (RXR) and thyroid hormone receptors (THRs), on the two different breast cancer (BC) entities: multifocal/multicentric versus unifocal. The overall and disease-free survival were considered as the prognosis determining ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(2):]

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Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Trophoblast Functions.

Lin Peng, Huixia Yang, Yao Ye, Zhi Ma, Christina Kuhn, Martina Rahmeh, Sven Mahner, Antonis Makrigiannakis, Udo Jeschke, Viktoria von Schönfeldt,

Peroxisome proliferator-activated receptors (PPARα, PPAR<i>β/δ</i>, and PPAR<i>γ</i>) belong to the transcription factor family, and they are highly expressed in all types of trophoblast during pregnancy. The present review discusses currently published papers that are related to the regulation of PPARs via lipid metabolism, glucose metabolism, and amino acid metabolism to ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(1):]

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Pregnancy Zone Protein (PZP) is significantly upregulated in the decidua of recurrent and spontaneous miscarriage and negatively correlated to Glycodelin A (GdA).

Sanja Löb, Aurelia Vattai, Christina Kuhn, Elisa Schmoeckel, Sven Mahner, Achim Wöckel, Thomas Kolben, Christiane Keil, Udo Jeschke, Theresa Vilsmaier,

<h4>Background</h4>Pregnancy Zone Protein (PZP) is an immunosuppressive protein that is expressed by the placenta and has also been identified in immune cells. When PZP and Glycodelin A (GdA) are combined, they act synergistically to inhibit Th-1 immune response. Little is known about its combined expression and role in normal and ... Read more >>

J Reprod Immunol (Journal of reproductive immunology)
[2021, 143:103267]

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L-Dopa-Decarboxylase (DDC) Is a Positive Prognosticator for Breast Cancer Patients and Epinephrine Regulates Breast Cancer Cell (MCF7 and T47D) Growth In Vitro According to Their Different Expression of Gi- Protein- Coupled Receptors.

Eileen Tremmel, Christina Kuhn, Till Kaltofen, Theresa Vilsmaier, Doris Mayr, Sven Mahner, Nina Ditsch, Udo Jeschke, Aurelia Vattai,

A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system. Catecholamines themselves are synthesized by the L-dopa decarboxylase (DDC). The aim of our study was to analyze the influence of catecholamines ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(24):]

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Pelvic Lymphadenectomy in Vulvar Cancer - Does it make sense?

Linn Woelber, Mareike Bommert, Katharina Prieske, Inger Fischer, Christine Zu Eulenburg, Eik Vettorazzi, Philipp Harter, Julia Jueckstock, Felix Hilpert, Niko de Gregorio, Severine Iborra, Jalid Sehouli, Atanas Ignatov, Peter Hillemanns, Sophie Fuerst, Hans-Georg Strauss, Klaus Baumann, Matthias Beckmann, Alexander Mustea, Werner Meier, Pauline Wimberger, Lars Hanker, Ulrich Canzler, Tanja Fehm, Alexander Luyten, Martin Hellriegel, Jens Kosse, Christoph Heiss, Peer Hantschmann, Peter Mallmann, Berno Tanner, Jacobus Pfisterer, Sven Mahner, Barbara Schmalfeldt, Anna Jaeger,

Since the publication of the updated German guideline in 2015, the recommendations for performing pelvic lymphadenectomy (LAE) in patients with vulvar cancer (VSCC) have changed considerably. The guideline recommends surgical lymph node staging in all patients with a higher risk of pelvic lymph node involvement. However, the current data do ... Read more >>

Geburtshilfe Frauenheilkd (Geburtshilfe und Frauenheilkunde)
[2020, 80(12):1221-1228]

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Development and Validation of a Novel 11-Gene Prognostic Model for Serous Ovarian Carcinomas Based on Lipid Metabolism Expression Profile.

Mingjun Zheng, Heather Mullikin, Anna Hester, Bastian Czogalla, Helene Heidegger, Theresa Vilsmaier, Aurelia Vattai, Anca Chelariu-Raicu, Udo Jeschke, Fabian Trillsch, Sven Mahner, Till Kaltofen,

(1) Background: Biomarkers might play a significant role in predicting the clinical outcomes of patients with ovarian cancer. By analyzing lipid metabolism genes, future perspectives may be uncovered; (2) Methods: RNA-seq data for serous ovarian cancer were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The non-negative ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(23):]

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