Full Text Journal Articles by
Author Suzanne R Thibodeaux

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Updates in Blood Banking and Transfusion Medicine.

Suzanne R Thibodeaux,

Clin Lab Med (Clinics in laboratory medicine)
[2021, 41(4):xiii-xiv]

Cited: 0 times

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Volume determination methods for hematopoietic progenitor cell products collected by apheresis.

Mei San Tang, Diane S Sempek, Karlyn J Rensing, Suzanne R Thibodeaux,

<h4>Background aims</h4>CD34<sup>+</sup> cell count of hematopoietic progenitor cell products is often first determined using a product sample, with the final reported cell count obtained by multiplying cell count from the sample by the total product volume. Product volume may be determined by apheresis instruments used for collection or calculated based ... Read more >>

Cytotherapy (Cytotherapy)
[2021, 23(11):991-995]

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IFNα Augments Clinical Efficacy of Regulatory T-cell Depletion with Denileukin Diftitox in Ovarian Cancer.

Suzanne R Thibodeaux, Brian B Barnett, Srilakshmi Pandeswara, Shawna R Wall, Vincent Hurez, Vinh Dao, Lishi Sun, Benjamin J Daniel, Michael J Brumlik, Justin Drerup, Álvaro Padrón, Teresa Whiteside, Ilona Kryczek, Weiping Zou, Tyler J Curiel,

<h4>Purpose</h4>Immunotherapy treats some cancers, but not ovarian cancer. Regulatory T cells (Tregs) impede anti-ovarian cancer immunity but effective human Treg-directed treatments are lacking. We tested Treg depletion with denileukin diftitox (DD) ± IFNα as ovarian cancer immunotherapy.<h4>Patients and methods</h4>Mice with syngeneic ID8 ovarian cancer challenge were treated with DD, IFNα, ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, 27(13):3661-3673]

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A multicenter evaluation of heterogeneity in cellular therapy processing laboratory procedure times to assess workload capacity.

Suzanne R Thibodeaux, David H McKenna, Zbigniew M Szczepiorkowski, Magali J Fontaine, Linda Kelley, Jo-Anna Reems, Pampee P Young, ,

<h4>Background</h4>Growth in size and complexity of clinical hematopoietic progenitor cell (HPC) transplant programs necessitates parallel increases in cellular therapy laboratory (CTL) workload. Typically individually developed, HPC product processing is labor and time intensive. Variation in procedure type and numbers across CTLs complicates direct comparisons, and benchmark data are not readily ... Read more >>

Transfusion (Transfusion)
[2020, 60(8):1811-1820]

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Commentary on Hemolytic Anemia and Thrombocytopenia: How to Treat?

Suzanne R Thibodeaux,

Clin Chem (Clinical chemistry)
[2020, 66(6):767]

Cited: 0 times

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Optimizing management of replacement fluids for therapeutic plasma exchange: Use of an automated mathematical model to predict post-procedure fibrinogen and antithrombin levels in high-risk patients.

Ray Zhang, Aaron B Dahl, Bryan Marchant, Ronald R Jackups, Hope E Karnes, Priyank Shah, Marian Dynis, Suzanne R Thibodeaux, George J Despotis,

<h4>Background</h4>Therapeutic plasma exchange (TPE) utilizes an extracorporeal circuit to remove pathologic proteins causing serious illness. When processing a patient's entire blood volume through an extracorporeal circuit, proteins responsible for maintaining hemostatic system homeostasis can reach critically low levels if replacement fluid types and volumes are not carefully titrated, which may ... Read more >>

J Clin Apher (Journal of clinical apheresis)
[2020, 35(1):41-49]

Cited: 0 times

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Ensuring safety of the blood supply in the United States: Donor screening, testing, emerging pathogens, and pathogen inactivation.

Elizabeth A Godbey, Suzanne R Thibodeaux,

Safety of the blood supply has been a critical aspect of the transfusion medicine field since its inception, including infections that can be passed to a blood product recipient. Reactive efforts to identify potentially infected blood products are used throughout the blood donation process and afterward. Before donation, potential donors ... Read more >>

Semin Hematol (Seminars in hematology)
[2019, 56(4):229-235]

Cited: 2 times

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A 54-Year-Old Man with Complicated Blood Bank Antibody Testing.

Rehan Rais, Suzanne R Thibodeaux,

Clin Chem (Clinical chemistry)
[2019, 65(12):1614]

Cited: 0 times

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More efficient exchange of sickle red blood cells can be achieved by exchanging the densest red blood cells: An ex vivo proof of concept study.

Suzanne R Thibodeaux, Yvette C Tanhehco, Leah Irwin, Lita Jamensky, Kevin Schell, Una O'Doherty,

<h4>Background</h4>In sickle cell disease (SCD), red blood cells (RBCs) containing hemoglobin S can be denser than RBCs containing wild-type hemoglobin, especially when dehydrated. We hypothesize that targeting denser RBCs during red blood cell (RBC) exchange for SCD could result in more efficient removal of dehydrated, sickled RBCs and preservation of ... Read more >>

Transfus Apher Sci (Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis)
[2019, 58(1):100-106]

Cited: 0 times

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Immunotherapy Using Chimeric Antigen Receptor-Engineered T Cells: A Novel Cellular Therapy with Important Implications for the Clinical Laboratory.

Suzanne R Thibodeaux, Michael C Milone,

<h4>Background</h4>We have entered a new era of cancer therapy, with a number of immune-based therapies already used clinically as a standard of care. Adoptive cellular immunotherapy using T cells genetically modified with chimeric antigen receptors (CAR-T cells) represents a novel therapeutic approach. CAR-T cells have produced clinical responses in B-cell ... Read more >>

Clin Chem (Clinical chemistry)
[2019, 65(4):519-529]

Cited: 1 time

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Vascular access for red blood cell exchange.

Zaher K Otrock, Suzanne R Thibodeaux, Ronald Jackups,

Red blood cell exchange is the process of removing red blood cells from a patient and replacing them with donated blood using either automated or manual techniques. Red blood cell exchange is a well-recognized and effective therapy for many red blood cell-related diseases, especially sickle cell disease. However, decisions regarding ... Read more >>

Transfusion (Transfusion)
[2018, 58 Suppl 1:569-579]

Cited: 2 times

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Novel gene and cellular therapy approaches for treating HIV.

Vijay G Bhoj, Suzanne R Thibodeaux, Bruce L Levine,

Advances in HIV drug therapy have drastically decreased mortality and significantly improved quality of life for HIV infected patients since the early days of the epidemic. However, HIV drug-resistance, drug toxicities, therapy adherence, and the need for life-long treatment remain major challenges that continue to contribute to HIV-related global health ... Read more >>

Discov Med (Discovery medicine)
[2016, 21(116):283-292]

Cited: 2 times

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TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production.

Michael J Brumlik, Srilakshmi Pandeswara, Sara M Ludwig, Duane P Jeansonne, Michelle R Lacey, Kruthi Murthy, Benjamin J Daniel, Rong-Fu Wang, Suzanne R Thibodeaux, Kristina M Church, Vincent Hurez, Mark J Kious, Bin Zhang, Adebusola Alagbala, Xiaojun Xia, Tyler J Curiel,

The parasite Toxoplasma gondii controls tissue-specific nitric oxide (NO), thereby augmenting virulence and immunopathology through poorly-understood mechanisms. We now identify TgMAPK1, a Toxoplasma mitogen-activated protein kinase (MAPK), as a virulence factor regulating tissue-specific parasite burden by manipulating host interferon (IFN)-γ-mediated inducible nitric oxide synthase (iNOS). Toxoplasma with reduced TgMAPK1 expression ... Read more >>

Exp Parasitol (Experimental parasitology)
[2013, 134(3):389-399]

Cited: 8 times

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Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells.

Lishi Sun, Vincent J Hurez, Suzanne R Thibodeaux, Mark J Kious, Aijie Liu, Peiyi Lin, Kruthi Murthy, Srilakshmi Pandeswara, Tahiro Shin, Tyler J Curiel,

Regulatory T cells (Tregs) are specialized CD4(+) T lymphocytes helping defend against autoimmunity and inflammation. Although age is associated with increased inflammation and autoimmunity, few reports address age effects of immune regulation or auto-aggressive T cells. We show here that young and aged naïve CD4(+) T cells are ... Read more >>

Aging Cell (Aging cell)
[2012, 11(3):509-519]

Cited: 29 times

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Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice.

Vincent Hurez, Benjamin J Daniel, Lishi Sun, Ai-Jie Liu, Sara M Ludwig, Mark J Kious, Suzanne R Thibodeaux, Srilakshmi Pandeswara, Kruthi Murthy, Carolina B Livi, Shawna Wall, Michael J Brumlik, Tahiro Shin, Bin Zhang, Tyler J Curiel,

Although cancer tends to affect the elderly, most preclinical studies are carried out in young subjects. In this study, we developed a melanoma-specific cancer immunotherapy that shows efficacy in aged but not young hosts by mitigating age-specific tumor-associated immune dysfunction. Both young and aged CD4(+)CD25(hi) regulatory T cells (Treg) exhibited ... Read more >>

Cancer Res (Cancer research)
[2012, 72(8):2089-2099]

Cited: 43 times

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Immune therapy for ovarian cancer: promise and pitfalls.

Suzanne R Thibodeaux, Tyler J Curiel,

This review covers immune and anatomic considerations specific for ovarian cancer immune therapy. Prior approaches and potential reasons for lack of better efficacy are discussed, along with newer approaches in pre-clinical and early clinical development. Potential means for future investigations and means to integrate immune with other approaches are discussed. ... Read more >>

Int Rev Immunol (International reviews of immunology)
[2011, 30(2-3):102-119]

Cited: 10 times

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B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.

Pei-Yi Lin, Lishi Sun, Suzanne R Thibodeaux, Sara M Ludwig, Ratna K Vadlamudi, Vincent J Hurez, Rumana Bahar, Mark J Kious, Carolina B Livi, Shawna R Wall, Lieping Chen, Bin Zhang, Tahiro Shin, Tyler J Curiel,

CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are immunopathogenic in cancers by impeding tumor-specific immunity. B7-homologue 1 (B7-H1) (CD274) is a cosignaling molecule with pleiotropic effects, including hindering antitumor immunity. In this study, we demonstrate sex-dependent, B7-H1-dependent differences in tumor immunity and response to immunotherapy in a hormone-independent cancer, murine B16 melanoma. ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2010, 185(5):2747-2753]

Cited: 73 times

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A simple method to detect Toxoplasma gondii-specific cytotoxic T cells in vivo.

Benjamin J Daniel, Srilakshmi Pandeswara, Michael J Brumlik, Aijie Liu, Suzanne R Thibodeaux, Sara M Ludwig, Xiuhua Sun, Tyler J Curiel,

Cytotoxic T cells (CTLs) are an important component of adaptive immunity. The study of antigen-specific CTLs in vivo is desirable yet difficult. Identification of the class I-restricted peptide used by CTLs for target recognition is often required for detailed studies, but is generally not known for most antigens. Toxoplasma gondii ... Read more >>

J Immunol Methods (Journal of immunological methods)
[2010, 355(1-2):86-90]

Cited: 2 times

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