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Author Suwon Kim

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Inhibition of SARS-CoV 3CL protease by flavonoids.

Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim,

There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):145-151]

Cited: 16 times

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Flavonoids with inhibitory activity against SARS-CoV-2 3CLpro.

Seri Jo, Suwon Kim, Dae Yong Kim, Mi-Sun Kim, Dong Hae Shin,

Coronavirus disease 2019 (COVID-19) has been a pandemic disease of which the termination is not yet predictable. Currently, researches to develop vaccines and treatments is going on globally to cope with this disastrous disease. Main protease (3CLpro) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the good targets ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):1539-1544]

Cited: 0 times

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A study of Rose Bengal against a 2-keto-3-deoxy-d-manno-octulosonate cytidylyltransferase as an antibiotic candidate.

Suwon Kim, Seri Jo, Mi-Sun Kim, Dong Hae Shin,

Frequent occurrences of multi-drug resistance of pathogenic Gram-negative bacteria threaten human beings. The CMP-2-keto-3-deoxy-d-manno-octulosonic acid biosynthesis pathway is one of the new targets for antibiotic design. 2-Keto-3-deoxy-d-manno-octulosonate cytidylyltransferase (KdsB) is the key enzyme in this pathway. KdsB proteins from Burkholderia pseudomallei (Bp), B. thailandensis (Bt), Pseudomonas aeruginosa (Pa), and Chlamydia ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):1414-1421]

Cited: 0 times

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A Tryptophan-based Assay Method to Search Regulatory Compounds for TCTP

Seri Jo, Eun-Wha Jang, Mi-Sun Kim, Suwon Kim, Kyunglim Lee, Dong Hae Shin,

Transcriptionally controlled tumor protein (TCTP) is a highly conserved protein performing a large number of cellular functions by binding with various partner proteins. The importance of its roles in many diseases requires an assay method to find regulatory compounds. However, the molecular characteristics of TCTP made it difficult to search ... Read more >>

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GTP Preference of d-Glycero-α-d-manno-Heptose-1-Phosphate Guanylyltransferase from Yersinia pseudotuberculosis.

Suwon Kim, Mi-Sun Kim, Seri Jo, Dong Hae Shin,

d-glycero-α-d-manno-heptose-1-phosphate guanylyltransferase (HddC) is the fourth enzyme synthesizing a building component of lipopolysaccharide (LPS) of Gram-negative bacteria. Since HddC is a potential new target to develop antibiotics, the analysis of the structural and functional relationship of the complex structure will lead to a better idea to design inhibitory compounds. X-ray ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 21(1):]

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PD-1-Associated Gene Expression Signature of Neoadjuvant Trastuzumab-Treated Tumors Correlates with Patient Survival in HER2-Positive Breast Cancer.

William P D Hendricks, Natalia Briones, Rebecca F Halperin, Salvatore Facista, Paul R Heaton, Daruka Mahadevan, Suwon Kim,

The therapeutic HER2-targeting antibody trastuzumab has been shown to elicit tumor immune response in a subset of HER2-positive (HER2+) breast cancer. We performed genomic and immunohistochemical profiling of tumors from eight patients who have completed multiple rounds of neoadjuvant trastuzumabb to identify predictive biomarkers for trastuzumab-elicited tumor immune responses. Immunohistochemistry ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(10):]

Cited: 1 time

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A Study of a Potent Inhibitor Against a GDP-6-Deoxy-α-d-Manno-Heptose Biosynthesis Pathway as Antibiotic Candidates.

Suwon Kim, Seri Jo, Mi-Sun Kim, Dong Hae Shin,

The GDP-6-deoxy-α-d-manno-heptose is a key building block molecule in constructing lipopolysaccharide of Gram-negative bacteria. Therefore, blockage of the biosynthesis pathway of GDP-6-deoxy-α-d-manno-heptose is lethal or increases antibiotics susceptibility to pathogens. In this study, we assayed d-glycero-α-d-manno-heptose-1-phosphate guanylyltransferase (HddC) from Yersinia pseudotuberculosis (Yp) using an efficient assay method supplying its natural ... Read more >>

Microb. Drug Resist. (Microbial drug resistance (Larchmont, N.Y.))
[2020, 26(4):385-390]

Cited: 0 times

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Crystal structure of d-glycero-α-d-manno-heptose-1-phosphate guanylyltransferase from Yersinia pseudotuberculosis.

Hyojin Kim, Jimin Park, Suwon Kim, Dong Hae Shin,

The Gram-negative bacterium Yersinia pseudotuberculosis is the causative agent of yersiniosis. d-glycero-α-d-manno-heptose-1-phosphate guanylyltransferase (HddC) is the fourth enzyme of the GDP-d-glycero-α-d-manno-heptose biosynthesis pathway which is important for the virulence of the microorganism. Therefore, HddC is a potential target of antibiotics against yersiniosis. In this study, HddC from the synthesized HddC ... Read more >>

Biochim Biophys Acta Proteins Proteom (Biochimica et biophysica acta. Proteins and proteomics)
[2018, 1866(3):482-487]

Cited: 1 time

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Crystal structure of D-glycero-Β-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei.

Jimin Park, Hyojin Kim, Suwon Kim, Daeun Lee, Mi-Sun Kim, Dong Hae Shin,

The crystal structure of HldC from B. pseudomallei (BpHldC), the fourth enzyme of the heptose biosynthesis pathway, has been determined. BpHldC converts ATP and d-glycero-β-d-manno-heptose-1-phosphate into ADP-d-glycero-β-d-manno-heptose and pyrophosphate. The crystal structure of BpHldC belongs to the nucleotidyltransferase α/β phosphodiesterase superfamily sharing a common Rossmann-like α/β fold with a conserved ... Read more >>

Proteins (Proteins)
[2018, 86(1):124-131]

Cited: 0 times

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Expression and crystallographic studies of D-glycero-β-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei.

Jimin Park, Hyojin Kim, Suwon Kim, Daeun Lee, Dong Hae Shin,

The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis. D-glycero-β-D-manno-Heptose-1-phosphate adenylyltransferase (HldC) is the fourth enzyme of the ADP-L-glycero-β-D-manno-heptose biosynthesis pathway, which produces an essential carbohydrate comprising the inner core of lipopolysaccharide. Therefore, HldC is a potential target of antibiotics against melioidosis. In this study, HldC from B. ... Read more >>

Acta Crystallogr F Struct Biol Commun (Acta crystallographica. Section F, Structural biology communications)
[2017, 73(Pt 2):90-94]

Cited: 1 time

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Tumor suppressor ING4 inhibits estrogen receptor activity in breast cancer cells.

Madeline M Keenen, Suwon Kim,

Resistance to antiestrogen therapy remains a significant problem in breast cancer. Low expression of inhibitor of growth 4 (ING4) in primary tumors has been correlated with increased rates of recurrence in estrogen receptor-positive (ER+) breast cancer patients, suggesting a role for ING4 in ER signaling. This study provides evidence that ... Read more >>

Breast Cancer (Dove Med Press) (Breast cancer (Dove Medical Press))
[2016, 8:211-221]

Cited: 1 time

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New and emerging factors in tumorigenesis: an overview.

Suwon Kim,

This article provides an overview of the genes and cellular processes that have emerged recently as new key factors in tumorigenesis. We review these in the context of three broad categories. First, genome-scale sequencing studies have revealed a set of frequently mutated genes in cancer. Genes that are mutated in ... Read more >>

Cancer Manag Res (Cancer management and research)
[2015, 7:225-239]

Cited: 14 times

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Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.

Penny L Berger, Sander B Frank, Veronique V Schulz, Eric A Nollet, Mathew J Edick, Brittany Holly, Ting-Tung A Chang, Galen Hostetter, Suwon Kim, Cindy K Miranti,

The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer development are poorly understood. We identified the chromatin remodeling protein, ING4, as a crucial switch downstream of Myc and Pten that is required for human prostate epithelial differentiation. Myc-induced transient expression of ING4 is required for the differentiation ... Read more >>

Cancer Res. (Cancer research)
[2014, 74(12):3357-3368]

Cited: 16 times

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Deletion of the inhibitor of growth 4 (ING4) tumor suppressor gene is prevalent in human epidermal growth factor 2 (HER2)-positive breast cancer.

Coya Tapia, Inti Zlobec, Sandra Schneider, Ergin Kilic, Uwe Güth, Lukas Bubendorf, Suwon Kim,

Inhibitor of growth 4 (ING4) is a candidate tumor suppressor gene that was shown to be deleted in 10% to 20% of breast cancers by array comparative genome hybridization analysis. We developed fluorescent in situ hybridization to detect the ING4 gene directly in the tissue samples on tumor tissue microarrays. ... Read more >>

Hum. Pathol. (Human pathology)
[2011, 42(7):983-990]

Cited: 17 times

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HuntING4 new tumor suppressors.

Suwon Kim,

The well-characterized function of many tumor suppressors is to directly regulate cell cycle events. We recently reported a genetic screen to identify genes that suppress loss of contact inhibition but do not inhibit normal cell proliferation. ING4, one of the genes identified by the screen, is frequently mutated in human ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2005, 4(4):516-517]

Cited: 18 times

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MET and MYC cooperate in mammary tumorigenesis.

Alana L Welm, Suwon Kim, Bryan E Welm, J Michael Bishop,

In human breast cancer, overexpression of the protooncogene MET is strongly associated with poor prognosis and high risk of metastasis. It stands out as a reliable prognostic indicator of survival and defines a set of tumors exclusive of those that express HER2 or hormone receptors. Studies have shown that overexpression ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2005, 102(12):4324-4329]

Cited: 57 times

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A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer.

Suwon Kim, Koei Chin, Joe W Gray, J Michael Bishop,

We have devised a screen for genes that suppress the loss of contact inhibition elicited by overexpression of the protooncogene MYCN. The initial application of this screen detected nine distinctive suppressors within a representative human cDNA library. One of these genes was ING4, a potential tumor suppressor gene that maps ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2004, 101(46):16251-16256]

Cited: 83 times

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Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins.

S Kim, B Schilke, E A Craig, A L Horwich,

The nature of chaperone action in the eukaryotic cytosol that assists newly translated cytosolic proteins to reach the native state has remained poorly defined. Actin, tubulin, and Galpha transducin are assisted by the cytosolic chaperonin, CCT, but many other proteins, for example, ornithine transcarbamoylase (OTC), a cytosolic homotrimeric enzyme of ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[1998, 95(22):12860-12865]

Cited: 41 times

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