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Suveer Singh, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Susanna Price, Sujal Desai, Carole A Ridge, Simon P G Padley, Saeed Mirsadraee,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1190-e1191]

Cited: 0 times

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Lung Function Deficits and Symptom Burden in Survivors of COVID-19 Requiring Mechanical Ventilation.

Lydia J Finney, Rachel Doughty, Samuel Lovage, Lydia Spurr, Bhavin Mehta, Samuel V Kemp, Felix Chua, Laura C Price, Suveer Singh, William D C Man,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(10):1740-1743]

Cited: 2 times

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Near-fatal Panton-Valentine leukocidin-positive Staphylococcus aureus pneumonia, shock and complicated extracorporeal membrane oxygenation cannulation: A case report.

Joshua Cuddihy, Shreena Patel, Nabeela Mughal, Christopher Lockie, Richard Trimlett, Stephane Ledot, Nicholas Cheshire, Ajay Desai, Suveer Singh,

<h4>Background</h4>Panton-Valentine leukocidin (PVL) is an exotoxin secreted by <i>Staphylococcus aureus</i> (<i>S. aureus</i>), responsible for skin and soft tissue infections. As a cause of severe necrotising pneumonia, it is associated with a high mortality rate. A rare entity, the epidemiology of PVL <i>S. aureus</i> (PVL<i>-SA</i>) pneumonia as a complication of influenza ... Read more >>

World J Crit Care Med (World journal of critical care medicine)
[2021, 10(5):301-309]

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Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial.

James J McNamee, Michael A Gillies, Nicholas A Barrett, Gavin D Perkins, William Tunnicliffe, Duncan Young, Andrew Bentley, David A Harrison, Daniel Brodie, Andrew J Boyle, Jonathan E Millar, Tamas Szakmany, Jonathan Bannard-Smith, Redmond P Tully, Ashley Agus, Clíona McDowell, Colette Jackson, Daniel F McAuley, ,

<h4>Importance</h4>In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.<h4>Objective</h4>To determine whether lower tidal volume mechanical ventilation using extracorporeal carbon dioxide removal improves outcomes in patients with acute hypoxemic respiratory failure.<h4>Design, setting, and participants</h4>This ... Read more >>

JAMA (JAMA)
[2021, 326(11):1013-1023]

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Six Month Mortality in Patients with COVID-19 and Non-COVID-19 Viral Pneumonitis Managed with Veno-Venous Extracorporeal Membrane Oxygenation.

Benjamin Garfield, Paolo Bianchi, Deepa Arachchillage, Philip Hartley, Vinci Naruka, Diana Shroff, Alexander Law, Maurizio Passariello, Brijesh Patel, Susanna Price, Alexander Rosenberg, Suveer Singh, Richard Trimlett, Tina Xu, James Doyle, Stephane Ledot,

A significant proportion of patients with COVID-19 develop acute respiratory distress syndrome (ARDS) with high risk of death. The efficacy of veno-venous extracorporeal membrane oxygenation (VV-ECMO) for COVID-19 on longer-term outcomes, unlike in other viral pneumonias, is unknown. In this study, we aimed to compare the 6 month mortality of ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(9):982-988]

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Pneumomediastinum in COVID-19: Merely a Matter of Lung Frailty?

Khevan Somasundram, Kaladerhan Agbontaen, Suveer Singh,

Respiration (Respiration; international review of thoracic diseases)
[2021, :1-5]

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Impact of Thrombosis and Bleeding in Patients with Severe COVID-19 versus Other Viral Pneumonias in the Context of Extracorporeal Membrane Oxygenation.

Anna Weatherill, Mike Laffan, Mihaela Gasper, Paolo Bianchi, Maurizio Passariello, Suveer Singh, James Doyle, Brijesh Patel, Stephane Ledot, Benjamin Garfield, Deepa J Arachchillage,

Semin Thromb Hemost (Seminars in thrombosis and hemostasis)
[2021, :]

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Intensivists' beliefs about rapid multiplex molecular diagnostic testing and its potential role in improving prescribing decisions and antimicrobial stewardship: a qualitative study.

Alyssa M Pandolfo, Robert Horne, Yogini Jani, Tom W Reader, Natalie Bidad, David Brealey, Virve I Enne, David M Livermore, Vanya Gant, Stephen J Brett, ,

<h4>Background</h4>Rapid molecular diagnostic tests to investigate the microbial aetiology of pneumonias may improve treatment and antimicrobial stewardship in intensive care units (ICUs). Clinicians' endorsement and uptake of these tests is crucial to maximise engagement; however, adoption may be impeded if users harbour unaddressed concerns or if device usage is incompatible ... Read more >>

Antimicrob Resist Infect Control (Antimicrobial resistance and infection control)
[2021, 10(1):95]

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Utility of echocardiographic right ventricular subcostal strain in critical care.

Caroline Bleakley, Antonio de Marvao, Marco Morosin, Emmanouil Androulakis, Clare Russell, Andre Athayde, Antonio Cannata, Maurizio Passariello, Stéphane Ledot, Suveer Singh, John Pepper, Jonathan Hill, Martin Cowie, Susanna Price,

<h4>Aims</h4>Right ventricular (RV) strain is a known predictor of outcomes in various heart and lung pathologies but has been considered too technically challenging for routine use in critical care. We examined whether RV strain acquired from the subcostal view, frequently more accessible in the critically ill, is an alternative to ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2021, :]

Cited: 0 times

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Understanding decisions about antibiotic prescribing in ICU: an application of the Necessity Concerns Framework.

Alyssa M Pandolfo, Robert Horne, Yogini Jani, Tom W Reader, Natalie Bidad, David Brealey, Virve I Enne, David M Livermore, Vanya Gant, Stephen J Brett, ,

<h4>Background</h4>Antibiotics are extensively prescribed in intensive care units (ICUs), yet little is known about how antibiotic-related decisions are made in this setting. We explored how beliefs, perceptions and contextual factors influenced ICU clinicians' antibiotic prescribing.<h4>Methods</h4>We conducted 4 focus groups and 34 semistructured interviews with clinicians involved in antibiotic prescribing in ... Read more >>

BMJ Qual Saf (BMJ quality & safety)
[2021, :]

Cited: 1 time

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Prevalence of Thrombotic Complications in ICU-Treated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning.

Saeed Mirsadraee, Diana A Gorog, Ciara F Mahon, Bhavin Rawal, Thomas R Semple, Edward D Nicol, Deepa R J Arachchillage, Anand Devaraj, Susanna Price, Sujal R Desai, Carole A Ridge, Suveer Singh, Simon P G Padley,

<h4>Objectives</h4>Severe coronavirus disease 2019 is associated with an extensive pneumonitis and frequent coagulopathy. We sought the true prevalence of thrombotic complications in critically ill patients with severe coronavirus disease 2019 on the ICU, with or without extracorporeal membrane oxygenation.<h4>Design</h4>We undertook a single-center, retrospective analysis of 72 critically ill patients with ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(5):804-815]

Cited: 4 times

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The Impact of Norepinephrine on Myocardial Perfusion in Critical Illness.

Caroline Bleakley, Antonio de Marvao, Andre Athayde, Timothy Kuhn, Tina Xu, Christine Weaver, Suveer Singh, Jonathan Hill, John Pepper, Susanna Price,

J Am Soc Echocardiogr (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)
[2021, 34(9):1019-1020]

Cited: 0 times

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Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.

Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.<h4>Methods</h4>Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):106]

Cited: 6 times

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Reply to: RV dysfunction in Covid-19 ARDS: Is there a difference in the impact of mechanical ventilation and ECMO?

Caroline Bleakley, Suveer Singh, Antonio de Marvao, Marco Morosin, Emmanouil Androulakis, Antonio Cannata, Susanna Price,

Int J Cardiol (International journal of cardiology)
[2021, 332:239]

Cited: 0 times

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Safe and Efficient Practice of Bronchoscopic Sampling from Mechanically Ventilated Patients: A Structured Evaluation of the Ambu Bronchosampler-Ascope 4 Integrated System.

Suveer Singh, Pallav L Shah,

<h4>Background</h4>Bronchoscopic sampling of bronchoalveolar fluid (BAL) should be safe and effective. Current sampling practice risks loss of sample to the attached negative flow, aerosolisation, or spillage, due to repeated circuit breaks, when replacing sample containers. Such concerns were highlighted during the recent coronavirus pandemic.<h4>Objectives</h4>Evaluation of an alternative integrated sampling solution, ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2021, 100(1):27-33]

Cited: 0 times

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Veno-venous extracorporeal membrane oxygenation for the acute respiratory distress syndrome: a bridge too far?

Alexander Smith, Cliff Morgan, Stéphane Ledot, James Doyle, Tina Xu, Lynn Shedden, Maurizioassariello Passariello, Brijesh Patel, Anne-Marie Doyle, Susanna Price, Christophe Vandenbriele, Suveer Singh,

Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) provides a bridge to recovery in patients with acute respiratory failure due to the acute respiratory distress syndrome (ARDS). Survival in ARDS has improved over 15 years, and VV-ECMO may rescue even the most severe of these patients. Predictors of survival on ICU are based upon ... Read more >>

Acta Cardiol (Acta cardiologica)
[2021, 76(5):455-458]

Cited: 0 times

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Corona Virus Disease 2019 in situ arterial and venous thrombosis in critically ill patients: a case series.

Mireya Castro-Verdes, Antonia Gkouma, John Wort, Carole Ridge, Saeed Mirsadraee, Simon Padley, Awais Sheikh, Suveer Singh,

<h4>Background</h4>Corona Virus Disease 2019 (COVID-19) pneumonitis associated with severe respiratory failure carries a high mortality. Coagulopathy has emerged as a significant contributor to thrombotic complications.<h4>Case summary</h4>We describe two cases of severe COVID-19 pneumonitis refractory to conventional mechanical ventilation and proning position, transferred to our specialist centre for cardiorespiratory failure. Cross-sectional ... Read more >>

Eur Heart J Case Rep (European heart journal. Case reports)
[2020, 4(6):1-7]

Cited: 1 time

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Right ventricular dysfunction in critically ill COVID-19 ARDS.

Caroline Bleakley, Suveer Singh, Benjamin Garfield, Marco Morosin, Elena Surkova, Ms Sundhiya Mandalia, Bernardo Dias, Emmanouil Androulakis, Laura C Price, Colm McCabe, Stephen John Wort, Cathy West, Wei Li, Rajdeep Khattar, Roxy Senior, Brijesh V Patel, Susanna Price,

<h4>Aims</h4>Comprehensive echocardiography assessment of right ventricular (RV) impairment has not been reported in critically ill patients with COVID-19. We detail the specific phenotype and clinical associations of RV impairment in COVID-19 acute respiratory distress syndrome (ARDS).<h4>Methods</h4>Transthoracic echocardiography (TTE) measures of RV function were collected in critically unwell patients for associations ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 327:251-258]

Cited: 18 times

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Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations.

Brijesh V Patel, Deepa J Arachchillage, Carole A Ridge, Paolo Bianchi, James F Doyle, Benjamin Garfield, Stephane Ledot, Cliff Morgan, Maurizio Passariello, Susanna Price, Suveer Singh, Louit Thakuria, Sarah Trenfield, Richard Trimlett, Christine Weaver, S John Wort, Tina Xu, Simon P G Padley, Anand Devaraj, Sujal R Desai,

<b>Rationale:</b> Clinical and epidemiologic data in coronavirus disease (COVID-19) have accrued rapidly since the outbreak, but few address the underlying pathophysiology.<b>Objectives:</b> To ascertain the physiologic, hematologic, and imaging basis of lung injury in severe COVID-19 pneumonia.<b>Methods:</b> Clinical, physiologic, and laboratory data were collated. Radiologic (computed tomography (CT) pulmonary angiography [<i>n</i> = 39] ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(5):690-699]

Cited: 73 times

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Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD.

Sanooj Soni, Justin L Garner, Kieran P O'Dea, Marissa Koh, Lydia Finney, Nikhil Tirlapur, Karthi Srikanthan, Eric D Tenda, Arafa M Aboelhassan, Suveer Singh, Michael R Wilson, Jadwiga A Wedzicha, Samuel V Kemp, Omar S Usmani, Pallav L Shah, Masao Takata,

Despite advances in the pathophysiology of chronic obstructive pulmonary disease (COPD), there is a distinct lack of biochemical markers to aid clinical management. Microvesicles (MVs) have been implicated in the pathophysiology of inflammatory diseases including COPD, but their association to COPD disease severity remains unknown. We analyzed different MV populations ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2021, 320(1):L73-L83]

Cited: 3 times

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Development and implementation of a COVID-19 near real-time traffic light system in an acute hospital setting.

Marcela P Vizcaychipi, Claire L Shovlin, Alex McCarthy, Alice Howard, Alexander Brown, Michelle Hayes, Suveer Singh, Linsey Christie, Alice Sisson, Roger Davies, Christopher Lockie, Monica Popescu, Amandeep Gupta, James Armstrong, Hisham Said, Timothy Peters, Richard T Keays, ,

Common causes of death in COVID-19 due to SARS-CoV-2 include thromboembolic disease, cytokine storm and adult respiratory distress syndrome (ARDS). Our aim was to develop a system for early detection of disease pattern in the emergency department (ED) that would enhance opportunities for personalised accelerated care to prevent disease progression. ... Read more >>

Emerg Med J (Emergency medicine journal : EMJ)
[2020, 37(10):630-636]

Cited: 1 time

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Intensive Care Weaning (iCareWean) protocol on weaning from mechanical ventilation: a single-blinded multicentre randomised control trial comparing an open-loop decision support system and routine care, in the general intensive care unit.

M P Vizcaychipi, Laura Martins, James R White, Dan Stleper Karbing, Amandeep Gupta, Suveer Singh, Leyla Osman, Jeronimo Moreno-Cuesta, Steve Rees,

<h4>Introduction</h4>Automated systems for ventilator management to date have been either fully heuristic rule-based systems or based on a combination of simple physiological models and rules. These have been shown to reduce the duration of mechanical ventilation in simple to wean patients. At present, there are no published studies that evaluate ... Read more >>

BMJ Open (BMJ open)
[2020, 10(9):e042145]

Cited: 0 times

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Multimodality assessment of sleep outcomes in people living with HIV performed using validated sleep questionnaires.

Ana Milinkovic, Suveer Singh, Bryony Simmons, Anton Pozniak, Marta Boffito, Nneka Nwokolo,

Studies conducted in people living with HIV (PLHIV) report high rates of sleep disturbance, without a clear explanation as to cause or effect. Therefore, we proposed use of multiple validated questionnaires that would allow a more comprehensive evaluation of sleep quality in PLHIV. We administered eight validated sleep and wellbeing ... Read more >>

Int J STD AIDS (International journal of STD & AIDS)
[2020, 31(10):996-1003]

Cited: 1 time

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Weaning by Surgical Tracheostomy and Portable Ventilators Released ICU Ventilators During Coronavirus Disease 2019 Surge in London.

Suveer Singh, Matthew Hind, Simon Jordan, Patrick Ward, Deborah Field, Michael Polkey, Jonathan Collier,

Crit Care Explor (Critical care explorations)
[2020, 2(8):e0193]

Cited: 3 times

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More research is required to understand factors influencing antibiotic prescribing in complex conditions like suspected ventilator-associated pneumonia.

Thomas P Hellyer, Daniel F McAuley, Timothy S Walsh, Niall Anderson, Andrew Conway Morris, Suveer Singh, Paul Dark, Alistair I Roy, Gavin D Perkins, Ronan McMullan, Lydia M Emerson, Bronagh Blackwood, Stephen E Wright, Kallirroi Kefala, Cecilia M O'Kane, Simon V Baudouin, Ross L Paterson, Anthony J Rostron, Ashley Agus, Jonathan Bannard-Smith, Nicole M Robin, Ingeborg D Welters, Christopher Bassford, Bryan Yates, Craig Spencer, Shondipon K Laha, Jonathan Hulme, Stephen Bonner, Vanessa Linnett, Julian Sonksen, Tina Van Den Broeck, Gert Boschman, D W James Keenan, Jonathan Scott, A Joy Allen, Glenn Phair, Jennie Parker, Susan A Bowett, A John Simpson,

Ann Transl Med (Annals of translational medicine)
[2020, 8(13):840]

Cited: 0 times

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