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Author Suvankar Pal

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Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease.

Peter Hermann, Brian Appleby, Jean-Philippe Brandel, Byron Caughey, Steven Collins, Michael D Geschwind, Alison Green, Stephane Haïk, Gabor G Kovacs, Anna Ladogana, Franc Llorens, Simon Mead, Noriyuki Nishida, Suvankar Pal, Piero Parchi, Maurizio Pocchiari, Katsuya Satoh, Gianluigi Zanusso, Inga Zerr,

Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused by misfolded prion proteins (PrP<sup>Sc</sup>). Effective therapeutics are currently not available and accurate diagnosis can be challenging. Clinical diagnostic criteria use a combination of characteristic neuropsychiatric symptoms, CSF proteins 14-3-3, MRI, and EEG. Supportive biomarkers, such as high CSF total tau, ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):235-246]

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Non-Invasive RF Technique for Detecting Different Stages of Alzheimer's Disease and Imaging Beta-Amyloid Plaques and Tau Tangles in the Brain.

Imran Saied, Tughrul Arslan, Siddharthan Chandran, Colin Smith, Tara Spires-Jones, Suvankar Pal,

This paper describes a novel approach of detecting different stages of Alzheimer's disease (AD) and imaging beta-amyloid plaques and tau tangles in the brain using RF sensors. Dielectric measurements were obtained from grey matter and white matter regions of brain tissues with severe AD pathology at a frequency range of ... Read more >>

IEEE Trans Med Imaging (IEEE transactions on medical imaging)
[2020, 39(12):4060-4070]

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Application of telehealth for comprehensive Creutzfeldt-Jakob disease surveillance in the United Kingdom.

Neil Watson, Hatice Kurudzhu, Alison Green, David Summers, Colin Smith, Suvankar Pal,

Creutzfeldt-Jakob disease (CJD) is a fatal human prion disease. Surveillance systems operate globally with the goals of accurate in-life case ascertainment, appropriate public health interventions to minimise secondary transmission, and monitoring trends in disease epidemiology. The UK experienced the highest incidence of variant CJD (vCJD) in the world following widespread ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2021, 420:117221]

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Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

Ramita Dewan, Ruth Chia, Jinhui Ding, Richard A Hickman, Thor D Stein, Yevgeniya Abramzon, Sarah Ahmed, Marya S Sabir, Makayla K Portley, Arianna Tucci, Kristina Ibáñez, F N U Shankaracharya, Pamela Keagle, Giacomina Rossi, Paola Caroppo, Fabrizio Tagliavini, Maria L Waldo, Per M Johansson, Christer F Nilsson, , , , , , , , , James B Rowe, Luisa Benussi, Giuliano Binetti, Roberta Ghidoni, Edwin Jabbari, Coralie Viollet, Jonathan D Glass, Andrew B Singleton, Vincenzo Silani, Owen A Ross, Mina Ryten, Ali Torkamani, Toshiko Tanaka, Luigi Ferrucci, Susan M Resnick, Stuart Pickering-Brown, Christopher B Brady, Neil Kowal, John A Hardy, Vivianna Van Deerlin, Jean Paul Vonsattel, Matthew B Harms, Huw R Morris, Raffaele Ferrari, John E Landers, Adriano Chiò, J Raphael Gibbs, Clifton L Dalgard, Sonja W Scholz, Bryan J Traynor,

We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 Lewy body dementia (LBD) patients, and 3,158 neurologically healthy subjects. Pathogenic expansions (range, 40-64 CAG repeats) in the huntingtin (HTT) gene ... Read more >>

Neuron (Neuron)
[2021, 109(3):448-460.e4]

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C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.

Beatrice Costa, Claudia Manzoni, Manuel Bernal-Quiros, Demis A Kia, Miquel Aguilar, Ignacio Alvarez, Victoria Alvarez, Ole Andreassen, Maria Anfossi, Silvia Bagnoli, Luisa Benussi, Livia Bernardi, Giuliano Binetti, Daniel Blackburn, Mercè Boada, Barbara Borroni, Lucy Bowns, Geir Bråthen, Amalia C Bruni, Huei-Hsin Chiang, Jordi Clarimon, Shuna Colville, Maria E Conidi, Tom E Cope, Carlos Cruchaga, Chiara Cupidi, Maria Elena Di Battista, Janine Diehl-Schmid, Monica Diez-Fairen, Oriol Dols-Icardo, Elisabetta Durante, Dušan Flisar, Francesca Frangipane, Daniela Galimberti, Maura Gallo, Maurizio Gallucci, Roberta Ghidoni, Caroline Graff, Jordan H Grafman, Murray Grossman, John Hardy, Isabel Hernández, Guy J T Holloway, Edward D Huey, Ignacio Illán-Gala, Anna Karydas, Behzad Khoshnood, Milica G Kramberger, Mark Kristiansen, Patrick A Lewis, Alberto Lleó, Gaganjit K Madhan, Raffaele Maletta, Aleš Maver, Manuel Menendez-Gonzalez, Graziella Milan, Bruce Miller, Merel O Mol, Parastoo Momeni, Sonia Moreno-Grau, Chris M Morris, Benedetta Nacmias, Christer Nilsson, Valeria Novelli, Linn Öijerstedt, Alessandro Padovani, Suvankar Pal, Yasmin Panchbhaya, Pau Pastor, Borut Peterlin, Irene Piaceri, Stuart Pickering-Brown, Yolande A L Pijnenburg, Annibale A Puca, Innocenzo Rainero, Antonella Rendina, Anna M T Richardson, Ekaterina Rogaeva, Boris Rogelj, Sara Rollinson, Giacomina Rossi, Carola Rossmeier, James B Rowe, Elisa Rubino, Agustín Ruiz, Raquel Sanchez-Valle, Sigrid B Sando, Alexander F Santillo, Jennifer Saxon, Elio Scarpini, Maria Serpente, Nicoletta Smirne, Sandro Sorbi, EunRan Suh, Fabrizio Tagliavini, Jennifer C Thompson, John Q Trojanowski, Vivianna M Van Deerlin, Julie Van der Zee, Christine Van Broeckhoven, Jeroen van Rooij, John C Van Swieten, Arianna Veronesi, Emilia Vitale, Maria L Waldö, Cathy Woodward, Jennifer Yokoyama, Valentina Escott-Price, James M Polke, Raffaele Ferrari, ,

<h4>Objective</h4>We sought to characterize <i>C9orf72</i> expansions in relation to genetic ancestry and age at onset (AAO) and to use these measures to discriminate the behavioral from the language variant syndrome in a large pan-European cohort of frontotemporal lobar degeneration (FTLD) cases.<h4>Methods</h4>We evaluated expansions frequency in the entire cohort (n = ... Read more >>

Neurology (Neurology)
[2020, 95(24):e3288-e3302]

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Understanding the risk of incidental findings: A qualitative study of people with cognitive symptoms.

Stella A Glasmacher, Fraser S Brown, Lucy Stirland, Tim Wilkinson, Guy Holloway, Suvankar Pal,

J Neurol Sci (Journal of the neurological sciences)
[2020, 419:117203]

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Correction to: The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland.

Stella A Glasmacher, Juan Larraz, Arpan R Mehta, Patrick K A Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal, ,

The article The immediate impact of the COVID‑19 pandemic on motor neuron disease services and mortality in Scotland, written by Stella A. Glasmacher, Juan Larraz, Arpan R. Mehta, Patrick K. A. Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal and ... Read more >>

J Neurol (Journal of neurology)
[2020, :]

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The immediate impact of the COVID-19 pandemic on motor neuron disease services and mortality in Scotland.

Stella A Glasmacher, Juan Larraz, Arpan R Mehta, Patrick K A Kearns, Michael Wong, Judith Newton, Richard Davenport, George Gorrie, Ian Morrison, Javier Carod Artal, Siddharthan Chandran, Suvankar Pal, ,

J Neurol (Journal of neurology)
[2020, :]

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Differential diagnosis of progressive intellectual and neurological deterioration in children.

Christopher Verity, Elaine Baker, Polly Maunder, Suvankar Pal, Anne Marie Winstone,

<h4>Aim</h4>To report the differential diagnosis in children with progressive intellectual and neurological deterioration (PIND) in the UK.<h4>Method</h4>Since 1997 the PIND Study has searched for variant Creutzfeldt-Jakob disease (vCJD) in children, using the British Paediatric Surveillance Unit to perform prospective surveillance of those younger than 16 years with PIND.<h4>Results</h4>From May 1997 to ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2021, 63(3):287-294]

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A systematic review of neuropsychiatric and cognitive assessments used in clinical trials for amyotrophic lateral sclerosis.

Emily Beswick, Emily Park, Charis Wong, Arpan R Mehta, Rachel Dakin, Siddharthan Chandran, Judith Newton, Alan Carson, Sharon Abrahams, Suvankar Pal,

<h4>Background</h4>Up to 50% of people with amyotrophic lateral sclerosis (ALS) experience cognitive dysfunction, whilst depression and anxiety are reported in up to 44% and 33%, respectively. These symptoms impact on quality of life, and are associated with a poorer prognosis. Historically, outcomes in clinical trials have focused on the effect of ... Read more >>

J Neurol (Journal of neurology)
[2020, :]

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Cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis: a systematic review of in vitro studies.

Koy Chong Ng Kee Kwong, Jenna M Gregory, Suvankar Pal, Siddharthan Chandran, Arpan R Mehta,

Various studies have suggested that a neurotoxic cerebrospinal fluid profile could be implicated in amyotrophic lateral sclerosis. Here, we systematically review the evidence for cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis and explore its clinical correlates. We searched the following databases with no restrictions on publication date: PubMed, Embase and ... Read more >>

Brain Commun (Brain communications)
[2020, 2(2):fcaa121]

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Excellent reliability of the ALSFRS-R administered via videoconferencing: A study of people with motor neuron disease in Scotland.

Judith Newton, Kiran Jayaprakash, Stella A Glasmacher, Alison McEleney, Andrew Bethell, Elizabeth Fraser, Janice Hatrick, Hanne Haagenrud, Gill Stott, Rachel Dakin, Siddharthan Chandran, Suvankar Pal,

J Neurol Sci (Journal of the neurological sciences)
[2020, 416:116991]

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Reliability and validity of the brief dimensional apathy scale.

Ratko Radakovic, Debbie Gray, Kaitlin Dudley, Eneida Mioshi, David Dick, Giulia Melchiorre, Harry Gordon, Judith Newton, Shuna Colville, Suvankar Pal, Siddharthan Chandran, Sharon Abrahams,

OBJECTIVE:Apathy is composed of different demotivational subtypes measurable by the dimensional apathy scale (DAS) and can be quickly assessed using the brief DAS (b-DAS). The aim was to determine the reliability and validity of the b-DAS. METHODS:53 amyotrophic lateral sclerosis (ALS) patients and 53 of their informants were recruited. Informants ... Read more >>

Arch Clin Neuropsychol (Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists)
[2020, 35(5):539-544]

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National audit of cognitive assessment in people with pwMND A national audit of cognitive assessment in people with motor neurone disease (pwMND) in Scotland.

Maria Stavrou, Judith Newton, Gill Stott, Shuna Colville, Siddharthan Chandran, Sharon Abrahams, Suvankar Pal, Richard Davenport,

Cognitive and behavioral abnormalities are recognized as an integral part of Motor Neurone Disease (MND) and occur at all stages of the disease. The early detection of cognitive and behavioral symptoms in MND is critical. Such symptoms are only reported when we explicitly ask, evaluate, document, and assess. In the ... Read more >>

Amyotroph Lateral Scler Frontotemporal Degener (Amyotrophic lateral sclerosis & frontotemporal degeneration)
[2020, 21(5-6):459-462]

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Assessment of visually guided reaching in prodromal Alzheimer's disease: a cross-sectional study protocol.

Alexandra G Mitchell, Robert D McIntosh, Stephanie Rossit, Michael Hornberger, Suvankar Pal,

<h4>Introduction</h4>Recent evidence has implicated the precuneus of the medial parietal lobe as one of the first brain areas to show pathological changes in Alzheimer's disease (AD). Damage to the precuneus through focal brain injury is associated with impaired visually guided reaching, particularly for objects in peripheral vision. This raises the ... Read more >>

BMJ Open (BMJ open)
[2020, 10(6):e035021]

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Riluzole prescribing, uptake and treatment discontinuation in people with amyotrophic lateral sclerosis in Scotland.

Kiran Jayaprakash, Stella A Glasmacher, Bernard Pang, Emily Beswick, Arpan R Mehta, Rachel Dakin, Judith Newton, Siddharthan Chandran, Suvankar Pal, ,

J Neurol (Journal of neurology)
[2020, 267(8):2459-2461]

Cited: 1 time

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Multidimensional Apathy in Behavioral Variant Frontotemporal Dementia, Primary Progressive Aphasia, and Alzheimer Disease.

Ratko Radakovic, Shuna Colville, Denise Cranley, John M Starr, Suvankar Pal, Sharon Abrahams,

Apathy is prevalent in dementia, such as behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), and Alzheimer disease (AD). As a multidimensional construct, it can be assessed and subsumed under a Dimensional Apathy Framework. A consistent apathy profile in bvFTD and PPA has yet to be established. The aim ... Read more >>

J Geriatr Psychiatry Neurol (Journal of geriatric psychiatry and neurology)
[2020, :891988720924716]

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Survival and Prognostic Factors in C9orf72 Repeat Expansion Carriers: A Systematic Review and Meta-analysis.

Stella A Glasmacher, Charis Wong, Iona E Pearson, Suvankar Pal,

<h4>Importance</h4>The c9orf72 repeat expansion (c9 or c9orf72RE) confers a survival disadvantage in amyotrophic lateral sclerosis (ALS); its effect on prognosis in frontotemporal dementia (FTD) remains uncertain. Data on prognostic factors in c9orf72RE disorders could inform patient care, genetic counseling, and trial design.<h4>Objective</h4>To examine prognostic factors in c9ALS, c9FTD, c9ALS-FTD, and ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, 77(3):367-376]

Cited: 1 time

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Relationship between neuropsychiatric disorders and cognitive and behavioural change in MND.

Caroline A McHutchison, Danielle Jane Leighton, Andrew McIntosh, Elaine Cleary, Jon Warner, Mary Porteous, Siddharthan Chandran, Suvankar Pal, Sharon Abrahams,

<h4>Objective</h4>In this population-based study, we aimed to determine whether neuropsychiatric history, medication or family history of neuropsychiatric disorders predicted cognitive and/or behavioural impairment in motor neuron disease (MND).<h4>Methods</h4>People with MND (pwMND) on the Scottish Clinical, Audit, Research and Evaluation of MND (CARE-MND) register, diagnosed from January 2015 to January 2018, ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(3):245-253]

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Incidental Findings Identified on Head MRI for Investigation of Cognitive Impairment: A Retrospective Review.

Stella Andrea Glasmacher, Hannah Sam Thomas, Lucy Stirland, Tim Wilkinson, Jane Lumsden, Gavin Langlands, Briony Waddell, Guy Holloway, Gerard Thompson, Suvankar Pal,

<h4>Introduction</h4>Incidental findings are common in presumed healthy volunteers but are infrequently studied in patients in a clinical context.<h4>Objective</h4>To determine the prevalence, nature, and management implications of incidental findings on head MRI in patients presenting with cognitive symptoms, and to quantify and describe unexpected MRI abnormalities that are of uncertain relevance ... Read more >>

Dement Geriatr Cogn Disord (Dementia and geriatric cognitive disorders)
[2019, 48(3-4):123-130]

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An epidemiological profile of dysarthria incidence and assistive technology use in the living population of people with MND in Scotland.

Elizabeth Elliott, Judith Newton, Phillipa Rewaj, Jenna M Gregory, Lynda Tomarelli, Shuna Colville, Siddharthan Chandran, Suvankar Pal, ,

<i>Objectives</i>: People with motor neurone disease (pwMND) experience communication impairments due to speech and motor dysfunction. Communication support in the form of Augmentative and Alternative Communication (AAC) in conjunction with Assistive Technology (AT) access methods are available, however, variation in provision care pathways exists across Scotland. We conducted a baseline ... Read more >>

Amyotroph Lateral Scler Frontotemporal Degener (Amyotrophic lateral sclerosis & frontotemporal degeneration)
[2020, 21(1-2):116-122]

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Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia.

Oliver H Tam, Nikolay V Rozhkov, Regina Shaw, Duyang Kim, Isabel Hubbard, Samantha Fennessey, Nadia Propp, , Delphine Fagegaltier, Brent T Harris, Lyle W Ostrow, Hemali Phatnani, John Ravits, Josh Dubnau, Molly Gale Hammell,

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. While several pathogenic mutations have been identified, the vast majority of ALS cases have no family history of disease. Thus, for most ALS cases, the disease may be a product of multiple pathways ... Read more >>

Cell Rep (Cell reports)
[2019, 29(5):1164-1177.e5]

Cited: 12 times

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Screening for cognitive impairment among patients with neuromyelitis optica using touchscreen cognitive testing in routine clinical care.

Jack Cotter, Fiona Trew, Shuna Colville, Dawn Lyle, Denise Cranley, Francesca Cormack, Jennifer H Barnett, Katy Murray, Suvankar Pal,

J Neurol (Journal of neurology)
[2019, 266(10):2571-2572]

Cited: 0 times

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Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS.

Jenna M Gregory, Karina McDade, Thomas H Bak, Suvankar Pal, Siddharthan Chandran, Colin Smith, Sharon Abrahams,

<h4>Objective</h4>Approximately 35% of patients with amyotrophic lateral sclerosis (ALS) exhibit mild cognitive deficits in executive functions, language and fluency, without dementia. The precise pathology of these extramotor symptoms has remained unknown. This study aimed to determine the pathological correlate of cognitive impairment in patients with non-demented ALS.<h4>Methods</h4>In-depth neuropathological analysis of ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(2):149-157]

Cited: 3 times

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Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Arpan R Mehta, Rachel Walters, Fergal M Waldron, Suvankar Pal, Bhuvaneish T Selvaraj, Malcolm R Macleod, Giles E Hardingham, Siddharthan Chandran, Jenna M Gregory,

Interventions targeting mitochondrial dysfunction have the potential to extend survival in preclinical models of amyotrophic lateral sclerosis. The aim of this systematic review was to assess the efficacy of targeting mitochondria as a potential therapeutic target in amyotrophic lateral sclerosis. Preclinical studies written in the English language were identified with ... Read more >>

Brain Commun (Brain communications)
[2019, 1(1):fcz009]

Cited: 3 times

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