Full Text Journal Articles by
Author Susanne von Gerlach

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Myocardial Accumulations of Reg3A, Reg3γ and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis.

Praveen Gajawada, Ayse Cetinkaya, Susanne von Gerlach, Natalia Kubin, Heiko Burger, Michael Näbauer, Carola Grinninger, Andreas Rolf, Markus Schönburg, Yeong-Hoon Choi, Thomas Kubin, Manfred Richter,

Cardiac sarcoidosis (CS) is a poorly understood disease and is characterized by the focal accumulation of immune cells, thus leading to the formation of granulomata (GL). To identify the developmental principles of fatal GL, fluorescence microscopy and Western blot analysis of CS and control patients is presented here. CS is ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(8):]

Cited: 1 time

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Reactive mesothelial hyperplasia mimicking mesothelioma in an African green monkey (Chlorocebus aethiops).

Roland Plesker, Kernt Köhler, Susanne von Gerlach, Klaus Boller, Markus Vogt, Inke S Feder,

A spontaneous reactive mesothelial hyperplasia occurred in a female, 15.7-year-old African green monkey (grivet; <i>Chlorocebus aethiops</i>). At necropsy, massive effusions were found in the abdomen, the thorax, and the pericardium. Additionally, multiple small, beige-gray nodules were detected on the serosal surfaces of the abdominal organs. Histopathologically, the mesothelial cells resembled ... Read more >>

Primate Biol (Primate biology)
[2020, 7(1):5-12]

Cited: 0 times

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Rapidly progressive hypertrophic cardiomyopathy in an infant with Noonan syndrome with multiple lentigines: palliative treatment with a rapamycin analog.

Andreas Hahn, Jessica Lauriol, Josef Thul, Kachina Behnke-Hall, Tushiha Logeswaran, Anne Schänzer, Nuray Böğürcü, Boyan K Garvalov, Martin Zenker, Bruce D Gelb, Susanne von Gerlach, Reinhard Kandolf, Maria I Kontaridis, Dietmar Schranz,

Noonan syndrome with multiple lentigines (NSML) frequently manifests with hypertrophic cardiomyopathy (HCM). Recently, it was demonstrated that mTOR inhibition reverses HCM in NSML mice. We report for the first time on the effects of treatment with a rapamycin analog in an infant with LS and malignant HCM. In the boy, ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2015, 167A(4):744-751]

Cited: 21 times

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Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-α/Raf-1/p44/42 signaling pathway.

Malgorzata Wygrecka, Bhola K Dahal, Djuro Kosanovic, Frank Petersen, Brigitte Taborski, Susanne von Gerlach, Miroslava Didiasova, Dariusz Zakrzewicz, Klaus T Preissner, Ralph T Schermuly, Philipp Markart,

Mast cell (MC) accumulation has been demonstrated in the lungs of idiopathic pulmonary fibrosis (IPF) patients. Mediators released from MCs may regulate tissue remodeling processes, thereby contributing to IPF pathogenesis. We investigated the role of MC-fibroblast interaction in the progression of lung fibrosis. Increased numbers of activated MCs, in close ... Read more >>

Am J Pathol (The American journal of pathology)
[2013, 182(6):2094-2108]

Cited: 45 times

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Pressure overload leads to an increase of cardiac resident stem cells.

Stefan Rupp, Jürgen Bauer, Susanne von Gerlach, Stephan Fichtlscherer, Andreas M Zeiher, Stefanie Dimmeler, Dietmar Schranz,

Recent studies suggest that the mammalian heart possesses some capacity for cardiac regeneration. This regenerative capacity is primarily documented postnatally and after myocardial infarction or pressure overload. Although the cell type that mediates endogenous regeneration is unclear, cardiac stem cells might be considered as potential candidates. To determine the number ... Read more >>

Basic Res Cardiol (Basic research in cardiology)
[2012, 107(2):252]

Cited: 21 times

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Induction of matrix metalloproteinases and TLR2 and 6 in murine colon after oral exposure to Mycobacterium avium subsp. paratuberculosis.

Martin Roderfeld, Arzu Koc, Timo Rath, Sonja Blöcher, Annette Tschuschner, Ömer Akineden, Marta Fischer, Susanne von Gerlach, Ralph Goethe, Elke Eckelt, Jochen Meens, Michael Bülte, Tina Basler, Elke Roeb,

Mycobacterium avium subspecies paratuberculosis (MAP) is suspected to be a causative agent in Crohn's disease. Recent evidence suggests that MAP can induce the expression of Matrix Metalloproteinases (MMPs), which are the main proteases in the pathogenesis of mucosal ulcerations in inflammatory bowel disease (IBD). Within the present study, we analysed ... Read more >>

Microbes Infect (Microbes and infection)
[2012, 14(6):545-553]

Cited: 9 times

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Role of protease-activated receptor-2 in idiopathic pulmonary fibrosis.

Malgorzata Wygrecka, Grazyna Kwapiszewska, Ewa Jablonska, Ewa Jablonska, Susanne von Gerlach, Ingrid Henneke, Dariusz Zakrzewicz, Andreas Guenther, Klaus T Preissner, Philipp Markart,

<h4>Rationale</h4>Activation of the coagulation cascade has been demonstrated in pulmonary fibrosis. In addition to its procoagulant function, various coagulation proteases exhibit cellular effects that may also contribute to fibrotic processes in the lung.<h4>Objective</h4>To investigate the importance of protease-activated receptor (PAR)-2 and its activators, coagulation factor VIIa (FVIIa)/tissue factor (TF), in ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2011, 183(12):1703-1714]

Cited: 44 times

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Pericardial hemangioma vascularized via left anterior descending.

Christoph Liebetrau, Zoltan Szalay, Susanne von Gerlach, Helge Möllmann, Holger Nef, Christian Hamm, Michael Weber,

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2010, 99(6):405-407]

Cited: 5 times

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Clinical value of optical coherence tomography in laryngology.

Marcel Kraft, Hiltrud Glanz, Susanne von Gerlach, Henning Wisweh, Holger Lubatschowski, Christoph Arens,

<h4>Background</h4>Optical coherence tomography (OCT) is a new, noninvasive imaging technology for the evaluation of superficial lesions. The objective of this study is to evaluate microlaryngoscopy in combination with OCT compared with microlaryngoscopy alone (ie, without OCT) in supplying a specific diagnosis, predicting invasive tumor growth and epithelial dysplasia in the ... Read more >>

Head Neck (Head & neck)
[2008, 30(12):1628-1635]

Cited: 31 times

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In vitro evaluation of the sinus sagittalis superior thrombosis model in the rat using 3D micro- and nanocomputed tomography.

Alexander Claus Langheinrich, Mesut Yeniguen, Anne Ostendorf, Simone Marhoffer, Christian Dierkes, Susanne von Gerlach, Max Nedelmann, Marian Kampschulte, Georg Bachmann, Erwin Stolz, Tibo Gerriets,

<h4>Introduction</h4>Thrombosis of the cerebral veins and sinus are common causes of stroke. Animal models help us to understand the underlying pathophysiology of this condition. Therefore, the purpose of our study was to evaluate a well-established model for sinus sagittalis (SSS) thrombosis using micro- and nanocomputed tomography (CT) imaging.<h4>Methods</h4>SSS thrombosis was ... Read more >>

Neuroradiology (Neuroradiology)
[2010, 52(9):815-821]

Cited: 7 times

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Characterization of long-term endogenous cardiac repair in children after heart transplantation.

Stefan Rupp, Masamichi Koyanagi, Masayoshi Iwasaki, Jürgen Bauer, Susanne von Gerlach, Dietmar Schranz, Andreas M Zeiher, Stefanie Dimmeler,

<h4>Aims</h4>Circulating cells repopulate the heart at a very low rate in adult humans. The knowledge about time-dependent cardiac regeneration is very limited and the contribution of circulating cells to cardiomyocytes or vascular cells in children is unknown. This study investigates the endogenous repair capacity and the long-term incorporation of circulating ... Read more >>

Eur Heart J (European heart journal)
[2008, 29(15):1867-1872]

Cited: 12 times

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Aortic valve stenosis due to alkaptonuria.

Martin Brueck, Dirk Bandorski, Wilfried Kramer, Markus Schoenburg, Susanne von Gerlach, Harald Tillmanns,

Cardiovascular disease is a less-well appreciated aspect of alkaptonuria. A 69-year-old man presented with shortness of breath and exertional chest pain. He had a previous diagnosis of alkaptonuria (endogenous ochronosis), confirmed on the basis of urine coloration, skin pigmentation and ochronotic arthropathy in the knees. Echocardiography and coronary angiography revealed ... Read more >>

J Heart Valve Dis (The Journal of heart valve disease)
[2008, 17(1):127-129]

Cited: 4 times

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Acute rat lung injury: feasibility of assessment with micro-CT.

Alexander Claus Langheinrich, Boris Leithäuser, Susanne Greschus, Susanne Von Gerlach, Andreas Breithecker, Fritz Reinhard Matthias, Wigbert Stephan Rau, Rainer Maria Bohle,

<h4>Purpose</h4>To evaluate the feasibility of micro-computed tomography (CT) for analysis of the lung fine structure and its alterations during endotoxin-induced lung injury.<h4>Materials and methods</h4>Intravital perfusion-fixed rat lungs with (n = 5) and without (n = 5) endotoxin perfusion were scanned with micro-CT. Three imaging modalities (conventional histology, intravital microscopy, and ... Read more >>

Radiology (Radiology)
[2004, 233(1):165-171]

Cited: 34 times

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Atherosclerotic lesions at micro CT: feasibility for analysis of coronary artery wall in autopsy specimens.

Alexander Claus Langheinrich, Rainer Maria Bohle, Susanne Greschus, Nils Hackstein, Gerhard Walker, Susanne von Gerlach, Wigbert Stephan Rau, Hans Hölschermann,

<h4>Purpose</h4>To evaluate the feasibility of micro computed tomography (CT) for analysis of the coronary artery wall.<h4>Materials and methods</h4>With micro CT, two-dimensional transverse images were generated from 10 human autopsy specimens of coronary arteries (2.5-3.5 cm long), with section thickness of 6 microm. Vessel wall perimeter, plaque area, calcified lesion area, ... Read more >>

Radiology (Radiology)
[2004, 231(3):675-681]

Cited: 47 times

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