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Author Susanne Saekmose

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PREVALENCE OF SARS-COV-2-ANTIBODIES IN DANISH CHILDREN AND ADULTS.

Maren J H Rytter, Ulrikka Nygaard, Ida Nikoline Mandic, Jonathan Peter Glenthøj, Lisbeth Samsø Schmidt, Dina Cortes, Birgitte Smith, Tatjana Zaharov, Mia Johanna Søndergaard, Marie Cecilie Lawaetz, Susanne Saekmose, Lise Heilmann Jensen, Kjeld Schmiegelow, Kim Kristensen,

In Denmark, severe acute respiratory syndrome coronavirus 2 antibodies were assessed in a cross-sectional study among 1033 children visiting pediatric departments and 750 blood donors in June 2020, using a point-of-care test. Antibodies were detected in 17 children (1.6%) and 15 blood donors (2.0%) (P = 0.58). In conclusion, children ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

Cited: 0 times

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SARS-CoV-2 infection fatality rate among elderly retired Danish blood donors - A cross-sectional study.

Ole Birger Pedersen, Janna Nissen, Khoa Manh Dinh, Michael Schwinn, Kathrine Agergård Kaspersen, Jens Kjærgaard Boldsen, Maria Didriksen, Joseph Dowsett, Erik Sørensen, Lise Wegner Thørner, Margit Anita Hørup Larsen, Birgitte Grum-Schwensen, Susanne Sækmose, Isabella Worlewenut Paulsen, Nanna Lond Skov Frisk, Thorsten Brodersen, Lasse Skafte Vestergaard, Klaus Rostgaard, Kåre Mølbak, Robert Leo Skov, Christian Erikstrup, Henrik Ullum, Henrik Hjalgrim,

<h4>Background</h4>Despite the vast majority of individuals succumbing to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are elderly, infection fatality rate (IFR) estimates for the age group 70 years older are still scarce. To this end we assessed SARS-CoV-2 seroprevalence among retired blood donors and combined it with national ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 0 times

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Comparison of sixteen serological SARS-CoV-2 immunoassays in sixteen clinical laboratories

Lene Harritshøj, Mikkel Gybel-Brask, Shoaib Afzal, Pia Kamstrup, Charlotte Jørgensen, Marianne Kragh Thomsen, Linda Hilsted, Lennart Friis-Hansen, Pal Szecsi, Lise Pedersen, Lene Nielsen, Cecilie Hansen, Peter Garred, Trine-Line Korsholm, Susan Mikkelsen, Kirstine Nielsen, Bjarne Møller, Anne Hansen, Kasper Iversen, Pernille Nielsen, Rasmus Hasselbalch, Kamille Fogh, Jakob Norsk, Jonas Henrik Kristensen, Kristian Schønning, Nikolai Kirkby, Alex Nielsen, Lone Landsy, Mette Loftager, Dorte Holm, Anna Nilsson, Susanne Sækmose, Birgitte Grum-Schwensen, Bitten Aagaard, Thøger Jensen, Dorte Nielsen, Henrik Ullum, Ram B.C. Dessau,

Serological SARS-CoV-2 assays are needed to support clinical diagnosis and epidemiological investigations. Recently, assays for the large-volume detection of total antibodies (Ab) and immunoglobulin (Ig) G and M against SARS-CoV-2 antigens have been developed, but there are limited data on the diagnostic accuracy of these assays. This study was organized ... Read more >>

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Estimation of SARS-CoV-2 infection fatality rate by real-time antibody screening of blood donors.

Christian Erikstrup, Christoffer Egeberg Hother, Ole Birger Vestager Pedersen, Kåre Mølbak, Robert Leo Skov, Dorte Kinggaard Holm, Susanne Gjørup Sækmose, Anna Christine Nilsson, Patrick Terrence Brooks, Jens Kjærgaard Boldsen, Christina Mikkelsen, Mikkel Gybel-Brask, Erik Sørensen, Khoa Manh Dinh, Susan Mikkelsen, Bjarne Kuno Møller, Thure Haunstrup, Lene Harritshøj, Bitten Aagaard Jensen, Henrik Hjalgrim, Søren Thue Lillevang, Henrik Ullum,

<h4>Background</h4>The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has tremendous consequences for our societies. Knowledge of the seroprevalence of SARS-CoV-2 is needed to accurately monitor the spread of the epidemic and to calculate the infection fatality rate (IFR). These measures may help the authorities to make informed ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 7 times

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Estimation of SARS-CoV-2 infection fatality rate by real-time antibody screening of blood donors

Christian Erikstrup, Christoffer Egeberg Hother, Ole Birger Vestager Pedersen, Kåre Mølbak, Robert Leo Skov, Dorte Kinggaard Holm, Susanne Sækmose, Anna Christine Nilsson, Patrick Terrence Brooks, Jens Kjærgaard Boldsen, Christina Mikkelsen, Mikkel Gybel-Brask, Erik Sørensen, Khoa Manh Dinh, Susan Mikkelsen, Bjarne Kuno Møller, Thure Haunstrup, Lene Harritshøj, Bitten Aagaard Jensen, Henrik Hjalgrim, Søren Thue Lillevang, Henrik Ullum,

<h4>Background</h4> The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has tremendous consequences for our societies. Knowledge of the seroprevalence of SARS-CoV-2 is needed to accurately monitor the spread of the epidemic and also to calculate the infection fatality rate (IFR). These measures may help the authorities to ... Read more >>

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Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: a national population-based cohort study.

Simon Husby, Francesco Favero, Christian Nielsen, Betina S Sørensen, John Bæch, Kathrine Grell, Jakob W Hansen, Francisco G Rodriguez-Gonzalez, Eva K Haastrup, Anne Fischer-Nielsen, Pernille Andersen, Bente Arboe, Susanne G Sækmose, Per B Hansen, Ilse Christiansen, Erik Clasen-Linde, Lene Meldgaard, Lene H Ebbesen, Erik K Segel, Pär Josefsson, Michael Thorsgaard, Tarec C El-Galaly, Peter Brown, Joachim Weischenfeldt, Thomas S Larsen, Kirsten Grønbæk,

Clonal hematopoiesis of indeterminate potential (CHIP) is suspected of being a risk factor for patients with cancer. This study aimed to assess the clinical consequences of CHIP in patients with lymphoma intended for high-dose chemotherapy and autologous stem-cell transplantation (ASCT) in a population-based setting. We identified 892 lymphoma patients who ... Read more >>

Leukemia (Leukemia)
[2020, 34(12):3256-3268]

Cited: 2 times

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Epidemiology of hepatitis E virus infection in a cohort of 4023 immunocompromised patients.

Lene H Harritshøj, Christoffer E Hother, Henrik Sengeløv, Gedske Daugaard, Søren S Sørensen, Søren Jacobsen, Michael Perch, Dorte K Holm, Susanne G Sækmose, Bitten Aagaard, Christian Erikstrup, Boris M Hogema, Jens D Lundgren, Henrik Ullum,

<h4>Objectives</h4>The prevalence of active, chronic, and former hepatitis E virus (HEV) infections was investigated in a cohort of immunocompromised patients. The association with transfusion transmitted HEV was evaluated, and the HEV seroprevalence was compared with that in healthy blood donors.<h4>Study design and methods</h4>Serum samples from 4023 immunocompromised patients at Rigshospitalet, ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2020, 91:188-195]

Cited: 2 times

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Low transfusion transmission of hepatitis E among 25,637 single-donation, nucleic acid-tested blood donors.

Lene H Harritshøj, Dorte K Holm, Susanne G Saekmose, Bitten A Jensen, Boris M Hogema, Thea K Fischer, Sofie E Midgley, Jesper S Krog, Christian Erikstrup, Henrik Ullum,

<h4>Background</h4>Hepatitis E virus genotype-3 (HEV-gt-3) causes autochthonous infections in western countries, with a primary reservoir in animals, especially pigs. HEV transfusion transmission has been reported, and HEV-gt-3 prevalence is high in some European countries. The prevalence of HEV RNA was investigated among Danish blood donors, and the prevalence of HEV ... Read more >>

Transfusion (Transfusion)
[2016, 56(9):2225-2232]

Cited: 18 times

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Microfibrillar-associated protein 4: a potential biomarker of chronic obstructive pulmonary disease.

Sofie Lock Johansson, Nassim Bazeghi Roberts, Anders Schlosser, Claus B Andersen, Jørn Carlsen, Helle Wulf-Johansson, Susanne Gjørup Sækmose, Ingrid L Titlestad, Ida Tornoe, Bruce Miller, Ruth Tal-Singer, Uffe Holmskov, Jørgen Vestbo, Grith Lykke Sorensen,

<h4>Background</h4>Microfibrillar-associated protein 4 (MFAP4) is a matricellular glycoprotein that co-localises with elastic fibres and is highly expressed in the lungs. The aim of this study was to test the hypothesis that plasma MFAP4 (pMFAP4) reflects clinical outcomes in chronic obstructive pulmonary disease (COPD).<h4>Methods</h4>pMFAP4 was measured by an AlphaLISA immunoassay in ... Read more >>

Respir Med (Respiratory medicine)
[2014, 108(9):1336-1344]

Cited: 18 times

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Localization of microfibrillar-associated protein 4 (MFAP4) in human tissues: clinical evaluation of serum MFAP4 and its association with various cardiovascular conditions.

Helle Wulf-Johansson, Sofie Lock Johansson, Anders Schlosser, Anne Trommelholt Holm, Lars Melholt Rasmussen, Hans Mickley, Axel C P Diederichsen, Henrik Munkholm, Tina Svenstrup Poulsen, Ida Tornøe, Vicki Nielsen, Niels Marcussen, Jørgen Vestbo, Susanne Gjørup Sækmose, Uffe Holmskov, Grith Lykke Sorensen,

Microfibrillar-associated protein 4 (MFAP4) is located in the extracellular matrix (ECM). We sought to identify tissues with high levels of MFAP4 mRNA and MFAP4 protein expression. Moreover, we aimed to evaluate the significance of MFAP4 as a marker of cardiovascular disease (CVD) and to correlate MFAP4 with other known ECM ... Read more >>

PLoS One (PloS one)
[2013, 8(12):e82243]

Cited: 28 times

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Enzyme-linked immunosorbent assay characterization of basal variation and heritability of systemic microfibrillar-associated protein 4.

Susanne Gjørup Sækmose, Anders Schlosser, René Holst, Sofie Lock Johansson, Helle Wulf-Johansson, Ida Tornøe, Jørgen Vestbo, Kirsten Ohm Kyvik, Torben Barington, Uffe Holmskov, Grith Lykke Sørensen,

<h4>Background</h4>Microfibrillar-associated protein 4 (MFAP4) is a systemic biomarker that is significantly elevated in samples from patients suffering from hepatic cirrhosis. The protein is generally localized to elastic fibers and other connective tissue fibers in the extracellular matrix (ECM), and variation in systemic MFAP4 (sMFAP4) has the potential to reflect diverse ... Read more >>

PLoS One (PloS one)
[2013, 8(12):e82383]

Cited: 10 times

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Changes in left ventricular filling patterns after repeated injection of autologous bone marrow cells in heart failure patients.

Axel C P Diederichsen, Jacob E Møller, Per Thayssen, Lars Videbaek, Susanne G Saekmose, Torben Barington, Moustapha Kassem,

<h4>Objectives</h4>We have previously shown that repeated intracoronary infusion of bone marrow cells (BMSC) did not improve left ventricular (LV) ejection fraction in patients with chronic ischemic heart failure. However, the impact of BMSC therapy on LV diastolic filling has remained uncertain.<h4>Design</h4>Thirty two patients with LV ejection fraction less than 40% ... Read more >>

Scand Cardiovasc J (Scandinavian cardiovascular journal : SCJ)
[2010, 44(3):139-145]

Cited: 13 times

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Effect of repeated intracoronary injection of bone marrow cells in patients with ischaemic heart failure the Danish stem cell study--congestive heart failure trial (DanCell-CHF).

Axel C P Diederichsen, Jacob E Møller, Per Thayssen, Anders B Junker, Lars Videbaek, Susanne G Saekmose, Torben Barington, Malthe Kristiansen, Moustapha Kassem,

BACKGROUND: It has been suggested that myocardial regeneration may be achieved by a single intracoronary bone marrow derived stem cell infusion in selected patients with ischaemic heart disease. The effect is uncertain in patients with chronic ischaemic heart failure and it is not known whether repeated infusions would have additional ... Read more >>

Eur J Heart Fail (European journal of heart failure)
[2008, 10(7):661-667]

Cited: 21 times

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[Stem cell therapy in ischemic heart disease].

Axel Cosmus Pyndt Diederichsen, Jacob Eifer Møller, Malthe A M Kristiansen, Susanne Gjørup Saekmose, Torben Barington, Lars M Videbaek, Moustapha S Kassem, Per Thayssen,

Stem cell therapy is a treatment of great potential, including in cardiology. In the past few years, it has been shown that the heart has the potential for regeneration. Clinical studies have shown that intracoronary or intracardiac transplantation of bone marrow stem cells to patients with chronic or acute ischemic ... Read more >>

Ugeskr Laeger (Ugeskrift for laeger)
[2006, 168(11):1111-1114]

Cited: 0 times

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