Full Text Journal Articles by
Author Susannah J Tye

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Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats.

Rajas P Kale, Thanh Thanh L Nguyen, J Blair Price, Nathanael J Yates, Ken Walder, Michael Berk, Roy V Sillitoe, Abbas Z Kouzani, Susannah J Tye,

The antidepressant actions of deep brain stimulation (DBS) are associated with progressive neuroadaptations within the mood network, modulated in part, by neurotrophic mechanisms. We investigated the antidepressant-like effects of chronic nucleus accumbens (NAc) DBS and its association with change in glycogen synthase kinase 3 (GSK3) and mammalian target of rapamycin ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2021, 15:644921]

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Interleukin-8 and lower severity of depression in females, but not males, with treatment-resistant depression.

Jennifer L Kruse, Richard Olmstead, Gerhard Hellemann, Elizabeth C Breen, Susannah J Tye, John O Brooks, Benjamin Wade, Eliza Congdon, Randall Espinoza, Katherine L Narr, Michael R Irwin,

<h4>Introduction</h4>In cross-sectional studies of depressed patients, relationships between depression and levels of IL-8 are inconsistent, and have not been examined in relation to sex. Given identified sex differences in longitudinal data, it is important to evaluate sex-specific cross-sectional relationships between IL-8 and depressive symptoms, which may explain some inconsistency in ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2021, 140:350-356]

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Cocaine-Induced Changes in Tonic Dopamine Concentrations Measured Using Multiple-Cyclic Square Wave Voltammetry in vivo.

Jason Yuen, Abhinav Goyal, Aaron E Rusheen, Abbas Z Kouzani, Michael Berk, Jee Hyun Kim, Susannah J Tye, Charles D Blaha, Kevin E Bennet, Dong-Pyo Jang, Kendall H Lee, Hojin Shin, Yoonbae Oh,

For over 40 years, <i>in vivo</i> microdialysis techniques have been at the forefront in measuring the effects of illicit substances on brain tonic extracellular levels of dopamine that underlie many aspects of drug addiction. However, the size of microdialysis probes and sampling rate may limit this technique's ability to provide an ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:705254]

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Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: Preliminary evidence for an association with lithium response in bipolar disorder.

Susannah J Tye, Kristin Borreggine, J Blair Price, Shari L Sutor, Alfredo B Cuéllar-Barboza, Susan L McElroy, Joanna M Biernacka, Mark A Frye,

<h4>Introduction</h4>A key mechanism of lithium is the inhibition of glycogen synthase kinase-3β (GSK3β) and activation of mammalian target of rapamycin (mTOR), two contributors to insulin signaling. We explored the relationship between these markers and clinical response to lithium in bipolar disorder (BD).<h4>Methods</h4>Thirty-four subjects with BD who had been taking lithium ... Read more >>

Bipolar Disord (Bipolar disorders)
[2021, :]

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Inflammatory Mechanisms in Parkinson's Disease: From Pathogenesis to Targeted Therapies.

Stellina Y H Lee, Nathanael J Yates, Susannah J Tye,

Inflammation is a critical factor contributing to the progressive neurodegenerative process observed in Parkinson's disease (PD). Microglia, the immune cells of the central nervous system, are activated early in PD pathogenesis and can both trigger and propagate early disease processes via innate and adaptive immune mechanisms such as upregulated immune ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421992265]

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Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: Preliminary evidence in adolescents with treatment-resistant depression.

Abhrajeet V Roy, Michelle Thai, Bonnie Klimes-Dougan, Mindy Westlund Schreiner, Bryon A Mueller, Christina Sophia Albott, Kelvin O Lim, Mark Fiecas, Susannah J Tye, Kathryn R Cullen,

<h4>Background</h4>Current theory suggests that treatment-resistant depression (TRD) involves impaired neuroplasticity resulting in cognitive and neural rigidity, and that clinical improvement may require increasing brain flexibility and adaptability.<h4>Aims</h4>In this hypothesis-generating study, we sought to identify preliminary evidence of brain flexibility correlates of clinical change within the context of an open-label ketamine ... Read more >>

J Psychopharmacol (Journal of psychopharmacology (Oxford, England))
[2021, 35(2):168-177]

Cited: 1 time

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Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation.

Roger B Varela, Wilson R Resende, Gustavo C Dal-Pont, Fernanda F Gava, Gabriella B Nadas, Susannah J Tye, Monica L Andersen, João Quevedo, Samira S Valvassori,

It is known that bipolar disorder has a multifactorial aetiology where the interaction between genetic and environmental factors is responsible for its development. Because of this, epigenetics has been largely studied in psychiatric disorders. The present study aims to evaluate the effects of histone deacetylase inhibitors on epigenetic enzyme alterations ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2021, 53(2):649-662]

Cited: 2 times

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Feasibility Study of Stress Management and Resiliency Training (SMART) in Patients With Major Depressive Disorder.

Ashok Seshadri, Matthew M Clark, Simon Kung, Matthew Fuller-Tyszkiewicz, Amit Sood, Kristina C Dammen, Jose A Rico, Susannah J Tye, Jane McGillivray, Mark A Frye,

<h4>Objective</h4>Stress is associated with the onset, maintenance, and recurrence of depression. This study investigated the feasibility of stress management and resiliency training (SMART) for enhancing resiliency in a group of patients with major depressive disorder.<h4>Methods</h4>In an open-label study, patients with major depressive disorder were invited to participate in an adjunctive ... Read more >>

Prim Care Companion CNS Disord (The primary care companion for CNS disorders)
[2020, 22(3):]

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HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain.

Roger B Varela, Wilson R Resende, Gustavo C Dal-Pont, Fernanda F Gava, Susannah J Tye, João Quevedo, Samira S Valvassori,

<h4>Background</h4>The etiology of bipolar disorder (BD) is multifactorial, involving both environmental and genetic factors. Current pharmacological treatment is associated with several side effects, which are the main reason patients discontinue treatment. Epigenetic alterations have been studied for their role in the pathophysiology of BD, as they bridge the gap between ... Read more >>

Pharmacol Biochem Behav (Pharmacology, biochemistry, and behavior)
[2020, 193:172917]

Cited: 3 times

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TinyFSCV: FSCV for the Masses.

Scott D Adams, Egan H Doeven, Susannah J Tye, Kevin E Bennet, Michael Berk, Abbas Z Kouzani,

The ability to monitor neurochemical dynamics in target brain regions with a high degree of temporal resolution has assisted researchers in investigating the pathogenesis, and pathophysiology of a variety of neurological and psychiatric disorders. Current systems for neurochemical monitoring are bulky or expensive, limiting widespread exploration of this research field ... Read more >>

IEEE Trans Neural Syst Rehabil Eng (IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society)
[2020, 28(1):133-142]

Cited: 2 times

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Insulin-stimulated mTOR activation in peripheral blood mononuclear cells associated with early treatment response to lithium augmentation in rodent model of antidepressant-resistance.

Adam J Walker, J Blair Price, Kristin Borreggine, Shari L Sutor, Andrea Gogos, Jane A McGillivray, Mark A Frye, Susannah J Tye,

Lithium has been shown to have some therapeutic efficacy as an adjunctive treatment for intractable forms of major depression. Activation of mammalian target of rapamycin (mTOR) and inhibition of glycogen synthase kinase-3β (GSK3β) have been implicated in its putative mechanisms of action. These proteins are integral components of the insulin ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2019, 9(1):113]

Cited: 1 time

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Development of a miniature device for emerging deep brain stimulation paradigms.

Scott D Adams, Kevin E Bennet, Susannah J Tye, Michael Berk, Abbas Z Kouzani,

Deep brain stimulation (DBS) is a neuromodulatory approach for treatment of several neurological and psychiatric disorders. A new focus on optimising the waveforms used for stimulation is emerging regarding the mechanism of DBS treatment. Many existing DBS devices offer only a limited set of predefined waveforms, mainly rectangular, and hence ... Read more >>

PLoS One (PloS one)
[2019, 14(2):e0212554]

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The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: Implications to the animal model of bipolar disorder.

Samira S Valvassori, Edemilson Mariot, Roger B Varela, Daniela V Bavaresco, Gustavo C Dal-Pont, Camila L Ferreira, Monica L Andersen, Susannah J Tye, João Quevedo,

BACKGROUND:Bipolar disorder (BD) and substance use disorders share common symptoms, such as behavioral sensitization. Amphetamine-induced behavioral sensitization can serve as an animal model of BD. Neurotrophic factors have an important role in BD pathophysiology. This study evaluated the effects of amphetamine sensitization on behavior and neurotrophic factor levels in the ... Read more >>

J Affect Disord (Journal of affective disorders)
[2019, 245:1106-1113]

Cited: 4 times

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Towards miniaturized closed-loop optogenetic stimulation devices.

Epsy S Edward, Abbas Z Kouzani, Susannah J Tye,

OBJECTIVE:Electrical brain stimulation provides therapeutic benefits for patients with drug-resistant neurological disorders. It, however, has restricted access to cell-type selectivity which limits its treatment effectiveness. Optogenetics, in contrast, enables precise targeting of a specific cell type which can address the issue with electrical brain stimulation. It, nonetheless, disregards real-time brain ... Read more >>

J Neural Eng (Journal of neural engineering)
[2018, 15(2):021002]

Cited: 3 times

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An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction.

Scott D Adams, Abbas Z Kouzani, Susannah J Tye, Kevin E Bennet, Michael Berk,

Dynamic feedback based closed-loop medical devices offer a number of advantages for treatment of heterogeneous neurological conditions. Closed-loop devices integrate a level of neurobiological feedback, which allows for real-time adjustments to be made with the overarching aim of improving treatment efficacy and minimizing risks for adverse events. One target which ... Read more >>

J Neuroeng Rehabil (Journal of neuroengineering and rehabilitation)
[2018, 15(1):8]

Cited: 1 time

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Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders.

Ahmed T Ahmed, Mark A Frye, A John Rush, Joanna M Biernacka, W Edward Craighead, William M McDonald, William V Bobo, Patricio Riva-Posse, Susannah J Tye, Helen S Mayberg, Daniel K Hall-Flavin, Michelle K Skime, Greg D Jenkins, Liewei Wang, Ranga Rama Krishnan, Richard M Weinshilboum, Rima Kaddurah-Daouk, Boadie W Dunlop, ,

<h4>Background</h4>Substantial research progress can be achieved if available clinical datasets can be mapped to the National Institute of Mental Health Research-Domain-Criteria (RDoC) constructs. This mapping would allow investigators to both explore more narrowly defined clinical phenotypes and the relationship of these phenotypes to biological markers and clinical outcomes approximating RDoC ... Read more >>

J Affect Disord (Journal of affective disorders)
[2018, 238:1-7]

Cited: 5 times

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A review of brain insulin signaling in mood disorders: From biomarker to clinical target.

Thanh Thanh L Nguyen, Lily C Chan, Kristin Borreginne, Rajas P Kale, Chunling Hu, Susannah J Tye,

Patients with mood disorders are at increased risk for metabolic dysfunction. Co-occurrence of the two conditions is typically associated with a more severe disease course and poorer treatment outcomes. The specific pathophysiological mechanisms underlying this bidirectional relationship between mood and metabolic dysfunction remains poorly understood. However, it is likely that ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2018, 92:7-15]

Cited: 6 times

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Adolescent mental health education InSciEd Out: a case study of an alternative middle school population.

Joanna Yang, Roberto Lopez Cervera, Susannah J Tye, Stephen C Ekker, Chris Pierret,

<h4>Background</h4>Mental illness contributes substantially to global disease burden, particularly when illness onset occurs during youth and help-seeking is delayed and/or limited. Yet, few mental health promotion interventions target youth, particularly those with or at high risk of developing mental illness ("at-risk" youth). Community-based translational research has the capacity to identify ... Read more >>

J Transl Med (Journal of translational medicine)
[2018, 16(1):84]

Cited: 5 times

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Bioenergetics and synaptic plasticity as potential targets for individualizing treatment for depression.

J Blair Price, Carrie Bronars, Sophie Erhardt, Kathyrn R Cullen, Lilly Schwieler, Michael Berk, Ken Walder, Sean L McGee, Mark A Frye, Susannah J Tye,

Disruptions of bioenergetic signaling and neurogenesis are hallmarks of depression physiology and are often the product of dysregulation of the inflammatory, stress-response, and metabolic systems. These systems are extensively interrelated at the physiological level, yet the bulk of the literature to date addresses pathophysiological mechanisms in isolation. A more integrated ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2018, 90:212-220]

Cited: 8 times

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Corrigendum to "Continuation phase intravenous ketamine in adults with treatment-resistant depression" [J. Affect. Disord. 206 (2016) 300-304].

Jennifer L Vande Voort, Robert J Morgan, Simon Kung, Keith G Rasmussen, Jose Rico, Brian A Palmer, Kathryn M Schak, Susannah J Tye, Matthew J Ritter, Mark A Frye, William V Bobo,

J Affect Disord (Journal of affective disorders)
[2018, 236:313]

Cited: 1 time

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The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases.

Gerwyn Morris, Ken Walder, André F Carvalho, Susannah J Tye, Kurt Lucas, Michael Berk, Michael Maes,

There is a wealth of data indicating that de novo protein S-nitrosylation in general and protein transnitrosylation in particular mediates the bulk of nitric oxide signalling. These processes enable redox sensing and facilitate homeostatic regulation of redox dependent protein signalling, function, stability and trafficking. Increased S-nitrosylation in an environment of ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2018, 84:453-469]

Cited: 7 times

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Fostering Resilience among Mothers under Stress: "Authentic Connections Groups" for Medical Professionals.

Suniya S Luthar, Alexandria Curlee, Susannah J Tye, Judith C Engelman, Cynthia M Stonnington,

<h4>Background</h4>We report on effects of an intervention to foster resilience among professional women at high risk for stress and burnout: health care providers (physicians, PhD clinicians, physician assistants, and nurse practitioners) who are mothers.<h4>Methods</h4>Between February and November 2015, 40 mothers on staff at the Mayo Clinic, Arizona, were assigned randomly ... Read more >>

Womens Health Issues (Women's health issues : official publication of the Jacobs Institute of Women's Health)
[2017, 27(3):382-390]

Cited: 9 times

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Validation of a Portable Low-Power Deep Brain Stimulation Device Through Anxiolytic Effects in a Laboratory Rat Model.

Abbas Z Kouzani, Rajas P Kale, Pablo Patricio Zarate-Garza, Michael Berk, Ken Walder, Susannah J Tye,

Deep brain stimulation (DBS) devices deliver electrical pulses to neural tissue through an electrode. To study the mechanisms and therapeutic benefits of deep brain stimulation, murine preclinical research is necessary. However, conducting naturalistic long-term, uninterrupted animal behavioral experiments can be difficult with bench-top systems. The reduction of size, weight, power ... Read more >>

IEEE Trans Neural Syst Rehabil Eng (IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society)
[2017, 25(9):1365-1374]

Cited: 2 times

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How Well Do We Understand the Long-Term Health Implications of Childhood Bullying?

Pablo Patricio Zarate-Garza, Bridget K Biggs, Paul Croarkin, Brooke Morath, Jarrod Leffler, Alfredo Cuellar-Barboza, Susannah J Tye,

Once dismissed as an innocuous experience of childhood, bullying is now recognized as having significant psychological effects, particularly with chronic exposure. Victims of bullying are at risk for a number of psychiatric disturbances, and growing evidence suggests that the pathophysiological effects of bullying, as with other forms of trauma and ... Read more >>

Harv Rev Psychiatry (Harvard review of psychiatry)
[2017, 25(2):89-95]

Cited: 5 times

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A model of the mitochondrial basis of bipolar disorder.

Gerwyn Morris, Ken Walder, Sean L McGee, Olivia M Dean, Susannah J Tye, Michael Maes, Michael Berk,

<h4>Background</h4>Bipolar disorder phenomenologically is a biphasic disorder of energy availability; increased in mania and decreased in depression. In consort, there is accumulating evidence indicating increased mitochondrial respiration and ATP production in bipolar mania which contrasts with decreased mitochondrial function in patients in the euthymic or depressive phase of the illness. ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2017, 74(Pt A):1-20]

Cited: 45 times

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