Full Text Journal Articles by
Author Susannah G Ellsworth

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Assessing the interactions between radiotherapy and antitumour immunity.

Clemens Grassberger, Susannah G Ellsworth, Moses Q Wilks, Florence K Keane, Jay S Loeffler,

Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has transformed the treatment of cancer, enabling long-term tumour control even in individuals with advanced-stage disease. Unfortunately, only a small subset of patients show a response to currently available immunotherapies. Despite a growing consensus that combining immune checkpoint inhibitors with radiotherapy can ... Read more >>

Nat Rev Clin Oncol (Nature reviews. Clinical oncology)
[2019, :]

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Nearly Half of Metastatic Brain Disease Patients Prescribed 10 Fractions of Whole-Brain Radiation Therapy Die Without Completing Treatment.

Shearwood McClelland, Namita Agrawal, Kevin Shiue, Gregory K Bartlett, Richard C Zellars, Gordon A Watson, Susannah G Ellsworth,

J Pain Symptom Manage (Journal of pain and symptom management)
[2019, 58(2):e5-e6]

Cited: 0 times

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Aquaporin-4 Expression Patterns in Glioblastoma Pre-Chemoradiation and at Time of Suspected Progression.

Michael Levy, Scott Barletta, Hwa Huang, Stuart A Grossman, Fausto J Rodriguez, Susannah G Ellsworth, Omar Dzaye, Matthias Holdhoff,

There has been controversy about the presence and potential role of aquaporin-4 (AQP4) in glioblastoma (GBM). We analyzed tissue from 22 patients with newly-diagnosed GBM as well as matching tissue from 17 of these cases who underwent repeat resection for suspected recurrence and performed immunohistochemical analysis for AQP-4 expression. While ... Read more >>

Cancer Invest. (Cancer investigation)
[2019, 37(2):67-72]

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In Regard to Schaub et al.

David E Long, Susannah G Ellsworth,

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2019, 103(5):1284-1285]

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Predictors of Nodal and Metastatic Failure in Early Stage Non-small-cell Lung Cancer After Stereotactic Body Radiation Therapy.

Alberto Cerra-Franco, Sheng Liu, Michella Azar, Kevin Shiue, Samantha Freije, Jason Hinton, Christopher R Deig, Donna Edwards, Neil C Estabrook, Susannah G Ellsworth, Ke Huang, Khalil Diab, Mark P Langer, Richard Zellars, Feng-Ming Kong, Jun Wan, Tim Lautenschlaeger,

INTRODUCTION/BACKGROUND:Many patients with early stage non-small-cell lung cancer (ES-NSCLC) undergoing stereotactic body radiation therapy (SBRT) develop metastases, which is associated with poor outcomes. We sought to identify factors predictive of metastases after lung SBRT and created a risk stratification tool. MATERIALS AND METHODS:We included 363 patients with ES-NSCLC who received ... Read more >>

Clin Lung Cancer (Clinical lung cancer)
[2019, 20(3):186-193.e3]

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Field size effects on the risk and severity of treatment-induced lymphopenia in patients undergoing radiation therapy for solid tumors.

Susannah G Ellsworth,

Purpose:Radiation-induced lymphopenia (RIL) is the result of direct toxicity to circulating lymphocytes as they traverse the irradiated field, occurs in 40% to 70% of patients who undergo conventional external beam radiation therapy, and is associated with worse outcomes in multiple solid tumors. As immunotherapy strategies evolve, a better understanding of ... Read more >>

Adv Radiat Oncol (Advances in radiation oncology)
[2018, 3(4):512-519]

Cited: 2 times

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Functional liver image guided hepatic therapy (FLIGHT) with hepatobiliary iminodiacetic acid (HIDA) scans.

David E Long, Mark Tann, Ke Colin Huang, Gregory Bartlett, James O Galle, Yukie Furukawa, Mary Maluccio, John A Cox, Feng-Ming Spring Kong, Susannah G Ellsworth,

PURPOSE:Hepatobiliary iminodiacetic acid (HIDA) scans provide global and regional assessments of liver function that can serve as a road map for functional avoidance in stereotactic body radiation therapy (SBRT) planning. Functional liver image guided hepatic therapy (FLIGHT), an innovative planning technique, is described and compared with standard planning using functional ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2018, 8(6):429-436]

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Effects of Proton Center Closure on Pediatric Case Volume and Resident Education at an Academic Cancer Center.

James O Galle, David E Long, Tim Lautenschlaeger, Richard C Zellars, Gordon A Watson, Susannah G Ellsworth,

PURPOSE:To analyze effects of closure of an academic proton treatment center (PTC) on pediatric case volume, distribution, and resident education. METHODS AND MATERIALS:This was a review of 412 consecutive pediatric (age ≤18 years) cases treated at a single institution from 2012 to 2016. Residents' Accreditation Council for Graduate Medical Education case ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2018, 100(3):710-718]

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Principal component analysis identifies patterns of cytokine expression in non-small cell lung cancer patients undergoing definitive radiation therapy.

Susannah G Ellsworth, Bryan M Rabatic, Jie Chen, Jing Zhao, Jeffrey Campbell, Weili Wang, Wenhu Pi, Paul Stanton, Martha Matuszak, Shruti Jolly, Amy Miller, Feng-Ming Kong,

Radiation treatment (RT) stimulates the release of many immunohumoral factors, complicating the identification of clinically significant cytokine expression patterns. This study used principal component analysis (PCA) to analyze cytokines in non-small cell lung cancer (NSCLC) patients undergoing RT and explore differences in changes after hypofractionated stereotactic body radiation therapy (SBRT) ... Read more >>

PLoS ONE (PloS one)
[2017, 12(9):e0183239]

Cited: 1 time

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Lymphocyte-Sparing Effect of Stereotactic Body Radiation Therapy in Patients With Unresectable Pancreatic Cancer.

Aaron T Wild, Joseph M Herman, Avani S Dholakia, Shalini Moningi, Yao Lu, Lauren M Rosati, Amy Hacker-Prietz, Ryan K Assadi, Ali M Saeed, Timothy M Pawlik, Elizabeth M Jaffee, Daniel A Laheru, Phuoc T Tran, Matthew J Weiss, Christopher L Wolfgang, Eric Ford, Stuart A Grossman, Xiaobu Ye, Susannah G Ellsworth,

Radiation-induced lymphopenia (RIL) is associated with inferior survival in patients with glioblastoma, lung cancer, and pancreatic cancer. We asked whether stereotactic body radiation therapy (SBRT) decreases severity of RIL compared to conventional chemoradiation therapy (CRT) in locally advanced pancreatic cancer (LAPC).Serial total lymphocyte counts (TLCs) from patients enrolled in a ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2016, 94(3):571-579]

Cited: 33 times

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The Association Between Chemoradiation-related Lymphopenia and Clinical Outcomes in Patients With Locally Advanced Pancreatic Adenocarcinoma.

Aaron T Wild, Xiaobu Ye, Susannah G Ellsworth, Jessica A Smith, Amol K Narang, Tanu Garg, Jian Campian, Daniel A Laheru, Lei Zheng, Christopher L Wolfgang, Phuoc T Tran, Stuart A Grossman, Joseph M Herman,

Lymphopenia is a common consequence of chemoradiation therapy yet is seldom addressed clinically. This study was conducted to determine if patients with locally advanced pancreatic cancer (LAPC) treated with definitive chemoradiation develop significant lymphopenia and if this affects clinical outcomes.A retrospective analysis of patients with LAPC treated with chemoradiation at ... Read more >>

Am. J. Clin. Oncol. (American journal of clinical oncology)
[2015, 38(3):259-265]

Cited: 41 times

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Efficacy of platinum chemotherapy agents in the adjuvant setting for adenosquamous carcinoma of the pancreas.

Aaron T Wild, Avani S Dholakia, Katherine Y Fan, Rachit Kumar, Shalini Moningi, Lauren M Rosati, Daniel A Laheru, Lei Zheng, Ana De Jesus-Acosta, Susannah G Ellsworth, Amy Hacker-Prietz, Khinh R Voong, Phuoc T Tran, Ralph H Hruban, Timothy M Pawlik, Christopher L Wolfgang, Joseph M Herman,

Pancreatic adenosquamous carcinoma (PASC) accounts for only 1-4% of all exocrine pancreatic cancers and carries a particularly poor prognosis. This retrospective study was performed to determine whether inclusion of a platinum agent as part of adjuvant therapy is associated with improved survival in patients with resected PASC.Records of all patients ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2015, 6(2):115-125]

Cited: 5 times

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Patterns of care among patients receiving radiation therapy for bone metastases at a large academic institution.

Susannah G Ellsworth, Sara R Alcorn, Russell K Hales, Todd R McNutt, Theodore L DeWeese, Thomas J Smith,

This study evaluates outcomes and patterns of care among patients receiving radiation therapy (RT) for bone metastases at a high-volume academic institution.Records of all patients whose final RT course was for bone metastases from April 2007 to July 2012 were identified from electronic medical records. Chart review yielded demographic and ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2014, 89(5):1100-1105]

Cited: 14 times

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High-dose-rate intraoperative radiation therapy: the nuts and bolts of starting a program.

Shalini Moningi, Elwood P Armour, Stephanie A Terezakis, Jonathan E Efron, Susan L Gearhart, Trinity J Bivalacqua, Rachit Kumar, Yi Le, Sook Kien Ng, Christopher L Wolfgang, Richard C Zellars, Susannah G Ellsworth, Nita Ahuja, Joseph M Herman,

High-dose-rate intraoperative radiation therapy (HDR-IORT) has historically provided effective local control (LC) for patients with unresectable and recurrent tumors. However, IORT is limited to only a few specialized institutions and it can be difficult to initiate an HDR-IORT program. Herein, we provide a brief overview on how to initiate and ... Read more >>

J Contemp Brachytherapy (Journal of contemporary brachytherapy)
[2014, 6(1):99-105]

Cited: 5 times

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Pain management and palliative care in pancreatic cancer.

Michael A Erdek, Lauren M King, Susannah G Ellsworth,

Curr Probl Cancer (Current problems in cancer)
[2013, 37(5):266-272]

Cited: 5 times

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