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Author Susana Ruiz

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Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The [email protected] project.

Sonia Moreno-Grau, Itziar de Rojas, Isabel Hernández, Inés Quintela, Laura Montrreal, Montserrat Alegret, Begoña Hernández-Olasagarre, Laura Madrid, Antonio González-Perez, Olalla Maroñas, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Carla Abdelnour, Octavio Rodríguez-Gómez, Silvia Gil, Miguel Ángel Santos-Santos, Ana Espinosa, Gemma Ortega, Ángela Sanabria, Alba Pérez-Cordón, Pilar Cañabate, Mariola Moreno, Silvia Preckler, Susana Ruiz, Nuria Aguilera, Juan Antonio Pineda, Juan Macías, Emilio Alarcón-Martín, Oscar Sotolongo-Grau, , , , Marta Marquié, Gemma Monté-Rubio, Sergi Valero, Alba Benaque, Jordi Clarimón, Maria Jesus Bullido, Guillermo García-Ribas, Pau Pástor, Pascual Sánchez-Juan, Victoria Álvarez, Gerard Piñol-Ripoll, Jose Maria García-Alberca, José Luis Royo, Emilio Franco, Pablo Mir, Miguel Calero, Miguel Medina, Alberto Rábano, Jesús Ávila, Carmen Antúnez, Luis Miguel Real, Adelina Orellana, Ángel Carracedo, María Eugenia Sáez, Lluís Tárraga, Mercè Boada, Agustín Ruiz,

INTRODUCTION:Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. METHODS:Genome Research at Fundacio ACE ([email protected]) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2019, 15(10):1333-1347]

Cited: 2 times

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Prevalence, risk factors and molecular characterization of Chlamydia trachomatis in pregnant women from Córdoba, Argentina: A prospective study.

Ana Ximena Kiguen, Marcela Marramá, Susana Ruiz, Patricia Estofan, Raúl Fernando Venezuela, Jessica Paola Mosmann, Marina Soledad Monetti, Virginia Rivero, Cecilia Gabriela Cuffini,

BACKGROUND:Chlamydia trachomatis causes the most prevalent bacterial Sexual Transmitted Infection. In pregnant women, untreated chlamydial infections are associated with abortions, premature rupture of membranes, postpartum endometritis, low birth weight and transmission to the newborn. In Córdoba, Argentina, there is little knowledge about the prevalence of Chlamydia trachomatis in women in ... Read more >>

PLoS ONE (PloS one)
[2019, 14(5):e0217245]

Cited: 0 times

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Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer’s disease and three causality networks of AD: the [email protected] project

Sonia Moreno-Grau, Itziar de Rojas, Isabel Hernández, Inés Quintela, Laura Montrreal, Montserrat Alegret, Begoña Hernández-Olasagarre, Laura Madrid, Antonio González-Perez, Olalla Maroña, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Carla Abdelnour, Octavio Rodríguez-Gómez, Silvia Gil, Miguel Ángel Santos-Santos, Ana Espinosa, Gemma Ortega, Ángela Sanabria, Alba Pérez-Cordón, Susana Ruiz, Nuria Aguilera, Juan Antonio Pineda, Juan Macías, Emilio Alarcón, Oscar Sotolongo-Grau, Marta Marquié, Gemma Montè-Rubio, Sergi Valero, Jordi Clarimón, Maria Jesus Bullido, Guillermo García-Ribas, Pau Pástor, Pascual Sánchez-Juan, Victoria Álvarez, Gerard Piñol-Ripoll, Jose Maria García-Alberca, José Luis Royo, Emilio Franco, Pablo Mir, Miguel Calero, Miguel Medina, Alberto Rábano, Jesús Ávila, Carmen Antúnez, Luis Miguel Real, Adelina Orellana, Ángel Carracedo, María Eugenia Sáez, Lluís Tárraga, Mercé Boada, Agustín Ruiz, , ,

Abstract Background Genetics plays a major role in Alzheimer’s Disease (AD). To date, 40 genes associated with AD have been identified, although most remain undiscovered. Clinical, neuropathological and genetic variability might impact genetic discoveries and complicate dissection of the biological pathways underlying AD. Methods [email protected] is a genome-wide study of ... Read more >>

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Exploring Genetic Associations of Alzheimer's Disease Loci With Mild Cognitive Impairment Neurocognitive Endophenotypes.

Ana Espinosa, Begoña Hernández-Olasagarre, Sonia Moreno-Grau, Luca Kleineidam, Stefanie Heilmann-Heimbach, Isabel Hernández, Steffen Wolfsgruber, Holger Wagner, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Octavio Rodríguez-Gómez, Carla Abdelnour, Silvia Gil, Marta Marquié, Miguel A Santos-Santos, Ángela Sanabria, Gemma Ortega, Gemma Monté-Rubio, Alba Pérez, Marta Ibarria, Susana Ruiz, Johannes Kornhuber, Oliver Peters, Lutz Frölich, Michael Hüll, Jens Wiltfang, Tobias Luck, Steffi Riedel-Heller, Laura Montrreal, Pilar Cañabate, Mariola Moreno, Silvia Preckler, Nuria Aguilera, Itziar de Rojas, Adelina Orellana, Montserrat Alegret, Sergi Valero, Markus M Nöthen, Michael Wagner, Frank Jessen, Lluis Tárraga, Mercè Boada, Alfredo Ramírez, Agustín Ruiz,

The role of genetic risk markers for Alzheimer's disease (AD) in mediating the neurocognitive endophenotypes (NEs) of subjects with mild cognitive impairment (MCI) has rarely been studied. The aim of the present study was to investigate the relationship between well-known AD-associated single-nucleotide polymorphisms (SNPs) and individual NEs routinely evaluated during ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2018, 10:340]

Cited: 1 time

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Genome-wide significant risk factors on chromosome 19 and the APOE locus.

Sonia Moreno-Grau, Isabel Hernández, Stefanie Heilmann-Heimbach, Susana Ruiz, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Octavio Rodríguez-Gómez, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Nuria Aguilera, Carla Abdelnour, Alzheimer's Disease Neuroimaging Initiative, Silvia Gil, Wolfgang Maier, Oscar Sotolongo-Grau, Lluís Tárraga, Alfredo Ramirez, Jesús López-Arrrieta, Carmen Antúnez, Manuel Serrano-Ríos, Mercè Boada, Agustín Ruiz,

The apolipoprotein E (APOE) gene on chromosome 19q13.32, was the first, and remains the strongest, genetic risk factor for Alzheimer's disease (AD). Additional signals associated with AD have been located in chromosome 19, including ABCA7 (19p13.3) and CD33 (19q13.41). The ABCA7 gene has been replicated in most populations. However, the ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(37):24590-24600]

Cited: 1 time

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Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy Brain Initiative (FACEHBI) study baseline results.

Sonia Moreno-Grau, Octavio Rodríguez-Gómez, Ángela Sanabria, Alba Pérez-Cordón, Domingo Sánchez-Ruiz, Carla Abdelnour, Sergi Valero, Isabel Hernández, Maitée Rosende-Roca, Ana Mauleón, Liliana Vargas, Asunción Lafuente, Silvia Gil, Miguel Ángel Santos-Santos, Montserrat Alegret, Ana Espinosa, Gemma Ortega, Marina Guitart, Anna Gailhajanet, Itziar de Rojas, Óscar Sotolongo-Grau, Susana Ruiz, Nuria Aguilera, Judith Papasey, Elvira Martín, Esther Peleja, , Francisco Lomeña, Francisco Campos, Assumpta Vivas, Marta Gómez-Chiari, Miguel Ángel Tejero, Joan Giménez, Manuel Serrano-Ríos, Adelina Orellana, Lluís Tárraga, Agustín Ruiz, Mercè Boada, ,

INTRODUCTION:Subjective cognitive decline (SCD) has been proposed as a potential preclinical stage of Alzheimer's disease (AD). Nevertheless, the genetic and biomarker profiles of SCD individuals remain mostly unexplored. METHODS:We evaluated apolipoprotein E (APOE) ε4's effect in the risk of presenting SCD, using the Fundacio ACE Healthy Brain Initiative (FACEHBI) SCD ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2018, 14(5):634-643]

Cited: 2 times

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Retinal vein occlusion and paroxysmal nocturnal hemoglobinuria.

Marc Sorigue, Jordi Juncà, Elisa Orna, Nevena Romanic, Edurne Sarrate, Jordi Castellvi, Montse Soler, Ines Rodríguez-Hernandez, Evarist Feliu, Susana Ruiz,

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder associated with increased risk for thrombosis and reduced life expectancy. Retinal vein occlusion (RVO) is a frequent cause of vision loss but its relationship with PNH has not been studied systematically. Patients followed up for RVO in our ophthalmology department were screened ... Read more >>

J. Thromb. Thrombolysis (Journal of thrombosis and thrombolysis)
[2017, 44(1):63-66]

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Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype.

Ana Espinosa, Montserrat Alegret, Pedro Pesini, Sergi Valero, Asunción Lafuente, Mar Buendía, Itziar San José, Marta Ibarria, Miguel A Tejero, Joan Giménez, Susana Ruiz, Isabel Hernández, Francesc Pujadas, Pablo Martínez-Lage, Josep Munuera, Javier Arbizu, Lluis Tárraga, Suzanne B Hendrix, Agustín Ruiz, James T Becker, Susan M Landau, Oscar Sotolongo-Grau, Manuel Sarasa, Mercè Boada, , ,

The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8.5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. The aim of this study was to find the optimized cognitive composites (CCs) domain scores most related to neuroimaging biomarkers ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2017, 57(2):447-459]

Cited: 4 times

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Association of GWAS Top Genes With Late-Onset Alzheimer's Disease in Colombian Population.

Diana Jennifer Moreno, Susana Ruiz, Ángela Ríos, Francisco Lopera, Henry Ostos, Marc Via, Gabriel Bedoya,

The association of variants in CLU, CR1, PICALM, BIN1, ABCA7, and CD33 genes with late-onset Alzheimer's disease (LOAD) was evaluated and confirmed through genome-wide association study. However, it is unknown whether these associations can be replicated in admixed populations.The association of 14 single-nucleotide polymorphisms in those genes was evaluated in ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2017, 32(1):27-35]

Cited: 8 times

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Decontamination of stethoscope membranes with chlorhexidine: Should it be recommended?

José A Álvarez, Susana R Ruíz, Juan L Mosqueda, Ximena León, Virginia Arreguín, Alejandro E Macías, Juan H Macias,

To determine differences in the recontamination of stethoscope membranes after cleaning with chlorhexidine, triclosan, or alcohol.Experimental, controlled, blinded trial to determine differences in the bacterial load on stethoscope membranes. Membranes were cultured by direct imprint after disinfection with 70% isopropyl alcohol, 1% triclosan, or 1% chlorhexidine and normal use for ... Read more >>

Am J Infect Control (American journal of infection control)
[2016, 44(11):e205-e209]

Cited: 2 times

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Immunization with LytB protein of Streptococcus pneumoniae activates complement-mediated phagocytosis and induces protection against pneumonia and sepsis.

Bruno Corsini, Leire Aguinagalde, Susana Ruiz, Mirian Domenech, María Luisa Antequera, Asunción Fenoll, Pedro García, Ernesto García, Jose Yuste,

The cell wall glucosaminidase LytB of Streptococcus pneumoniae is a surface exposed protein involved in daughter cell separation, biofilm formation and contributes to different aspects of the pathogenesis process. In this study we have characterized the antibody responses after immunization of mice with LytB in the presence of alhydrogel as ... Read more >>

Vaccine (Vaccine)
[2016, 34(50):6148-6157]

Cited: 1 time

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MAPT H1 Haplotype is Associated with Late-Onset Alzheimer's Disease Risk in APOEɛ4 Noncarriers: Results from the Dementia Genetics Spanish Consortium.

Pau Pastor, Fermín Moreno, Jordi Clarimón, Agustín Ruiz, Onofre Combarros, Miguel Calero, Adolfo López de Munain, Maria J Bullido, Marian M de Pancorbo, Eva Carro, Anna Antonell, Eliecer Coto, Sara Ortega-Cubero, Isabel Hernandez, Lluís Tárraga, Mercè Boada, Alberto Lleó, Oriol Dols-Icardo, Jaime Kulisevsky, José Luis Vázquez-Higuera, Jon Infante, Alberto Rábano, Miguel Ángel Fernández-Blázquez, Meritxell Valentí, Begoña Indakoetxea, Myriam Barandiarán, Ana Gorostidi, Ana Frank-García, Isabel Sastre, Elena Lorenzo, María A Pastor, Xabier Elcoroaristizabal, Martina Lennarz, Wolfang Maier, Alfredo Rámirez, Manuel Serrano-Ríos, Suzee E Lee, Pascual Sánchez-Juan, ,

The MAPT H1 haplotype has been linked to several disorders, but its relationship with Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p.A152T) has been linked with frontotemporal dementia (FTD) and AD. We genotyped H1/H2 and p.A152T MAPT in 11,572 subjects from Spain (4,327 AD, 563 FTD, 648 ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2016, 49(2):343-352]

Cited: 12 times

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In vitro biofilm development of Streptococcus pneumoniae and formation of choline-binding protein-DNA complexes.

Mirian Domenech, Susana Ruiz, Miriam Moscoso, Ernesto García,

Extracellular deoxyribonucleic acid (eDNA) is an essential component of bacterial biofilm matrices, and is required in their formation and maintenance. Extracellular DNA binds to exopolysaccharides or extracellular proteins, affording biofilms greater structural integrity. Recently, we reported evidence of intercellular eDNA-LytC complexes in pneumococcal biofilms. The LytC lysozyme is a member ... Read more >>

Environ Microbiol Rep (Environmental microbiology reports)
[2015, 7(5):715-727]

Cited: 6 times

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Correction: Blood Amyloid Beta Levels in Healthy, Mild Cognitive Impairment and Alzheimer’s Disease Individuals: Replication of Diastolic Blood Pressure Correlations and Analysis of Critical Covariates.

Agustín Ruiz, Pedro Pesini, Ana Espinosa, Virginia Pérez-Grijalba, Sergi Valero, Oscar Sotolongo-Grau, Montserrat Alegret, Inmaculada Monleón, Asunción Lafuente, Mar Buendía, Marta Ibarria, Susana Ruiz, Isabel Hernández, Itziar San José, Lluís Tárraga, Mercè Boada, Manuel Sarasa,

PLoS ONE (PloS one)
[2014, 9(1):]

Cited: 0 times

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Blood amyloid beta levels in healthy, mild cognitive impairment and Alzheimer's disease individuals: replication of diastolic blood pressure correlations and analysis of critical covariates.

Agustín Ruiz, Pedro Pesini, Ana Espinosa, Virginia Pérez-Grijalba, Sergi Valero, Oscar Sotolongo-Grau, Montserrat Alegret, Inmaculada Monleón, Asunción Lafuente, Mar Buendía, Marta Ibarria, Susana Ruiz, Isabel Hernández, Itziar San José, Lluís Tárraga, Mercè Boada, Manuel Sarasa,

Plasma amyloid beta (Aβ) levels are being investigated as potential biomarkers for Alzheimer's disease. In AB128 cross-sectional study, a number of medical relevant correlates of blood Aβ40 or Aβ42 were analyzed in 140 subjects (51 Alzheimer's disease patients, 53 healthy controls and 36 individuals diagnosed with mild cognitive impairment). We ... Read more >>

PLoS ONE (PloS one)
[2013, 8(11):e81334]

Cited: 13 times

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Design of a comprehensive Alzheimer's disease clinic and research center in Spain to meet critical patient and family needs.

Mercè Boada, Lluís Tárraga, Isabel Hernández, Sergi Valero, Montserrat Alegret, Agustín Ruiz, Oscar L Lopez, James T Becker, ,

Alzheimer's disease (AD) affects people worldwide, and the prevalence is increasing as the population ages. There is an international effort to understand the biology of AD to develop primary and secondary prevention strategies, and to develop effective therapeutic interventions for individuals who are already symptomatic. One of the critically important ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2014, 10(3):409-415]

Cited: 13 times

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Public hospital palliative social work: addressing patient cultural diversity and psychosocial needs.

Monique Parrish, Yvette Cárdenas, Regina Epperhart, Jose Hernandez, Susana Ruiz, Linda Russell, Karolina Soriano, Kathryn Thornberry,

Through creative practice innovations and a wide range of professional competencies, social work has contributed substantively to the development of the palliative care field (Harper, 2011 ). As the field continues to grow and evolve, new opportunities are emerging to profile palliative social work in diverse health care settings. ... Read more >>

J Soc Work End Life Palliat Care (Journal of social work in end-of-life & palliative care)
[2012, 8(3):214-228]

Cited: 2 times

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The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.

Carmen Antúnez, Mercè Boada, Antonio González-Pérez, Javier Gayán, Reposo Ramírez-Lorca, Juan Marín, Isabel Hernández, Concha Moreno-Rey, Francisco Jesús Morón, Jesús López-Arrieta, Ana Mauleón, Maitée Rosende-Roca, Fuensanta Noguera-Perea, Agustina Legaz-García, Laura Vivancos-Moreau, Juan Velasco, José Miguel Carrasco, Montserrat Alegret, Martirio Antequera-Torres, Salvadora Manzanares, Alejandro Romo, Irene Blanca, Susana Ruiz, Anna Espinosa, Sandra Castaño, Blanca García, Begoña Martínez-Herrada, Georgina Vinyes, Asunción Lafuente, James T Becker, José Jorge Galán, Manuel Serrano-Ríos, , Enrique Vázquez, Lluís Tárraga, María Eugenia Sáez, Oscar L López, Luis Miguel Real, Agustín Ruiz,

In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population.We genotyped 1,128 individuals using the Affymetrix Nsp I 250K chip. A sample of 327 sporadic AD patients and 801 controls with unknown cognitive status from the Spanish general ... Read more >>

Genome Med (Genome medicine)
[2011, 3(5):33]

Cited: 44 times

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Shiga toxin-associated hemolytic uremic syndrome: absence of recurrence after renal transplantation.

Jorge R Ferraris, Jose A Ramirez, Susana Ruiz, María G Caletti, Graciela Vallejo, Juan J Piantanida, Jose L Araujo, Ernesto T Sojo,

We evaluated the relationship between the acute phase and the development of end-stage renal disease (ESRD) and the outcome of renal transplant in patients with Shiga toxin-associated hemolytic uremic syndrome (Stx-HUS). A 20-year retrospective study was performed of 66 renal transplants in 62 patients with Stx-HUS compared with 189 renal ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2002, 17(10):809-814]

Cited: 23 times

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