Full Text Journal Articles by
Author Susan R Heckbert

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Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.

Heidi M Crane, Robin M Nance, Bridget M Whitney, Susan R Heckbert, Matthew Budoff, Kevin High, Alan Landay, Matthew Feinstein, Richard D Moore, William Christopher Mathews, Katerina Christopoulos, Michael S Saag, Amanda Willig, Joseph J Eron, Mari M Kitahata, Joseph A C Delaney, ,

<h4>Background</h4>Type 1 myocardial infarctions (T1MIs) result from atherosclerotic plaque instability, rupture, and/or erosion. Type 2 MIs (T2MIs) are secondary to causes such as sepsis and cocaine-induced vasospasm resulting in an oxygen demand-supply mismatch and are associated with higher mortality than T1MIs. T2MIs account for a higher proportion of MIs among ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):208-212]

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The relationship between body mass index, disease activity, and exercise in ankylosing spondylitis.

Jean W Liew, Milena A Gianfrancesco, Susan R Heckbert, Lianne S Gensler,

<h4>Background</h4>Ankylosing spondylitis (AS) is associated with elevated cardiovascular (CV) risk and obesity is a common, modifiable risk factor. Our aims were 1) to assess the relationship of BMI with disease activity in AS patients, and 2) to assess the extent to which the effect is mediated through exercise.<h4>Methods</h4>We used data ... Read more >>

Arthritis Care Res (Hoboken) (Arthritis care & research)
[2021, :]

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Association of longitudinal changes in NT-proBNP with changes in Left Atrial Volume and Function: MESA.

Vinithra Varadarajan, Bharath Ambale-Venkatesh, Seo Young Hong, Mohammadali Habibi, Hiroshi Ashikaga, Colin O Wu, Lin Y Chen, Susan R Heckbert, David A Bluemke, Joao A C Lima,

<h4>Background</h4>The mechanism of left atrial (LA) remodeling is poorly understood. The aim of this longitudinal study was to investigate whether changes in NT-proBNP levels relate to alterations of LA structure and function over time in a multi-ethnic population.<h4>Methods</h4>From the prospective cohort study, the Multi-Ethnic Study of Atherosclerosis, our analysis included ... Read more >>

Am J Hypertens (American journal of hypertension)
[2021, :]

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Individual non-esterified fatty acids and incident atrial fibrillation late in life.

Cara N Pellegrini, Petra Buzkova, Alice H Lichtenstein, Nirupa R Matthan, Joachim H Ix, David S Siscovick, Susan R Heckbert, Russell P Tracy, Kenneth J Mukamal, Luc Djoussé, Jorge R Kizer,

<h4>Objective</h4>Obesity and dysmetabolism are major risk factors for atrial fibrillation (AF). Expansion of fat depots is associated with increased circulating total non-esterified fatty acids (NEFAs), elevated levels of which are associated with incident AF. We undertook comprehensive serum measurement of individual NEFA to identify specific associations with new-onset AF late ... Read more >>

Heart (Heart (British Cardiac Society))
[2021, :]

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Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study.

Yan Chen, Leila R Zelnick, Matthew P Huber, Ke Wang, Nisha Bansal, Andrew N Hoofnagle, Rajan K Paranji, Susan R Heckbert, Noel S Weiss, Alan S Go, Chi-Yuan Hsu, Harold I Feldman, Sushrut S Waikar, Rupal C Mehta, Anand Srivastava, Stephen L Seliger, James P Lash, Anna C Porter, Dominic S Raj, Bryan R Kestenbaum, ,

<h4>Rational & objective</h4>The clearance of protein-bound solutes by the proximal tubules is an innate kidney mechanism for removing putative uremic toxins that could exert cardiovascular toxicity in humans. However, potential associations between impaired kidney clearances of secretory solutes and cardiovascular events among patients with chronic kidney disease (CKD) remains uncertain.<h4>Study ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2021, :]

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Prediction of Kidney Drug Clearance: A Comparison of Tubular Secretory Clearance and Glomerular Filtration Rate.

Yan Chen, Leila R Zelnick, Andrew N Hoofnagle, Catherine K Yeung, Laura M Shireman, Brian Phillips, Calder C Brauchla, Ian de Boer, Linda Manahan, Susan R Heckbert, Jonathan Himmelfarb, Bryan R Kestenbaum,

<h4>Background</h4>Although proximal tubular secretion is the primary mechanism of kidney drug elimination, current kidney drug dosing strategies are on the basis of eGFR.<h4>Methods</h4>In a dedicated pharmacokinetic study to compare GFR with tubular secretory clearance for predicting kidney drug elimination, we evaluated stable outpatients with eGFRs ranging from 21 to 140 ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2020, :]

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Coagulation factor VIII, white matter hyperintensities and cognitive function: Results from the Cardiovascular Health Study.

Jessica L Rohmann, W T Longstreth, Mary Cushman, Annette L Fitzpatrick, Susan R Heckbert, Kenneth Rice, Frits R Rosendaal, Colleen M Sitlani, Bruce M Psaty, Bob Siegerink,

<h4>Objective</h4>To investigate the relationship between high FVIII clotting activity (FVIII:C), MRI-defined white matter hyperintensities (WMH) and cognitive function over time.<h4>Methods</h4>Data from the population-based Cardiovascular Health Study (n = 5,888, aged ≥65) were used. FVIII:C was measured in blood samples taken at baseline. WMH burden was assessed on two cranial MRI ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242062]

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Nonsteroidal Antiinflammatory Drug Use and Association With Incident Hypertension in Ankylosing Spondylitis.

Jean W Liew, Michael M Ward, John D Reveille, Michael Weisman, Matthew A Brown, MinJae Lee, Mohammed Rahbar, Susan R Heckbert, Lianne S Gensler,

<h4>Objective</h4>Nonsteroidal antiinflammatory drugs (NSAIDs) increase blood pressure and potentially cardiovascular burden, which may limit their use in ankylosing spondylitis (AS). Our objective was to determine the association of NSAID use with incident hypertension in a longitudinal AS cohort.<h4>Methods</h4>Adults with AS were enrolled in a prospective cohort study of patient outcomes ... Read more >>

Arthritis Care Res (Hoboken) (Arthritis care & research)
[2020, 72(11):1645-1652]

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Atypical Femur Fracture Risk versus Fragility Fracture Prevention with Bisphosphonates.

Susan M Ott, Susan R Heckbert,

N Engl J Med (The New England journal of medicine)
[2020, 383(22):2188-2189]

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Inherited causes of clonal haematopoiesis in 97,691 whole genomes.

Alexander G Bick, Joshua S Weinstock, Satish K Nandakumar, Charles P Fulco, Erik L Bao, Seyedeh M Zekavat, Mindy D Szeto, Xiaotian Liao, Matthew J Leventhal, Joseph Nasser, Kyle Chang, Cecelia Laurie, Bala Bharathi Burugula, Christopher J Gibson, Amy E Lin, Margaret A Taub, Francois Aguet, Kristin Ardlie, Braxton D Mitchell, Kathleen C Barnes, Arden Moscati, Myriam Fornage, Susan Redline, Bruce M Psaty, Edwin K Silverman, Scott T Weiss, Nicholette D Palmer, Ramachandran S Vasan, Esteban G Burchard, Sharon L R Kardia, Jiang He, Robert C Kaplan, Nicholas L Smith, Donna K Arnett, David A Schwartz, Adolfo Correa, Mariza de Andrade, Xiuqing Guo, Barbara A Konkle, Brian Custer, Juan M Peralta, Hongsheng Gui, Deborah A Meyers, Stephen T McGarvey, Ida Yii-Der Chen, M Benjamin Shoemaker, Patricia A Peyser, Jai G Broome, Stephanie M Gogarten, Fei Fei Wang, Quenna Wong, May E Montasser, Michelle Daya, Eimear E Kenny, Kari E North, Lenore J Launer, Brian E Cade, Joshua C Bis, Michael H Cho, Jessica Lasky-Su, Donald W Bowden, L Adrienne Cupples, Angel C Y Mak, Lewis C Becker, Jennifer A Smith, Tanika N Kelly, Stella Aslibekyan, Susan R Heckbert, Hemant K Tiwari, Ivana V Yang, John A Heit, Steven A Lubitz, Jill M Johnsen, Joanne E Curran, Sally E Wenzel, Daniel E Weeks, Dabeeru C Rao, Dawood Darbar, Jee-Young Moon, Russell P Tracy, Erin J Buth, Nicholas Rafaels, Ruth J F Loos, Peter Durda, Yongmei Liu, Lifang Hou, Jiwon Lee, Priyadarshini Kachroo, Barry I Freedman, Daniel Levy, Lawrence F Bielak, James E Hixson, James S Floyd, Eric A Whitsel, Patrick T Ellinor, Marguerite R Irvin, Tasha E Fingerlin, Laura M Raffield, Sebastian M Armasu, Marsha M Wheeler, Ester C Sabino, John Blangero, L Keoki Williams, Bruce D Levy, Wayne Huey-Herng Sheu, Dan M Roden, Eric Boerwinkle, JoAnn E Manson, Rasika A Mathias, Pinkal Desai, Kent D Taylor, Andrew D Johnson, , Paul L Auer, Charles Kooperberg, Cathy C Laurie, Thomas W Blackwell, Albert V Smith, Hongyu Zhao, Ethan Lange, Leslie Lange, Stephen S Rich, Jerome I Rotter, James G Wilson, Paul Scheet, Jacob O Kitzman, Eric S Lander, Jesse M Engreitz, Benjamin L Ebert, Alexander P Reiner, Siddhartha Jaiswal, Gonçalo Abecasis, Vijay G Sankaran, Sekar Kathiresan, Pradeep Natarajan,

Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown<sup>1</sup>. The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoietic stem cell populations has recently been associated with both haematological cancer<sup>2-4</sup> and coronary ... Read more >>

Nature (Nature)
[2020, 586(7831):763-768]

Cited: 2 times

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Fragmented sinoatrial dynamics in the prediction of atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis.

Madalena D Costa, Susan Redline, Elsayed Z Soliman, Ary L Goldberger, Susan R Heckbert,

Heart rate fragmentation (HRF), a marker of abnormal sinoatrial dynamics, was shown to be associated with incident cardiovascular events in the Multi-Ethnic Study of Atherosclerosis (MESA). Here, we test the hypothesis that HRF is also associated with incident atrial fibrillation (AF) in the MESA cohort of participants who underwent in-home ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2021, 320(1):H256-H271]

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Characterization of cardiac mechanics and incident atrial fibrillation in participants of the Cardiovascular Health Study.

Ravi B Patel, Joseph A Delaney, Mo Hu, Harnish Patel, Jeanette Cheng, John Gottdiener, Jorge R Kizer, Gregory M Marcus, Mintu P Turakhia, Rajat Deo, Susan R Heckbert, Bruce M Psaty, Sanjiv J Shah,

<h4>Background</h4>Left atrial (LA) and left ventricular (LV) remodeling are associated with atrial fibrillation (AF). The prospective associations of impairment in cardiac mechanical function, as assessed by speckle-tracking echocardiography, with incident AF are less clear.<h4>Methods</h4>In the Cardiovascular Health Study, a community-based cohort of older adults, participants free of AF with echocardiograms ... Read more >>

JCI Insight (JCI insight)
[2020, 5(19):]

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Lifestyle Moderates Genetic Risk of Venous Thromboembolism: The ARIC Study.

Christina R Evans, Ching-Ping Hong, Aaron R Folsom, Susan R Heckbert, Nicholas L Smith, Kerri Wiggins, Pamela L Lutsey, Mary Cushman,

<h4>Objective</h4>Venous thromboembolism (VTE) is a common disease that has a genetic basis. Lifestyle factors contribute to risk, but it is unknown whether healthy lifestyle can mitigate the genetic risk. We studied whether greater adherence to the American Heart Association's cardiovascular health metric, Life's Simple 7 (LS7), is associated with lower ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2020, 40(11):2756-2763]

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Mitochondrial DNA copy number and incident atrial fibrillation.

Di Zhao, Traci M Bartz, Nona Sotoodehnia, Wendy S Post, Susan R Heckbert, Alvaro Alonso, Ryan J Longchamps, Christina A Castellani, Yun Soo Hong, Jerome I Rotter, Henry J Lin, Brian O'Rourke, Nathan Pankratz, John A Lane, Stephanie Y Yang, Eliseo Guallar, Dan E Arking,

<h4>Background</h4>Mechanistic studies suggest that mitochondria DNA (mtDNA) dysfunction may be associated with increased risk of atrial fibrillation (AF). The association between mtDNA copy number (mtDNA-CN) and incident AF in the general population, however, remains unknown.<h4>Methods</h4>We conducted prospective analyses of 19,709 participants from the Atherosclerosis Risk in Communities Study (ARIC), the ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):246]

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Genetic Determinants of Electrocardiographic P-Wave Duration and Relation to Atrial Fibrillation.

Lu-Chen Weng, Amelia Weber Hall, Seung Hoan Choi, Sean J Jurgens, Jeffrey Haessler, Nathan A Bihlmeyer, Niels Grarup, Honghuang Lin, Alexander Teumer, Ruifang Li-Gao, Jie Yao, Xiuqing Guo, Jennifer A Brody, Martina Müller-Nurasyid, Katharina Schramm, Niek Verweij, Marten E van den Berg, Jessica van Setten, Aaron Isaacs, Julia Ramírez, Helen R Warren, Sandosh Padmanabhan, Jan A Kors, Rudolf A de Boer, Peter van der Meer, Moritz F Sinner, Melanie Waldenberger, Bruce M Psaty, Kent D Taylor, Uwe Völker, Jørgen K Kanters, Man Li, Alvaro Alonso, Marco V Perez, Ilonca Vaartjes, Michiel L Bots, Paul L Huang, Susan R Heckbert, Henry J Lin, Jelena Kornej, Patricia B Munroe, Cornelia M van Duijn, Folkert W Asselbergs, Bruno H Stricker, Pim van der Harst, Stefan Kääb, Annette Peters, Nona Sotoodehnia, Jerome I Rotter, Dennis O Mook-Kanamori, Marcus Dörr, Stephan B Felix, Allan Linneberg, Torben Hansen, Dan E Arking, Charles Kooperberg, Emelia J Benjamin, Kathryn L Lunetta, Patrick T Ellinor, Steven A Lubitz,

<h4>Background</h4>The P-wave duration (PWD) is an electrocardiographic measurement that represents cardiac conduction in the atria. Shortened or prolonged PWD is associated with atrial fibrillation (AF). We used exome-chip data to examine the associations between common and rare variants with PWD.<h4>Methods</h4>Fifteen studies comprising 64 440 individuals (56 943 European, 5681 African, 1186 Hispanic, ... Read more >>

Circ Genom Precis Med (Circulation. Genomic and precision medicine)
[2020, 13(5):387-395]

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Cardiovascular Risk Scores in Axial Spondyloarthritis Versus the General Population: A Cross-sectional Study.

Jean W Liew, John D Reveille, Maria Castillo, Henna Sawhney, Benjamin S Naovarat, Susan R Heckbert, Lianne S Gensler,

<h4>Objective</h4>Cardiovascular (CV) morbidity and mortality are increased in axial spondyloarthritis (axSpA). We conducted a cross-sectional study evaluating the 10-year atherosclerotic cardiovascular disease (ASCVD) risk in axSpA compared to the general US population.<h4>Methods</h4>We included 211 adults, 40-75 years old with ankylosing spondylitis (AS) or nonradiographic axSpA from 2 sites, who had ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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Multi-Ethnic Genome-Wide Association Study of Decomposed Cardioelectric Phenotypes Illustrates Strategies to Identify and Characterize Evidence of Shared Genetic Effects for Complex Traits.

Antoine R Baldassari, Colleen M Sitlani, Heather M Highland, Dan E Arking, Steve Buyske, Dawood Darbar, Rahul Gondalia, Misa Graff, Xiuqing Guo, Susan R Heckbert, Lucia A Hindorff, Chani J Hodonsky, Yii-Der Ida Chen, Robert C Kaplan, Ulrike Peters, Wendy Post, Alex P Reiner, Jerome I Rotter, Ralph V Shohet, Amanda A Seyerle, Nona Sotoodehnia, Ran Tao, Kent D Taylor, Genevieve L Wojcik, Jie Yao, Eimear E Kenny, Henry J Lin, Elsayed Z Soliman, Eric A Whitsel, Kari E North, Charles Kooperberg, Christy L Avery,

<h4>Background</h4>We examined how expanding electrocardiographic trait genome-wide association studies to include ancestrally diverse populations, prioritize more precise phenotypic measures, and evaluate evidence for shared genetic effects enabled the detection and characterization of loci.<h4>Methods</h4>We decomposed 10 seconds, 12-lead electrocardiograms from 34 668 multi-ethnic participants (15% Black; 30% Hispanic/Latino) into 6 contiguous, physiologically ... Read more >>

Circ Genom Precis Med (Circulation. Genomic and precision medicine)
[2020, 13(4):e002680]

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Opioid, gabapentinoid, and nonsteroidal anti-inflammatory medication use and the risks of atrial fibrillation and supraventricular ectopy in the Multi-Ethnic Study of Atherosclerosis.

Barbara N Harding, Kerri L Wiggins, Paul N Jensen, Barbara McKnight, Bruce M Psaty, Susan R Heckbert, James S Floyd,

<h4>Purpose</h4>Opioids, gabapentinoids, and nonsteroidal anti-inflammatory drugs (NSAIDs) may have adverse cardiovascular effects. We evaluated whether these medications were associated with incident clinically detected atrial fibrillation (AF) or monitor-detected supraventricular ectopy (SVE), including premature atrial contractions (PACs) and supraventricular tachycardia (SVT).<h4>Methods</h4>We used data from the Multi-Ethnic Study of Atherosclerosis (MESA), a ... Read more >>

Pharmacoepidemiol Drug Saf (Pharmacoepidemiology and drug safety)
[2020, 29(9):1175-1182]

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Association of Retinal Microvascular Signs with Incident Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis.

Gen-Min Lin, Laura A Colangelo, Barbara E K Klein, Mary Frances Cotch, Tien Y Wong, Carol Y Cheung, Susan R Heckbert, Alvaro Alonso, Younghoon Kwon, Richard A Kronmal, Donald M Lloyd-Jones, Kiang Liu,

<h4>Purpose</h4>Microvascular diseases may contribute to the occurrence of atrial fibrillation (AF). Retinal microvascular signs that are similar to other microvasculature in the body and can be visualized directly via ophthalmoscopy may provide insights into such a relationship.<h4>Design</h4>Prospective, longitudinal, multiethnic study.<h4>Participants</h4>We examined the association between retinal microvascular signs and incident AF ... Read more >>

Ophthalmol Retina (Ophthalmology. Retina)
[2021, 5(1):78-85]

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Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study.

Marios K Georgakis, Rainer Malik, Dipender Gill, Nora Franceschini, Cathie L M Sudlow, Martin Dichgans, ,

Circ Genom Precis Med (Circulation. Genomic and precision medicine)
[2020, 13(3):e002872]

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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.

Ioanna Ntalla, Lu-Chen Weng, James H Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R Tucker, Seung Hoan Choi, Mark D Chaffin, Carolina Roselli, Michael R Barnes, Borbala Mifsud, Helen R Warren, Caroline Hayward, Jonathan Marten, James J Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolcic, Ozren Polasek, Igor Rudan, Nathalia M Araujo, Maria Fernanda Lima-Costa, Antonio Luiz P Ribeiro, Renan P Souza, Eduardo Tarazona-Santos, Vilmantas Giedraitis, Erik Ingelsson, Anubha Mahajan, Andrew P Morris, Fabiola Del Greco M, Luisa Foco, Martin Gögele, Andrew A Hicks, James P Cook, Lars Lind, Cecilia M Lindgren, Johan Sundström, Christopher P Nelson, Muhammad B Riaz, Nilesh J Samani, Gianfranco Sinagra, Sheila Ulivi, Mika Kähönen, Pashupati P Mishra, Nina Mononen, Kjell Nikus, Mark J Caulfield, Anna Dominiczak, Sandosh Padmanabhan, May E Montasser, Jeff R O'Connell, Kathleen Ryan, Alan R Shuldiner, Stefanie Aeschbacher, David Conen, Lorenz Risch, Sébastien Thériault, Nina Hutri-Kähönen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Olli T Raitakari, Catriona L K Barnes, Harry Campbell, Peter K Joshi, James F Wilson, Aaron Isaacs, Jan A Kors, Cornelia M van Duijn, Paul L Huang, Vilmundur Gudnason, Tamara B Harris, Lenore J Launer, Albert V Smith, Erwin P Bottinger, Ruth J F Loos, Girish N Nadkarni, Michael H Preuss, Adolfo Correa, Hao Mei, James Wilson, Thomas Meitinger, Martina Müller-Nurasyid, Annette Peters, Melanie Waldenberger, Massimo Mangino, Timothy D Spector, Michiel Rienstra, Yordi J van de Vegte, Pim van der Harst, Niek Verweij, Stefan Kääb, Katharina Schramm, Moritz F Sinner, Konstantin Strauch, Michael J Cutler, Diane Fatkin, Barry London, Morten Olesen, Dan M Roden, M Benjamin Shoemaker, J Gustav Smith, Mary L Biggs, Joshua C Bis, Jennifer A Brody, Bruce M Psaty, Kenneth Rice, Nona Sotoodehnia, Alessandro De Grandi, Christian Fuchsberger, Cristian Pattaro, Peter P Pramstaller, Ian Ford, J Wouter Jukema, Peter W Macfarlane, Stella Trompet, Marcus Dörr, Stephan B Felix, Uwe Völker, Stefan Weiss, Aki S Havulinna, Antti Jula, Katri Sääksjärvi, Veikko Salomaa, Xiuqing Guo, Susan R Heckbert, Henry J Lin, Jerome I Rotter, Kent D Taylor, Jie Yao, Renée de Mutsert, Arie C Maan, Dennis O Mook-Kanamori, Raymond Noordam, Francesco Cucca, Jun Ding, Edward G Lakatta, Yong Qian, Kirill V Tarasov, Daniel Levy, Honghuang Lin, Christopher H Newton-Cheh, Kathryn L Lunetta, Alison D Murray, David J Porteous, Blair H Smith, Bruno H Stricker, André Uitterlinden, Marten E van den Berg, Jeffrey Haessler, Rebecca D Jackson, Charles Kooperberg, Ulrike Peters, Alexander P Reiner, Eric A Whitsel, Alvaro Alonso, Dan E Arking, Eric Boerwinkle, Georg B Ehret, Elsayed Z Soliman, Christy L Avery, Stephanie M Gogarten, Kathleen F Kerr, Cathy C Laurie, Amanda A Seyerle, Adrienne Stilp, Solmaz Assa, M Abdullah Said, M Yldau van der Ende, Pier D Lambiase, Michele Orini, Julia Ramirez, Stefan Van Duijvenboden, David O Arnar, Daniel F Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa B Thorolfsdottir, Unnur Thorsteinsdottir, Emelia J Benjamin, Andrew Tinker, Kari Stefansson, Patrick T Ellinor, Yalda Jamshidi, Steven A Lubitz, Patricia B Munroe,

The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):2542]

Cited: 1 time

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Association Between Chronic Hepatitis C Virus Infection and Myocardial Infarction Among People Living With HIV in the United States.

Jessica Williams-Nguyen, Stephen E Hawes, Robin M Nance, Sara Lindström, Susan R Heckbert, H Nina Kim, W Chris Mathews, Edward R Cachay, Matt Budoff, Christopher B Hurt, Peter W Hunt, Elvin Geng, Richard D Moore, Michael J Mugavero, Inga Peter, Mari M Kitahata, Michael S Saag, Heidi M Crane, Joseph A Delaney,

Hepatitis C virus (HCV) infection is common among people living with human immunodeficiency virus (PLWH). Extrahepatic manifestations of HCV, including myocardial infarction (MI), are a topic of active research. MI is classified into types, predominantly atheroembolic type 1 MI (T1MI) and supply-demand mismatch type 2 MI (T2MI). We examined the ... Read more >>

Am J Epidemiol (American journal of epidemiology)
[2020, 189(6):554-563]

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Patient-Reported Receipt of Goal-Concordant Care Among Seriously Ill Outpatients-Prevalence and Associated Factors.

Matthew E Modes, Susan R Heckbert, Ruth A Engelberg, Elizabeth L Nielsen, J Randall Curtis, Erin K Kross,

<h4>Context</h4>Goal-concordant care is an important indicator of high-quality care in serious illness.<h4>Objectives</h4>To estimate the prevalence of patient-reported receipt of goal-concordant care among seriously ill outpatients and identify factors associated with the absence of patient-reported goal concordance.<h4>Methods</h4>Analysis of enrollment surveys from a multicenter cluster-randomized trial of outpatients with serious illness. Patients ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2020, 60(4):765-773]

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Association of right atrial structure with incident atrial fibrillation: a longitudinal cohort cardiovascular magnetic resonance study from the Multi-Ethnic Study of Atherosclerosis (MESA).

Eric Xie, Ricky Yu, Bharath Ambale-Venkatesh, Hooman Bakhshi, Susan R Heckbert, Elsayed Z Soliman, David A Bluemke, Steven M Kawut, Colin O Wu, Saman Nazarian, João A C Lima,

BACKGROUND:While studies of the left atrium (LA) have demonstrated associations between volumes and emptying fraction with atrial fibrillation (AF), the contribution of right atrial (RA) abnormalities to incident AF remains poorly understood. OBJECTIVES:Assess the association between RA structure and function with incident AF using feature-tracking cardiovascular magnetic resonance (CMR). METHODS:This ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2020, 22(1):36]

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Lp(a) (Lipoprotein [a]) and Risk for Incident Atrial Fibrillation: Multi-Ethnic Study of Atherosclerosis.

Parveen K Garg, Weihua Guan, Amy B Karger, Brian T Steffen, Wesley O'Neal, Susan R Heckbert, Erin D Michos, Michael Y Tsai,

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2020, 13(5):e008401]

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