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A Multicentered Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended-Spectrum Beta-Lactamase Producing Enterobacterales Infections in Children.

Latania K Logan, Jared R Rispens, Rachel L Medernach, T Nicholas Domitrovic, Andrea M Hujer, Steven H Marshall, Susan D Rudin, Nadia K Qureshi, Xiaotian Zheng, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales-(Ent) infections are increasing in pediatrics. Before CTX-M ESBL emerged, the most common infection-associated ESBL genes were TEM and SHV-type ESBLs. We sought to define the current epidemiology of Ent infections in children due to blaTEM and blaSHV (TEM-SHV-Ent).<h4>Methods</h4>A retrospective case-control analysis of children with TEM-SHV-Ent infections ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):39-43]

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A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli.

Joel A Goldberg, Ha Nguyen, Vijay Kumar, Elizabeth J Spencer, Denton Hoyer, Emma K Marshall, Anna Cmolik, Margaret O'Shea, Steven H Marshall, Andrea M Hujer, Kristine M Hujer, Susan D Rudin, T Nicholas Domitrovic, Christopher R Bethel, Krisztina M Papp-Wallace, Latania K Logan, Federico Perez, Michael R Jacobs, David van Duin, Barry M Kreiswirth, Robert A Bonomo, Mark S Plummer, Focco van den Akker,

Treatment of multidrug-resistant Gram-negative bacterial pathogens represents a critical clinical need. Here, we report a novel γ-lactam pyrazolidinone that targets penicillin-binding proteins (PBPs) and incorporates a siderophore moiety to facilitate uptake into the periplasm. The MIC values of γ-lactam YU253434, 1, are reported along with the finding that 1 is ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2020, 63(11):5990-6002]

Cited: 1 time

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ARGONAUT II Study of the In Vitro Activity of Plazomicin against Carbapenemase-Producing Klebsiella pneumoniae.

Michael R Jacobs, Caryn E Good, Andrea M Hujer, Ayman M Abdelhamed, Daniel D Rhoads, Kristine M Hujer, Susan D Rudin, T Nicholas Domitrovic, Lynn E Connolly, Kevin M Krause, Robin Patel, Cesar A Arias, Barry N Kreiswirth, Laura J Rojas, Roshan D'Souza, Richard C White, Lauren M Brinkac, Kevin Nguyen, Indresh Singh, Derrick E Fouts, David van Duin, Robert A Bonomo, ,

Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2020, 64(5):]

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594. A Multi-Centered Study of the Clinical and Molecular Epidemiology of AmpC Cephalosporinase-Producing (AmpC) Enterobacteriaceae (Ent) Infections in Children

Rachel L Medernach, T Nicholas Domitrovic, Karen C Hayani, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Jared R Rispens, Xiaotian Zheng, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

Abstract Background AmpC producing Ent are an important cause of multidrug-resistant (MDR) infections in pediatrics. Since most AmpC Ent studies have been conducted in adults, we characterized the molecular epidemiology of AmpC Ent strains with transmissible resistance and identified factors associated with AmpC Ent infections in children. Methods A case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S280-S280]

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234. Reversal of Carbapenem and Amikacin Susceptibilities in Isogenic Klebsiella pneumoniae From a Patient with Persistent Bacteriuria.

Laura J Rojas, Steven Marshall, Mohamad Yasmin, Susan D Rudin, Federico Perez, Curtis Donskey, Michelle Hecker, Robert A Bonomo,

AbstractBackgroundGenomic tools permit a detailed analysis of antibiotic resistance determinants in bacteria, or resistome. Here we discuss variations in antibiotic resistance in K. pneumoniae (Kp) not explained by changes in the resistomeMethodsWe compared Kp strains with divergent carbapenem and aminoglycoside susceptibilities. After identification of bacteria, antibiotic susceptibility testing was performed ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S134-S134]

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Identification of four patients with colistin-resistant Escherichia coli containing the mobile colistin resistance mcr-1 gene from a single health system in Michigan.

Oryan Henig, Laura J Rojas, Michael A Bachman, Susan D Rudin, Brenda M Brennan, Marty K Soehnlen, Kelly L Jones, John P Mills, Carey R Dombecki, Amanda M Valyko, Steven H Marshall, Robert A Bonomo, Keith S Kaye, Laraine Washer,

Clinical Enterobacteriacae isolates with a colistin minimum inhibitory concentration (MIC) ≥4 mg/L from a United States hospital were screened for the mcr-1 gene using real-time polymerase chain reaction (RT-PCR) and confirmed by whole-genome sequencing. Four colistin-resistant Escherichia coli isolates contained mcr-1. Two isolates belonged to the same sequence type (ST-632). ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2019, 40(9):1059-1062]

Cited: 1 time

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Community Origins and Regional Differences Highlight Risk of Plasmid-mediated Fluoroquinolone Resistant Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, Jared R Rispens, Steven H Marshall, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Sreenivas Konda, Mary K Hayden, Robert A Weinstein, Robert A Bonomo,

<h4>Background</h4>Fluoroquinolones are uncommonly prescribed in children, yet pediatric multidrug resistant (MDR) enterobacteriaceae (Ent) infections often reveal fluoroquinolone resistance (FQR). We sought to define the molecular epidemiology of FQR and MDR-Ent in children.<h4>Methods</h4>A case-control analysis of children with MDR-Ent infections at 3 Chicago hospitals was performed. Cases were children with third-generation ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2019, 38(6):595-599]

Cited: 2 times

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ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases.

Michael R Jacobs, Ayman M Abdelhamed, Caryn E Good, Daniel D Rhoads, Kristine M Hujer, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Sandra S Richter, David van Duin, Barry N Kreiswirth, Chris Greco, Derrick E Fouts, Robert A Bonomo,

The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant <i>Acinetobacter baumannii</i> complex, <i>Stenotrophomonas maltophilia</i>, <i>Pseudomonas aeruginosa</i>, and <i>Enterobacteriaceae</i> strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC<sub>90</sub>s against <i>A. baumannii</i>, <i>S. maltophilia</i>, and <i>P. ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2019, 63(1):]

Cited: 12 times

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The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

Courtney L Luterbach, Ashley Boshe, Heather I Henderson, Eric Cober, Sandra S Richter, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Andrea M Hujer, Kristine M Hujer, Susan D Rudin, T Nicholas Domitrovic, Yohei Doi, Keith S Kaye, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin,

In the Consortium on Resistance Against Carbapenems in <i>Klebsiella</i> and other <i>Enterobacteriaceae</i> (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant <i>Enterobacteriaceae</i> (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(1):ofy351]

Cited: 1 time

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The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Latania K Logan, Rachel L Medernach, T Nicholas Domitrovic, Jared R Rispens, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Xiaotian Zheng, Sreenivas Konda, Robert A Weinstein, Robert A Bonomo,

<h4>Introduction</h4>The pandemic of extended-spectrum beta-lactamase-(ESBL)-producing Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent).<h4>Methods</h4>A retrospective matched case-control analysis of children with CTX-M-9-grp-Ent infections who received medical care at three Chicago area ... Read more >>

Infect Dis Ther (Infectious diseases and therapy)
[2019, 8(2):243-254]

Cited: 2 times

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1348. In vitro Activity of Plazomicin, a Next-Generation Aminoglycoside, Against Carbapenemase-Producing Klebsiella pneumoniae

Michael R Jacobs, Caryn E Good, Ayman M Abdelhamed, Daniel D Rhoads, Kristine M Hujer, Andrea M Hujer, Susan D Rudin, T Nicholas Domitrovic, Lynn Connolly, Kevin M Krause, Sandra S Richter, David Van Duin, Barry N Kreiswirth, Robert A Bonomo, Antibiotic Resistance Leadership Group,

Abstract <h4>Background</h4> Plazomicin is a next-generation aminoglycoside with in vitro activity against multidrug-resistant Gram-negative species, including carbapenem-resistant isolates. The Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE) is a federally funded, prospective multicenter consortium of 20 hospitals from nine US healthcare systems to track carbapenem-resistant Enterobacteriaceae. <h4>Methods</h4> ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S412-S413]

Cited: 0 times

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2336. Resistance Mechanisms and Factors Associated With CTX-M-9 Group Extended-Spectrum β-Lactamase (ESBL)-Producing Infections in Children.

Rachel L Medernach, T Nicholas Domitrovic, Jared R Rispens, Andrea M Hujer, Nadia K Qureshi, Steven H Marshall, David C Nguyen, Susan D Rudin, Xiaotian Zheng, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

AbstractBackgroundThere is an increasing incidence of extended-spectrum β-lactamase (ESBL) producing infections in children. However, most studies focus only on CTX-M-1 group (CTX-M-15). We sought to define the epidemiology of the CTX-M-9 group (CTX-M-9) producing infections in children to devise more effective treatment and prevention strategies.MethodsA case–control study of ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S694-S694]

Cited: 0 times

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Acinetobacter nosocomialis: Defining the Role of Efflux Pumps in Resistance to Antimicrobial Therapy, Surface Motility, and Biofilm Formation.

Daniel B Knight, Susan D Rudin, Robert A Bonomo, Philip N Rather,

<i>Acinetobacter nosocomialis</i> is a member of the <i>Acinetobacter calcoaceticus-Acinetobacter baumannii</i> (ACB) complex. Increasingly, reports are emerging of the pathogenic profile and multidrug resistance (MDR) phenotype of this species. To define novel therapies to overcome resistance, we queried the role of the major efflux pumps in <i>A. nosocomialis</i> strain M2 on ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2018, 9:1902]

Cited: 4 times

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Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae.

Anubhav Kanwar, Steven H Marshall, Federico Perez, Myreen Tomas, Michael R Jacobs, Andrea M Hujer, T Nicholas Domitrovic, Susan D Rudin, Laura J Rojas, Barry N Kreiswirth, Liang Chen, Miguel Quinones-Mateu, David van Duin, Robert A Bonomo, ,

We report the emergence of colistin resistance in <i>Klebsiella pneumoniae</i> carbapenemase (KPC)-producing <i>Klebsiella pneumoniae</i> after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the <i>mgrB</i> gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(4):ofy054]

Cited: 0 times

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Nosocomial Outbreak of Extensively Drug-Resistant Acinetobacter baumannii Isolates Containing blaOXA-237 Carried on a Plasmid.

Andrea M Hujer, Paul G Higgins, Susan D Rudin, Genevieve L Buser, Steven H Marshall, Kyriaki Xanthopoulou, Harald Seifert, Laura J Rojas, T Nicholas Domitrovic, P Maureen Cassidy, Margaret C Cunningham, Robert Vega, Jon P Furuno, Christopher D Pfeiffer, Zintars G Beldavs, Meredith S Wright, Michael R Jacobs, Mark D Adams, Robert A Bonomo,

Carbapenem antibiotics are among the mainstays for treating infections caused by <i>Acinetobacter baumannii</i>, especially in the Northwest United States, where carbapenem-resistant <i>A. baumannii</i> remains relatively rare. However, between June 2012 and October 2014, an outbreak of carbapenem-resistant <i>A. baumannii</i> occurred in 16 patients from five health care facilities in the ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2017, 61(11):]

Cited: 5 times

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Evaluation of Sensititre Broth Microdilution Plate for determining the susceptibility of carbapenem-resistant Klebsiella pneumoniae to polymyxins.

Sandra S Richter, James Karichu, Joshua Otiso, Hillary Van Heule, George Keller, Eric Cober, Laura J Rojas, Andrea M Hujer, Kristine M Hujer, Steve Marshall, Frederico Perez, Susan D Rudin, T Nicholas Domitrovic, Keith S Kaye, Robert Salata, David van Duin, Robert A Bonomo,

Colistin and polymyxin B MICs were determined for 106 carbapenem-resistant Klebsiella pneumoniae (CR-Kp) isolates using Sensititre Research Use Only GNX2F plates (Thermo Fisher) and compared to CLSI broth macrodilution (BMD) as the reference method. For colistin, EUCAST breakpoints were applied and testing of isolates with very major (VM) errors was ... Read more >>

Diagn Microbiol Infect Dis (Diagnostic microbiology and infectious disease)
[2018, 91(1):89-92]

Cited: 3 times

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The Antimicrobial Scrub Contamination and Transmission (ASCOT) Trial: A Three-Arm, Blinded, Randomized Controlled Trial With Crossover Design to Determine the Efficacy of Antimicrobial-Impregnated Scrubs in Preventing Healthcare Provider Contamination.

Deverick J Anderson, Rachel Addison, Yuliya Lokhnygina, Bobby Warren, Batu Sharma-Kuinkel, Laura J Rojas, Susan D Rudin, Sarah S Lewis, Rebekah W Moehring, David J Weber, William A Rutala, Robert A Bonomo, Vance G Fowler, Daniel J Sexton, ,

OBJECTIVE To determine whether antimicrobial-impregnated textiles decrease the acquisition of pathogens by healthcare provider (HCP) clothing. DESIGN We completed a 3-arm randomized controlled trial to test the efficacy of 2 types of antimicrobial-impregnated clothing compared to standard HCP clothing. Cultures were obtained from each nurse participant, the healthcare environment, and ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2017, 38(10):1147-1154]

Cited: 2 times

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"Double carbapenem" and oral fosfomycin for the treatment of complicated urinary tract infections caused by blaNDM -harboring Enterobacteriaceae in kidney transplantation.

Rossana Rosa, Susan D Rudin, Laura J Rojas, Andrea M Hujer, Armando Perez-Cardona, Federico Perez, Robert A Bonomo, Octavio Martinez, Lilian M Abbo, Jose F Camargo,

Infections with carbapenemase-producing carbapenem-resistant Enterobacteriaceae represent an emergent problem worldwide. Treatment of infections caused by New Delhi metallo-beta-lactamase (NDM)-harboring Enterobacteriaceae is particularly challenging as it frequently involves the use of nephrotoxic agents, which is problematic in kidney transplant recipients and non-renal transplant patients with marginal kidney function. We present two ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2018, 20(1):]

Cited: 6 times

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NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas.

Laura J Rojas, Andrea M Hujer, Susan D Rudin, Meredith S Wright, T Nicholas Domitrovic, Steven H Marshall, Kristine M Hujer, Sandra S Richter, Eric Cober, Federico Perez, Mark D Adams, David van Duin, Robert A Bonomo,

Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant <i>Klebsiella pneumoniae</i> ST147 isolate harboring <i>bla</i><sub>NDM-5</sub> and <i>bla</i><sub>OXA-181</sub> from a young man who underwent abdominal surgery in India. <i>bla</i><sub>NDM-5</sub> was located on an IncFII plasmid of ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2017, 61(7):]

Cited: 18 times

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A Prospective Observational Study of the Epidemiology, Management, and Outcomes of Skin and Soft Tissue Infections Due to Carbapenem-Resistant Enterobacteriaceae.

Oryan Henig, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Steve Marshall, Susan D Rudin, T Nicholas Domitrovic, Andrea M Hujer, Kristine M Hujer, Yohei Doi, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin, Keith S Kaye, ,

<h4>Background</h4>This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant <i>Enterobacteriaceae</i> (CRE).<h4>Methods</h4>Patients from the Consortium on Resistance Against Carbapenem in <i>Klebsiella</i> and Other <i>Enterobacteriaceae</i> (CRACKLE-1) from December 24, 2011 to October 1, 2014 with wound cultures positive ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(3):ofx157]

Cited: 3 times

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A Multicenter Study of the Clinical and Molecular Epidemiology of TEM- and SHV-type Extended- Spectrum β-Lactamase producing (ESBL) () Infections in Children.

Jared R Rispens, Rachel L Medernach, Andrea M Hujer, T Nicholas Domitrovic, Steven H Marshall, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Mary K Hayden, Robert A Weinstein, Robert A Bonomo, Latania K Logan,

AbstractBackgroundESBL infections are increasingly prevalent in the pediatric population; however, most ESBL studies have focused on adults and/or CTX-M-type strains. We sought to characterize the molecular epidemiology of ESBL strains and to identify factors associated with TEM- and SHV-type ESBL (TEMSHV ) infections in children.MethodsA case–control ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(Suppl 1):S679-S679]

Cited: 0 times

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Application of "Precision Medicine" Through the Molecular Characterization of Extensively Drug-Resistant Klebsiella pneumoniae in a Multivisceral Transplant Patient.

Rossana Rosa, Susan D Rudin, Laura J Rojas, Armando Perez-Cardona, Laura Aragon, David P Nicolau, Federico Perez, Andrea M Hujer, Akin Tekin, Octavio Martinez, Jose F Camargo, Robert A Bonomo, Lilian M Abbo,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 65(4):701-702]

Cited: 3 times

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Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?

Steven Marshall, Andrea M Hujer, Laura J Rojas, Krisztina M Papp-Wallace, Romney M Humphries, Brad Spellberg, Kristine M Hujer, Emma K Marshall, Susan D Rudin, Federico Perez, Brigid M Wilson, Ronald B Wasserman, Linda Chikowski, David L Paterson, Alejandro J Vila, David van Duin, Barry N Kreiswirth, Henry F Chambers, Vance G Fowler, Michael R Jacobs, Mark E Pulse, William J Weiss, Robert A Bonomo,

Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram-negative bacteria, we tested the efficacy of the combination of ceftazidime-avibactam (CAZ-AVI) with aztreonam (ATM) against carbapenem-resistant enteric bacteria possessing metallo-β-lactamases (MBLs). Disk diffusion and agar-based antimicrobial susceptibility testing were initially performed to determine the <i>in vitro</i> efficacy ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2017, 61(4):]

Cited: 50 times

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Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.

Laura J Rojas, Madiha Salim, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Steve Marshall, Susan D Rudin, T Nicholas Domitrovic, Andrea M Hujer, Kristine M Hujer, Yohei Doi, Keith S Kaye, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin, ,

<h4>Background</h4>Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp). Increasing use of colistin has led to resistance to this cationic antimicrobial peptide.<h4>Methods</h4>A cohort nested within the Consortium on Resistance against Carbapenems in Klebsiella pneumoniae (CRACKLE) was constructed of patients with infection, or colonization ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 64(6):711-718]

Cited: 49 times

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Analysis of β-Lactamase Resistance Determinants in Enterobacteriaceae from Chicago Children: a Multicenter Survey.

Latania K Logan, Andrea M Hujer, Steven H Marshall, T Nicholas Domitrovic, Susan D Rudin, Xiaotian Zheng, Nadia K Qureshi, Mary K Hayden, Felicia A Scaggs, Anand Karadkhele, Robert A Bonomo,

Multidrug-resistant (MDR) Enterobacteriaceae infections are increasing in U.S. children; however, there is a paucity of multicentered analyses of antibiotic resistance genes responsible for MDR phenotypes among pediatric Enterobacteriaceae isolates. In this study, 225 isolates phenotypically identified as extended-spectrum β-lactamase (ESBL) or carbapenemase producers, recovered from children ages 0 to 18 ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2016, 60(6):3462-3469]

Cited: 11 times

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