Full Text Journal Articles by
Author Susan C Nagel

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Endocrine disrupting activities and geochemistry of water resources associated with unconventional oil and gas activity.

Christopher D Kassotis, Jennifer S Harkness, Phuc H Vo, Danh C Vu, Kate Hoffman, Katelyn M Cinnamon, Jennifer N Cornelius-Green, Avner Vengosh, Chung-Ho Lin, Donald E Tillitt, Robin L Kruse, Jane A McElroy, Susan C Nagel,

The rise of hydraulic fracturing and unconventional oil and gas (UOG) exploration in the United States has increased public concerns for water contamination induced from hydraulic fracturing fluids and associated wastewater spills. Herein, we collected surface and groundwater samples across Garfield County, Colorado, a drilling-dense region, and measured endocrine bioactivities, ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 748:142236]

Cited: 0 times

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GenomeForest: An Ensemble Machine Learning Classifier for Endometriosis.

Sadia Akter, Dong Xu, Susan C Nagel, John J Bromfield, Katherine E Pelch, Gilbert B Wilshire, Trupti Joshi,

Endometriosis is a complex and high impact disease affecting 176 million women worldwide with diagnostic latency between 4 to 11 years due to lack of a definitive clinical symptom or a minimally invasive diagnostic method. In this study, we developed a new ensemble machine learning classifier based on chromosomal partitioning, ... Read more >>

AMIA Jt Summits Transl Sci Proc (AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science)
[2020, 2020:33-42]

Cited: 0 times

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Constructing and influencing perceived authenticity in science communication: Experimenting with narrative.

Lise Saffran, Sisi Hu, Amanda Hinnant, Laura D Scherer, Susan C Nagel,

This study develops a measure of perceived authenticity in science communication and then explores communication strategies to improve the perceived authenticity of a scientific message. The findings are consistent with literature around trust and credibility, but indicate that authenticity-the perception that the scientist is a unique individual with qualities beyond ... Read more >>

PLoS One (PloS one)
[2020, 15(1):e0226711]

Cited: 1 time

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Machine Learning Classifiers for Endometriosis Using Transcriptomics and Methylomics Data.

Sadia Akter, Dong Xu, Susan C Nagel, John J Bromfield, Katherine Pelch, Gilbert B Wilshire, Trupti Joshi,

Endometriosis is a complex and common gynecological disorder yet a poorly understood disease affecting about 176 million women worldwide and causing significant impact on their quality of life and economic burden. Neither a definitive clinical symptom nor a minimally invasive diagnostic method is available, thus leading to an average of ... Read more >>

Front Genet (Frontiers in genetics)
[2019, 10:766]

Cited: 3 times

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Developmental Exposure to a Mixture of Unconventional Oil and Gas Chemicals Increased Risk-Taking Behavior, Activity and Energy Expenditure in Aged Female Mice After a Metabolic Challenge.

Victoria D Balise, Jennifer N Cornelius-Green, Brittany Parmenter, Sierra Baxter, Christopher D Kassotis, R Scott Rector, John P Thyfault, Silvia Paterlini, Paola Palanza, Daniel Ruiz, Robert Sargis, Susan C Nagel,

Chemicals used in unconventional oil and gas (UOG) operations can act as endocrine disrupting chemicals and metabolic disruptors. Our lab has reported altered energy expenditure and activity in C57BL/6J mice that were preconceptionally, gestationally, and lactationally exposed via maternal drinking water to a laboratory-created mixture of 23 UOG chemicals from ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2019, 10:460]

Cited: 0 times

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Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice.

Victoria D Balise, Jennifer N Cornelius-Green, Christopher D Kassotis, R Scott Rector, John P Thyfault, Susan C Nagel,

Previous studies conducted in our laboratory have found altered adult health outcomes in animals with prenatal exposure to environmentally relevant levels of unconventional oil and gas (UOG) chemicals with endocrine-disrupting activity. This study aimed to examine potential metabolic health outcomes following a preconception, prenatal and postnatal exposure to a mixture ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2019, 10:323]

Cited: 1 time

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Exposure to environmental toxicants and young children's cognitive and social development.

Alexandra N Davis, Gustavo Carlo, Zehra Gulseven, Francisco Palermo, Chung-Ho Lin, Susan C Nagel, Danh C Vu, Phuc H Vo, Thi L Ho, Jane A McElroy,

Background Understanding the role of environmental toxicant exposure on children's development is an important area of inquiry in order to better understand contextual factors that shape development and ultimately school readiness among young children. There is evidence suggesting negative links between exposure to environmental toxicants and negative physical health outcomes ... Read more >>

Rev Environ Health (Reviews on environmental health)
[2019, 34(1):35-56]

Cited: 1 time

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Reduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice.

Julia A Taylor, Jennifer M Sommerfeld-Sager, Chun-Xia Meng, Susan C Nagel, Toshi Shioda, Frederick S Vom Saal,

There is evidence from longitudinal studies that being light at birth and weaning is associated with subsequent rapid weight gain in infants. This is referred to as "centile crossing", which can lead to increased risk of lifetime obesity, glucose dysregulation and type 2 diabetes. Here, pregnant CD-1 mice were hemi-ovariectomized ... Read more >>

PLoS One (PloS one)
[2018, 13(12):e0208846]

Cited: 1 time

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Water Contaminants Associated With Unconventional Oil and Gas Extraction Cause Immunotoxicity to Amphibian Tadpoles.

Jacques Robert, Connor C McGuire, Fayth Kim, Susan C Nagel, Stephen J Price, B Paige Lawrence, Francisco De Jesús Andino,

Chemicals associated with unconventional oil and gas (UOG) operations have been shown to contaminate surface and ground water with a variety of endocrine disrupting compounds (EDCs) inducing multiple developmental alteration in mice. However, little is known about the impacts of UOG-associated contaminants on amphibian health and resistance to an emerging ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2018, 166(1):39-50]

Cited: 3 times

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Unconventional oil and gas chemicals and wastewater-impacted water samples promote adipogenesis via PPARγ-dependent and independent mechanisms in 3T3-L1 cells.

Christopher D Kassotis, Susan C Nagel, Heather M Stapleton,

Unconventional oil and natural gas (UOG) operations have contributed to a surge in domestic oil and natural gas production in the United States, combining horizontal drilling with hydraulic fracturing to unlock previously inaccessible fossil fuel deposits. >1000 organic chemicals are used in the production process, and wastewater is produced following ... Read more >>

Sci Total Environ (The Science of the total environment)
[2018, 640-641:1601-1610]

Cited: 3 times

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Developmental Exposure to a Mixture of 23 Chemicals Associated With Unconventional Oil and Gas Operations Alters the Immune System of Mice.

Lisbeth A Boulé, Timothy J Chapman, Sara E Hillman, Christopher D Kassotis, Colleen O'Dell, Jacques Robert, Steve N Georas, Susan C Nagel, B Paige Lawrence,

Chemicals used in unconventional oil and gas (UOG) operations have the potential to cause adverse biological effects, but this has not been thoroughly evaluated. A notable knowledge gap is their impact on development and function of the immune system. Herein, we report an investigation of whether developmental exposure to a ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2018, 163(2):639-654]

Cited: 4 times

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Correction to: Parma consensus statement on metabolic disruptors.

Jerrold J Heindel, Frederick S Vom Saal, Bruce Blumberg, Patrizia Bovolin, Gemma Calamandrei, Graziano Ceresini, Barbara A Cohn, Elena Fabbri, Laura Gioiosa, Christopher Kassotis, Juliette Legler, Michele La Merrill, Laura Rizzi, Ronit Machtinger, Alberto Mantovani, Michelle A Mendez, Luisa Montanini, Laura Molteni, Susan C Nagel, Stefano Parmigiani, Giancarlo Panzica, Silvia Paterlini, Valentina Pomatto, Jérôme Ruzzin, Giorgio Sartor, Thaddeus T Schug, Maria E Street, Alexander Suvorov, Riccardo Volpi, R Thomas Zoeller, Paola Palanza,

CORRECTION:After publication of the article [1], it has been brought to our attention that the thirteenth author of this article has had their name spelt incorrectly. In the original article the spelling "Laura Rizzir" was used. In fact the correct spelling should be "Laura Rizzi". ... Read more >>

Environ Health (Environmental health : a global access science source)
[2017, 16(1):130]

Cited: 1 time

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Endocrine-Disrupting Activities and Organic Contaminants Associated with Oil and Gas Operations in Wyoming Groundwater.

Christopher D Kassotis, Danh C Vu, Phuc H Vo, Chung-Ho Lin, Jennifer N Cornelius-Green, Sharyle Patton, Susan C Nagel,

Unconventional oil and natural gas (UOG) operations couple horizontal drilling with hydraulic fracturing to access previously inaccessible fossil fuel deposits. Hydraulic fracturing, a common form of stimulation, involves the high-pressure injection of water, chemicals, and sand to fracture the target layer and release trapped natural gas and/or oil. Spills and/or ... Read more >>

Arch Environ Contam Toxicol (Archives of environmental contamination and toxicology)
[2018, 75(2):247-258]

Cited: 2 times

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Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice.

Sarah A Sapouckey, Christopher D Kassotis, Susan C Nagel, Laura N Vandenberg,

Unconventional oil and gas (UOG) operations, which combine hydraulic fracturing (fracking) and directional drilling, involve the use of hundreds of chemicals, including many with endocrine-disrupting properties. Two previous studies examined mice exposed during early development to a 23-chemical mixture of UOG compounds (UOG-MIX) commonly used or produced in the process. ... Read more >>

Endocrinology (Endocrinology)
[2018, 159(3):1277-1289]

Cited: 5 times

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Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.

Julia A Taylor, Keiko Shioda, Shino Mitsunaga, Shiomi Yawata, Brittany M Angle, Susan C Nagel, Frederick S Vom Saal, Toshi Shioda,

Exposure of mammalian fetuses to endocrine disruptors can increase the risk of adult-onset diseases. We previously showed that exposure of mouse fetuses to bisphenol A (BPA) caused adult-onset obesity. To examine roles of epigenetic changes in this delayed toxicity, we determined the effects of fetal mouse exposure to BPA on ... Read more >>

Endocrinology (Endocrinology)
[2018, 159(2):779-794]

Cited: 5 times

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Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice.

Christopher D Kassotis, John J Bromfield, Kara C Klemp, Chun-Xia Meng, Andrew Wolfe, R Thomas Zoeller, Victoria D Balise, Chiamaka J Isiguzo, Donald E Tillitt, Susan C Nagel,

Unconventional oil and gas operations using hydraulic fracturing can contaminate surface and groundwater with endocrine-disrupting chemicals. We have previously shown that 23 of 24 commonly used hydraulic fracturing chemicals can activate or inhibit the estrogen, androgen, glucocorticoid, progesterone, and/or thyroid receptors in a human endometrial cancer cell reporter gene assay ... Read more >>

Endocrinology (Endocrinology)
[2016, 157(9):3469-3481]

Cited: 15 times

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Endocrine disrupting activities of surface water associated with a West Virginia oil and gas industry wastewater disposal site.

Christopher D Kassotis, Luke R Iwanowicz, Denise M Akob, Isabelle M Cozzarelli, Adam C Mumford, William H Orem, Susan C Nagel,

Currently, >95% of end disposal of hydraulic fracturing wastewater from unconventional oil and gas operations in the US occurs via injection wells. Key data gaps exist in understanding the potential impact of underground injection on surface water quality and environmental health. The goal of this study was to assess endocrine ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2016, 557-558:901-910]

Cited: 22 times

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Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints.

Paola Palanza, Susan C Nagel, Stefano Parmigiani, Frederick S Vom Saal,

Of the approximately 85,000 chemicals in use, 1000 have been identified as having the ability to disrupt normal endocrine function. Exposure to endocrine disrupting chemicals (EDCs) during critical period in brain differentiation (prenatal and neonatal life) via the mother can alter the course of the development of sexually dimorphic behaviors. ... Read more >>

Curr Opin Behav Sci (Current opinion in behavioral sciences)
[2016, 7:69-75]

Cited: 29 times

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Endocrine-Disrupting Chemicals and Oil and Natural Gas Operations: Potential Environmental Contamination and Recommendations to Assess Complex Environmental Mixtures.

Christopher D Kassotis, Donald E Tillitt, Chung-Ho Lin, Jane A McElroy, Susan C Nagel,

Hydraulic fracturing technologies, developed over the last 65 years, have only recently been combined with horizontal drilling to unlock oil and gas reserves previously deemed inaccessible. Although these technologies have dramatically increased domestic oil and natural gas production, they have also raised concerns for the potential contamination of local water ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2016, 124(3):256-264]

Cited: 19 times

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Endocrine-Disrupting Activity of Hydraulic Fracturing Chemicals and Adverse Health Outcomes After Prenatal Exposure in Male Mice.

Christopher D Kassotis, Kara C Klemp, Danh C Vu, Chung-Ho Lin, Chun-Xia Meng, Cynthia L Besch-Williford, Lisa Pinatti, R Thomas Zoeller, Erma Z Drobnis, Victoria D Balise, Chiamaka J Isiguzo, Michelle A Williams, Donald E Tillitt, Susan C Nagel,

Oil and natural gas operations have been shown to contaminate surface and ground water with endocrine-disrupting chemicals. In the current study, we fill several gaps in our understanding of the potential environmental impacts related to this process. We measured the endocrine-disrupting activities of 24 chemicals used and/or produced by oil ... Read more >>

Endocrinology (Endocrinology)
[2015, 156(12):4458-4473]

Cited: 28 times

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Characterization of Missouri surface waters near point sources of pollution reveals potential novel atmospheric route of exposure for bisphenol A and wastewater hormonal activity pattern.

Christopher D Kassotis, David A Alvarez, Julia A Taylor, Frederick S vom Saal, Susan C Nagel, Donald E Tillitt,

Surface water contamination by chemical pollutants increasingly threatens water quality around the world. Among the many contaminants found in surface water, there is growing concern regarding endocrine disrupting chemicals, based on their ability to interfere with some aspect of hormone action in exposed organisms, including humans. This study assessed water ... Read more >>

Sci Total Environ (The Science of the total environment)
[2015, 524-525:384-393]

Cited: 5 times

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Parma consensus statement on metabolic disruptors.

Jerrold J Heindel, Frederick S Vom Saal, Bruce Blumberg, Patrizia Bovolin, Gemma Calamandrei, Graziano Ceresini, Barbara A Cohn, Elena Fabbri, Laura Gioiosa, Christopher Kassotis, Juliette Legler, Michele La Merrill, Laura Rizzir, Ronit Machtinger, Alberto Mantovani, Michelle A Mendez, Luisa Montanini, Laura Molteni, Susan C Nagel, Stefano Parmigiani, Giancarlo Panzica, Silvia Paterlini, Valentina Pomatto, Jérôme Ruzzin, Giorgio Sartor, Thaddeus T Schug, Maria E Street, Alexander Suvorov, Riccardo Volpi, R Thomas Zoeller, Paola Palanza,

A multidisciplinary group of experts gathered in Parma Italy for a workshop hosted by the University of Parma, May 16-18, 2014 to address concerns about the potential relationship between environmental metabolic disrupting chemicals, obesity and related metabolic disorders. The objectives of the workshop were to: 1. Review findings related to ... Read more >>

Environ Health (Environmental health : a global access science source)
[2015, 14:54]

Cited: 60 times

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Effects of the environmental estrogenic contaminants bisphenol A and 17α-ethinyl estradiol on sexual development and adult behaviors in aquatic wildlife species.

Ramji K Bhandari, Sharon L Deem, Dawn K Holliday, Caitlin M Jandegian, Christopher D Kassotis, Susan C Nagel, Donald E Tillitt, Frederick S Vom Saal, Cheryl S Rosenfeld,

Endocrine disrupting chemicals (EDCs), including the mass-produced component of plastics, bisphenol A (BPA) are widely prevalent in aquatic and terrestrial habitats. Many aquatic species, such as fish, amphibians, aquatic reptiles and mammals, are exposed daily to high concentrations of BPA and ethinyl estradiol (EE2), estrogen in birth control pills. In ... Read more >>

Gen. Comp. Endocrinol. (General and comparative endocrinology)
[2015, 214:195-219]

Cited: 52 times

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Holding thermal receipt paper and eating food after using hand sanitizer results in high serum bioactive and urine total levels of bisphenol A (BPA).

Annette M Hormann, Frederick S Vom Saal, Susan C Nagel, Richard W Stahlhut, Carol L Moyer, Mark R Ellersieck, Wade V Welshons, Pierre-Louis Toutain, Julia A Taylor,

Bisphenol A (BPA) is an endocrine disrupting environmental contaminant used in a wide variety of products, and BPA metabolites are found in almost everyone's urine, suggesting widespread exposure from multiple sources. Regulatory agencies estimate that virtually all BPA exposure is from food and beverage packaging. However, free BPA is applied ... Read more >>

PLoS One (PloS one)
[2014, 9(10):e110509]

Cited: 58 times

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Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations.

Ellen Webb, Sheila Bushkin-Bedient, Amanda Cheng, Christopher D Kassotis, Victoria Balise, Susan C Nagel,

Unconventional oil and gas (UOG) operations have the potential to increase air and water pollution in communities located near UOG operations. Every stage of UOG operation from well construction to extraction, operations, transportation, and distribution can lead to air and water contamination. Hundreds of chemicals are associated with the process ... Read more >>

Rev Environ Health (Reviews on environmental health)
[2014, 29(4):307-318]

Cited: 31 times

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