Full Text Journal Articles by
Author Sunil Kumar Raghav

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Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity.

Voddu Suresh, Varshasnata Mohanty, Kiran Avula, Arup Ghosh, Bharati Singh, Rajendra Kumar Reddy, Deepti Parida, Amol Ratnakar Suryawanshi, Sunil Kumar Raghav, Soma Chattopadhyay, Punit Prasad, Rajeeb Kumar Swain, Rupesh Dash, Ajay Parida, Gulam Hussain Syed, Shantibhusan Senapati,

Syrian golden hamsters (Mesocricetus auratus) infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manifests lung pathology. In this study, efforts were made to check the infectivity of a local SARS-CoV-2 isolate in a self-limiting and non-lethal hamster model and evaluate the differential expression of lung proteins during acute infection ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21713]

Cited: 0 times

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Differential mitochondrial genome in patients with Rheumatoid Arthritis.

Kumar Sagar Jaiswal, Shweta Khanna, Arup Ghosh, Prasanta Padhan, Sunil Kumar Raghav, Bhawna Gupta,

<h4>Background</h4>Mitochondria play an important role in cell survival, function and lineage differentiation. Changes in mitochondrial DNA (mtDNA) may control mitochondrial functions and thus may impart an alternative cellular state thereby leading to a disease condition in the body. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease wherein immune cells ... Read more >>

Autoimmunity (Autoimmunity)
[2021, 54(1):1-12]

Cited: 0 times

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BedSect: An Integrated Web Server Application to Perform Intersection, Visualization, and Functional Annotation of Genomic Regions From Multiple Datasets.

Gyan Prakash Mishra, Arup Ghosh, Atimukta Jha, Sunil Kumar Raghav,

A large number of genomic regions, such as transcription factor binding sites (TFBSs) captured from next generation sequencing (NGS) data analyses or those available from the public resource database ENCODE, are generally overlapped to answer a variety of biological questions. Though several command-line tools are available to perform such an ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:3]

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NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance.

Abdul Ahad, Mathias Stevanin, Shuchi Smita, Gyan Prakash Mishra, Dheerendra Gupta, Sebastian Waszak, Uday Aditya Sarkar, Soumen Basak, Bhawna Gupta, Hans Acha-Orbea, Sunil Kumar Raghav,

Understanding the mechanisms fine-tuning immunogenic versus tolerogenic balance in dendritic cells (DCs) is of high importance for therapeutic approaches. We found that NCoR1-mediated direct repression of the tolerogenic program in conventional DCs is essential for induction of an optimal immunogenic response. NCoR1 depletion upregulated a wide variety of tolerogenic genes ... Read more >>

iScience (iScience)
[2019, 19:996-1011]

Cited: 5 times

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Withdrawal: Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages.

Srabasti Sengupta, Saba Naz, Ishani Das, Abdul Ahad, Avinash Padhi, Sumanta Kumar Naik, Geetanjali Ganguli, Kali Prasad Pattanaik, Sunil Kumar Raghav, Vinay Kumar Nandicoori, Avinash Sonawane,

J Biol Chem (The Journal of biological chemistry)
[2019, 294(5):1632]

Cited: 0 times

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Bedsect: An integrated web server application to perform intersection, visualization and functional annotation of genomic regions from multiple datasets

Gyan Prakash Mishra, Arup Ghosh, Atimukta Jha, Sunil Kumar Raghav,

A large number of genomic regions captured during next generation sequencing (NGS) data analyses are generally overlapped to answer a variety of biological questions. Though several command-line tools are available to perform such analysis, there is lack of a comprehensive web server application to perform the genomic region intersections from ... Read more >>

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Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages.

Srabasti Sengupta, Saba Naz, Ishani Das, Abdul Ahad, Avinash Padhi, Sumanta Kumar Naik, Geetanjali Ganguli, Kali Prasad Pattanaik, Sunil Kumar Raghav, Vinay Kumar Nandicoori, Avinash Sonawane,

<i>Mycobacterium tuberculosis</i> is known to modulate the host immune responses to facilitate its persistence inside the host cells. One of the key mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise mechanism of CIITA and MHC-II down-regulation is not well studied. <i>M. tuberculosis</i> ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2017, 292(17):6855-6868]

Cited: 5 times

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A novel coumarin derivative, 8-methoxy chromen-2-one alleviates collagen induced arthritis by down regulating nitric oxide, NFκB and proinflammatory cytokines.

Debasis Sahu, Sunil Kumar Raghav, Hemlata Gautam, Hasi R Das,

Ruta graveolens (Rue) is a well-known medicinal plant having anti-inflammatory and other healing properties. This contains many active phytochemicals such as coumarins which possess anti-inflammatory and anti-cancer activities. The present study was carried out to evaluate the therapeutic potential of a newly isolated coumarin derivative from rue plant, 8-methoxy-chromen-2-one (MCO) ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2015, 29(2):891-900]

Cited: 2 times

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Genome-wide profiling of DNA-binding proteins using barcode-based multiplex Solexa sequencing.

Sunil Kumar Raghav, Bart Deplancke,

Chromatin immunoprecipitation (ChIP) is a commonly used technique to detect the in vivo binding of proteins to DNA. ChIP is now routinely paired to microarray analysis (ChIP-chip) or next-generation sequencing (ChIP-Seq) to profile the DNA occupancy of proteins of interest on a genome-wide level. Because ChIP-chip introduces several biases, most ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2012, 786:247-262]

Cited: 5 times

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Anti-MBL autoantibodies in patients with rheumatoid arthritis: prevalence and clinical significance.

Bhawna Gupta, Sunil Kumar Raghav, Charu Agrawal, Ved Prakash Chaturvedi, Rakha Hari Das, Hasi Rani Das,

Occurrence of autoantibodies in patients' sera is the characteristic feature of autoimmune disorders. We assessed the presence of anti-mannose binding lectin (MBL) autoantibodies in the sera of 107 rheumatoid arthritis (RA) patients and 121 control subjects by enzyme immunoassay. Elevated levels of anti-MBL autoantibodies in the sera of RA patients ... Read more >>

J Autoimmun (Journal of autoimmunity)
[2006, 27(2):125-133]

Cited: 24 times

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Expression of TNF-alpha and related signaling molecules in the peripheral blood mononuclear cells of rheumatoid arthritis patients.

Sunil Kumar Raghav, Bhawna Gupta, Charu Agrawal, Ved P Chaturvedi, Hasi R Das,

We examined the role of tumor necrosis factor (TNF-alpha) and its related signaling intermediates leading to apoptosis/proliferation in the peripheral blood mononuclear cells (PBMCs) of RA patients. The constitutive expression of mRNA for TNF-alpha receptors (TNFR-I and TNFR-II) and the adapter molecules, such as the TNF receptor-associated death domain protein ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2006, 2006(3):12682]

Cited: 14 times

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Inhibition of lipopolysaccharide-inducible nitric oxide synthase and IL-1beta through suppression of NF-kappaB activation by 3-(1'-1'-dimethyl-allyl)-6-hydroxy-7-methoxy-coumarin isolated from Ruta graveolens L.

Sunil Kumar Raghav, Bhawna Gupta, Anju Shrivastava, Hasi Rani Das,

The Ruta graveolens L. plant is used in traditional medicine to treat a large number of diseases. The methanol (50%) extract of the whole plant was observed to inhibit the expression of inducible nitric oxide synthase (iNOS) and the cycloxygenase-2 (COX-2) gene in lipopolysaccharide (LPS)-induced macrophage cells (J774A.1, [Raghav, S.K., ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2007, 560(1):69-80]

Cited: 20 times

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Tumor necrosis factor-alpha microsatellite polymorphism association with rheumatoid arthritis in Indian patients.

Charu Agrawal, Sunil Kumar Raghav, Bhawna Gupta, Rakha Hari Das, Ved Prakash Chaturvedi, Kalyan Goswami, Hasi Rani Das,

<h4>Background</h4>Level of TNF-alpha increases significantly in synovial fluid of rheumatoid arthritis (RA) patients. It is proposed that tumor necrosis factor (TNF) microsatellite alleles may influence its expression and presumably can contribute to the disease severity. However, there is a lack of such study to predict any such association with RA ... Read more >>

Arch Med Res (Archives of medical research)
[2005, 36(5):555-559]

Cited: 9 times

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